Drug Metabolism and Disposition: 35 (11)

November 01, 2007; Volume 35,Issue 11

Short Communications

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NC100668, a New Tracer Tested for Imaging of Venous Thromboembolism: Pharmacokinetics and Metabolism in Humans
Kim G. Toft, Judith A. Johnson, Inger Oulie and Tore Skotland

Drug Metabolism and Disposition November 2007, 35 (11) 1979-1984; DOI: https://doi.org/10.1124/dmd.106.014126
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Bioavailable Flavonoids: Cytochrome P450-Mediated Metabolism of Methoxyflavones
U. Kristina Walle and Thomas Walle

Drug Metabolism and Disposition November 2007, 35 (11) 1985-1989; DOI: https://doi.org/10.1124/dmd.107.016782
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Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P450 2B6- and 2C8-Dependent Activity in Human Liver Microsomes
Ragini Vuppugalla, Shu-Ying Chang, Hongjian Zhang, Punit H. Marathe and David A. Rodrigues

Drug Metabolism and Disposition November 2007, 35 (11) 1990-1995; DOI: https://doi.org/10.1124/dmd.107.016816

Articles

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Functional Induction of P-glycoprotein in the Blood-Brain Barrier of Streptozotocin-Induced Diabetic Rats: Evidence for the Involvement of Nuclear Factor-κB, a Nitrosative Stress-Sensitive Transcription Factor, in the Regulation
Han-Joo Maeng, Mi-Hwa Kim, Hyo-Eon Jin, Sang Mi Shin, Takasi Tsuruo, Sang Geon Kim, Dae-Duk Kim, Chang-Koo Shim and Suk-Jae Chung

Drug Metabolism and Disposition November 2007, 35 (11) 1996-2005; DOI: https://doi.org/10.1124/dmd.107.015800
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Glucuronidation of Active Tamoxifen Metabolites by the Human UDP Glucuronosyltransferases
Dongxiao Sun, Arun K. Sharma, Ryan W. Dellinger, Andrea S. Blevins-Primeau, Renee M. Balliet, Gang Chen, Telih Boyiri, Shantu Amin and Philip Lazarus

Drug Metabolism and Disposition November 2007, 35 (11) 2006-2014; DOI: https://doi.org/10.1124/dmd.107.017145
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Specificity of Procaine and Ester Hydrolysis by Human, Minipig, and Rat Skin and Liver
Christopher Jewell, Chrisita Ackermann, N. Ann Payne, Gwendolyn Fate, Richard Voorman and Faith M. Williams

Drug Metabolism and Disposition November 2007, 35 (11) 2015-2022; DOI: https://doi.org/10.1124/dmd.107.015727
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Identification of New Flavone-8-Acetic Acid Metabolites Using Mouse Microsomes and Comparison with Human Microsomes
Minh Hien Pham, Nicolas Auzeil, Anne Regazzetti, Daniel Dauzonne, Annabelle Dugay, Marie-Claude Menet, Daniel Scherman and Guy G. Chabot

Drug Metabolism and Disposition November 2007, 35 (11) 2023-2034; DOI: https://doi.org/10.1124/dmd.107.017012
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Silybin Is Metabolized by Cytochrome P450 2C8 in Vitro
Petra Jančová, Eva Anzenbacherová, Barbora Papoušková, Karel Lemr, Pavla Lužná, Alena Veinlichová, Pavel Anzenbacher and Vilím Šimánek

Drug Metabolism and Disposition November 2007, 35 (11) 2035-2039; DOI: https://doi.org/10.1124/dmd.107.016410
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The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver
Yuji Mano, Takashi Usui and Hidetaka Kamimura

Drug Metabolism and Disposition November 2007, 35 (11) 2040-2044; DOI: https://doi.org/10.1124/dmd.107.017269
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Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)
Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, John D. Schuetz, Takuro Niwa and Yuichi Sugiyama

Drug Metabolism and Disposition November 2007, 35 (11) 2045-2052; DOI: https://doi.org/10.1124/dmd.107.016352
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A Comparison of 2-Phenyl-2-(1-piperidinyl)propane (PPP), 1,1′,1″-Phosphinothioylidynetrisaziridine (ThioTEPA), Clopidogrel, and Ticlopidine as Selective Inactivators of Human Cytochrome P450 2B6
Robert L. Walsky and R. Scott Obach

