Drug Metabolism and Disposition: 34 (3)

March 01, 2006; Volume 34,Issue 3

Short Communications

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DIGITAL FLUORESCENCE IMAGING OF ORGANIC CATION TRANSPORT IN FRESHLY ISOLATED RAT PROXIMAL TUBULES
Frank Pietruck, Markus Horbelt, Thorsten Feldkamp, Katrin Engeln, Stefan Herget-Rosenthal, Thomas Philipp and Andreas Kribben

Drug Metabolism and Disposition March 2006, 34 (3) 339-342; DOI: https://doi.org/10.1124/dmd.105.006403
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TRANSIENT INHIBITION OF CYP3A IN RATS BY STAR FRUIT JUICE
Muneaki Hidaka, Manabu Okumura, Tetsuya Ogikubo, Hirofumi Kai, Ken-Ichi Fujita, Tomomi Iwakiri, Keishi Yamasaki, Nao Setoguchi, Naoya Matsunaga and Kazuhiko Arimori

Drug Metabolism and Disposition March 2006, 34 (3) 343-345; DOI: https://doi.org/10.1124/dmd.105.006486
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BENZO[A]PYRENE-INDUCED ORAL CARCINOGENESIS AND CHEMOPREVENTION: STUDIES IN BIOENGINEERED HUMAN TISSUE
Thomas Walle, U. Kristina Walle, David Sedmera and Mitch Klausner

Drug Metabolism and Disposition March 2006, 34 (3) 346-350; DOI: https://doi.org/10.1124/dmd.105.007948
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EXPRESSION OF UDP-GLUCURONOSYLTRANSFERASE ISOFORM mRNAS DURING INFLAMMATION AND INFECTION IN MOUSE LIVER AND KIDNEY
Terrilyn A. Richardson, Melanie Sherman, Daniel Kalman and Edward T. Morgan

Drug Metabolism and Disposition March 2006, 34 (3) 351-353; DOI: https://doi.org/10.1124/dmd.105.007435

Articles

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HEPATIC AND RENAL CYTOCHROME P450 GENE REGULATION DURING CITROBACTER RODENTIUM INFECTION IN WILD-TYPE AND TOLL-LIKE RECEPTOR 4 MUTANT MICE
Terrilyn A. Richardson, Melanie Sherman, Leposava Antonovic, Sean S. Kardar, Henry W. Strobel, Daniel Kalman and Edward T. Morgan

Drug Metabolism and Disposition March 2006, 34 (3) 354-360; DOI: https://doi.org/10.1124/dmd.105.007393
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SULFATION OF RALOXIFENE AND 4-HYDROXYTAMOXIFEN BY HUMAN CYTOSOLIC SULFOTRANSFERASES
Josie L. Falany, Daniel E. Pilloff, Thomas S. Leyh and Charles N. Falany

Drug Metabolism and Disposition March 2006, 34 (3) 361-368; DOI: https://doi.org/10.1124/dmd.105.006551
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IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST
Masato Nakamura, Yasunori Kawakita, Akito Yasuhara, Yoshiki Fukasawa, Koji Yoshida, Kazunari Sakagami and Atsuro Nakazato

Drug Metabolism and Disposition March 2006, 34 (3) 369-374; DOI: https://doi.org/10.1124/dmd.105.006213
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SELECTIVE PATHWAYS FOR THE METABOLISM OF PHENCYCLIDINE BY CYTOCHROME P450 2B ENZYMES: IDENTIFICATION OF ELECTROPHILIC METABOLITES, GLUTATHIONE, AND N-ACETYL CYSTEINE ADDUCTS
Mohamad Shebley, Monica I. Jushchyshyn and Paul F. Hollenberg

Drug Metabolism and Disposition March 2006, 34 (3) 375-383; DOI: https://doi.org/10.1124/dmd.105.007047
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EVALUATION OF MICRODOSING TO ASSESS PHARMACOKINETIC LINEARITY IN RATS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Suresh K. Balani, Nelamangala V. Nagaraja, Mark G. Qian, Arnaldo O. Costa, J. Scott Daniels, Hua Yang, Prakash R. Shimoga, Jing-Tao Wu, Liang-Shang Gan, Frank W. Lee and Gerald T. Miwa

