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Research ArticleArticle

QUINACRINE IS MAINLY METABOLIZED TO MONO-DESETHYL QUINACRINE BY CYP3A4/5 AND ITS BRAIN ACCUMULATION IS LIMITED BY P-GLYCOPROTEIN

Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo and Emil T. Lin
Drug Metabolism and Disposition July 2006, 34 (7) 1136-1144; DOI: https://doi.org/10.1124/dmd.105.008664

Article Information

vol. 34 no. 7 1136-1144
DOI 
https://doi.org/10.1124/dmd.105.008664
PubMed 
16581945
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 28, 2005
  • Accepted March 27, 2006
  • Published online June 21, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yong Huang,
  2. Hideaki Okochi,
  3. Barnaby C. H. May,
  4. Giuseppe Legname,
  5. Stanley B. Prusiner,
  6. Leslie Z. Benet,
  7. B. Joseph Guglielmo and
  8. Emil T. Lin
  1. Department of Biopharmaceutical Sciences (Y.H., H.O., L.Z.B., E.T.L.), Institute for Neurodegenerative Diseases and Department of Neurology (B.C.H.M., G.L., S.B.P.), Department of Biochemistry and Biophysics (S.B.P), and Department of Clinical Pharmacy (B.J.G.), University of California, San Francisco, California
  1. Address correspondence to:
    Dr. Emil T. Lin, Department of Biopharmaceutical Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143-0446. E-mail: etlin{at}itsa.ucsf.edu
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Research ArticleArticle

QUINACRINE IS MAINLY METABOLIZED TO MONO-DESETHYL QUINACRINE BY CYP3A4/5 AND ITS BRAIN ACCUMULATION IS LIMITED BY P-GLYCOPROTEIN

Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo and Emil T. Lin
Drug Metabolism and Disposition July 1, 2006, 34 (7) 1136-1144; DOI: https://doi.org/10.1124/dmd.105.008664
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