Drug Metabolism and Disposition: 34 (8)

August 01, 2006; Volume 34,Issue 8

Short Communications

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INHIBITION OF UDP-GLUCURONOSYLTRANSFERASE 2B7-CATALYZED MORPHINE GLUCURONIDATION BY KETOCONAZOLE: DUAL MECHANISMS INVOLVING A NOVEL NONCOMPETITIVE MODE
Shuso Takeda, Yurie Kitajima, Yuji Ishii, Yoshio Nishimura, Peter I. Mackenzie, Kazuta Oguri and Hideyuki Yamada

Drug Metabolism and Disposition August 2006, 34 (8) 1277-1282; DOI: https://doi.org/10.1124/dmd.106.009738
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NMR CHARACTERIZATION OF AN S-LINKED GLUCURONIDE METABOLITE OF THE POTENT, NOVEL, NONSTEROIDAL PROGESTERONE AGONIST TANAPROGET
Kelly A. Keating, Oliver McConnell, Yingru Zhang, Li Shen, William Demaio, Larry Mallis, Sayed Elmarakby and Appavu Chandrasekaran

Drug Metabolism and Disposition August 2006, 34 (8) 1283-1287; DOI: https://doi.org/10.1124/dmd.105.008763
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KINETIC ISOTOPE EFFECTS IMPLICATE A SINGLE OXIDANT FOR CYTOCHROME P450-MEDIATED O-DEALKYLATION, N-OXYGENATION, AND AROMATIC HYDROXYLATION OF 6-METHOXYQUINOLINE
Tamara S. Dowers and Jeffrey P. Jones

Drug Metabolism and Disposition August 2006, 34 (8) 1288-1290; DOI: https://doi.org/10.1124/dmd.106.010280

Articles

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EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES
Dermot F. McGinnity, Amanda J. Berry, Jane R. Kenny, Ken Grime and Robert J. Riley

Drug Metabolism and Disposition August 2006, 34 (8) 1291-1300; DOI: https://doi.org/10.1124/dmd.106.009969
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HEPATIC AND EXTRAHEPATIC SYNTHESIS AND DISPOSITION OF DINITROPHENYL-S-GLUTATHIONE IN BILE DUCT-LIGATED RATS
Silvina S. M. Villanueva, María L. Ruiz, Carol J. Soroka, Shi-Ying Cai, Marcelo G. Luquita, Adriana M. Torres, Enrique J. Sánchez Pozzi, José M. Pellegrino, James L. Boyer, Viviana A. Catania and Aldo D. Mottino

Drug Metabolism and Disposition August 2006, 34 (8) 1301-1309; DOI: https://doi.org/10.1124/dmd.106.009415
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METABOLISM OF NOMIFENSINE TO A DIHYDROISOQUINOLINIUM ION METABOLITE BY HUMAN MYELOPEROXIDASE, HEMOGLOBIN, MONOAMINE OXIDASE A, AND CYTOCHROME P450 ENZYMES
R. Scott Obach and Deepak K. Dalvie

Drug Metabolism and Disposition August 2006, 34 (8) 1310-1316; DOI: https://doi.org/10.1124/dmd.106.010173
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SELECTIVE METABOLISM OF VINCRISTINE IN VITRO BY CYP3A5
Jennifer B. Dennison, Palaniappan Kulanthaivel, Robert J. Barbuch, Jamie L. Renbarger, William J. Ehlhardt and Stephen D. Hall

Drug Metabolism and Disposition August 2006, 34 (8) 1317-1327; DOI: https://doi.org/10.1124/dmd.106.009902
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QUANTITATIVE DETERMINATION OF METABOLIC PRODUCTS OF 19-NORANDROSTENEDIOL IN HUMAN PLASMA USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Yvonne Schrader, Mario Thevis and Wilhelm Schänzer

Drug Metabolism and Disposition August 2006, 34 (8) 1328-1335; DOI: https://doi.org/10.1124/dmd.106.010165
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IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
Justine L. Lam, Hideaki Okochi, Yong Huang and Leslie Z. Benet

Drug Metabolism and Disposition August 2006, 34 (8) 1336-1344; DOI: https://doi.org/10.1124/dmd.106.009258
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PHARMACOKINETICS AND METABOLISM OF THE FLAVONOID SCUTELLARIN IN HUMANS AFTER A SINGLE ORAL ADMINISTRATION
Xiaoyan Chen, Liang Cui, Xiaotao Duan, Bin Ma and Dafang Zhong

Drug Metabolism and Disposition August 2006, 34 (8) 1345-1352; DOI: https://doi.org/10.1124/dmd.106.009779
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DIFFERENTIAL EFFECTS OF THE OXIDIZED METABOLITES OF OLTIPRAZ ON THE ACTIVATION OF CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 FOR GSTA2 GENE INDUCTION
Myong Suk Ko, Seung Jin Lee, Jin Wan Kim, Jee Woong Lim and Sang Geon Kim