Drug Metabolism and Disposition March 2006, 34 (3) 384-388; DOI: https://doi.org/10.1124/dmd.105.007195
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ONTOGENY OF HEPATIC AND PLASMA METABOLISM OF DELTAMETHRIN IN VITRO: ROLE IN AGE-DEPENDENT ACUTE NEUROTOXICITY
Sathanandam S. Anand, Kyu-Bong Kim, Stephanie Padilla, Srinivasa Muralidhara, Hyo J. Kim, Jeffrey W. Fisher and James V. Bruckner

Drug Metabolism and Disposition March 2006, 34 (3) 389-397; DOI: https://doi.org/10.1124/dmd.105.007807
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FIRST-PASS HYDROLYSIS OF A PROPRANOLOL ESTER DERIVATIVE IN RAT SMALL INTESTINE
Kenji Masaki, Megumi Taketani and Teruko Imai

Drug Metabolism and Disposition March 2006, 34 (3) 398-404; DOI: https://doi.org/10.1124/dmd.105.007682
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THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED INDUCTION OF DRUG TRANSPORT AND -METABOLIZING ENZYMES IN MICE
Alexander Anapolsky, Shirley Teng, Santosh Dixit and Micheline Piquette-Miller

Drug Metabolism and Disposition March 2006, 34 (3) 405-409; DOI: https://doi.org/10.1124/dmd.105.006197
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INDUCIBILITY OF MALE-SPECIFIC ISOFORMS OF CYTOCHROME P450 BY SEX-DEPENDENT GROWTH HORMONE PROFILES IN HEPATOCYTE CULTURES FROM MALE BUT NOT FEMALE RATS
Chellappagounder Thangavel, Wojciech Dworakowski and Bernard H. Shapiro

Drug Metabolism and Disposition March 2006, 34 (3) 410-419; DOI: https://doi.org/10.1124/dmd.105.007716
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METABOLISM AND EXCRETION OF ERLOTINIB, A SMALL MOLECULE INHIBITOR OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE, IN HEALTHY MALE VOLUNTEERS
Jie Ling, Kim A. Johnson, Zhuang Miao, Ashok Rakhit, Michael P. Pantze, Marta Hamilton, Bert L. Lum and Chandra Prakash

Drug Metabolism and Disposition March 2006, 34 (3) 420-426; DOI: https://doi.org/10.1124/dmd.105.007765
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GLUCURONIDATION AS A MAJOR METABOLIC CLEARANCE PATHWAY OF ¹⁴C-LABELED MURAGLITAZAR IN HUMANS: METABOLIC PROFILES IN SUBJECTS WITH OR WITHOUT BILE COLLECTION
Lifei Wang, Donglu Zhang, Arun Swaminathan, Yongjun Xue, Peter T. Cheng, Shung Wu, Rogelio Mosqueda-Garcia, Catherine Aurang, Donald W. Everett and W. Griffith Humphreys

Drug Metabolism and Disposition March 2006, 34 (3) 427-439; DOI: https://doi.org/10.1124/dmd.105.007617
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NOVEL METABOLITES OF BUPRENORPHINE DETECTED IN HUMAN LIVER MICROSOMES AND HUMAN URINE
Yan Chang, David E. Moody and Elinore F. McCance-Katz

Drug Metabolism and Disposition March 2006, 34 (3) 440-448; DOI: https://doi.org/10.1124/dmd.105.006148
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SELECTIVITY OF SUBSTRATE (TRIFLUOPERAZINE) AND INHIBITOR (AMITRIPTYLINE, ANDROSTERONE, CANRENOIC ACID, HECOGENIN, PHENYLBUTAZONE, QUINIDINE, QUININE, AND SULFINPYRAZONE) “PROBES” FOR HUMAN UDP-GLUCURONOSYLTRANSFERASES
Verawan Uchaipichat, Peter I. Mackenzie, David J. Elliot and John O. Miners

Drug Metabolism and Disposition March 2006, 34 (3) 449-456; DOI: https://doi.org/10.1124/dmd.105.007369
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MODULATION OF THE P-GLYCOPROTEIN-MEDIATED INTESTINAL SECRETION OF IVERMECTIN: IN VITRO AND IN VIVO ASSESSMENTS
M. Ballent, A. Lifschitz, G. Virkel, J. Sallovitz and C. Lanusse

