Drug Metabolism and Disposition: 34 (4)

April 01, 2006; Volume 34,Issue 4

MINIREVIEWS

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CHOLESTEROL-METABOLIZING CYTOCHROMES P450
Irina A. Pikuleva

Drug Metabolism and Disposition April 2006, 34 (4) 513-520; DOI: https://doi.org/10.1124/dmd.105.008789

Short Communication

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INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY
Hyunmi Kim, Yune-Jung Yoon, Ji-Hong Shon, In-June Cha, Jae-Gook Shin and Kwang-Hyeon Liu

Drug Metabolism and Disposition April 2006, 34 (4) 521-523; DOI: https://doi.org/10.1124/dmd.105.007930

Articles

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EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP)
Henriette E. Meyer zu Schwabedissen, Markus Grube, Annette Dreisbach, Gabriele Jedlitschky, Konrad Meissner, Knud Linnemann, Christoph Fusch, Christoph A. Ritter, Uwe Völker and Heyo K. Kroemer

Drug Metabolism and Disposition April 2006, 34 (4) 524-533; DOI: https://doi.org/10.1124/dmd.105.007591
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IN SILICO AND IN VITRO SCREENING FOR INHIBITION OF CYTOCHROME P450 CYP3A4 BY COMEDICATIONS COMMONLY USED BY PATIENTS WITH CANCER
Jean-Didier Marechal, Jinglei Yu, Simon Brown, Iouri Kapelioukh, Elaine M. Rankin, C. Roland Wolf, Gordon C. K. Roberts, Mark. J. I. Paine and Michael J. Sutcliffe

Drug Metabolism and Disposition April 2006, 34 (4) 534-538; DOI: https://doi.org/10.1124/dmd.105.007625
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MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY
Da-Wei Zhang, Kenichi Nunoya, Monika Vasa, Hong-Mei Gu, Susan P. C. Cole and Roger G. Deeley

Drug Metabolism and Disposition April 2006, 34 (4) 539-546; DOI: https://doi.org/10.1124/dmd.105.007740
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INTERACTIONS OF AMOXICILLIN AND CEFACLOR WITH HUMAN RENAL ORGANIC ANION AND PEPTIDE TRANSPORTERS
Meng Li, Gail D. Anderson, Brian R. Phillips, Wei Kong, Danny D. Shen and Joanne Wang

Drug Metabolism and Disposition April 2006, 34 (4) 547-555; DOI: https://doi.org/10.1124/dmd.105.006791
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CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS
Brendan M. Johnson, Peijin Zhang, John D. Schuetz and Kim L. R. Brouwer

Drug Metabolism and Disposition April 2006, 34 (4) 556-562; DOI: https://doi.org/10.1124/dmd.105.005793
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CYP2D6*36 GENE ARRANGEMENTS WITHIN THE CYP2D6 LOCUS: ASSOCIATION OF CYP2D6*36 WITH POOR METABOLIZER STATUS
Andrea Gaedigk, L. DiAnne Bradford, Sarah W. Alander and J. Steven Leeder

Drug Metabolism and Disposition April 2006, 34 (4) 563-569; DOI: https://doi.org/10.1124/dmd.105.008292
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METABOLISM OF THE A₁ ADENOSINE RECEPTOR POSITRON EMISSION TOMOGRAPHY LIGAND [¹⁸F]8-CYCLOPENTYL-3-(3-FLUOROPROPYL)-1-PROPYLXANTHINE ([¹⁸F]CPFPX) IN RODENTS AND HUMANS
Dirk Bier, Marcus H. Holschbach, Walter Wutz, Ray A. Olsson and Heinz H. Coenen

Drug Metabolism and Disposition April 2006, 34 (4) 570-576; DOI: https://doi.org/10.1124/dmd.105.006411
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EFFECTS OF HERBAL EXTRACTS ON THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
Hiromi Fuchikami, Hiroki Satoh, Masayuki Tsujimoto, Shigehiro Ohdo, Hisakazu Ohtani and Yasufumi Sawada

Drug Metabolism and Disposition April 2006, 34 (4) 577-582; DOI: https://doi.org/10.1124/dmd.105.007872
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STEREOCHEMICAL ASPECTS OF ITRACONAZOLE METABOLISM IN VITRO AND IN VIVO
Kent L. Kunze, Wendel L. Nelson, Evan D. Kharasch, Kenneth E. Thummel and Nina Isoherranen

