Table of Contents

Articles

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  INDUCTION OF DETOXIFYING ENZYMES IN RODENT WHITE ADIPOSE TISSUE BY ARYL HYDROCARBON RECEPTOR AGONISTS AND ANTIOXIDANTS

  Kouichi Yoshinari, Nao Okino, Takeshi Sato, Junko Sugatani and Masao Miwa

  Drug Metabolism and Disposition July 2006, 34 (7) 1081-1089; DOI: https://doi.org/10.1124/dmd.105.007286
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  STEREOSELECTIVE METABOLISM OF ENDOSULFAN BY HUMAN LIVER MICROSOMES AND HUMAN CYTOCHROME P450 ISOFORMS

  Hwa-Kyung Lee, Joon-Kwan Moon, Chul-Hee Chang, Hoon Choi, Hee-Won Park, Byeoung-Soo Park, Hye-Suk Lee, Eul-Chul Hwang, Young-Deuk Lee, Kwang-Hyeon Liu and Jeong-Han Kim

  Drug Metabolism and Disposition July 2006, 34 (7) 1090-1095; DOI: https://doi.org/10.1124/dmd.105.009134
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  REGULATION OF CYP1A1 GENE EXPRESSION BY THE ANTIOXIDANT TERT-BUTYLHYDROQUINONE

  Thomas D. Schreiber, Christoph Köhle, Felicitas Buckler, Stefan Schmohl, Albert Braeuning, Alexander Schmiechen, Michael Schwarz and Peter A. Münzel

  Drug Metabolism and Disposition July 2006, 34 (7) 1096-1101; DOI: https://doi.org/10.1124/dmd.106.009662
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  HUMAN UDP-GLUCURONOSYLTRANSFERASE, UGT1A8, GLUCURONIDATES DIHYDROTESTOSTERONE TO A MONOGLUCURONIDE AND FURTHER TO A STRUCTURALLY NOVEL DIGLUCURONIDE

  Takahiro Murai, Naozumi Samata, Haruo Iwabuchi and Toshihiko Ikeda

  Drug Metabolism and Disposition July 2006, 34 (7) 1102-1108; DOI: https://doi.org/10.1124/dmd.106.009621
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  PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS

  Naoki Ishiguro, Kazuya Maeda, Wataru Kishimoto, Asami Saito, Akiko Harada, Thomas Ebner, Willy Roth, Takashi Igarashi and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2006, 34 (7) 1109-1115; DOI: https://doi.org/10.1124/dmd.105.009175
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  THE ROLE OF THE POLYMORPHIC EFFLUX TRANSPORTER P-GLYCOPROTEIN ON THE BRAIN ACCUMULATION OF d-METHYLPHENIDATE AND d-AMPHETAMINE

  Hao-Jie Zhu, Jun-Sheng Wang, C. Lindsay DeVane, Robin L. Williard, Jennifer L. Donovan, Lawrence D. Middaugh, Brian B. Gibson, Kennerly S. Patrick and John S. Markowitz

  Drug Metabolism and Disposition July 2006, 34 (7) 1116-1121; DOI: https://doi.org/10.1124/dmd.106.009605
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  QUANTITATIVE DETERMINATION OF ARISTOLOCHIC ACID-DERIVED DNA ADDUCTS IN RATS USING ³²P-POSTLABELING/POLYACRYLAMIDE GEL ELECTROPHORESIS ANALYSIS

  Huan Dong, Naomi Suzuki, Maria C. Torres, Radha R. Bonala, Francis Johnson, Arthur P. Grollman and Shinya Shibutani

  Drug Metabolism and Disposition July 2006, 34 (7) 1122-1127; DOI: https://doi.org/10.1124/dmd.105.008706
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  THE IN VIVO AND IN VITRO METABOLIC PROFILE OF ^99MTC-NC100668, A NEW TRACER FOR IMAGING VENOUS THROMBOEMBOLISM: IDENTIFICATION AND BIODISTRIBUTION OF THE PRINCIPAL RADIOLABELED METABOLITE

  David Edwards, Mark Battle, Rochelle Lear, Gill Farrar, D. Jon Barnett, Vanessa Godden, Catherine Coombes, Alexandra Oliveira and Håkan Ahlström

  Drug Metabolism and Disposition July 2006, 34 (7) 1128-1135; DOI: https://doi.org/10.1124/dmd.106.009696
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  QUINACRINE IS MAINLY METABOLIZED TO MONO-DESETHYL QUINACRINE BY CYP3A4/5 AND ITS BRAIN ACCUMULATION IS LIMITED BY P-GLYCOPROTEIN

  Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo and Emil T. Lin

  Drug Metabolism and Disposition July 2006, 34 (7) 1136-1144; DOI: https://doi.org/10.1124/dmd.105.008664
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  NEUROTOXIC PYRIDINIUM METABOLITES OF HALOPERIDOL ARE SUBSTRATES OF HUMAN ORGANIC CATION TRANSPORTERS

  Ho-Jin Kang, Sang-Seop Lee, Chung-Hee Lee, Ju-Cheol Shim, Ho Jung Shin, Kwang-Hyeon Liu, Mi-Ae Yoo and Jae-Gook Shin

  Drug Metabolism and Disposition July 2006, 34 (7) 1145-1151; DOI: https://doi.org/10.1124/dmd.105.009126
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  IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS (HUMULUS LUPULUS L.)

