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Drug Metabolism & Disposition

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Table of Contents

April 01, 2006; Volume 34,Issue 4

MINIREVIEWS

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    CHOLESTEROL-METABOLIZING CYTOCHROMES P450
    Irina A. Pikuleva
    Drug Metabolism and Disposition April 2006, 34 (4) 513-520; DOI: https://doi.org/10.1124/dmd.105.008789

Short Communication

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    INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY
    Hyunmi Kim, Yune-Jung Yoon, Ji-Hong Shon, In-June Cha, Jae-Gook Shin and Kwang-Hyeon Liu
    Drug Metabolism and Disposition April 2006, 34 (4) 521-523; DOI: https://doi.org/10.1124/dmd.105.007930

Articles

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    EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP)
    Henriette E. Meyer zu Schwabedissen, Markus Grube, Annette Dreisbach, Gabriele Jedlitschky, Konrad Meissner, Knud Linnemann, Christoph Fusch, Christoph A. Ritter, Uwe Völker and Heyo K. Kroemer
    Drug Metabolism and Disposition April 2006, 34 (4) 524-533; DOI: https://doi.org/10.1124/dmd.105.007591
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    IN SILICO AND IN VITRO SCREENING FOR INHIBITION OF CYTOCHROME P450 CYP3A4 BY COMEDICATIONS COMMONLY USED BY PATIENTS WITH CANCER
    Jean-Didier Marechal, Jinglei Yu, Simon Brown, Iouri Kapelioukh, Elaine M. Rankin, C. Roland Wolf, Gordon C. K. Roberts, Mark. J. I. Paine and Michael J. Sutcliffe
    Drug Metabolism and Disposition April 2006, 34 (4) 534-538; DOI: https://doi.org/10.1124/dmd.105.007625
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    MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY
    Da-Wei Zhang, Kenichi Nunoya, Monika Vasa, Hong-Mei Gu, Susan P. C. Cole and Roger G. Deeley
    Drug Metabolism and Disposition April 2006, 34 (4) 539-546; DOI: https://doi.org/10.1124/dmd.105.007740
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    INTERACTIONS OF AMOXICILLIN AND CEFACLOR WITH HUMAN RENAL ORGANIC ANION AND PEPTIDE TRANSPORTERS
    Meng Li, Gail D. Anderson, Brian R. Phillips, Wei Kong, Danny D. Shen and Joanne Wang
    Drug Metabolism and Disposition April 2006, 34 (4) 547-555; DOI: https://doi.org/10.1124/dmd.105.006791
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    CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS
    Brendan M. Johnson, Peijin Zhang, John D. Schuetz and Kim L. R. Brouwer
    Drug Metabolism and Disposition April 2006, 34 (4) 556-562; DOI: https://doi.org/10.1124/dmd.105.005793
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    CYP2D6*36 GENE ARRANGEMENTS WITHIN THE CYP2D6 LOCUS: ASSOCIATION OF CYP2D6*36 WITH POOR METABOLIZER STATUS
    Andrea Gaedigk, L. DiAnne Bradford, Sarah W. Alander and J. Steven Leeder
    Drug Metabolism and Disposition April 2006, 34 (4) 563-569; DOI: https://doi.org/10.1124/dmd.105.008292
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    METABOLISM OF THE A1 ADENOSINE RECEPTOR POSITRON EMISSION TOMOGRAPHY LIGAND [18F]8-CYCLOPENTYL-3-(3-FLUOROPROPYL)-1-PROPYLXANTHINE ([18F]CPFPX) IN RODENTS AND HUMANS
    Dirk Bier, Marcus H. Holschbach, Walter Wutz, Ray A. Olsson and Heinz H. Coenen
    Drug Metabolism and Disposition April 2006, 34 (4) 570-576; DOI: https://doi.org/10.1124/dmd.105.006411
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    EFFECTS OF HERBAL EXTRACTS ON THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
    Hiromi Fuchikami, Hiroki Satoh, Masayuki Tsujimoto, Shigehiro Ohdo, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition April 2006, 34 (4) 577-582; DOI: https://doi.org/10.1124/dmd.105.007872
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    STEREOCHEMICAL ASPECTS OF ITRACONAZOLE METABOLISM IN VITRO AND IN VIVO