Drug Metabolism and Disposition April 2006, 34 (4) 583-590; DOI: https://doi.org/10.1124/dmd.105.008508
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EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION
Inge A. M. de Graaf, Ruben de Kanter, Marina H. de Jager, Raquel Camacho, Elise Langenkamp, Esther G. van de Kerkhof and Geny M. M. Groothuis

Drug Metabolism and Disposition April 2006, 34 (4) 591-599; DOI: https://doi.org/10.1124/dmd.105.006726
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INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
Jessica L. Fayer Rehmel, James A. Eckstein, Nagy A. Farid, John B. Heim, Steve C. Kasper, Atsushi Kurihara, Steven A. Wrighton and Barbara J. Ring

Drug Metabolism and Disposition April 2006, 34 (4) 600-607; DOI: https://doi.org/10.1124/dmd.105.007989
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IN VITRO AND IN VIVO INHIBITORY EFFECT OF STIRIPENTOL ON CLOBAZAM METABOLISM
Carole Giraud, Jean-Marc Treluyer, Elisabeth Rey, Catherine Chiron, Jean Vincent, Gérard Pons and Agnès Tran

Drug Metabolism and Disposition April 2006, 34 (4) 608-611; DOI: https://doi.org/10.1124/dmd.105.007237
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S-2-PENTYL-4-PENTYNOIC HYDROXAMIC ACID AND ITS METABOLITE S-2-PENTYL-4-PENTYNOIC ACID IN THE NMRI-EXENCEPHALY-MOUSE MODEL: PHARMACOKINETIC PROFILES, TERATOGENIC EFFECTS, AND HISTONE DEACETYLASE INHIBITION ABILITIES OF FURTHER VALPROIC ACID HYDROXAMATES AND AMIDES
Daniel Eikel, Katrin Hoffmann, Karolin Zoll, Alfonso Lampen and Heinz Nau

Drug Metabolism and Disposition April 2006, 34 (4) 612-620; DOI: https://doi.org/10.1124/dmd.105.008078
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EFFECT OF CHRONIC RENAL INSUFFICIENCY ON HEPATIC AND RENAL UDP-GLUCURONYLTRANSFERASES IN RATS
Chuanhui Yu, Joseph K. Ritter, Richard J. Krieg, Bhaskar Rege, Thomas H. Karnes and Mohamadi A. Sarkar

Drug Metabolism and Disposition April 2006, 34 (4) 621-627; DOI: https://doi.org/10.1124/dmd.105.006601
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IDENTIFICATION OF HUMAN LIVER CYTOCHROME P450 ENZYMES RESPONSIBLE FOR THE METABOLISM OF LONAFARNIB (SARASAR)
Anima Ghosal, Swapan K. Chowdhury, Wei Tong, Neil Hapangama, Yuan Yuan, Ai-Duen Su and Shmuel Zbaida

Drug Metabolism and Disposition April 2006, 34 (4) 628-635; DOI: https://doi.org/10.1124/dmd.105.007906
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FETAL MORPHINE METABOLISM AND CLEARANCE ARE CONSTANT DURING LATE GESTATION
Marianne Garland, Kirsten M. Abildskov, Samantha Taylor, Kenza Benzeroual, Casper S. Caspersen, Sylvia E. Arroyo, Tung-wah Kiu, Boris Reznik, Piper Weldy, Salha S. Daniel and Raymond I. Stark

Drug Metabolism and Disposition April 2006, 34 (4) 636-646; DOI: https://doi.org/10.1124/dmd.105.007567
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INDUCTION AND RECOVERY TIME COURSE OF RAT BRAIN CYP2E1 AFTER NICOTINE TREATMENT
Meenal Joshi and Rachel F. Tyndale

Drug Metabolism and Disposition April 2006, 34 (4) 647-652; DOI: https://doi.org/10.1124/dmd.105.008029
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DEPENDENCE OF NELFINAVIR BRAIN UPTAKE ON DOSE AND TISSUE CONCENTRATIONS OF THE SELECTIVE P-GLYCOPROTEIN INHIBITOR ZOSUQUIDAR IN RATS
Bradley D. Anderson, Melissa J. May, Sherri Jordan, Lin Song, Michael J. Roberts and Markos Leggas

Drug Metabolism and Disposition April 2006, 34 (4) 653-659; DOI: https://doi.org/10.1124/dmd.105.006536
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AN EVALUATION OF METHODS FOR THE RECONSTITUTION OF CYTOCHROMES P450 AND NADPH P450 REDUCTASE INTO LIPID VESICLES
James R. Reed, Rusty W. Kelley and Wayne L. Backes

