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Drug Metabolism & Disposition

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Table of Contents

June 01, 2006; Volume 34,Issue 6

Short Communications

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    FORMATION OF N-ALKYLPROTOPORPHYRIN IX FROM METABOLISM OF DIALLYL SULFONE IN LUNG AND LIVER
    Gordon P. Black, Kathy S. Collins, Dylan P. Blacquiere and Poh-Gek Forkert
    Drug Metabolism and Disposition June 2006, 34 (6) 895-900; DOI: https://doi.org/10.1124/dmd.106.009928
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    IDENTIFICATION OF A NOVEL IN VITRO METABONATE FROM LIVER MICROSOMAL INCUBATIONS
    Chun Li, Sekhar Surapaneni, QingPing Zeng, Brian Marquez, David Chow and Gondi Kumar
    Drug Metabolism and Disposition June 2006, 34 (6) 901-905; DOI: https://doi.org/10.1124/dmd.105.008367

Articles

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    ANTI-PHENCYCLIDINE MONOCLONAL ANTIBODY BINDING CAPACITY IS NOT THE ONLY DETERMINANT OF EFFECTIVENESS, DISPROVING THE CONCEPT THAT ANTIBODY CAPACITY IS EASILY SURMOUNTED
    Grzegorz Pitas, Elizabeth M. Laurenzana, D. Keith Williams, S. Michael Owens and W. Brooks Gentry
    Drug Metabolism and Disposition June 2006, 34 (6) 906-912; DOI: https://doi.org/10.1124/dmd.105.005934
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    ABSORPTION AND METABOLISM OF ASTRAGALI RADIX DECOCTION: IN SILICO, IN VITRO, AND A CASE STUDY IN VIVO
    Feng Xu, Yue Zhang, Shengyuan Xiao, Xiaowei Lu, Donghui Yang, Xiaoda Yang, Changling Li, Mingying Shang, Pengfei Tu and Shaoqing Cai
    Drug Metabolism and Disposition June 2006, 34 (6) 913-924; DOI: https://doi.org/10.1124/dmd.105.008300
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    APPLICATION OF BIOCATALYSIS TO DRUG METABOLISM: PREPARATION OF MAMMALIAN METABOLITES OF A BIARYL-BIS-SULFONAMIDE AMPA (α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID) RECEPTOR POTENTIATOR USING Actinoplanes missouriensis
    Milton Zmijewski, Todd A. Gillespie, David A. Jackson, Douglas F. Schmidt, Ping Yi and Palaniappan Kulanthaivel
    Drug Metabolism and Disposition June 2006, 34 (6) 925-931; DOI: https://doi.org/10.1124/dmd.106.009522
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    DEMETHYLATION OF THE PESTICIDE METHOXYCHLOR IN LIVER AND INTESTINE FROM UNTREATED, METHOXYCHLOR-TREATED, AND 3-METHYLCHOLANTHRENE-TREATED CHANNEL CATFISH (ICTALURUS PUNCTATUS): EVIDENCE FOR ROLES OF CYP1 AND CYP3A FAMILY ISOZYMES
    Leah D. Stuchal, Kevin M. Kleinow, John J. Stegeman and Margaret O. James
    Drug Metabolism and Disposition June 2006, 34 (6) 932-938; DOI: https://doi.org/10.1124/dmd.105.009068
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    CONTRARY TO ADULT, NEONATAL RATS SHOW PRONOUNCED BRAIN UPTAKE OF CORTICOSTEROIDS
    Vikram Arya, Vincent G. Demarco, Manish Issar and Günther Hochhaus
    Drug Metabolism and Disposition June 2006, 34 (6) 939-942; DOI: https://doi.org/10.1124/dmd.105.007419
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    IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10) IN THE DETOXIFICATION OF POLYCYCLIC AROMATIC HYDROCARBONS: DECREASED GLUCURONIDATIVE ACTIVITY OF THE UGT1A10139LYS ISOFORM
    Ryan W. Dellinger, Jia-Long Fang, Gang Chen, Rebecca Weinberg and Philip Lazarus
    Drug Metabolism and Disposition June 2006, 34 (6) 943-949; DOI: https://doi.org/10.1124/dmd.105.009100
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    AUTOINDUCTION OF MKC-963 [(R)-1-(1-CYCLOHEXYLETHYLAMINO)-4-PHENYLPHTHALAZINE] METABOLISM IN HEALTHY VOLUNTEERS AND ITS RETROSPECTIVE EVALUATION USING PRIMARY HUMAN HEPATOCYTES AND CDNA-EXPRESSED ENZYMES
