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Structural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and Plasma

Zhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. Smith
Drug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233

Article Information

vol. 34 no. 9 1436-1442
DOI 
https://doi.org/10.1124/dmd.106.009233
PubMed 
16751262
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 3, 2006
  • Accepted May 31, 2006
  • Published online August 22, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhiming Wen,
  2. Stephan T. Stern1,
  3. David E. Martin,
  4. Kuo-Hsiung Lee and
  5. Philip C. Smith
  1. School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Z.W., S.T.S., K.H.L., P.C.S.); and Research & Development Center, Panacos Pharmaceuticals, Gaithersburg, Maryland (D.E.M.)
  1. Address correspondence to:
    Dr. Philip C. Smith, School of Pharmacy, CB 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360. E-mail: pcs{at}email.unc.edu
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OtherShort Communication

Structural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and Plasma

Zhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. Smith
Drug Metabolism and Disposition September 1, 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
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