Table of Contents

Articles

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  IN VIVO METABOLISM OF [¹⁴C]RUBOXISTAURIN IN DOGS, MICE, AND RATS FOLLOWING ORAL ADMINISTRATION AND THE STRUCTURE DETERMINATION OF ITS METABOLITES BY LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY AND NMR SPECTROSCOPY

  Robert J. Barbuch, Kristina Campanale, Chad E. Hadden, Milton Zmijewski, Ping Yi, Douglas D. O'Bannon, Jennifer L. Burkey and Palaniappan Kulanthaivel

  Drug Metabolism and Disposition February 2006, 34 (2) 213-224; DOI: https://doi.org/10.1124/dmd.105.007401
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  METABOLISM OF MOMETASONE FUROATE AND BIOLOGICAL ACTIVITY OF THE METABOLITES

  S. Sahasranaman, M. Issar and G. Hochhaus

  Drug Metabolism and Disposition February 2006, 34 (2) 225-233; DOI: https://doi.org/10.1124/dmd.105.005702
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  DISTINCT ROLE OF BILOBALIDE AND GINKGOLIDE A IN THE MODULATION OF RAT CYP2B1 AND CYP3A23 GENE EXPRESSION BY GINKGO BILOBA EXTRACT IN CULTURED HEPATOCYTES

  Thomas K. H. Chang, Jie Chen and Xiao Wei Teng

  Drug Metabolism and Disposition February 2006, 34 (2) 234-242; DOI: https://doi.org/10.1124/dmd.105.005751
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  CHARACTERIZATION OF THE IN VITRO METABOLISM OF SELECTIVE ANDROGEN RECEPTOR MODULATOR USING HUMAN, RAT, AND DOG LIVER ENZYME PREPARATIONS

  Wenqing Gao, Zengru Wu, Casey E. Bohl, Jun Yang, Duane D. Miller and James T. Dalton

  Drug Metabolism and Disposition February 2006, 34 (2) 243-253; DOI: https://doi.org/10.1124/dmd.105.007112
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  INTERSPECIES DIFFERENCES IN PHARMACOKINETICS AND METABOLISM OF S-3-(4-ACETYLAMINO-PHENOXY)-2-HYDROXY-2-METHYL-N-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-PROPIONAMIDE: THE ROLE OF N-ACETYLTRANSFERASE

  Wenqing Gao, Jeffrey S. Johnston, Duane D. Miller and James T. Dalton

  Drug Metabolism and Disposition February 2006, 34 (2) 254-260; DOI: https://doi.org/10.1124/dmd.105.007120
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  ROLE OF MRP2 IN THE HEPATIC DISPOSITION OF MYCOPHENOLIC ACID AND ITS GLUCURONIDE METABOLITES: EFFECT OF CYCLOSPORINE

  Ian S. Westley, Leonie R. Brogan, Raymond G. Morris, Allan M. Evans and Benedetta C. Sallustio

  Drug Metabolism and Disposition February 2006, 34 (2) 261-266; DOI: https://doi.org/10.1124/dmd.105.006122
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  STRUCTURAL ELUCIDATION OF HUMAN OXIDATIVE METABOLITES OF MURAGLITAZAR: USE OF MICROBIAL BIOREACTORS IN THE BIOSYNTHESIS OF METABOLITE STANDARDS

  Donglu Zhang, Haiying Zhang, Nelly Aranibar, Ronald Hanson, Yande Huang, Peter T. Cheng, Shung Wu, Samuel Bonacorsi, Mingshe Zhu, Arun Swaminathan and W. Griffith Humphreys

  Drug Metabolism and Disposition February 2006, 34 (2) 267-280; DOI: https://doi.org/10.1124/dmd.105.007153
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  METABOLISM OF THE PSYCHOTOMIMETIC TRYPTAMINE DERIVATIVE 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE IN HUMANS: IDENTIFICATION AND QUANTIFICATION OF ITS URINARY METABOLITES