    Toshiyuki Shimizu, Kei Akimoto, Takuya Yoshimura, Takuro Niwa, Kaoru Kobayashi, Michio Tsunoo and Kan Chiba
    Drug Metabolism and Disposition June 2006, 34 (6) 950-954; DOI: https://doi.org/10.1124/dmd.105.007997
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    A PHARMACOKINETIC STUDY OF DIPHENHYDRAMINE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN ADULT SHEEP: POTENTIAL INVOLVEMENT OF A CARRIER-MEDIATED MECHANISM
    Sam C. S. Au-Yeung, Dan W. Rurak, Nancy Gruber and K. Wayne Riggs
    Drug Metabolism and Disposition June 2006, 34 (6) 955-960; DOI: https://doi.org/10.1124/dmd.105.007898
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    METABOLISM OF [14C]GEMOPATRILAT AFTER ORAL ADMINISTRATION TO RATS, DOGS, AND HUMANS
    Jill C. M. Wait, Nimish Vaccharajani, James Mitroka, Mohammed Jemal, Sanaullah Khan, Samuel J. Bonacorsi, J. Kent Rinehart and Ramaswamy A. Iyer
    Drug Metabolism and Disposition June 2006, 34 (6) 961-970; DOI: https://doi.org/10.1124/dmd.105.007500
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    IN VITRO BLOOD DISTRIBUTION AND PLASMA PROTEIN BINDING OF THE IRON CHELATOR DEFERASIROX (ICL670) AND ITS IRON COMPLEX FE-[ICL670]2 FOR RAT, MARMOSET, RABBIT, MOUSE, DOG, AND HUMAN
    H. Markus Weiss, Marcel Fresneau, Gian P. Camenisch, Olivier Kretz and Gerhard Gross
    Drug Metabolism and Disposition June 2006, 34 (6) 971-975; DOI: https://doi.org/10.1124/dmd.105.006429
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    COMPARISON OF METHODS FOR THE PREDICTION OF THE METABOLIC SITES FOR CYP3A4-MEDIATED METABOLIC REACTIONS
    Diansong Zhou, Lovisa Afzelius, Scott W. Grimm, Tommy B. Andersson, Randy J. Zauhar and Ismael Zamora
    Drug Metabolism and Disposition June 2006, 34 (6) 976-983; DOI: https://doi.org/10.1124/dmd.105.008631
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    FLUTAMIDE METABOLISM IN FOUR DIFFERENT SPECIES IN VITRO AND IDENTIFICATION OF FLUTAMIDE METABOLITES IN HUMAN PATIENT URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
    Annica Tevell, Hans Lennernäs, Mats Jönsson, Maria Norlin, Bo Lennernäs, Ulf Bondesson and Mikael Hedeland
    Drug Metabolism and Disposition June 2006, 34 (6) 984-992; DOI: https://doi.org/10.1124/dmd.105.008516
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    GALACTOSAMINE PREVENTS ETHINYLESTRADIOL-INDUCED CHOLESTASIS
    Fernando A. Crocenzi, José M. Pellegrino, Viviana A. Catania, Marcelo G. Luquita, Marcelo G. Roma, Aldo D. Mottino and Enrique J. Sánchez Pozzi
    Drug Metabolism and Disposition June 2006, 34 (6) 993-997; DOI: https://doi.org/10.1124/dmd.106.009308
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    COMPARISON OF DRUG EFFLUX TRANSPORT KINETICS IN VARIOUS BLOOD-BRAIN BARRIER MODELS
    Corbin J. Bachmeier, William J. Trickler and Donald W. Miller
    Drug Metabolism and Disposition June 2006, 34 (6) 998-1003; DOI: https://doi.org/10.1124/dmd.105.006999
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    METABOLISM AND DISPOSITION OF A POTENT AND SELECTIVE GABA-Aα2/3 RECEPTOR AGONIST IN HEALTHY MALE VOLUNTEERS
    Stacey L. Polsky-Fisher, Stanley Vickers, Donghui Cui, Raju Subramanian, Byron H. Arison, Nancy G. B. Agrawal, Thanh V. Goel, Laura K. Vessey, M. Gail Murphy, Kenneth C. Lasseter, Richard C. Simpson, Jose M. Vega and A. David Rodrigues
    Drug Metabolism and Disposition June 2006, 34 (6) 1004-1011; DOI: https://doi.org/10.1124/dmd.105.008193
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    INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER
    Sachiyo Kawashima, Kaoru Kobayashi, Kaori Takama, Tomoaki Higuchi, Tomomi Furihata, Masakiyo Hosokawa and Kan Chiba
