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Drug Metabolism & Disposition

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Table of Contents

January 01, 2007; Volume 35,Issue 1

THE 2006 BERNARD B. BRODIE AWARD LECTURE

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    CYP2E1
    Frank J. Gonzalez
    Drug Metabolism and Disposition January 2007, 35 (1) 1-8; DOI: https://doi.org/10.1124/dmd.106.012492

MINIREVIEW

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    PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism Studies
    Rob Webster, Eric Didier, Philip Harris, Ned Siegel, Jeanne Stadler, Lorraine Tilbury and Dennis Smith
    Drug Metabolism and Disposition January 2007, 35 (1) 9-16; DOI: https://doi.org/10.1124/dmd.106.012419

Short Communication

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    Cellular Localization Studies on Human Estrogen Sulfotransferase SULT1E1 in Human Embryonic Kidney 293 Cells
    Ruchita Kapoor, Deepthi Nimmagadda and Jonathan J. Sheng
    Drug Metabolism and Disposition January 2007, 35 (1) 17-20; DOI: https://doi.org/10.1124/dmd.106.011247

Articles

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    Biotransformation of Geldanamycin and 17-Allylamino-17-Demethoxygeldanamycin by Human Liver Microsomes: Reductive versus Oxidative Metabolism and Implications
    Wensheng Lang, Gary W. Caldwell, Jian Li, Gregory C. Leo, William J. Jones and John A. Masucci
    Drug Metabolism and Disposition January 2007, 35 (1) 21-29; DOI: https://doi.org/10.1124/dmd.106.009639
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    Organic Anion Transporting Polypeptide 2B1 and Breast Cancer Resistance Protein Interact in the Transepithelial Transport of Steroid Sulfates in Human Placenta
    Markus Grube, Sebastian Reuther, Henriette Meyer zu Schwabedissen, Kathleen Köck, Katrin Draber, Christoph A. Ritter, Christoph Fusch, Gabriele Jedlitschky and Heyo K. Kroemer
    Drug Metabolism and Disposition January 2007, 35 (1) 30-35; DOI: https://doi.org/10.1124/dmd.106.011411
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    Gender Dictates the Nuclear Receptor-Mediated Regulation of CYP3A44
    Sayeepriyadarshini Anakk, Wendong Huang, Jeffrey L. Staudinger, Kheng Tan, Timothy J. Cole, David D. Moore and Henry W. Strobel
    Drug Metabolism and Disposition January 2007, 35 (1) 36-42; DOI: https://doi.org/10.1124/dmd.106.011270
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    Specificity of Aminoacylase III-Mediated Deacetylation of Mercapturic Acids
    Debra Newman, Natalia Abuladze, Karoline Scholz, Wolfgang Dekant, Vladimir Tsuprun, Sergey Ryazantsev, Galyna Bondar, Pakan Sassani, Ira Kurtz and Alexander Pushkin
    Drug Metabolism and Disposition January 2007, 35 (1) 43-50; DOI: https://doi.org/10.1124/dmd.106.012062
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    The Disposition and Metabolism of Naveglitazar, a Peroxisome Proliferator-Activated Receptor α-γ Dual, γ-Dominant Agonist in Mice, Rats, and Monkeys
    Ping Yi, Chad E. Hadden, William F. Annes, David A. Jackson, Barry C. Peterson, Todd A. Gillespie and Jason T. Johnson
    Drug Metabolism and Disposition January 2007, 35 (1) 51-61; DOI: https://doi.org/10.1124/dmd.106.012328
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    Elevated Warfarin Metabolism in Warfarin-Resistant Roof Rats (Rattus rattus) in Tokyo
    Mayumi Ishizuka, Fumie Okajima, Tsutomu Tanikawa, Heewon Min, Kazuyuki D. Tanaka, Kentaro Q. Sakamoto and Shoichi Fujita
    Drug Metabolism and Disposition January 2007, 35 (1) 62-66; DOI: https://doi.org/10.1124/dmd.106.011775
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    A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System
    Su-Jun Lee, Ilse P. van der Heiden, Joyce A. Goldstein and Ron H. N. van Schaik
    Drug Metabolism and Disposition January 2007, 35 (1) 67-71; DOI: https://doi.org/10.1124/dmd.106.012310
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    Identification of Human Cytochrome P450 Isozymes Involved in Diphenhydramine N-Demethylation
    Tomoko Akutsu, Kaoru Kobayashi, Koichi Sakurada, Hiroshi Ikegaya, Tomomi Furihata and Kan Chiba
    Drug Metabolism and Disposition January 2007, 35 (1) 72-78; DOI: https://doi.org/10.1124/dmd.106.012088
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    A Novel Model for the Prediction of Drug-Drug Interactions in Humans Based on in Vitro Cytochrome P450 Phenotypic Data
    Chuang Lu, Gerald T. Miwa, Shimoga R. Prakash, Liang-Shang Gan and Suresh K. Balani
    Drug Metabolism and Disposition January 2007, 35 (1) 79-85; DOI: https://doi.org/10.1124/dmd.106.011346
