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Drug Metabolism & Disposition

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Table of Contents

November 01, 2007; Volume 35,Issue 11

Short Communications

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    NC100668, a New Tracer Tested for Imaging of Venous Thromboembolism: Pharmacokinetics and Metabolism in Humans
    Kim G. Toft, Judith A. Johnson, Inger Oulie and Tore Skotland
    Drug Metabolism and Disposition November 2007, 35 (11) 1979-1984; DOI: https://doi.org/10.1124/dmd.106.014126
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    Bioavailable Flavonoids: Cytochrome P450-Mediated Metabolism of Methoxyflavones
    U. Kristina Walle and Thomas Walle
    Drug Metabolism and Disposition November 2007, 35 (11) 1985-1989; DOI: https://doi.org/10.1124/dmd.107.016782
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    Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P450 2B6- and 2C8-Dependent Activity in Human Liver Microsomes
    Ragini Vuppugalla, Shu-Ying Chang, Hongjian Zhang, Punit H. Marathe and David A. Rodrigues
    Drug Metabolism and Disposition November 2007, 35 (11) 1990-1995; DOI: https://doi.org/10.1124/dmd.107.016816

Articles

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    Functional Induction of P-glycoprotein in the Blood-Brain Barrier of Streptozotocin-Induced Diabetic Rats: Evidence for the Involvement of Nuclear Factor-κB, a Nitrosative Stress-Sensitive Transcription Factor, in the Regulation
    Han-Joo Maeng, Mi-Hwa Kim, Hyo-Eon Jin, Sang Mi Shin, Takasi Tsuruo, Sang Geon Kim, Dae-Duk Kim, Chang-Koo Shim and Suk-Jae Chung
    Drug Metabolism and Disposition November 2007, 35 (11) 1996-2005; DOI: https://doi.org/10.1124/dmd.107.015800
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    Glucuronidation of Active Tamoxifen Metabolites by the Human UDP Glucuronosyltransferases
    Dongxiao Sun, Arun K. Sharma, Ryan W. Dellinger, Andrea S. Blevins-Primeau, Renee M. Balliet, Gang Chen, Telih Boyiri, Shantu Amin and Philip Lazarus
    Drug Metabolism and Disposition November 2007, 35 (11) 2006-2014; DOI: https://doi.org/10.1124/dmd.107.017145
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    Specificity of Procaine and Ester Hydrolysis by Human, Minipig, and Rat Skin and Liver
    Christopher Jewell, Chrisita Ackermann, N. Ann Payne, Gwendolyn Fate, Richard Voorman and Faith M. Williams
    Drug Metabolism and Disposition November 2007, 35 (11) 2015-2022; DOI: https://doi.org/10.1124/dmd.107.015727
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    Identification of New Flavone-8-Acetic Acid Metabolites Using Mouse Microsomes and Comparison with Human Microsomes
    Minh Hien Pham, Nicolas Auzeil, Anne Regazzetti, Daniel Dauzonne, Annabelle Dugay, Marie-Claude Menet, Daniel Scherman and Guy G. Chabot
    Drug Metabolism and Disposition November 2007, 35 (11) 2023-2034; DOI: https://doi.org/10.1124/dmd.107.017012
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    Silybin Is Metabolized by Cytochrome P450 2C8 in Vitro
    Petra Jančová, Eva Anzenbacherová, Barbora Papoušková, Karel Lemr, Pavla Lužná, Alena Veinlichová, Pavel Anzenbacher and Vilím Šimánek
    Drug Metabolism and Disposition November 2007, 35 (11) 2035-2039; DOI: https://doi.org/10.1124/dmd.107.016410
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    The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver
    Yuji Mano, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition November 2007, 35 (11) 2040-2044; DOI: https://doi.org/10.1124/dmd.107.017269
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    Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)
    Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, John D. Schuetz, Takuro Niwa and Yuichi Sugiyama
    Drug Metabolism and Disposition November 2007, 35 (11) 2045-2052; DOI: https://doi.org/10.1124/dmd.107.016352
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    A Comparison of 2-Phenyl-2-(1-piperidinyl)propane (PPP), 1,1′,1″-Phosphinothioylidynetrisaziridine (ThioTEPA), Clopidogrel, and Ticlopidine as Selective Inactivators of Human Cytochrome P450 2B6
    Robert L. Walsky and R. Scott Obach
