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Drug Metabolism & Disposition

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Table of Contents

July 01, 2006; Volume 34,Issue 7

Articles

  • You have access
    INDUCTION OF DETOXIFYING ENZYMES IN RODENT WHITE ADIPOSE TISSUE BY ARYL HYDROCARBON RECEPTOR AGONISTS AND ANTIOXIDANTS
    Kouichi Yoshinari, Nao Okino, Takeshi Sato, Junko Sugatani and Masao Miwa
    Drug Metabolism and Disposition July 2006, 34 (7) 1081-1089; DOI: https://doi.org/10.1124/dmd.105.007286
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    STEREOSELECTIVE METABOLISM OF ENDOSULFAN BY HUMAN LIVER MICROSOMES AND HUMAN CYTOCHROME P450 ISOFORMS
    Hwa-Kyung Lee, Joon-Kwan Moon, Chul-Hee Chang, Hoon Choi, Hee-Won Park, Byeoung-Soo Park, Hye-Suk Lee, Eul-Chul Hwang, Young-Deuk Lee, Kwang-Hyeon Liu and Jeong-Han Kim
    Drug Metabolism and Disposition July 2006, 34 (7) 1090-1095; DOI: https://doi.org/10.1124/dmd.105.009134
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    REGULATION OF CYP1A1 GENE EXPRESSION BY THE ANTIOXIDANT TERT-BUTYLHYDROQUINONE
    Thomas D. Schreiber, Christoph Köhle, Felicitas Buckler, Stefan Schmohl, Albert Braeuning, Alexander Schmiechen, Michael Schwarz and Peter A. Münzel
    Drug Metabolism and Disposition July 2006, 34 (7) 1096-1101; DOI: https://doi.org/10.1124/dmd.106.009662
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    HUMAN UDP-GLUCURONOSYLTRANSFERASE, UGT1A8, GLUCURONIDATES DIHYDROTESTOSTERONE TO A MONOGLUCURONIDE AND FURTHER TO A STRUCTURALLY NOVEL DIGLUCURONIDE
    Takahiro Murai, Naozumi Samata, Haruo Iwabuchi and Toshihiko Ikeda
    Drug Metabolism and Disposition July 2006, 34 (7) 1102-1108; DOI: https://doi.org/10.1124/dmd.106.009621
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    PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS
    Naoki Ishiguro, Kazuya Maeda, Wataru Kishimoto, Asami Saito, Akiko Harada, Thomas Ebner, Willy Roth, Takashi Igarashi and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2006, 34 (7) 1109-1115; DOI: https://doi.org/10.1124/dmd.105.009175
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    THE ROLE OF THE POLYMORPHIC EFFLUX TRANSPORTER P-GLYCOPROTEIN ON THE BRAIN ACCUMULATION OF d-METHYLPHENIDATE AND d-AMPHETAMINE
    Hao-Jie Zhu, Jun-Sheng Wang, C. Lindsay DeVane, Robin L. Williard, Jennifer L. Donovan, Lawrence D. Middaugh, Brian B. Gibson, Kennerly S. Patrick and John S. Markowitz
    Drug Metabolism and Disposition July 2006, 34 (7) 1116-1121; DOI: https://doi.org/10.1124/dmd.106.009605
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    QUANTITATIVE DETERMINATION OF ARISTOLOCHIC ACID-DERIVED DNA ADDUCTS IN RATS USING 32P-POSTLABELING/POLYACRYLAMIDE GEL ELECTROPHORESIS ANALYSIS
    Huan Dong, Naomi Suzuki, Maria C. Torres, Radha R. Bonala, Francis Johnson, Arthur P. Grollman and Shinya Shibutani
    Drug Metabolism and Disposition July 2006, 34 (7) 1122-1127; DOI: https://doi.org/10.1124/dmd.105.008706
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    THE IN VIVO AND IN VITRO METABOLIC PROFILE OF 99MTC-NC100668, A NEW TRACER FOR IMAGING VENOUS THROMBOEMBOLISM: IDENTIFICATION AND BIODISTRIBUTION OF THE PRINCIPAL RADIOLABELED METABOLITE
    David Edwards, Mark Battle, Rochelle Lear, Gill Farrar, D. Jon Barnett, Vanessa Godden, Catherine Coombes, Alexandra Oliveira and Håkan Ahlström
    Drug Metabolism and Disposition July 2006, 34 (7) 1128-1135; DOI: https://doi.org/10.1124/dmd.106.009696
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    QUINACRINE IS MAINLY METABOLIZED TO MONO-DESETHYL QUINACRINE BY CYP3A4/5 AND ITS BRAIN ACCUMULATION IS LIMITED BY P-GLYCOPROTEIN
    Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo and Emil T. Lin
    Drug Metabolism and Disposition July 2006, 34 (7) 1136-1144; DOI: https://doi.org/10.1124/dmd.105.008664
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    NEUROTOXIC PYRIDINIUM METABOLITES OF HALOPERIDOL ARE SUBSTRATES OF HUMAN ORGANIC CATION TRANSPORTERS
    Ho-Jin Kang, Sang-Seop Lee, Chung-Hee Lee, Ju-Cheol Shim, Ho Jung Shin, Kwang-Hyeon Liu, Mi-Ae Yoo and Jae-Gook Shin
    Drug Metabolism and Disposition July 2006, 34 (7) 1145-1151; DOI: https://doi.org/10.1124/dmd.105.009126
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    IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS (HUMULUS LUPULUS L.)
    Jian Guo, Dejan Nikolic, Lucas R. Chadwick, Guido F. Pauli and Richard B. van Breemen
    Drug Metabolism and Disposition July 2006, 34 (7) 1152-1159; DOI: https://doi.org/10.1124/dmd.105.008250