  Jian Guo, Dejan Nikolic, Lucas R. Chadwick, Guido F. Pauli and Richard B. van Breemen

  Drug Metabolism and Disposition July 2006, 34 (7) 1152-1159; DOI: https://doi.org/10.1124/dmd.105.008250
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  SELECTIVE EFFECTS OF NITRIC OXIDE ON THE DISPOSITION OF CHLORZOXAZONE AND DEXTROMETHORPHAN IN ISOLATED PERFUSED RAT LIVERS

  Ragini Vuppugalla and Reza Mehvar

  Drug Metabolism and Disposition July 2006, 34 (7) 1160-1166; DOI: https://doi.org/10.1124/dmd.105.009050
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  EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF MOUSE CYP2D22

  Ai-Ming Yu and Robert L. Haining

  Drug Metabolism and Disposition July 2006, 34 (7) 1167-1174; DOI: https://doi.org/10.1124/dmd.105.008870
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  PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM

  Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet

  Drug Metabolism and Disposition July 2006, 34 (7) 1175-1181; DOI: https://doi.org/10.1124/dmd.105.009076
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  FIRST-PASS EFFECTS OF VERAPAMIL ON THE INTESTINAL ABSORPTION AND LIVER DISPOSITION OF FEXOFENADINE IN THE PORCINE MODEL

  Niclas Petri, Ebba Bergman, Patrik Forsell, Mikael Hedeland, Ulf Bondesson, Lars Knutson and Hans Lennernäs

  Drug Metabolism and Disposition July 2006, 34 (7) 1182-1189; DOI: https://doi.org/10.1124/dmd.105.008409
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  INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS

  A. L. Slitt, N. J. Cherrington, C. D. Fisher, M. Negishi and C. D. Klaassen

  Drug Metabolism and Disposition July 2006, 34 (7) 1190-1197; DOI: https://doi.org/10.1124/dmd.105.007542
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  FACTORS INFLUENCING MIDAZOLAM HYDROXYLATION ACTIVITY IN HUMAN LIVER MICROSOMES

  Ping He, Michael H. Court, David J. Greenblatt and Lisa L. von Moltke

  Drug Metabolism and Disposition July 2006, 34 (7) 1198-1207; DOI: https://doi.org/10.1124/dmd.105.008904
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  STOCHASTIC PREDICTION OF CYP3A-MEDIATED INHIBITION OF MIDAZOLAM CLEARANCE BY KETOCONAZOLE

  Jenny Y. Chien, Aroonrut Lucksiri, Charles S. Ernest, J. Christopher Gorski, Steven A. Wrighton and Stephen D. Hall

  Drug Metabolism and Disposition July 2006, 34 (7) 1208-1219; DOI: https://doi.org/10.1124/dmd.105.008730
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  THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

  Hugo Girard, Lyne Villeneuve, Michael H. Court, Louis-Charles Fortier, Patrick Caron, Qin Hao, Lisa L. von Moltke, David J. Greenblatt and Chantal Guillemette

  Drug Metabolism and Disposition July 2006, 34 (7) 1220-1228; DOI: https://doi.org/10.1124/dmd.106.009787
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  DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1

  Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2006, 34 (7) 1229-1236; DOI: https://doi.org/10.1124/dmd.106.009290
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  GLUTATHIONE S-TRANSFERASE OMEGA 1 AND OMEGA 2 PHARMACOGENOMICS

  Baidehi Mukherjee, Oreste E. Salavaggione, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Daniel J. Schaid, Eric D. Wieben and Richard M. Weinshilboum

  Drug Metabolism and Disposition July 2006, 34 (7) 1237-1246; DOI: https://doi.org/10.1124/dmd.106.009613
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  INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC UPTAKE AND BILIARY EXCRETION OF VALSARTAN, A SELECTIVE ANTAGONIST OF THE ANGIOTENSIN II AT1-RECEPTOR, IN HUMANS

  Wakaba Yamashiro, Kazuya Maeda, Masakazu Hirouchi, Yasuhisa Adachi, Zhuohan Hu and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2006, 34 (7) 1247-1254; DOI: https://doi.org/10.1124/dmd.105.008938
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  EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF “DISCOVERY-LIKE” MOLECULES TO PREDICT HUMAN PHARMACOKINETICS

  Christopher A. Evans, Larry J. Jolivette, Rakesh Nagilla and Keith W. Ward

  Drug Metabolism and Disposition July 2006, 34 (7) 1255-1265; DOI: https://doi.org/10.1124/dmd.105.006619
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  PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS

  Kevin J. Coe, Sidney D. Nelson, Roger G. Ulrich, Yudong He, Xudong Dai, Olivia Cheng, Michelle Caguyong, Chris J. Roberts and J. Greg Slatter

  Drug Metabolism and Disposition July 2006, 34 (7) 1266-1275; DOI: https://doi.org/10.1124/dmd.105.009159