Advertisement

Index by author

October 01, 2007; Volume 35,Issue 10

A

  1. Abraham, Trent

    1. Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in Rats and Dogs: Assessment of First-Pass Bioactivation and Dose Linearity
      Everett J. Perkins and Trent Abraham
      Drug Metabolism and Disposition October 2007, 35 (10) 1903-1909; DOI: https://doi.org/10.1124/dmd.107.016154

  2. Adachi, Mayuko

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  3. Aimová, Dagmar

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  4. Akao, Teruaki

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  5. Akasawa, Akira

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  6. Aleksunes, Lauren M.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170
    2. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  7. Alvarez, Ana I.

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  8. Amin, Shantu

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  9. Ando, Tomohiro

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  10. Augustine, Lisa

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  11. Augustine, Lisa M.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  12. Axelsson, Bengt-Olof

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

B

  1. Bai, Stephen A.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  2. Bakhiya, Nadiya

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  3. Banks, Matthew L.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

  4. Barnes, Sarah N.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  5. Barter, Z. E.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

  6. Batke, Monika

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  7. Bayliss, M. K.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  8. Besselsen, David G.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  9. Bhadhprasit, Wattanaporn

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

  10. Black, Christopher B.

    1. In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
      Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye
      Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875

  11. Brogdon, Bernice

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  12. Brüggemann, Svenja Kristin

    1. Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
      Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters and Thomas Wagner
      Drug Metabolism and Disposition October 2007, 35 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.106.014043

  13. Buerger, C.

    1. Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
      N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
      Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755

C

  1. Cameron, Michael D.

    1. In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
      Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye
      Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875

  2. Cellucci, Antonella

    1. High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
      Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
      Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345

  3. Chaudhary, Ashok

    1. High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
      Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
      Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345

  4. Chen, Cuiping

    1. P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
      Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
      Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677

  5. Chen, Gang

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  6. Cherrington, Nathan J.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170
    2. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  7. Chovan, James P.

    1. Metabolic Profile of [14C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
      James P. Chovan, Feng Li, Erya Yu and Steven C. Ring
      Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958

  8. Christ, David D.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  9. Covington, Maryanne B.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  10. Czoty, Paul W.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

D

  1. De Buck, Stefan S.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

  2. Decicco, Carl P.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  3. Degawa, Masakuni

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  4. Deng, Yuzhong

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  5. Desai, Pankaj

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

  6. Di Marco, Annalise

    1. High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
      Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
      Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345

  7. Dixit, Vaishali

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

  8. Duan, James J.-W.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

E

  1. Engst, Wolfram

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

F

  1. Fenu, Luca A.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

  2. Fisher, Craig D.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  3. Fluhler, Eric

    1. Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
      Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
      Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188

  4. Fonsi, Massimiliano

    1. High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
      Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
      Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345

  5. Fossler, Michael J.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  6. Frank, Heinz

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  7. Freathy, C.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  8. Frei, Eva

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  9. Fujiwara, Ryoichi

    1. Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
      Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402

  10. Fukami, Tatsuki

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568

  11. Fuwa, Masahiro

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

G

  1. Garner, C. Edwin

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  2. Gilissen, Ron A. H. J.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

  3. Glatt, Hansruedi

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  4. Goedken, Michael J.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  5. Gullstrand, Helena

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

H

  1. Haraguchi, Koichi

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  2. Hariparsad, Niresh

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

  3. Hatakeyama, Nobuyuki

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

  4. Hattori, Masao

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  5. Higashi, Eriko

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568

  6. Hinai, Yudai

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  7. Hiratsuka, Masahiro

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  8. Hirota, Takashi

    1. Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
      Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
      Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121

  9. Ho, S.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  10. Hodek, Petr

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  11. Hoshino, Kouichi

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  12. Hudeček, Jiří

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  13. Hussain, Azher

    1. Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
      Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
      Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188

I

  1. Ikeda, Toshihiko

    1. Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
      Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
      Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121

  2. Ikushiro, Shin-ichi

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  3. Imagawa, Kenichi

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  4. Inoue, Masaki

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568

  5. Ishikawa, Masaaki

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  6. Itoh, Kunio

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  7. Itoh, Masahiro

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568

J

  1. Jakowski, Amy B.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  2. Jinno, Hideto

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  3. Jones, A. E.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  4. Jones, B. C.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

  5. Joukhadar, C.

    1. Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
      N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
      Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755

  6. Jung, Da W.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

  7. Jung, Young S.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

K

  1. Kamatani, Naoyuki

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  2. Kaniwa, Nahoko

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  3. Kanno, Jun

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  4. Kato, Yoshihisa

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  5. Katoh, Miki

    1. Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
      Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402