Drug Metabolism and Disposition November 2007, 35 (11) 2053-2059; DOI: https://doi.org/10.1124/dmd.107.015883
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Beneficial Effect of Spironolactone Administration on Ethynylestradiol-Induced Cholestasis in the Rat: Involvement of Up-Regulation of Multidrug Resistance-Associated Protein 2
María L. Ruiz, Silvina S.M. Villanueva, Marcelo G. Luquita, Shin-ichi Ikushiro, Aldo D. Mottino and Viviana A. Catania

Drug Metabolism and Disposition November 2007, 35 (11) 2060-2066; DOI: https://doi.org/10.1124/dmd.107.016519
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Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine
Michael Zhuo Wang, Judy Qiju Wu, Arlene S. Bridges, Darryl C. Zeldin, Sally Kornbluth, Richard R. Tidwell, James Edwin Hall and Mary F. Paine

Drug Metabolism and Disposition November 2007, 35 (11) 2067-2075; DOI: https://doi.org/10.1124/dmd.107.016428
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P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution
Naveed Shaik, Nagdeep Giri, Guoyu Pan and William F. Elmquist

Drug Metabolism and Disposition November 2007, 35 (11) 2076-2085; DOI: https://doi.org/10.1124/dmd.107.017723
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Analysis of CYP2A Contributions to Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Human Peripheral Lung Microsomes
Pamela J. Brown, Leanne L. Bedard, Ken R. Reid, Dimitri Petsikas and Thomas E. Massey

Drug Metabolism and Disposition November 2007, 35 (11) 2086-2094; DOI: https://doi.org/10.1124/dmd.107.017343
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The CYP3A4^*18 Allele, the Most Frequent Coding Variant in Asian Populations, Does Not Significantly Affect the Midazolam Disposition in Heterozygous Individuals
Su-Jun Lee, Sang Seop Lee, Hye-Eun Jeong, Ji-Hong Shon, Ji-Young Ryu, Yu Eun Sunwoo, Kwang-Hyeon Liu, Wonku Kang, Young-Ju Park, Chi-Mann Shin and Jae-Gook Shin

Drug Metabolism and Disposition November 2007, 35 (11) 2095-2101; DOI: https://doi.org/10.1124/dmd.107.016733
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Attenuated Expression of Episodic Growth Hormone-Induced CYP2C11 in Female Rats Associated with Suboptimal Activation of the Jak2/Stat5B and Other Modulating Signaling Pathways
Ravindra N. Dhir, Chellappagounder Thangavel and Bernard H. Shapiro

Drug Metabolism and Disposition November 2007, 35 (11) 2102-2110; DOI: https://doi.org/10.1124/dmd.107.017475
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Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human
Amit S. Kalgutkar, Bo Feng, Hang T. Nguyen, Kosea S. Frederick, Scott D. Campbell, Heather L. Hatch, Yi-An Bi, Diana C. Kazolias, Ralph E. Davidson, Rouchelle J. Mireles, David B. Duignan, Edna F. Choo and Sabrina X. Zhao

Drug Metabolism and Disposition November 2007, 35 (11) 2111-2118; DOI: https://doi.org/10.1124/dmd.107.016162
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Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for K_i Determination
Hayley S. Brown, Anthony Chadwick and J. Brian Houston

Drug Metabolism and Disposition November 2007, 35 (11) 2119-2126; DOI: https://doi.org/10.1124/dmd.107.017095
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Serine Hydroxymethyltransferase Isoforms Are Differentially Inhibited by Leucovorin: Characterization and Comparison of Recombinant Zebrafish Serine Hydroxymethyltransferases
Wen-Ni Chang, Jen-Ning Tsai, Bing-Hung Chen, Huei-Sheng Huang and Tzu-Fun Fu

Drug Metabolism and Disposition November 2007, 35 (11) 2127-2137; DOI: https://doi.org/10.1124/dmd.107.016840

Erratum

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CORRECTION TO “IN VITRO METABOLIC STUDY OF TEMSIROLIMUS: PREPARATION, ISOLATION, AND IDENTIFICATION OF THE METABOLITES”
Drug Metabolism and Disposition November 2007, 35 (11) 2138; DOI: https://doi.org/10.1124/dmd.35.11.2138

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