    Drug Metabolism and Disposition November 2007, 35 (11) 2053-2059; DOI: https://doi.org/10.1124/dmd.107.015883
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    Beneficial Effect of Spironolactone Administration on Ethynylestradiol-Induced Cholestasis in the Rat: Involvement of Up-Regulation of Multidrug Resistance-Associated Protein 2
    María L. Ruiz, Silvina S.M. Villanueva, Marcelo G. Luquita, Shin-ichi Ikushiro, Aldo D. Mottino and Viviana A. Catania
    Drug Metabolism and Disposition November 2007, 35 (11) 2060-2066; DOI: https://doi.org/10.1124/dmd.107.016519
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    Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine
    Michael Zhuo Wang, Judy Qiju Wu, Arlene S. Bridges, Darryl C. Zeldin, Sally Kornbluth, Richard R. Tidwell, James Edwin Hall and Mary F. Paine
    Drug Metabolism and Disposition November 2007, 35 (11) 2067-2075; DOI: https://doi.org/10.1124/dmd.107.016428
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    P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution
    Naveed Shaik, Nagdeep Giri, Guoyu Pan and William F. Elmquist
    Drug Metabolism and Disposition November 2007, 35 (11) 2076-2085; DOI: https://doi.org/10.1124/dmd.107.017723
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    Analysis of CYP2A Contributions to Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Human Peripheral Lung Microsomes
    Pamela J. Brown, Leanne L. Bedard, Ken R. Reid, Dimitri Petsikas and Thomas E. Massey
    Drug Metabolism and Disposition November 2007, 35 (11) 2086-2094; DOI: https://doi.org/10.1124/dmd.107.017343
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    The CYP3A4*18 Allele, the Most Frequent Coding Variant in Asian Populations, Does Not Significantly Affect the Midazolam Disposition in Heterozygous Individuals
    Su-Jun Lee, Sang Seop Lee, Hye-Eun Jeong, Ji-Hong Shon, Ji-Young Ryu, Yu Eun Sunwoo, Kwang-Hyeon Liu, Wonku Kang, Young-Ju Park, Chi-Mann Shin and Jae-Gook Shin
    Drug Metabolism and Disposition November 2007, 35 (11) 2095-2101; DOI: https://doi.org/10.1124/dmd.107.016733
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    Attenuated Expression of Episodic Growth Hormone-Induced CYP2C11 in Female Rats Associated with Suboptimal Activation of the Jak2/Stat5B and Other Modulating Signaling Pathways
    Ravindra N. Dhir, Chellappagounder Thangavel and Bernard H. Shapiro
    Drug Metabolism and Disposition November 2007, 35 (11) 2102-2110; DOI: https://doi.org/10.1124/dmd.107.017475
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    Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human
    Amit S. Kalgutkar, Bo Feng, Hang T. Nguyen, Kosea S. Frederick, Scott D. Campbell, Heather L. Hatch, Yi-An Bi, Diana C. Kazolias, Ralph E. Davidson, Rouchelle J. Mireles, David B. Duignan, Edna F. Choo and Sabrina X. Zhao
    Drug Metabolism and Disposition November 2007, 35 (11) 2111-2118; DOI: https://doi.org/10.1124/dmd.107.016162
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    Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination
    Hayley S. Brown, Anthony Chadwick and J. Brian Houston
    Drug Metabolism and Disposition November 2007, 35 (11) 2119-2126; DOI: https://doi.org/10.1124/dmd.107.017095
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    Serine Hydroxymethyltransferase Isoforms Are Differentially Inhibited by Leucovorin: Characterization and Comparison of Recombinant Zebrafish Serine Hydroxymethyltransferases
    Wen-Ni Chang, Jen-Ning Tsai, Bing-Hung Chen, Huei-Sheng Huang and Tzu-Fun Fu
    Drug Metabolism and Disposition November 2007, 35 (11) 2127-2137; DOI: https://doi.org/10.1124/dmd.107.016840

Erratum

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    CORRECTION TO “IN VITRO METABOLIC STUDY OF TEMSIROLIMUS: PREPARATION, ISOLATION, AND IDENTIFICATION OF THE METABOLITES”
    Drug Metabolism and Disposition November 2007, 35 (11) 2138; DOI: https://doi.org/10.1124/dmd.35.11.2138
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In this issue

Drug Metabolism and Disposition: 35 (11)
Drug Metabolism and Disposition
Vol. 35, Issue 11
1 Nov 2007
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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