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    SELECTIVE EFFECTS OF NITRIC OXIDE ON THE DISPOSITION OF CHLORZOXAZONE AND DEXTROMETHORPHAN IN ISOLATED PERFUSED RAT LIVERS
    Ragini Vuppugalla and Reza Mehvar
    Drug Metabolism and Disposition July 2006, 34 (7) 1160-1166; DOI: https://doi.org/10.1124/dmd.105.009050
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    EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF MOUSE CYP2D22
    Ai-Ming Yu and Robert L. Haining
    Drug Metabolism and Disposition July 2006, 34 (7) 1167-1174; DOI: https://doi.org/10.1124/dmd.105.008870
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    PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM
    Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet
    Drug Metabolism and Disposition July 2006, 34 (7) 1175-1181; DOI: https://doi.org/10.1124/dmd.105.009076
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    FIRST-PASS EFFECTS OF VERAPAMIL ON THE INTESTINAL ABSORPTION AND LIVER DISPOSITION OF FEXOFENADINE IN THE PORCINE MODEL
    Niclas Petri, Ebba Bergman, Patrik Forsell, Mikael Hedeland, Ulf Bondesson, Lars Knutson and Hans Lennernäs
    Drug Metabolism and Disposition July 2006, 34 (7) 1182-1189; DOI: https://doi.org/10.1124/dmd.105.008409
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    INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS
    A. L. Slitt, N. J. Cherrington, C. D. Fisher, M. Negishi and C. D. Klaassen
    Drug Metabolism and Disposition July 2006, 34 (7) 1190-1197; DOI: https://doi.org/10.1124/dmd.105.007542
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    FACTORS INFLUENCING MIDAZOLAM HYDROXYLATION ACTIVITY IN HUMAN LIVER MICROSOMES
    Ping He, Michael H. Court, David J. Greenblatt and Lisa L. von Moltke
    Drug Metabolism and Disposition July 2006, 34 (7) 1198-1207; DOI: https://doi.org/10.1124/dmd.105.008904
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    STOCHASTIC PREDICTION OF CYP3A-MEDIATED INHIBITION OF MIDAZOLAM CLEARANCE BY KETOCONAZOLE
    Jenny Y. Chien, Aroonrut Lucksiri, Charles S. Ernest, J. Christopher Gorski, Steven A. Wrighton and Stephen D. Hall
    Drug Metabolism and Disposition July 2006, 34 (7) 1208-1219; DOI: https://doi.org/10.1124/dmd.105.008730
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    THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER
    Hugo Girard, Lyne Villeneuve, Michael H. Court, Louis-Charles Fortier, Patrick Caron, Qin Hao, Lisa L. von Moltke, David J. Greenblatt and Chantal Guillemette
    Drug Metabolism and Disposition July 2006, 34 (7) 1220-1228; DOI: https://doi.org/10.1124/dmd.106.009787
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    DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1
    Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2006, 34 (7) 1229-1236; DOI: https://doi.org/10.1124/dmd.106.009290
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    GLUTATHIONE S-TRANSFERASE OMEGA 1 AND OMEGA 2 PHARMACOGENOMICS
    Baidehi Mukherjee, Oreste E. Salavaggione, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Daniel J. Schaid, Eric D. Wieben and Richard M. Weinshilboum
    Drug Metabolism and Disposition July 2006, 34 (7) 1237-1246; DOI: https://doi.org/10.1124/dmd.106.009613
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    INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC UPTAKE AND BILIARY EXCRETION OF VALSARTAN, A SELECTIVE ANTAGONIST OF THE ANGIOTENSIN II AT1-RECEPTOR, IN HUMANS
    Wakaba Yamashiro, Kazuya Maeda, Masakazu Hirouchi, Yasuhisa Adachi, Zhuohan Hu and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2006, 34 (7) 1247-1254; DOI: https://doi.org/10.1124/dmd.105.008938
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    EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF “DISCOVERY-LIKE” MOLECULES TO PREDICT HUMAN PHARMACOKINETICS
    Christopher A. Evans, Larry J. Jolivette, Rakesh Nagilla and Keith W. Ward
    Drug Metabolism and Disposition July 2006, 34 (7) 1255-1265; DOI: https://doi.org/10.1124/dmd.105.006619
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    PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS
    Kevin J. Coe, Sidney D. Nelson, Roger G. Ulrich, Yudong He, Xudong Dai, Olivia Cheng, Michelle Caguyong, Chris J. Roberts and J. Greg Slatter
    Drug Metabolism and Disposition July 2006, 34 (7) 1266-1275; DOI: https://doi.org/10.1124/dmd.105.009159
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Drug Metabolism and Disposition: 34 (7)
Drug Metabolism and Disposition
Vol. 34, Issue 7
1 Jul 2006
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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