  6. Kim, Dong-Hyun

    1. Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
      Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584

  7. Kim, Su-Ryang

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  8. Kim, Su N.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

  9. Kim, Young C.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

  10. Kim, Young Choong

    1. Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
      Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584

  11. Kisor, David F.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

  12. Kitajima, Kaori

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

  13. Klaassen, Curtis D.

    1. Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport
      Jay S. Petrick and Curtis D. Klaassen
      Drug Metabolism and Disposition October 2007, 35 (10) 1806-1815; DOI: https://doi.org/10.1124/dmd.107.015974

  14. Kljucar, S.

    1. Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
      N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
      Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755

  15. Kloft, C.

    1. Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
      N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
      Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755

  16. Koga, Nobuyuki

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  17. Konno, Yumiko

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  18. Korn, Solange H.

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

  19. Kotrbová, Věra

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  20. Kuester, R. K.

    1. Prediction of Metabolic Clearance of Bisphenol A (4,4 ′-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes
      R. K. Kuester and I. G. Sipes
      Drug Metabolism and Disposition October 2007, 35 (10) 1910-1915; DOI: https://doi.org/10.1124/dmd.107.014787

  21. Kusuhara, Hiroyuki

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  22. Kyo, Satoru

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568

L

  1. Laake, Janet

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  2. Laufer, Ralph

    1. High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
      Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi and Ralph Laufer
      Drug Metabolism and Disposition October 2007, 35 (10) 1737-1743; DOI: https://doi.org/10.1124/dmd.107.016345

  3. Lazarus, Philip

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  4. Leal, Mauricio

    1. Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
      Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
      Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188

  5. Lee, Min Woo

    1. Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
      Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584

  6. Lee, Min Y.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

  7. Lexmüller, Kristina

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

  8. Li, Fang

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

  9. Li, Feng

    1. Metabolic Profile of [14C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
      James P. Chovan, Feng Li, Erya Yu and Steven C. Ring
      Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958

  10. Lickteig, Andrew J.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  11. Lin, Jian

    1. P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
      Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
      Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677

  12. Lindsay, N.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  13. Liu, Rui-Qin

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  14. Lowdon, B. M.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

M

  1. Mackie, Claire E.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

  2. Maduskuie, Thomas

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  3. Manautou, Jose E.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  4. Manautou, José E.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  5. Manchee, G. R.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  6. Maruyama, Hiroaki

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  7. Matsumoto, Kenji

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  8. Mayersohn, Michael

    1. Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
      Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
      Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188

  9. Merino, Gracia

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  10. Miller-Larsson, Anna

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

  11. Minami, Hironobu

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  12. Miura, Shin-ichi

    1. Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
      Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
      Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121

  13. Mizugaki, Michinao

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  14. Monien, Bernhard H.

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  15. Mrázová, Barbora

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  16. Murai, Takahiro

    1. Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
      Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
      Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121

N

  1. Nader, Michael A.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

  2. Nakajima, Miki

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568
    2. Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
      Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402

  3. Nakamura, Norio

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  4. Nemoto, Nobuo

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

  5. Newton, Robert C.

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  6. Nichols, David E.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

  7. Nijsen, Marjoleen J.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

O

  1. Ohtsu, Atsushi

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  2. Oitate, Masataka

    1. Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
      Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura and Toshihiko Ikeda
      Drug Metabolism and Disposition October 2007, 35 (10) 1846-1852; DOI: https://doi.org/10.1124/dmd.107.016121

  3. Ozawa, Shogo

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

P

  1. Perkins, Everett J.

    1. Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in Rats and Dogs: Assessment of First-Pass Bioactivation and Dose Linearity
      Everett J. Perkins and Trent Abraham
      Drug Metabolism and Disposition October 2007, 35 (10) 1903-1909; DOI: https://doi.org/10.1124/dmd.107.016154

  2. Perrett, H. F.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

  3. Peters, Stefan Oliver

    1. Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
      Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters and Thomas Wagner
      Drug Metabolism and Disposition October 2007, 35 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.106.014043

  4. Petrick, Jay S.

    1. Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport
      Jay S. Petrick and Curtis D. Klaassen
      Drug Metabolism and Disposition October 2007, 35 (10) 1806-1815; DOI: https://doi.org/10.1124/dmd.107.015974

  5. Pfäffle, Sonja

    1. Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
      Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters and Thomas Wagner
      Drug Metabolism and Disposition October 2007, 35 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.106.014043