  Tooru Kamata, Munehiro Katagi, Hiroe T. Kamata, Akihiro Miki, Noriaki Shima, Kei Zaitsu, Mayumi Nishikawa, Einosuke Tanaka, Katsuya Honda and Hitoshi Tsuchihashi

  Drug Metabolism and Disposition February 2006, 34 (2) 281-287; DOI: https://doi.org/10.1124/dmd.105.005835
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  BRAIN CYCLOSPORIN A LEVELS ARE DETERMINED BY ONTOGENIC REGULATION OF MDR1A EXPRESSION

  Kerry B. Goralski, Philip D. Acott, Albert D. Fraser, David Worth and Christopher J. Sinal

  Drug Metabolism and Disposition February 2006, 34 (2) 288-295; DOI: https://doi.org/10.1124/dmd.105.007427
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  INHIBITION OF LUNG CANCER CELL GROWTH BY QUERCETIN GLUCURONIDES VIA G₂/M ARREST AND INDUCTION OF APOPTOSIS

  Jen-Hung Yang, Te-Chun Hsia, Hsiu-Maan Kuo, Pei-Dawn Lee Chao, Chi-Chung Chou, Yau-Huei Wei and Jing-Gung Chung

  Drug Metabolism and Disposition February 2006, 34 (2) 296-304; DOI: https://doi.org/10.1124/dmd.105.005280
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  DEMONSTRATION OF DOCOSAHEXAENOIC ACID AS A BIOAVAILABILITY ENHANCER FOR CYP3A SUBSTRATES: IN VITRO AND IN VIVO EVIDENCE USING CYCLOSPORIN IN RATS

  Vilasinee Hirunpanich, Jun Katagi, Benjabhorn Sethabouppha and Hitoshi Sato

  Drug Metabolism and Disposition February 2006, 34 (2) 305-310; DOI: https://doi.org/10.1124/dmd.105.007088
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  INEFFICIENT REPAIR OF TAMOXIFEN-DNA ADDUCTS IN RATS AND MICE

  Sung Yeon Kim, Naomi Suzuki, Y. R. Santosh Laxmi and Shinya Shibutani

  Drug Metabolism and Disposition February 2006, 34 (2) 311-317; DOI: https://doi.org/10.1124/dmd.105.007013
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  BRAIN DISTRIBUTION OF CETIRIZINE ENANTIOMERS: COMPARISON OF THREE DIFFERENT TISSUE-TO-PLASMA PARTITION COEFFICIENTS: K_p, K_p,u, AND K_p,uu

  Anubha Gupta, Pierre Chatelain, Roy Massingham, E. Niclas Jonsson and Margareta Hammarlund-Udenaes

  Drug Metabolism and Disposition February 2006, 34 (2) 318-323; DOI: https://doi.org/10.1124/dmd.105.007211
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  DEVELOPMENT OF NOVEL FURANOCOUMARIN DIMERS AS POTENT AND SELECTIVE INHIBITORS OF CYP3A4

  E. Row, S. A. Brown, A. V. Stachulski and M. S. Lennard

  Drug Metabolism and Disposition February 2006, 34 (2) 324-330; DOI: https://doi.org/10.1124/dmd.105.007294
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  DISTRIBUTION OF (7α)-21-[4-[(DIETHYLAMINO) METHYL]-2-METHOXYPHENOXY]-7-METHYL-19-NORPREGNA-1,3,5(10)-TRIEN-3-OL-20-[¹⁴C]2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE ([¹⁴C]TAS-108) AND ITS METABOLITES AFTER SINGLE ORAL ADMINISTRATION TO RATS BEARING 7,12-DIMETHYLBENZ(α)ANTHRACENE-INDUCED MAMMARY TUMOR

  Hidetoshi Yamaya, Mayuko Saeki, Ken-ichiro Yoshida, Jiro Shibata, Shingo Yano, Yoshiaki Sato, Atsushi Takao, Takashi Shindo, Aman U. Buzdar and Sekio Nagayama

  Drug Metabolism and Disposition February 2006, 34 (2) 331-338; DOI: https://doi.org/10.1124/dmd.105.005504