Drug Metabolism and Disposition August 2006, 34 (8) 1353-1360; DOI: https://doi.org/10.1124/dmd.106.009514
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EFFECT OF CYTOCHROMES P450 CHEMICAL INHIBITORS AND MONOCLONAL ANTIBODIES ON HUMAN LIVER MICROSOMAL ESTERASE ACTIVITY
Stacey L. Polsky-Fisher, Hong Cao, Ping Lu and Christopher R. Gibson

Drug Metabolism and Disposition August 2006, 34 (8) 1361-1366; DOI: https://doi.org/10.1124/dmd.106.009704
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SPECIES DIFFERENCES IN METABOLISM AND PHARMACOKINETICS OF A SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST IN RATS AND DOGS: FORMATION OF A UNIQUE GLUTATHIONE ADDUCT IN THE RAT
M. Reza Anari, Mellissa D. Creighton, Jason S. Ngui, Richard A. Tschirret-Guth, Yohannes Teffera, George A. Doss, Wei Tang, Nathan X. Yu, Suzanne L. Ciccotto, Donald F. Hobra, John B. Coleman, Stella H. Vincent and David C. Evans

Drug Metabolism and Disposition August 2006, 34 (8) 1367-1375; DOI: https://doi.org/10.1124/dmd.105.009027
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INDUCTION OF CYP1A AND CYP2-MEDIATED ARACHIDONIC ACID EPOXYGENATION AND SUPPRESSION OF 20-HYDROXYEICOSATETRAENOIC ACID BY IMIDAZOLE DERIVATIVES INCLUDING THE AROMATASE INHIBITOR VOROZOLE
Silvia Diani-Moore, Fotini Papachristou, Erin Labitzke and Arleen B. Rifkind

Drug Metabolism and Disposition August 2006, 34 (8) 1376-1385; DOI: https://doi.org/10.1124/dmd.106.009498
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IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE
Jinglei Yu, Mark J. I. Paine, Jean-Didier Maréchal, Carol A. Kemp, Clive J. Ward, Simon Brown, Michael J. Sutcliffe, Gordon C. K. Roberts, Elaine M. Rankin and C. Roland Wolf

Drug Metabolism and Disposition August 2006, 34 (8) 1386-1392; DOI: https://doi.org/10.1124/dmd.106.009852
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INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES
Femke M. van de Water, Otto C. Boerman, Alfons C. Wouterse, Janny G. P. Peters, Frans G. M. Russel and Rosalinde Masereeuw

Drug Metabolism and Disposition August 2006, 34 (8) 1393-1397; DOI: https://doi.org/10.1124/dmd.106.009555
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THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE
Marie Stiborová, Helena Dračínská, Jana Hájková, Pavla Kadeřábková, Eva Frei, Heinz H. Schmeiser, Pavel Souček, David H. Phillips and Volker M. Arlt

Drug Metabolism and Disposition August 2006, 34 (8) 1398-1405; DOI: https://doi.org/10.1124/dmd.106.009373
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N-GLUCURONIDATION OF PERFLUOROOCTANESULFONAMIDE BY HUMAN, RAT, DOG, AND MONKEY LIVER MICROSOMES AND BY EXPRESSED RAT AND HUMAN UDP-GLUCURONOSYLTRANSFERASES
Lin Xu, Daria M. Krenitsky, Andrew M. Seacat, John L. Butenhoff, Thomas R. Tephly and M. W. Anders

Drug Metabolism and Disposition August 2006, 34 (8) 1406-1410; DOI: https://doi.org/10.1124/dmd.106.009399
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NEW CYTOCHROME P450 2D6*56 ALLELE IDENTIFIED BY GENOTYPE/PHENOTYPE ANALYSIS OF CRYOPRESERVED HUMAN HEPATOCYTES
Li Li, Run-Mei Pan, Todd D. Porter, Neil S. Jensen, Paul Silber, Guy Russo, John A. Tine, John Heim, Barbara Ring and Peter J. Wedlund

Drug Metabolism and Disposition August 2006, 34 (8) 1411-1416; DOI: https://doi.org/10.1124/dmd.106.009548
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COVALENT BINDING OF RADIOACTIVITY FROM [¹⁴C]ROFECOXIB, BUT NOT [¹⁴C]CELECOXIB OR [¹⁴C]CS-706, TO THE ARTERIAL ELASTIN OF RATS
Masataka Oitate, Takashi Hirota, Kumiko Koyama, Shin-ichi Inoue, Kenji Kawai and Toshihiko Ikeda

Drug Metabolism and Disposition August 2006, 34 (8) 1417-1422; DOI: https://doi.org/10.1124/dmd.106.009860
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PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS
Yoshimichi Sai, Yosuke Kaneko, Satsuki Ito, Keisuke Mitsuoka, Yukio Kato, Ikumi Tamai, Per Artursson and Akira Tsuji

Drug Metabolism and Disposition August 2006, 34 (8) 1423-1431; DOI: https://doi.org/10.1124/dmd.106.009530

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