Drug Metabolism and Disposition: 34 (2)

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A schematic degradation pathway for conversion of MF into its degradation products D1, D2, and D3 on incubation of MF (C₀ = 6.2µM) in plasma at 37°C for 72 h. See the article by Sahasranaman et al. on page 225 of this issue.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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