    Kent L. Kunze, Wendel L. Nelson, Evan D. Kharasch, Kenneth E. Thummel and Nina Isoherranen
    Drug Metabolism and Disposition April 2006, 34 (4) 583-590; DOI: https://doi.org/10.1124/dmd.105.008508
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    EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION
    Inge A. M. de Graaf, Ruben de Kanter, Marina H. de Jager, Raquel Camacho, Elise Langenkamp, Esther G. van de Kerkhof and Geny M. M. Groothuis
    Drug Metabolism and Disposition April 2006, 34 (4) 591-599; DOI: https://doi.org/10.1124/dmd.105.006726
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    INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
    Jessica L. Fayer Rehmel, James A. Eckstein, Nagy A. Farid, John B. Heim, Steve C. Kasper, Atsushi Kurihara, Steven A. Wrighton and Barbara J. Ring
    Drug Metabolism and Disposition April 2006, 34 (4) 600-607; DOI: https://doi.org/10.1124/dmd.105.007989
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    IN VITRO AND IN VIVO INHIBITORY EFFECT OF STIRIPENTOL ON CLOBAZAM METABOLISM
    Carole Giraud, Jean-Marc Treluyer, Elisabeth Rey, Catherine Chiron, Jean Vincent, Gérard Pons and Agnès Tran
    Drug Metabolism and Disposition April 2006, 34 (4) 608-611; DOI: https://doi.org/10.1124/dmd.105.007237
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    S-2-PENTYL-4-PENTYNOIC HYDROXAMIC ACID AND ITS METABOLITE S-2-PENTYL-4-PENTYNOIC ACID IN THE NMRI-EXENCEPHALY-MOUSE MODEL: PHARMACOKINETIC PROFILES, TERATOGENIC EFFECTS, AND HISTONE DEACETYLASE INHIBITION ABILITIES OF FURTHER VALPROIC ACID HYDROXAMATES AND AMIDES
    Daniel Eikel, Katrin Hoffmann, Karolin Zoll, Alfonso Lampen and Heinz Nau
    Drug Metabolism and Disposition April 2006, 34 (4) 612-620; DOI: https://doi.org/10.1124/dmd.105.008078
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    EFFECT OF CHRONIC RENAL INSUFFICIENCY ON HEPATIC AND RENAL UDP-GLUCURONYLTRANSFERASES IN RATS
    Chuanhui Yu, Joseph K. Ritter, Richard J. Krieg, Bhaskar Rege, Thomas H. Karnes and Mohamadi A. Sarkar
    Drug Metabolism and Disposition April 2006, 34 (4) 621-627; DOI: https://doi.org/10.1124/dmd.105.006601
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    IDENTIFICATION OF HUMAN LIVER CYTOCHROME P450 ENZYMES RESPONSIBLE FOR THE METABOLISM OF LONAFARNIB (SARASAR)
    Anima Ghosal, Swapan K. Chowdhury, Wei Tong, Neil Hapangama, Yuan Yuan, Ai-Duen Su and Shmuel Zbaida
    Drug Metabolism and Disposition April 2006, 34 (4) 628-635; DOI: https://doi.org/10.1124/dmd.105.007906
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    FETAL MORPHINE METABOLISM AND CLEARANCE ARE CONSTANT DURING LATE GESTATION
    Marianne Garland, Kirsten M. Abildskov, Samantha Taylor, Kenza Benzeroual, Casper S. Caspersen, Sylvia E. Arroyo, Tung-wah Kiu, Boris Reznik, Piper Weldy, Salha S. Daniel and Raymond I. Stark
    Drug Metabolism and Disposition April 2006, 34 (4) 636-646; DOI: https://doi.org/10.1124/dmd.105.007567
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    INDUCTION AND RECOVERY TIME COURSE OF RAT BRAIN CYP2E1 AFTER NICOTINE TREATMENT
    Meenal Joshi and Rachel F. Tyndale
    Drug Metabolism and Disposition April 2006, 34 (4) 647-652; DOI: https://doi.org/10.1124/dmd.105.008029
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    DEPENDENCE OF NELFINAVIR BRAIN UPTAKE ON DOSE AND TISSUE CONCENTRATIONS OF THE SELECTIVE P-GLYCOPROTEIN INHIBITOR ZOSUQUIDAR IN RATS
    Bradley D. Anderson, Melissa J. May, Sherri Jordan, Lin Song, Michael J. Roberts and Markos Leggas
    Drug Metabolism and Disposition April 2006, 34 (4) 653-659; DOI: https://doi.org/10.1124/dmd.105.006536
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    AN EVALUATION OF METHODS FOR THE RECONSTITUTION OF CYTOCHROMES P450 AND NADPH P450 REDUCTASE INTO LIPID VESICLES
    James R. Reed, Rusty W. Kelley and Wayne L. Backes