  6. Plock, N.

    1. Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
      N. Plock, C. Buerger, C. Joukhadar, S. Kljucar and C. Kloft
      Drug Metabolism and Disposition October 2007, 35 (10) 1816-1823; DOI: https://doi.org/10.1124/dmd.106.013755

  7. Pruimboom-Brees, Ingrid M.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

Q

  1. Qian, Mingxin

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

R

  1. Ring, Steven C.

    1. Metabolic Profile of [14C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
      James P. Chovan, Feng Li, Erya Yu and Steven C. Ring
      Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958

  2. Rostami-Hodjegan, A.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

S

  1. Sai, Kimie

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  2. Saijo, Nagahiro

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  3. Saito, Hirohisa

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  4. Saito, Yoshiro

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  5. Sakaki, Toshiyuki

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  6. Sakuma, Tsutomu

    1. Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
      Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima and Nobuo Nemoto
      Drug Metabolism and Disposition October 2007, 35 (10) 1880-1885; DOI: https://doi.org/10.1124/dmd.107.016832

  7. Sasahara, Masakiyo

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  8. Sasaki, Takamitsu

    1. Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
      Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa and Michinao Mizugaki
      Drug Metabolism and Disposition October 2007, 35 (10) 1730-1732; DOI: https://doi.org/10.1124/dmd.107.016758

  9. Sawada, Jun-ichi

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  10. Scheffer, George L.

    1. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
      Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington and José E. Manautou
      Drug Metabolism and Disposition October 2007, 35 (10) 1963-1969; DOI: https://doi.org/10.1124/dmd.107.016170

  11. Schinkel, Alfred H.

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  12. Seidel, Albrecht

    1. Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
      Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst and Hansruedi Glatt
      Drug Metabolism and Disposition October 2007, 35 (10) 1824-1831; DOI: https://doi.org/10.1124/dmd.107.016964

  13. Seo, Ji Y.

    1. Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
      Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung and Young C. Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1754-1758; DOI: https://doi.org/10.1124/dmd.107.015545

  14. Sharma, Arun K.

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  15. Shirao, Kuniaki

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  16. Silberstein, David S.

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

  17. Sinha, Vikash K.

    1. Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
      Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie and Ron A. H. J. Gilissen
      Drug Metabolism and Disposition October 2007, 35 (10) 1766-1780; DOI: https://doi.org/10.1124/dmd.107.015644

  18. Sipes, I. G.

    1. Prediction of Metabolic Clearance of Bisphenol A (4,4 ′-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes
      R. K. Kuester and I. G. Sipes
      Drug Metabolism and Disposition October 2007, 35 (10) 1910-1915; DOI: https://doi.org/10.1124/dmd.107.014787

  19. Sjölin, Petter

    1. Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
      Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein and Anna Miller-Larsson
      Drug Metabolism and Disposition October 2007, 35 (10) 1788-1796; DOI: https://doi.org/10.1124/dmd.107.015297

  20. Slitt, Angela L.

    1. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
      Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2007, 35 (10) 1970-1978; DOI: https://doi.org/10.1124/dmd.107.015107

  21. Smolarek, Teresa

    1. P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
      Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
      Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677

  22. Somers, G. I.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  23. Sprague, Jon E.

    1. Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
      Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols and Michael A. Nader
      Drug Metabolism and Disposition October 2007, 35 (10) 1840-1845; DOI: https://doi.org/10.1124/dmd.107.016261

  24. Stiborová, Marie

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  25. Sugiyama, Yuichi

    1. Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
      Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel and Yuichi Sugiyama
      Drug Metabolism and Disposition October 2007, 35 (10) 1873-1879; DOI: https://doi.org/10.1124/dmd.107.014969

  26. Sun, Dongxiao

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  27. Svobodová, Lucie

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

T

  1. Takagawa, Kiyoshi

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  2. Takiguchi, Rie

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  3. Tanaka, Yorihisa

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  4. Tanaka-Kagawa, Toshiko

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  5. Tang, Huadong

    1. Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
      Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn and Eric Fluhler
      Drug Metabolism and Disposition October 2007, 35 (10) 1886-1893; DOI: https://doi.org/10.1124/dmd.107.016188

  6. Tang, Jun

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  7. Thummel, Kenneth E.

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

  8. Tremaine, Larry

    1. P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
      Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
      Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677

  9. Trzaskos, James

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

  10. Tucker, G. T.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

U

  1. Uchida, Shinya

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  2. Unadkat, Jashvant D.

