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Drug Metabolism & Disposition

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Table of Contents

December 01, 2007; Volume 35,Issue 12

Short Communication

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    Utility of the Coefficient of Determination (r2) in Assessing the Accuracy of Interspecies Allometric Predictions: Illumination or Illusion?
    Huadong Tang and Michael Mayersohn
    Drug Metabolism and Disposition December 2007, 35 (12) 2139-2142; DOI: https://doi.org/10.1124/dmd.107.016444

Articles

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    Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor
    Koichi Omura, Takashi Nakazawa, Takahiro Sato, Takashi Iwanaga and Osamu Nagata
    Drug Metabolism and Disposition December 2007, 35 (12) 2143-2148; DOI: https://doi.org/10.1124/dmd.107.017251
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    Lack of Association between Common Polymorphisms in UGT1A9 and Gene Expression and Activity
    Jacqueline Ramírez, Wanqing Liu, Snezana Mirkov, Apurva A. Desai, Peixian Chen, Soma Das, Federico Innocenti and Mark J. Ratain
    Drug Metabolism and Disposition December 2007, 35 (12) 2149-2153; DOI: https://doi.org/10.1124/dmd.107.015446
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    Breast Cancer Resistance Protein 1 Limits Fetal Distribution of Nitrofurantoin in the Pregnant Mouse
    Yi Zhang, Honggang Wang, Jashvant D. Unadkat and Qingcheng Mao
    Drug Metabolism and Disposition December 2007, 35 (12) 2154-2158; DOI: https://doi.org/10.1124/dmd.107.018044
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    Progress Curve Analysis of CYP1A2 Inhibition: A More Informative Approach to the Assessment of Mechanism-Based Inactivation?
    D. A. Fairman, C. Collins and S. Chapple
    Drug Metabolism and Disposition December 2007, 35 (12) 2159-2165; DOI: https://doi.org/10.1124/dmd.107.017236
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    Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor
    Akihiro Yamada, Kazuya Maeda, Emi Kamiyama, Daisuke Sugiyama, Tsunenori Kondo, Yoshiyuki Shiroyanagi, Hayakazu Nakazawa, Teruo Okano, Masashi Adachi, John D. Schuetz, Yasuhisa Adachi, Zhuohan Hu, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition December 2007, 35 (12) 2166-2176; DOI: https://doi.org/10.1124/dmd.107.017459
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    A Shuffled CYP1A Library Shows Both Structural Integrity and Functional Diversity
    Wayne A. Johnston, Weiliang Huang, James J. De Voss, Martin A. Hayes and Elizabeth M.J. Gillam
    Drug Metabolism and Disposition December 2007, 35 (12) 2177-2185; DOI: https://doi.org/10.1124/dmd.107.017939
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    Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist
    Anima Ghosal, Ragu Ramanathan, Yuan Yuan, Neil Hapangama, Swapan K. Chowdhury, Narendra S. Kishnani and Kevin B. Alton
    Drug Metabolism and Disposition December 2007, 35 (12) 2186-2195; DOI: https://doi.org/10.1124/dmd.107.017517
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    Generation and Functional Characterization of Mice with a Disrupted Glutathione S-Transferase, Theta 1 Gene
    Kazunori Fujimoto, Shingo Arakawa, Toshiyuki Watanabe, Hiroaki Yasumo, Yosuke Ando, Wataru Takasaki, Sunao Manabe, Takashi Yamoto and Sen-ichi Oda
    Drug Metabolism and Disposition December 2007, 35 (12) 2196-2202; DOI: https://doi.org/10.1124/dmd.107.017905
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    In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP-Glucuronosyltransferases
    Zeen Tong, Hongshan Li, Igor Goljer, Oliver McConnell and Appavu Chandrasekaran
    Drug Metabolism and Disposition December 2007, 35 (12) 2203-2210; DOI: https://doi.org/10.1124/dmd.107.016972
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    Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model
    Jagannath Kota, Krishna K. Machavaram, Danielle N. McLennan, Glenn A. Edwards, Christopher J. H. Porter and Susan A. Charman
    Drug Metabolism and Disposition December 2007, 35 (12) 2211-2217; DOI: https://doi.org/10.1124/dmd.107.015669
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    Metabolism and Disposition of n-Butyl Glycidyl Ether in F344 Rats and B6C3F1 Mice
    L.-J. Chen, E. H. Lebetkin, E. I. Nwakpuda and L. T. Burka
    Drug Metabolism and Disposition December 2007, 35 (12) 2218-2224; DOI: https://doi.org/10.1124/dmd.107.016931
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    Evaluation of the Assumptions of an Ontogeny Model of Rat Hepatic Cytochrome P450 Activity
    Jane Alcorn, Fawzy A. Elbarbry, Mohammed Z. Allouh and Patrick J. McNamara
    Drug Metabolism and Disposition December 2007, 35 (12) 2225-2231; DOI: https://doi.org/10.1124/dmd.107.017590
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    In Vitro Metabolism of the Analgesic Bicifadine in the Mouse, Rat, Monkey, and Human
    David A. Erickson, Stacy Hollfelder, Justin Tenge, Mark Gohdes, Jeffrey J. Burkhardt and Philip A. Krieter
    Drug Metabolism and Disposition December 2007, 35 (12) 2232-2241; DOI: https://doi.org/10.1124/dmd.107.016055
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    Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase
    Ahmed Kousba, Richard Soll, Shiyin Yee and Michael Martin
    Drug Metabolism and Disposition December 2007, 35 (12) 2242-2251; DOI: https://doi.org/10.1124/dmd.107.017384
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    In Vitro Metabolism Study of Combretastatin A-4 in Rat and Human Liver Microsomes
    Silvio Aprile, Erika Del Grosso, Gian Cesare Tron and Giorgio Grosa
    Drug Metabolism and Disposition December 2007, 35 (12) 2252-2261; DOI: https://doi.org/10.1124/dmd.107.016998
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    Analysis of the Transcriptional Regulation and Molecular Function of the Aryl Hydrocarbon Receptor Repressor in Human Cell Lines
    Thomas Haarmann-Stemmann, Hanno Bothe, Amitabh Kohli, Ulrich Sydlik, Josef Abel and Ellen Fritsche
    Drug Metabolism and Disposition December 2007, 35 (12) 2262-2269; DOI: https://doi.org/10.1124/dmd.107.016253
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    Characterization of the UDP Glucuronosyltransferase Activity of Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism
    Donglu Zhang, Duxi Zhang, Dan Cui, Janice Gambardella, Li Ma, Anthony Barros, Lifei Wang, Yunlin Fu, Sandhya Rahematpura, Julia Nielsen, Michael Donegan, Hongjian Zhang and W. Griffith Humphreys
    Drug Metabolism and Disposition December 2007, 35 (12) 2270-2280; DOI: https://doi.org/10.1124/dmd.107.017806
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Drug Metabolism and Disposition: 35 (12)
Drug Metabolism and Disposition
Vol. 35, Issue 12
1 Dec 2007
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