THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

General Clinical Research Center (M.F.P., H.L.H., S.S.L.) and Division of Pharmacotherapy and Experimental Therapeutics (M.F.P.), University of North Carolina, Chapel Hill, North Carolina; Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia (R.L.H.); Department of Medicinal Chemistry, University of Washington, Seattle, Washington (A.E.R.); and Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (D.C.Z.)

Address correspondence to:
Dr. Mary F. Paine, General Clinical Research Center, Room 3005 Bldg APCF, CB# 7600, UNC Hospitals, Chapel Hill, NC 27599-7600. E-mail: mpaine{at}med.unc.edu

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	Abstract	Full	Pdf
Feb 2006	70	0	256
Mar 2006	33	0	173
Apr 2006	217	57	334
May 2006	117	89	194
Jun 2006	44	49	102
Jul 2006	34	68	93
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Jan 2008	20	57	43
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May 2008	29	48	56
Jun 2008	17	28	42
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Mar 2009	27	43	57
Apr 2009	36	35	38
May 2009	11	28	31
Jun 2009	24	29	35
Jul 2009	19	31	35
Aug 2009	10	32	45
Sep 2009	25	27	40
Oct 2009	29	36	39
Nov 2009	19	19	27
Dec 2009	27	14	26
Jan 2010	33	16	35
Feb 2010	59	28	56
Mar 2010	40	26	65
Apr 2010	31	29	32
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Jun 2010	34	32	20
Jul 2010	43	31	37
Aug 2010	63	38	33
Sep 2010	22	51	33
Oct 2010	56	67	39
Nov 2010	28	64	35
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Jan 2011	30	48	28
Feb 2011	22	29	33
Mar 2011	41	57	43
Apr 2011	59	68	65
May 2011	26	50	34
Jun 2011	43	41	43
Jul 2011	49	61	46
Aug 2011	51	37	64
Sep 2011	69	55	41
Oct 2011	56	47	33
Nov 2011	64	69	56
Dec 2011	48	54	41
Jan 2012	41	52	33
Feb 2012	55	67	49
Mar 2012	57	64	45
Apr 2012	59	80	54
May 2012	68	67	42
Jun 2012	60	82	46
Jul 2012	49	60	40
Aug 2012	27	51	39
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Oct 2012	68	87	61
Nov 2012	63	50	53
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Jan 2013	72	73	47
Feb 2013	109	62	50
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Jun 2013	45	54	35
Jul 2013	47	44	41
Aug 2013	41	48	36
Sep 2013	171	64	59
Oct 2013	374	57	32
Nov 2013	312	76	44
Dec 2013	51	50	34
Jan 2014	55	74	38
Feb 2014	35	52	39
Mar 2014	43	95	75
Apr 2014	71	93	66
May 2014	78	95	52
Jun 2014	51	141	47
Jul 2014	75	125	38
Aug 2014	39	59	45
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Mar 2015	63	61	33
Apr 2015	43	66	28
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Jul 2015	65	61	48
Aug 2015	41	44	27
Sep 2015	68	59	38
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Feb 2016	39	64	37
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Jul 2016	64	43	35
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Jan 2017	9	93	21
Feb 2017	4	71	37
Mar 2017	6	55	25
Apr 2017	12	62	25
May 2017	8	49	23
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Jul 2017	4	40	21
Aug 2017	9	62	24
Sep 2017	9	65	19
Oct 2017	10	93	35
Nov 2017	9	125	26
Dec 2017	9	36	21
Jan 2018	13	69	20
Feb 2018	16	96	26
Mar 2018	8	66	41
Apr 2018	9	66	29
May 2018	5	62	24
Jun 2018	6	68	23
Jul 2018	0	43	30
Aug 2018	1	63	36
Sep 2018	0	47	53
Oct 2018	0	72	41
Nov 2018	0	76	39
Dec 2018	81	24	27
Jan 2019	89	35	37
Feb 2019	65	19	17
Mar 2019	63	19	35
Apr 2019	57	23	17
May 2019	77	21	21
Jun 2019	28	18	24
Jul 2019	60	14	18
Aug 2019	58	11	14
Sep 2019	46	22	19
Oct 2019	33	9	9
Nov 2019	46	15	8
Dec 2019	84	23	14
Jan 2020	49	35	15
Feb 2020	44	15	7
Mar 2020	64	18	6
Apr 2020	69	14	10
May 2020	58	26	9
Jun 2020	43	19	15
Jul 2020	60	5	5
Aug 2020	19	11	8
Sep 2020	61	18	10
Oct 2020	56	11	9
Nov 2020	67	14	19
Dec 2020	47	24	4
Jan 2021	34	97	21
Feb 2021	48	93	8
Mar 2021	75	34	21
Apr 2021	71	27	8
May 2021	59	50	13
Jun 2021	69	78	12
Jul 2021	53	27	14
Aug 2021	52	71	10
Sep 2021	38	46	7
Oct 2021	73	21	5
Nov 2021	66	17	17
Dec 2021	46	14	4
Jan 2022	34	9	3