Table of Contents

Articles

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  Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

  H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan

  Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743
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  High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin

  Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer

  Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345
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  Metabolic Profile of [¹⁴C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites

  James P. Chovan, Feng Li, Erya Yu and Steven C. Ring

  Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958
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  Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation

  Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim

  Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545
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  Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas

  Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim

  Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584
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  Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs

  Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen

  Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644
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  Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities

  Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi

  Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402
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  Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite

  Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson

  Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297
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  A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes

  G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee

  Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966
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  Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport

  Jay S. Petrick and Curtis D. Klaassen

  Drug Metabolism and Disposition October 2007, 35 (10) 1806-1815; DOI: https://doi.org/10.1124/dmd.107.015974
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  Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients

  N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft

  Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755
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  Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons

  Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt

  Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964
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  In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors

  Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori

  Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311
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  Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys

  Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader

  Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261
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  Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta

  Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda

  Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121
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  Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions

  Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat

  Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089
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  Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution

  Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka

  Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503
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  Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population

  Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada

  Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339
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  Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones

  Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama

  Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969
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  Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone

  Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto

  Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832
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  Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species

  Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler

  Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188
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  In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles

  Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye

  Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875
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  Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in Rats and Dogs: Assessment of First-Pass Bioactivation and Dose Linearity

  Everett J. Perkins and Trent Abraham

  Drug Metabolism and Disposition October 2007, 35 (10) 1903-1909; DOI: https://doi.org/10.1124/dmd.107.016154
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  Prediction of Metabolic Clearance of Bisphenol A (4,4 ′-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes

  R. K. Kuester and I. G. Sipes

  Drug Metabolism and Disposition October 2007, 35 (10) 1910-1915; DOI: https://doi.org/10.1124/dmd.107.014787
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  Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans

  Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ

  Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933
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  The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism

  Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová

  Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048
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  Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor

  Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima

  Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568
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  Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation

  Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus

  Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279
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  A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

  Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa

  Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327
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  Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine

  Mingyan Zhou, Li Xia and Joanne Wang

  Drug Metabolism and Disposition October 2007, 35 (10) 1956-1962; DOI: https://doi.org/10.1124/dmd.107.015495
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  Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases

  Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou

  Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170
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  Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

  Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington

  Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107