Drug Metabolism and Disposition April 2006, 34 (4) 660-666; DOI: https://doi.org/10.1124/dmd.105.006825
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IN VITRO METABOLISM OF FERROQUINE (SSR97193) IN ANIMAL AND HUMAN HEPATIC MODELS AND ANTIMALARIAL ACTIVITY OF MAJOR METABOLITES ON PLASMODIUM FALCIPARUM
Wassim Daher, Lydie Pelinski, Sylvie Klieber, Freddy Sadoun, Viviane Meunier, Martine Bourrié, Christophe Biot, François Guillou, Gérard Fabre, Jacques Brocard, Laurent Fraisse, Jean-Pierre Maffrand, Jamal Khalife and Daniel Dive

Drug Metabolism and Disposition April 2006, 34 (4) 667-682; DOI: https://doi.org/10.1124/dmd.104.003202
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THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK
Sang K. Kim, Mohamed A. Abdelmegeed and Raymond F. Novak

Drug Metabolism and Disposition April 2006, 34 (4) 683-689; DOI: https://doi.org/10.1124/dmd.105.007666
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BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) TRANSPORTS FLUOROQUINOLONE ANTIBIOTICS AND AFFECTS THEIR ORAL AVAILABILITY, PHARMACOKINETICS, AND MILK SECRETION
Gracia Merino, Ana I. Álvarez, Mivis M. Pulido, Antonio J. Molina, Alfred H. Schinkel and Julio G. Prieto

Drug Metabolism and Disposition April 2006, 34 (4) 690-695; DOI: https://doi.org/10.1124/dmd.105.008219
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CHARACTERIZATION OF CYTOCHROME P450 EXPRESSION IN MURINE EMBRYONIC STEM CELL-DERIVED HEPATIC TISSUE SYSTEM
Masaru Tsutsui, Shinichiro Ogawa, Yoichi Inada, Eisuke Tomioka, Akiko Kamiyoshi, Satoru Tanaka, Tomoyuki Kishida, Masahiko Nishiyama, Makoto Murakami, Junji Kuroda, Yasuhiko Hashikura, Shinichi Miyagawa, Fumiyasu Satoh, Nobuo Shibata and Yoh-ichi Tagawa

Drug Metabolism and Disposition April 2006, 34 (4) 696-701; DOI: https://doi.org/10.1124/dmd.105.007674
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INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES
Chuang Lu, Richard Gallegos, Ping Li, Cindy Q. Xia, Sandeepraj Pusalkar, Vinita Uttamsingh, Darrell Nix, Gerald T. Miwa and Liang-Shang Gan

Drug Metabolism and Disposition April 2006, 34 (4) 702-708; DOI: https://doi.org/10.1124/dmd.105.008060
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IN VITRO METABOLIC ACTIVATION OF THIABENDAZOLE VIA 5-HYDROXYTHIABENDAZOLE: IDENTIFICATION OF A GLUTATHIONE CONJUGATE OF 5-HYDROXYTHIABENDAZOLE
Deepak Dalvie, Evan Smith, Alan Deese and Stephen Bowlin

Drug Metabolism and Disposition April 2006, 34 (4) 709-717; DOI: https://doi.org/10.1124/dmd.105.008094
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ALTERED HEPATOBILIARY DISPOSITION OF 5 (AND 6)-CARBOXY-2′,7′-DICHLOROFLUORESCEIN IN Abcg2 (Bcrp1) AND Abcc2 (Mrp2) KNOCKOUT MICE
Ken-ichi Nezasa, Xianbin Tian, Maciej J. Zamek-Gliszczynski, Nita J. Patel, Thomas J. Raub and Kim L. R. Brouwer

Drug Metabolism and Disposition April 2006, 34 (4) 718-723; DOI: https://doi.org/10.1124/dmd.105.007922

Letters to the Editor

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BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT
David Hallifax and J. Brian Houston

Drug Metabolism and Disposition April 2006, 34 (4) 724-726; DOI: https://doi.org/10.1124/dmd.105.007658
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RESPONSE TO “BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT”
R. P. Austin, P. Barton and R. J. Riley

Drug Metabolism and Disposition April 2006, 34 (4) 727; DOI: https://doi.org/10.1124/dmd.105.009142

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