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Drug Metabolism & Disposition

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Table of Contents

October 01, 2007; Volume 35,Issue 10

Short Communications

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    Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
    Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters and Thomas Wagner
    Drug Metabolism and Disposition October 2007, 35 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.106.014043
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    P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
    Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
    Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677
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    Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
    Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
    Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

Articles

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    Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
    H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
    Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743
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    High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
    Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
    Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345
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    Metabolic Profile of [14C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
    James P. Chovan, Feng Li, Erya Yu and Steven C. Ring
    Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958
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    Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
    Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
    Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545
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    Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
    Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
    Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584
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    Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
    Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
    Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644
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    Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
    Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
    Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402
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    Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
    Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
    Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297
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    A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
    G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
    Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966
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    Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport
    Jay S. Petrick and Curtis D. Klaassen
    Drug Metabolism and Disposition October 2007, 35 (10) 1806-1815; DOI: https://doi.org/10.1124/dmd.107.015974
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    Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
    N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
    Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755
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    Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
    Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
    Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964
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    In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
    Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
    Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311
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    Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
    Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
    Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261
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    Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
    Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
    Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121
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    Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
    Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
    Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089
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    Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
    Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
    Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503
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    Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
    Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
    Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339
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    Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
    Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969
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    Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
    Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
    Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832
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    Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
    Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
    Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188
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    In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
    Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye
    Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875
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    Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in Rats and Dogs: Assessment of First-Pass Bioactivation and Dose Linearity
    Everett J. Perkins and Trent Abraham
    Drug Metabolism and Disposition October 2007, 35 (10) 1903-1909; DOI: https://doi.org/10.1124/dmd.107.016154
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    Prediction of Metabolic Clearance of Bisphenol A (4,4 ′-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes
    R. K. Kuester and I. G. Sipes
    Drug Metabolism and Disposition October 2007, 35 (10) 1910-1915; DOI: https://doi.org/10.1124/dmd.107.014787
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    Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
    Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
    Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933
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    The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
    Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
    Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048
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    Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
    Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
    Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568
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    Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
    Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
    Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279
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    A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
    Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
    Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327
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    Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
    Mingyan Zhou, Li Xia and Joanne Wang
    Drug Metabolism and Disposition October 2007, 35 (10) 1956-1962; DOI: https://doi.org/10.1124/dmd.107.015495
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    Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
    Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
    Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170
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    Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
    Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
    Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107
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Drug Metabolism and Disposition: 35 (10)
Drug Metabolism and Disposition
Vol. 35, Issue 10
1 Oct 2007
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