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    Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates
    Amita Datta-Mannan, Derrick R. Witcher, Ying Tang, Jeffry Watkins, Weidong Jiang and Victor J. Wroblewski
    Drug Metabolism and Disposition January 2007, 35 (1) 86-94; DOI: https://doi.org/10.1124/dmd.106.011734
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    Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p′-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane
    Irma M. Medina-Díaz, Georgina Arteaga-Illán, Mario Bermudez de León, Bulmaro Cisneros, Adolfo Sierra-Santoyo, Libia Vega, Frank J. Gonzalez and Guillermo Elizondo
    Drug Metabolism and Disposition January 2007, 35 (1) 95-102; DOI: https://doi.org/10.1124/dmd.106.011759
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    A Real-Time Fluorescence Assay for Measuring N-Dealkylation
    Richard T. Mayer, E. Kurt Dolence and Gabriele E. Mayer
    Drug Metabolism and Disposition January 2007, 35 (1) 103-109; DOI: https://doi.org/10.1124/dmd.106.011601
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    Impact of Curcumin-Induced Changes in P-Glycoprotein and CYP3A Expression on the Pharmacokinetics of Peroral Celiprolol and Midazolam in Rats
    Wenxia Zhang, Theresa May Chin Tan and Lee-Yong Lim
    Drug Metabolism and Disposition January 2007, 35 (1) 110-115; DOI: https://doi.org/10.1124/dmd.106.011072
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    Isolation of the UDP-Glucuronosyltransferase 1A3 and 1A4 Proximal Promoters and Characterization of Their Dependence on the Transcription Factor Hepatocyte Nuclear Factor 1α
    Dione A. Gardner-Stephen and Peter I. Mackenzie
    Drug Metabolism and Disposition January 2007, 35 (1) 116-120; DOI: https://doi.org/10.1124/dmd.106.012203
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    Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice
    David B. Buckley and Curtis D. Klaassen
    Drug Metabolism and Disposition January 2007, 35 (1) 121-127; DOI: https://doi.org/10.1124/dmd.106.012070
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    CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative Metabolism of Perhexiline Enantiomers by Human Liver Microsomes
    Benjamin J. Davies, Janet K. Coller, Andrew A. Somogyi, Robert W. Milne and Benedetta C. Sallustio
    Drug Metabolism and Disposition January 2007, 35 (1) 128-138; DOI: https://doi.org/10.1124/dmd.106.012252
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    Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar
    Donglu Zhang, Lifei Wang, Gamini Chandrasena, Li Ma, Mingshe Zhu, Hongjian Zhang, Carl D. Davis and W. Griffith Humphreys
    Drug Metabolism and Disposition January 2007, 35 (1) 139-149; DOI: https://doi.org/10.1124/dmd.106.011932
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    Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling
    Donglu Zhang, Lifei Wang, Nirmala Raghavan, Haiying Zhang, Wenying Li, Peter T. Cheng, Ming Yao, Litao Zhang, Mingshe Zhu, Samuel Bonacorsi, Suresh Yeola, James Mitroka, Narayanan Hariharan, Vinayak Hosagrahara, Gamini Chandrasena, Wen Chyi Shyu and W. Griffith Humphreys
    Drug Metabolism and Disposition January 2007, 35 (1) 150-167; DOI: https://doi.org/10.1124/dmd.106.012450
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    Cytochrome P450 and Glutathione S-Transferase mRNA Expression in Human Fetal Liver Hematopoietic Stem Cells
    Jing Shao, Patricia L. Stapleton, Yvonne S. Lin and Evan P. Gallagher
    Drug Metabolism and Disposition January 2007, 35 (1) 168-175; DOI: https://doi.org/10.1124/dmd.106.012757
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    Genetic Variation of Human Cytochrome P450 Reductase as a Potential Biomarker for Mitomycin C-Induced Cytotoxicity
    Shou-Lin Wang, Jing-Fen Han, Xiao-Yang He, Xin-Ru Wang and Jun-Yan Hong
    Drug Metabolism and Disposition January 2007, 35 (1) 176-179; DOI: https://doi.org/10.1124/dmd.106.011056
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    An Evaluation of the Cytochrome P450 Inhibition Potential of Lisdexamfetamine in Human Liver Microsomes
    Suma Krishnan and Scott Moncrief
    Drug Metabolism and Disposition January 2007, 35 (1) 180-184; DOI: https://doi.org/10.1124/dmd.106.011973
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In this issue

Drug Metabolism and Disposition: 35 (1)
Drug Metabolism and Disposition
Vol. 35, Issue 1
1 Jan 2007
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
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  • THE 2006 BERNARD B. BRODIE AWARD LECTURE
  • MINIREVIEW
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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