Table of Contents

Articles

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  The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A

  Xiaochao Ma, Yatrik Shah, Connie Cheung, Grace L. Guo, Lionel Feigenbaum, Kristopher W. Krausz, Jeffrey R. Idle and Frank J. Gonzalez

  Drug Metabolism and Disposition February 2007, 35 (2) 194-200; DOI: https://doi.org/10.1124/dmd.106.012831
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  Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of γ-Hydroxybutyrate in Vitro and in Vivo

  Qi Wang and Marilyn E. Morris

  Drug Metabolism and Disposition February 2007, 35 (2) 201-208; DOI: https://doi.org/10.1124/dmd.106.012369
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  Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect

  Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition February 2007, 35 (2) 209-214; DOI: https://doi.org/10.1124/dmd.106.012567
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  Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction

  Georgina Meneses-Lorente, Christine Pattison, Claire Guyomard, Christophe Chesné, Robert Heavens, Alan P. Watt and Bindi Sohal

  Drug Metabolism and Disposition February 2007, 35 (2) 215-220; DOI: https://doi.org/10.1124/dmd.106.009423
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  Triethylenetetramine and Metabolites: Levels in Relation to Copper and Zinc Excretion in Urine of Healthy Volunteers and Type 2 Diabetic Patients

  Jun Lu, Yi-Kai Chan, Gregory D. Gamble, Sally D. Poppitt, Asma A. Othman and Garth J. S. Cooper

  Drug Metabolism and Disposition February 2007, 35 (2) 221-227; DOI: https://doi.org/10.1124/dmd.106.012922
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  Effects of Green Tea Compounds on Irinotecan Metabolism

  Snezana Mirkov, Bernard J. Komoroski, Jacqueline Ramírez, Andrea Yoder Graber, Mark J. Ratain, Stephen C. Strom and Federico Innocenti

  Drug Metabolism and Disposition February 2007, 35 (2) 228-233; DOI: https://doi.org/10.1124/dmd.106.012047
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  Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Depside Salts from Salvia miltiorrhiza in Rats

  Xiaochuan Li, Chen Yu, Youli Lu, Yunlong Gu, Jie Lu, Wei Xu, Lijiang Xuan and Yiping Wang

  Drug Metabolism and Disposition February 2007, 35 (2) 234-239; DOI: https://doi.org/10.1124/dmd.106.013045
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  Effect of Goldenseal (Hydrastis canadensis) and Kava Kava (Piper methysticum) Supplementation on Digoxin Pharmacokinetics in Humans

  Bill J. Gurley, Ashley Swain, Gary W. Barone, D. Keith Williams, Philip Breen, C. Ryan Yates, Leslie B. Stuart, Martha A. Hubbard, Yudong Tong and Sreekhar Cheboyina

  Drug Metabolism and Disposition February 2007, 35 (2) 240-245; DOI: https://doi.org/10.1124/dmd.106.012708
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  Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

  R. Scott Obach, Robert L. Walsky and Karthik Venkatakrishnan

  Drug Metabolism and Disposition February 2007, 35 (2) 246-255; DOI: https://doi.org/10.1124/dmd.106.012633
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  Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis

  Atsushi Kawase, You Tsunokuni and Masahiro Iwaki

  Drug Metabolism and Disposition February 2007, 35 (2) 256-261; DOI: https://doi.org/10.1124/dmd.106.011536
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  Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs

  Michael J. Avram, Thomas K. Henthorn, Daniel A. Spyker, Tom C. Krejcie, Peter M. Lloyd, James V. Cassella and Joshua D. Rabinowitz

  Drug Metabolism and Disposition February 2007, 35 (2) 262-267; DOI: https://doi.org/10.1124/dmd.106.010652
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  Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2

  Xiaodong Wang and Marilyn E. Morris

  Drug Metabolism and Disposition February 2007, 35 (2) 268-274; DOI: https://doi.org/10.1124/dmd.106.011684
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  Induction of Cytochrome P450: Assessment in an Immortalized Human Hepatocyte Cell Line (Fa2N4) Using a Novel Higher Throughput Cocktail Assay

  Kuresh A. Youdim, Christine A. Tyman, Barry C. Jones and Ruth Hyland

  Drug Metabolism and Disposition February 2007, 35 (2) 275-282; DOI: https://doi.org/10.1124/dmd.106.012864
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  Metabolism of MK-0524, a Prostaglandin D₂ Receptor 1 Antagonist, in Microsomes and Hepatocytes from Preclinical Species and Humans

  Brian J. Dean, Steve Chang, Maria Victoria Silva Elipe, Yuan-Qing Xia, Matt Braun, Eric Soli, Yuming Zhao, Ronald B. Franklin and Bindhu Karanam

  Drug Metabolism and Disposition February 2007, 35 (2) 283-292; DOI: https://doi.org/10.1124/dmd.106.011551
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  Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

  Hayley S. Brown, Michael Griffin and J. Brian Houston

  Drug Metabolism and Disposition February 2007, 35 (2) 293-301; DOI: https://doi.org/10.1124/dmd.106.011569
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  Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats

  Masashi Nagata, Muneaki Hidaka, Hiroshi Sekiya, Yohei Kawano, Keishi Yamasaki, Manabu Okumura and Kazuhiko Arimori

  Drug Metabolism and Disposition February 2007, 35 (2) 302-305; DOI: https://doi.org/10.1124/dmd.106.011718
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  Induction of Glutathione Synthesis Explains Pharmacodynamics of High-Dose Busulfan in Mice and Highlights Putative Mechanisms of Drug Interaction

  Jérôme Bouligand, Alain Deroussent, Nicolas Simonnard, Paule Opolon, Jackie Morizet, Elisabeth Connault, Estelle Daudigeos, Micheline Re, Angelo Paci and Gilles Vassal

  Drug Metabolism and Disposition February 2007, 35 (2) 306-314; DOI: https://doi.org/10.1124/dmd.106.012880
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  The Relationship between PON1 Phenotype and PON1-192 Genotype in Detoxification of Three Oxons by Human Liver

  Elaine Mutch, Ann K. Daly and Faith M. Williams

  Drug Metabolism and Disposition February 2007, 35 (2) 315-320; DOI: https://doi.org/10.1124/dmd.106.013193