    Drug Metabolism and Disposition April 2006, 34 (4) 660-666; DOI: https://doi.org/10.1124/dmd.105.006825
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    IN VITRO METABOLISM OF FERROQUINE (SSR97193) IN ANIMAL AND HUMAN HEPATIC MODELS AND ANTIMALARIAL ACTIVITY OF MAJOR METABOLITES ON PLASMODIUM FALCIPARUM
    Wassim Daher, Lydie Pelinski, Sylvie Klieber, Freddy Sadoun, Viviane Meunier, Martine Bourrié, Christophe Biot, François Guillou, Gérard Fabre, Jacques Brocard, Laurent Fraisse, Jean-Pierre Maffrand, Jamal Khalife and Daniel Dive
    Drug Metabolism and Disposition April 2006, 34 (4) 667-682; DOI: https://doi.org/10.1124/dmd.104.003202
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    THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK
    Sang K. Kim, Mohamed A. Abdelmegeed and Raymond F. Novak
    Drug Metabolism and Disposition April 2006, 34 (4) 683-689; DOI: https://doi.org/10.1124/dmd.105.007666
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    BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) TRANSPORTS FLUOROQUINOLONE ANTIBIOTICS AND AFFECTS THEIR ORAL AVAILABILITY, PHARMACOKINETICS, AND MILK SECRETION
    Gracia Merino, Ana I. Álvarez, Mivis M. Pulido, Antonio J. Molina, Alfred H. Schinkel and Julio G. Prieto
    Drug Metabolism and Disposition April 2006, 34 (4) 690-695; DOI: https://doi.org/10.1124/dmd.105.008219
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    CHARACTERIZATION OF CYTOCHROME P450 EXPRESSION IN MURINE EMBRYONIC STEM CELL-DERIVED HEPATIC TISSUE SYSTEM
    Masaru Tsutsui, Shinichiro Ogawa, Yoichi Inada, Eisuke Tomioka, Akiko Kamiyoshi, Satoru Tanaka, Tomoyuki Kishida, Masahiko Nishiyama, Makoto Murakami, Junji Kuroda, Yasuhiko Hashikura, Shinichi Miyagawa, Fumiyasu Satoh, Nobuo Shibata and Yoh-ichi Tagawa
    Drug Metabolism and Disposition April 2006, 34 (4) 696-701; DOI: https://doi.org/10.1124/dmd.105.007674
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    INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES
    Chuang Lu, Richard Gallegos, Ping Li, Cindy Q. Xia, Sandeepraj Pusalkar, Vinita Uttamsingh, Darrell Nix, Gerald T. Miwa and Liang-Shang Gan
    Drug Metabolism and Disposition April 2006, 34 (4) 702-708; DOI: https://doi.org/10.1124/dmd.105.008060
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    IN VITRO METABOLIC ACTIVATION OF THIABENDAZOLE VIA 5-HYDROXYTHIABENDAZOLE: IDENTIFICATION OF A GLUTATHIONE CONJUGATE OF 5-HYDROXYTHIABENDAZOLE
    Deepak Dalvie, Evan Smith, Alan Deese and Stephen Bowlin
    Drug Metabolism and Disposition April 2006, 34 (4) 709-717; DOI: https://doi.org/10.1124/dmd.105.008094
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    ALTERED HEPATOBILIARY DISPOSITION OF 5 (AND 6)-CARBOXY-2′,7′-DICHLOROFLUORESCEIN IN Abcg2 (Bcrp1) AND Abcc2 (Mrp2) KNOCKOUT MICE
    Ken-ichi Nezasa, Xianbin Tian, Maciej J. Zamek-Gliszczynski, Nita J. Patel, Thomas J. Raub and Kim L. R. Brouwer
    Drug Metabolism and Disposition April 2006, 34 (4) 718-723; DOI: https://doi.org/10.1124/dmd.105.007922

Letters to the Editor

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    BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT
    David Hallifax and J. Brian Houston
    Drug Metabolism and Disposition April 2006, 34 (4) 724-726; DOI: https://doi.org/10.1124/dmd.105.007658
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    RESPONSE TO “BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT”
    R. P. Austin, P. Barton and R. J. Riley
    Drug Metabolism and Disposition April 2006, 34 (4) 727; DOI: https://doi.org/10.1124/dmd.105.009142
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Drug Metabolism and Disposition: 34 (4)
Drug Metabolism and Disposition
Vol. 34, Issue 4
1 Apr 2006
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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