    Drug Metabolism and Disposition June 2006, 34 (6) 1012-1018; DOI: https://doi.org/10.1124/dmd.106.009365
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    COMPARATIVE METABOLISM OF GERANYL NITRILE AND CITRONELLYL NITRILE IN MOUSE, RAT, AND HUMAN HEPATOCYTES
    Raymond A. Kemper, Diane L. Nabb, Shawn A. Gannon, Timothy A. Snow and Anne Marie Api
    Drug Metabolism and Disposition June 2006, 34 (6) 1019-1029; DOI: https://doi.org/10.1124/dmd.105.005496
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    ETHYNYLESTRADIOL INCREASES EXPRESSION AND ACTIVITY OF RAT LIVER MRP3
    María L. Ruiz, Silvina S. M. Villanueva, Marcelo G. Luquita, Mary Vore, Aldo D. Mottino and Viviana A. Catania
    Drug Metabolism and Disposition June 2006, 34 (6) 1030-1034; DOI: https://doi.org/10.1124/dmd.106.009316
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    BIOTRANSFORMATION OF FLUTICASONE: IN VITRO CHARACTERIZATION
    Robin E. Pearce, J. Steven Leeder and Gregory L. Kearns
    Drug Metabolism and Disposition June 2006, 34 (6) 1035-1040; DOI: https://doi.org/10.1124/dmd.105.009043
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    SATURABLE BINDING OF INDISULAM TO PLASMA PROTEINS AND DISTRIBUTION TO HUMAN ERYTHROCYTES
    Anthe S. Zandvliet, William Copalu, Jan H. M. Schellens, Jos H. Beijnen and Alwin D. R. Huitema
    Drug Metabolism and Disposition June 2006, 34 (6) 1041-1046; DOI: https://doi.org/10.1124/dmd.105.008326
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    COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE
    Marcella Martignoni, Geny Groothuis and Ruben de Kanter
    Drug Metabolism and Disposition June 2006, 34 (6) 1047-1054; DOI: https://doi.org/10.1124/dmd.105.009035
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    IN VITRO CHARACTERIZATION OF LAMOTRIGINE N2-GLUCURONIDATION AND THE LAMOTRIGINE-VALPROIC ACID INTERACTION
    Andrew Rowland, David J. Elliot, J. Andrew Williams, Peter I. Mackenzie, Ronald G. Dickinson and John O. Miners
    Drug Metabolism and Disposition June 2006, 34 (6) 1055-1062; DOI: https://doi.org/10.1124/dmd.106.009340
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    CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)
    Sandra J. Baldwin, Jo L. Bramhall, Charlotte A. Ashby, Lin Yue, Paul R. Murdock, Steven R. Hood, Andrew D. Ayrton and Stephen E. Clarke
    Drug Metabolism and Disposition June 2006, 34 (6) 1063-1069; DOI: https://doi.org/10.1124/dmd.105.008185
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    N-METHYLPURINE DNA GLYCOSYLASE AND 8-OXOGUANINE DNA GLYCOSYLASE METABOLIZE THE ANTIVIRAL NUCLEOSIDE 2-BROMO-5,6-DICHLORO-1-(β-D-RIBOFURANOSYL)BENZIMIDAZOLE
    Philip L. Lorenzi, Christopher P. Landowski, Andrea Brancale, Xueqin Song, Leroy B. Townsend, John C. Drach and Gordon L. Amidon
    Drug Metabolism and Disposition June 2006, 34 (6) 1070-1077; DOI: https://doi.org/10.1124/dmd.105.009209

Errata

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    CORRECTION TO “BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT”
    Drug Metabolism and Disposition June 2006, 34 (6) 1078; DOI: https://doi.org/10.1124/dmd.34.6.1078
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    CORRECTION TO “P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION”
    Drug Metabolism and Disposition June 2006, 34 (6) 1079; DOI: https://doi.org/10.1124/dmd.34.6.1079
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Drug Metabolism and Disposition: 34 (6)
Drug Metabolism and Disposition
Vol. 34, Issue 6
1 Jun 2006
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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