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Drug Metabolism & Disposition

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Table of Contents

February 01, 2007; Volume 35,Issue 2

Short Communications

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    The in Vitro Drug Interaction Potential of Dietary Supplements Containing Multiple Herbal Components
    Robert S. Foti, Jan L. Wahlstrom and Larry C. Wienkers
    Drug Metabolism and Disposition February 2007, 35 (2) 185-188; DOI: https://doi.org/10.1124/dmd.106.012724
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    Human Hepatic Cytochrome P450-Specific Metabolism of Parathion and Chlorpyrifos
    Robert J. Foxenberg, Barbara P. McGarrigle, James B. Knaak, Paul J. Kostyniak and James R. Olson
    Drug Metabolism and Disposition February 2007, 35 (2) 189-193; DOI: https://doi.org/10.1124/dmd.106.012427

Articles

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    The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A
    Xiaochao Ma, Yatrik Shah, Connie Cheung, Grace L. Guo, Lionel Feigenbaum, Kristopher W. Krausz, Jeffrey R. Idle and Frank J. Gonzalez
    Drug Metabolism and Disposition February 2007, 35 (2) 194-200; DOI: https://doi.org/10.1124/dmd.106.012831
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    Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of γ-Hydroxybutyrate in Vitro and in Vivo
    Qi Wang and Marilyn E. Morris
    Drug Metabolism and Disposition February 2007, 35 (2) 201-208; DOI: https://doi.org/10.1124/dmd.106.012369
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    Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect
    Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition February 2007, 35 (2) 209-214; DOI: https://doi.org/10.1124/dmd.106.012567
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    Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction
    Georgina Meneses-Lorente, Christine Pattison, Claire Guyomard, Christophe Chesné, Robert Heavens, Alan P. Watt and Bindi Sohal
    Drug Metabolism and Disposition February 2007, 35 (2) 215-220; DOI: https://doi.org/10.1124/dmd.106.009423
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    Triethylenetetramine and Metabolites: Levels in Relation to Copper and Zinc Excretion in Urine of Healthy Volunteers and Type 2 Diabetic Patients
    Jun Lu, Yi-Kai Chan, Gregory D. Gamble, Sally D. Poppitt, Asma A. Othman and Garth J. S. Cooper
    Drug Metabolism and Disposition February 2007, 35 (2) 221-227; DOI: https://doi.org/10.1124/dmd.106.012922
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    Effects of Green Tea Compounds on Irinotecan Metabolism
    Snezana Mirkov, Bernard J. Komoroski, Jacqueline Ramírez, Andrea Yoder Graber, Mark J. Ratain, Stephen C. Strom and Federico Innocenti
    Drug Metabolism and Disposition February 2007, 35 (2) 228-233; DOI: https://doi.org/10.1124/dmd.106.012047
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    Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Depside Salts from Salvia miltiorrhiza in Rats
    Xiaochuan Li, Chen Yu, Youli Lu, Yunlong Gu, Jie Lu, Wei Xu, Lijiang Xuan and Yiping Wang
    Drug Metabolism and Disposition February 2007, 35 (2) 234-239; DOI: https://doi.org/10.1124/dmd.106.013045
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    Effect of Goldenseal (Hydrastis canadensis) and Kava Kava (Piper methysticum) Supplementation on Digoxin Pharmacokinetics in Humans
    Bill J. Gurley, Ashley Swain, Gary W. Barone, D. Keith Williams, Philip Breen, C. Ryan Yates, Leslie B. Stuart, Martha A. Hubbard, Yudong Tong and Sreekhar Cheboyina
    Drug Metabolism and Disposition February 2007, 35 (2) 240-245; DOI: https://doi.org/10.1124/dmd.106.012708
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    Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions
    R. Scott Obach, Robert L. Walsky and Karthik Venkatakrishnan
    Drug Metabolism and Disposition February 2007, 35 (2) 246-255; DOI: https://doi.org/10.1124/dmd.106.012633
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    Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis
    Atsushi Kawase, You Tsunokuni and Masahiro Iwaki
    Drug Metabolism and Disposition February 2007, 35 (2) 256-261; DOI: https://doi.org/10.1124/dmd.106.011536
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    Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs
    Michael J. Avram, Thomas K. Henthorn, Daniel A. Spyker, Tom C. Krejcie, Peter M. Lloyd, James V. Cassella and Joshua D. Rabinowitz
    Drug Metabolism and Disposition February 2007, 35 (2) 262-267; DOI: https://doi.org/10.1124/dmd.106.010652
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    Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2
    Xiaodong Wang and Marilyn E. Morris
    Drug Metabolism and Disposition February 2007, 35 (2) 268-274; DOI: https://doi.org/10.1124/dmd.106.011684
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    Induction of Cytochrome P450: Assessment in an Immortalized Human Hepatocyte Cell Line (Fa2N4) Using a Novel Higher Throughput Cocktail Assay
    Kuresh A. Youdim, Christine A. Tyman, Barry C. Jones and Ruth Hyland
    Drug Metabolism and Disposition February 2007, 35 (2) 275-282; DOI: https://doi.org/10.1124/dmd.106.012864
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    Metabolism of MK-0524, a Prostaglandin D2 Receptor 1 Antagonist, in Microsomes and Hepatocytes from Preclinical Species and Humans
    Brian J. Dean, Steve Chang, Maria Victoria Silva Elipe, Yuan-Qing Xia, Matt Braun, Eric Soli, Yuming Zhao, Ronald B. Franklin and Bindhu Karanam
    Drug Metabolism and Disposition February 2007, 35 (2) 283-292; DOI: https://doi.org/10.1124/dmd.106.011551
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    Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance
    Hayley S. Brown, Michael Griffin and J. Brian Houston
    Drug Metabolism and Disposition February 2007, 35 (2) 293-301; DOI: https://doi.org/10.1124/dmd.106.011569
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    Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats
    Masashi Nagata, Muneaki Hidaka, Hiroshi Sekiya, Yohei Kawano, Keishi Yamasaki, Manabu Okumura and Kazuhiko Arimori
    Drug Metabolism and Disposition February 2007, 35 (2) 302-305; DOI: https://doi.org/10.1124/dmd.106.011718
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    Induction of Glutathione Synthesis Explains Pharmacodynamics of High-Dose Busulfan in Mice and Highlights Putative Mechanisms of Drug Interaction
    Jérôme Bouligand, Alain Deroussent, Nicolas Simonnard, Paule Opolon, Jackie Morizet, Elisabeth Connault, Estelle Daudigeos, Micheline Re, Angelo Paci and Gilles Vassal
    Drug Metabolism and Disposition February 2007, 35 (2) 306-314; DOI: https://doi.org/10.1124/dmd.106.012880
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    The Relationship between PON1 Phenotype and PON1-192 Genotype in Detoxification of Three Oxons by Human Liver
    Elaine Mutch, Ann K. Daly and Faith M. Williams
    Drug Metabolism and Disposition February 2007, 35 (2) 315-320; DOI: https://doi.org/10.1124/dmd.106.013193

Accelerated Communication

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    Mode of Administration-Dependent Brain Uptake of Indomethacin: Sustained Systemic Input Increases Brain Influx
    Arik Dahan and Amnon Hoffman
    Drug Metabolism and Disposition February 2007, 35 (2) 321-324; DOI: https://doi.org/10.1124/dmd.106.011817
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In this issue

Drug Metabolism and Disposition: 35 (2)
Drug Metabolism and Disposition
Vol. 35, Issue 2
1 Feb 2007
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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