Drug Metabolism and Disposition March 2006, 34 (3) 457-463; DOI: https://doi.org/10.1124/dmd.105.007757
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PURIFICATION AND CHARACTERIZATION OF AKR1B10 FROM HUMAN LIVER: ROLE IN CARBONYL REDUCTION OF XENOBIOTICS
Hans-Jörg Martin, Ursula Breyer-Pfaff, Vladimir Wsol, Simone Venz, Simone Block and Edmund Maser

Drug Metabolism and Disposition March 2006, 34 (3) 464-470; DOI: https://doi.org/10.1124/dmd.105.007971
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CHARACTERIZATION OF HUMAN CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF THE PIPERIDINE-TYPE PHENOTHIAZINE NEUROLEPTIC THIORIDAZINE
Jacek Wójcikowski, Patrick Maurel and Władysława A. Daniel

Drug Metabolism and Disposition March 2006, 34 (3) 471-476; DOI: https://doi.org/10.1124/dmd.105.006445
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TISSUE DISTRIBUTION AND ONTOGENY OF ORGANIC CATION TRANSPORTERS IN MICE
Yazen Alnouti, Jay S. Petrick and Curtis D. Klaassen

Drug Metabolism and Disposition March 2006, 34 (3) 477-482; DOI: https://doi.org/10.1124/dmd.105.006932
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PHARMACOKINETICS AND METABOLISM OF A SELECTIVE ANDROGEN RECEPTOR MODULATOR IN RATS: IMPLICATION OF MOLECULAR PROPERTIES AND INTENSIVE METABOLIC PROFILE TO INVESTIGATE IDEAL PHARMACOKINETIC CHARACTERISTICS OF A PROPANAMIDE IN PRECLINICAL STUDY
Di Wu, Zengru Wu, Jun Yang, Vipin A. Nair, Duane D. Miller and James T. Dalton

Drug Metabolism and Disposition March 2006, 34 (3) 483-494; DOI: https://doi.org/10.1124/dmd.105.006643
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A COMBINED APPROACH TO DRUG METABOLISM AND TOXICITY ASSESSMENT
Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A. Rakhmatulin, Svetlana Sorokina, Andrej Bugrim and Tatiana Nikolskaya

Drug Metabolism and Disposition March 2006, 34 (3) 495-503; DOI: https://doi.org/10.1124/dmd.105.008458

Letters to the Editor

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COMMENTS ON HOSKINS ET AL. [(2005) DRUG METAB DISPOS 33:1564–1565]
Andrea Gaedigk and J. Steven Leeder

Drug Metabolism and Disposition March 2006, 34 (3) 504-505; DOI: https://doi.org/10.1124/dmd.105.007799
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RESPONSE TO COMMENTS ON HOSKINS ET AL. [(2005) DRUG METAB DISPOS 33:1564–1565]
Harish V. Pai and Vijayalakshmi Ravindranath

Drug Metabolism and Disposition March 2006, 34 (3) 506; DOI: https://doi.org/10.1124/dmd.105.008862
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COMMENTS ON “A MATHEMATICAL DESCRIPTION OF THE FUNCTIONALITY OF CORRECTION FACTORS USED IN ALLOMETRY FOR PREDICTING HUMAN DRUG CLEARANCE”
Iftekhar Mahmood

Drug Metabolism and Disposition March 2006, 34 (3) 507-509; DOI: https://doi.org/10.1124/dmd.105.007187
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RESPONSE TO COMMENTS ON “A MATHEMATICAL DESCRIPTION OF THE FUNCTIONALITY OF CORRECTION FACTORS USED IN ALLOMETRY FOR PREDICTING HUMAN DRUG CLEARANCE”
Huadong Tang and Michael Mayersohn

Drug Metabolism and Disposition March 2006, 34 (3) 510-511; DOI: https://doi.org/10.1124/dmd.105.008359

Erratum

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CORRECTION TO “METABOLISM OF THE PSYCHOTOMIMETIC TRYPTAMINE DERIVATIVE 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE IN HUMANS: IDENTIFICATION AND QUANTIFICATION OF ITS URINARY METABOLITES”
Drug Metabolism and Disposition March 2006, 34 (3) 512; DOI: https://doi.org/10.1124/dmd.34.3.512

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