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Research ArticleArticle

Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo

Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian Springthorpe
Drug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Iain J. Martin
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Richard J. Lewis
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Michael A. Bernstein
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Iain G. Beattie
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Craig A. Martin
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Robert J. Riley
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Brian Springthorpe
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Article Information

vol. 34 no. 9 1502-1507
DOI 
https://doi.org/10.1124/dmd.106.009282
PubMed 
16763016

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 9, 2006
  • Accepted June 7, 2006
  • Published online August 22, 2006.

Article Versions

  • Earlier version (June 8, 2006 - 07:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Iain J. Martin1,
  2. Richard J. Lewis,
  3. Michael A. Bernstein,
  4. Iain G. Beattie,
  5. Craig A. Martin2,
  6. Robert J. Riley and
  7. Brian Springthorpe
  1. Department of Physical and Metabolic Science (I.J.M., R.J.L., M.A.B., I.G.B., C.A.M., R.J.R.) and Department of Medicinal Chemistry (B.S.), AstraZeneca R&D Charnwood, Loughborough, United Kingdom
  1. Address correspondence to:
    Dr. Richard J. Lewis, Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK. E-mail: Richard.J.Lewis{at}astrazeneca.com
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Drug Metabolism and Disposition: 34 (9)
Drug Metabolism and Disposition
Vol. 34, Issue 9
1 Sep 2006
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Research ArticleArticle

Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo

Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian Springthorpe
Drug Metabolism and Disposition September 1, 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282

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Research ArticleArticle

Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo

Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian Springthorpe
Drug Metabolism and Disposition September 1, 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
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