Table of Contents

Articles

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  Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor

  Koichi Omura, Takashi Nakazawa, Takahiro Sato, Takashi Iwanaga and Osamu Nagata

  Drug Metabolism and Disposition December 2007, 35 (12) 2143-2148; DOI: https://doi.org/10.1124/dmd.107.017251
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  Lack of Association between Common Polymorphisms in UGT1A9 and Gene Expression and Activity

  Jacqueline Ramírez, Wanqing Liu, Snezana Mirkov, Apurva A. Desai, Peixian Chen, Soma Das, Federico Innocenti and Mark J. Ratain

  Drug Metabolism and Disposition December 2007, 35 (12) 2149-2153; DOI: https://doi.org/10.1124/dmd.107.015446
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  Breast Cancer Resistance Protein 1 Limits Fetal Distribution of Nitrofurantoin in the Pregnant Mouse

  Yi Zhang, Honggang Wang, Jashvant D. Unadkat and Qingcheng Mao

  Drug Metabolism and Disposition December 2007, 35 (12) 2154-2158; DOI: https://doi.org/10.1124/dmd.107.018044
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  Progress Curve Analysis of CYP1A2 Inhibition: A More Informative Approach to the Assessment of Mechanism-Based Inactivation?

  D. A. Fairman, C. Collins and S. Chapple

  Drug Metabolism and Disposition December 2007, 35 (12) 2159-2165; DOI: https://doi.org/10.1124/dmd.107.017236
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  Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor

  Akihiro Yamada, Kazuya Maeda, Emi Kamiyama, Daisuke Sugiyama, Tsunenori Kondo, Yoshiyuki Shiroyanagi, Hayakazu Nakazawa, Teruo Okano, Masashi Adachi, John D. Schuetz, Yasuhisa Adachi, Zhuohan Hu, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition December 2007, 35 (12) 2166-2176; DOI: https://doi.org/10.1124/dmd.107.017459
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  A Shuffled CYP1A Library Shows Both Structural Integrity and Functional Diversity

  Wayne A. Johnston, Weiliang Huang, James J. De Voss, Martin A. Hayes and Elizabeth M.J. Gillam

  Drug Metabolism and Disposition December 2007, 35 (12) 2177-2185; DOI: https://doi.org/10.1124/dmd.107.017939
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  Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist

  Anima Ghosal, Ragu Ramanathan, Yuan Yuan, Neil Hapangama, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton

  Drug Metabolism and Disposition December 2007, 35 (12) 2186-2195; DOI: https://doi.org/10.1124/dmd.107.017517
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  Generation and Functional Characterization of Mice with a Disrupted Glutathione S-Transferase, Theta 1 Gene

  Kazunori Fujimoto, Shingo Arakawa, Toshiyuki Watanabe, Hiroaki Yasumo, Yosuke Ando, Wataru Takasaki, Sunao Manabe, Takashi Yamoto and Sen-ichi Oda

  Drug Metabolism and Disposition December 2007, 35 (12) 2196-2202; DOI: https://doi.org/10.1124/dmd.107.017905
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  In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP-Glucuronosyltransferases

  Zeen Tong, Hongshan Li, Igor Goljer, Oliver McConnell and Appavu Chandrasekaran

  Drug Metabolism and Disposition December 2007, 35 (12) 2203-2210; DOI: https://doi.org/10.1124/dmd.107.016972
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  Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model

  Jagannath Kota, Krishna K. Machavaram, Danielle N. McLennan, Glenn A. Edwards, Christopher J. H. Porter and Susan A. Charman

  Drug Metabolism and Disposition December 2007, 35 (12) 2211-2217; DOI: https://doi.org/10.1124/dmd.107.015669
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  Metabolism and Disposition of n-Butyl Glycidyl Ether in F344 Rats and B6C3F1 Mice

  L.-J. Chen, E. H. Lebetkin, E. I. Nwakpuda and L. T. Burka

  Drug Metabolism and Disposition December 2007, 35 (12) 2218-2224; DOI: https://doi.org/10.1124/dmd.107.016931
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  Evaluation of the Assumptions of an Ontogeny Model of Rat Hepatic Cytochrome P450 Activity

  Jane Alcorn, Fawzy A. Elbarbry, Mohammed Z. Allouh and Patrick J. McNamara

  Drug Metabolism and Disposition December 2007, 35 (12) 2225-2231; DOI: https://doi.org/10.1124/dmd.107.017590
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  In Vitro Metabolism of the Analgesic Bicifadine in the Mouse, Rat, Monkey, and Human

  David A. Erickson, Stacy Hollfelder, Justin Tenge, Mark Gohdes, Jeffrey J. Burkhardt and Philip A. Krieter

  Drug Metabolism and Disposition December 2007, 35 (12) 2232-2241; DOI: https://doi.org/10.1124/dmd.107.016055
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  Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase

  Ahmed Kousba, Richard Soll, Shiyin Yee and Michael Martin

  Drug Metabolism and Disposition December 2007, 35 (12) 2242-2251; DOI: https://doi.org/10.1124/dmd.107.017384
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  In Vitro Metabolism Study of Combretastatin A-4 in Rat and Human Liver Microsomes

  Silvio Aprile, Erika Del Grosso, Gian Cesare Tron and Giorgio Grosa

  Drug Metabolism and Disposition December 2007, 35 (12) 2252-2261; DOI: https://doi.org/10.1124/dmd.107.016998
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  Analysis of the Transcriptional Regulation and Molecular Function of the Aryl Hydrocarbon Receptor Repressor in Human Cell Lines

  Thomas Haarmann-Stemmann, Hanno Bothe, Amitabh Kohli, Ulrich Sydlik, Josef Abel and Ellen Fritsche

  Drug Metabolism and Disposition December 2007, 35 (12) 2262-2269; DOI: https://doi.org/10.1124/dmd.107.016253
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  Characterization of the UDP Glucuronosyltransferase Activity of Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism

  Donglu Zhang, Duxi Zhang, Dan Cui, Janice Gambardella, Li Ma, Anthony Barros, Lifei Wang, Yunlin Fu, Sandhya Rahematpura, Julia Nielsen, Michael Donegan, Hongjian Zhang and W. Griffith Humphreys

  Drug Metabolism and Disposition December 2007, 35 (12) 2270-2280; DOI: https://doi.org/10.1124/dmd.107.017806