    1. Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
      Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition October 2007, 35 (10) 1853-1859; DOI: https://doi.org/10.1124/dmd.107.016089

V

  1. Václavíková, Radka

    1. The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
      Dagmar Aimová, Lucie Svobodová, Věra Kotrbová, Barbora Mrázová, Petr Hodek, Jiří Hudeček, Radka Václavíková, Eva Frei and Marie Stiborová
      Drug Metabolism and Disposition October 2007, 35 (10) 1926-1934; DOI: https://doi.org/10.1124/dmd.107.016048

  2. Vaddi, Kris

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

W

  1. Wagner, Thomas

    1. Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
      Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters and Thomas Wagner
      Drug Metabolism and Disposition October 2007, 35 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.106.014043

  2. Wang, Joanne

    1. Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
      Mingyan Zhou, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2007, 35 (10) 1956-1962; DOI: https://doi.org/10.1124/dmd.107.015495

  3. Wang, Zheng-Tao

    1. In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
      Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara and Masao Hattori
      Drug Metabolism and Disposition October 2007, 35 (10) 1832-1839; DOI: https://doi.org/10.1124/dmd.107.016311

  4. Watanabe, Nobuaki

    1. Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
      Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe and Yorihisa Tanaka
      Drug Metabolism and Disposition October 2007, 35 (10) 1860-1864; DOI: https://doi.org/10.1124/dmd.107.015503

  5. Woodrooffe, A. J. M.

    1. A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
      G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss and G. R. Manchee
      Drug Metabolism and Disposition October 2007, 35 (10) 1797-1805; DOI: https://doi.org/10.1124/dmd.107.015966

  6. Wright, Jason

    1. In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
      Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye
      Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875

  7. Wu, Jing-Tao

    1. Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
      Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco and David D. Christ
      Drug Metabolism and Disposition October 2007, 35 (10) 1916-1925; DOI: https://doi.org/10.1124/dmd.107.015933

X

  1. Xia, Li

    1. Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
      Mingyan Zhou, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2007, 35 (10) 1956-1962; DOI: https://doi.org/10.1124/dmd.107.015495

Y

  1. Yamada, Shizuo

    1. A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
      Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa
      Drug Metabolism and Disposition October 2007, 35 (10) 1949-1955; DOI: https://doi.org/10.1124/dmd.107.017327

  2. Yamamoto, Noboru

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  3. Yamanaka, Hiroyuki

    1. Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
      Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402

  4. Yamazaki, H.

    1. Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
      H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker and A. Rostami-Hodjegan
      Drug Metabolism and Disposition October 2007, 35 (10) 1733-1736; DOI: https://doi.org/10.1124/dmd.107.015743

  5. Ye, Naidong

    1. In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
      Michael D. Cameron, Jason Wright, Christopher B. Black and Naidong Ye
      Drug Metabolism and Disposition October 2007, 35 (10) 1894-1902; DOI: https://doi.org/10.1124/dmd.107.015875

  6. Yokoi, Tsuyoshi

    1. Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
      Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi and Miki Nakajima
      Drug Metabolism and Disposition October 2007, 35 (10) 1935-1941; DOI: https://doi.org/10.1124/dmd.107.016568
    2. Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh and Tsuyoshi Yokoi
      Drug Metabolism and Disposition October 2007, 35 (10) 1781-1787; DOI: https://doi.org/10.1124/dmd.107.016402

  7. Yoo, Hye Hyun

    1. Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
      Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584

  8. Yoshida, Teruhiko

    1. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
      Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo and Jun-ichi Sawada
      Drug Metabolism and Disposition October 2007, 35 (10) 1865-1872; DOI: https://doi.org/10.1124/dmd.107.015339

  9. Yu, Erya

    1. Metabolic Profile of [14C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
      James P. Chovan, Feng Li, Erya Yu and Steven C. Ring
      Drug Metabolism and Disposition October 2007, 35 (10) 1744-1753; DOI: https://doi.org/10.1124/dmd.107.015958

  10. Yun, Chul-Ho

    1. Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
      Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun and Dong-Hyun Kim
      Drug Metabolism and Disposition October 2007, 35 (10) 1759-1765; DOI: https://doi.org/10.1124/dmd.107.016584

Z

  1. Zheng, Yan

    1. Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
      Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin and Philip Lazarus
      Drug Metabolism and Disposition October 2007, 35 (10) 1942-1948; DOI: https://doi.org/10.1124/dmd.107.016279

  2. Zhou, Mingyan

    1. Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
      Mingyan Zhou, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2007, 35 (10) 1956-1962; DOI: https://doi.org/10.1124/dmd.107.015495
Back to top

In this issue