Table of Contents

Articles

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  Tetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in Vivo

  Anwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi Osawa

  Drug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
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  Absorption, Metabolism, and Excretion of [¹⁴C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in Humans

  Christopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John Wagner

  Drug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
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  Genetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han Population

  Yakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su Zeng

  Drug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
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  P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile

  Shanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy Pang

  Drug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
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  Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses

  Guy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. Jusko

  Drug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
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  Prominent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10

  Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe Finel

  Drug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
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  Characterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-Nitrobenzene

  Kazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi Yamoto

  Drug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
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  Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo

  Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian Springthorpe

  Drug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
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  In Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine Treatment

  Anna M. Lee, Jiang Yue and Rachel F. Tyndale

  Drug Metabolism and Disposition September 2006, 34 (9) 1508-1515; DOI: https://doi.org/10.1124/dmd.106.010363
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  Minimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 Metabolism

  John P. Gibbs, Ruth Hyland and Kuresh Youdim

  Drug Metabolism and Disposition September 2006, 34 (9) 1516-1522; DOI: https://doi.org/10.1124/dmd.105.008714
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  Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine

  Monica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. Wienkers

  Drug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
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  Regulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-Methylcholanthrene

  Chunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. Riddick

  Drug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
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  Influence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic Acid

  Olivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal Guillemette

  Drug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
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  In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies

  Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. Lin

  Drug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
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  Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts

  M. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-Lechón

  Drug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
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  3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio

  Yueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. Idle

  Drug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
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  Inhibition of Bile Acid Transport across Na⁺/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs

  Sachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi Sugiyama

  Drug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
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  Genetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)

  Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold Kerb

  Drug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
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  Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes

  Chuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang Gan

  Drug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
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  Inhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other Chemicals

  Khawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest Hodgson

  Drug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
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  Using a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange Risk

  Christopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. Fate

  Drug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
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  In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/Pharmacodynamics

  Emma Boström, Ulrika S. H. Simonsson and Margareta Hammarlund-Udenaes

  Drug Metabolism and Disposition September 2006, 34 (9) 1624-1631; DOI: https://doi.org/10.1124/dmd.106.009746
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  Characterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic Acid

  Kristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. Ritter

  Drug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
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  On-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor Modulators

  S. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. Vermeulen

  Drug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
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  Small Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 Gene

  Jie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng Zhou

  Drug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
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  Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport

  Yi-an Bi, Diana Kazolias and David B. Duignan

  Drug Metabolism and Disposition September 2006, 34 (9) 1658-1665; DOI: https://doi.org/10.1124/dmd.105.009118