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Research ArticleArticle

PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM

Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet
Drug Metabolism and Disposition July 2006, 34 (7) 1175-1181; DOI: https://doi.org/10.1124/dmd.105.009076

Article Information

vol. 34 no. 7 1175-1181
DOI 
https://doi.org/10.1124/dmd.105.009076
PubMed 
16624870
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 21, 2005
  • Accepted April 11, 2006
  • Published online June 21, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yvonne Y. Lau,
  2. Hideaki Okochi,
  3. Yong Huang and
  4. Leslie Z. Benet
  1. Department of Biopharmaceutical Sciences, University of California, San Francisco, California
  1. Address correspondence to:
    Dr. Leslie Z. Benet, Professor, Department of Biopharmaceutical Sciences, 533 Parnassus, Room U-68, University of California San Francisco, San Francisco, CA 94143-0446. E-mail: leslie.benet{at}ucsf.edu
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Research ArticleArticle

PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM

Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet
Drug Metabolism and Disposition July 1, 2006, 34 (7) 1175-1181; DOI: https://doi.org/10.1124/dmd.105.009076
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