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Drug Metabolism & Disposition

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Table of Contents

September 01, 2006; Volume 34,Issue 9

Short Communications

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    A Theoretical Validation of the Substrate Depletion Approach to Determining Kinetic Parameters
    Abhinav Nath and William M. Atkins
    Drug Metabolism and Disposition September 2006, 34 (9) 1433-1435; DOI: https://doi.org/10.1124/dmd.106.010777
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    Structural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and Plasma
    Zhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. Smith
    Drug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
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    Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration
    Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van Deusen
    Drug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201

Articles

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    Tetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in Vivo
    Anwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi Osawa
    Drug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
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    Absorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in Humans
    Christopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John Wagner
    Drug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
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    Genetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han Population
    Yakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su Zeng
    Drug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
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    P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile
    Shanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy Pang
    Drug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
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    Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses
    Guy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. Jusko
    Drug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
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    Prominent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10
    Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe Finel
    Drug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
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    Characterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-Nitrobenzene
    Kazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi Yamoto
    Drug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
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    Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo
    Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian Springthorpe
    Drug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
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    In Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine Treatment
    Anna M. Lee, Jiang Yue and Rachel F. Tyndale
    Drug Metabolism and Disposition September 2006, 34 (9) 1508-1515; DOI: https://doi.org/10.1124/dmd.106.010363
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    Minimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 Metabolism
    John P. Gibbs, Ruth Hyland and Kuresh Youdim
    Drug Metabolism and Disposition September 2006, 34 (9) 1516-1522; DOI: https://doi.org/10.1124/dmd.105.008714
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    Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine
    Monica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. Wienkers
    Drug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
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    Regulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-Methylcholanthrene
    Chunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. Riddick
    Drug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
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    Influence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic Acid
    Olivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal Guillemette
    Drug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
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    In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies
    Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. Lin
    Drug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
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    Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts
    M. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-Lechón
    Drug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
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    3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio
    Yueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. Idle
    Drug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
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    Inhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs
    Sachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi Sugiyama
    Drug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
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    Genetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)
    Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold Kerb
    Drug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
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    Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes
    Chuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang Gan
    Drug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
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    Inhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other Chemicals
    Khawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest Hodgson
    Drug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
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    Using a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange Risk
    Christopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. Fate
    Drug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
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    In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/Pharmacodynamics
    Emma Boström, Ulrika S. H. Simonsson and Margareta Hammarlund-Udenaes
    Drug Metabolism and Disposition September 2006, 34 (9) 1624-1631; DOI: https://doi.org/10.1124/dmd.106.009746
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    Characterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic Acid
    Kristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. Ritter
    Drug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
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    On-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor Modulators
    S. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. Vermeulen
    Drug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
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    Small Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 Gene
    Jie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng Zhou
    Drug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
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    Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport
    Yi-an Bi, Diana Kazolias and David B. Duignan
    Drug Metabolism and Disposition September 2006, 34 (9) 1658-1665; DOI: https://doi.org/10.1124/dmd.105.009118

Erratum

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    Correction To “Glutathione S-Transferase Omega 1 and Omega 2 Pharmacogenomics”
    Drug Metabolism and Disposition September 2006, 34 (9) 1666; DOI: https://doi.org/10.1124/dmd.34.9.1666
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Drug Metabolism and Disposition: 34 (9)
Drug Metabolism and Disposition
Vol. 34, Issue 9
1 Sep 2006
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