Table of Contents

Articles

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  Metabolism of Sirolimus in the Presence or Absence of Cyclosporine by Genotyped Human Liver Microsomes and Recombinant Cytochromes P450 3A4 and 3A5

  Nicolas Picard, Nassim Djebli, François-Ludovic Sauvage and Pierre Marquet

  Drug Metabolism and Disposition March 2007, 35 (3) 350-355; DOI: https://doi.org/10.1124/dmd.106.012161
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  Functional Expression of Stereoselective Metabolism of Cephalexin by Exogenous Transfection of Oligopeptide Transporter PEPT1

  Keisuke Mitsuoka, Yukio Kato, Yoshiyuki Kubo and Akira Tsuji

  Drug Metabolism and Disposition March 2007, 35 (3) 356-362; DOI: https://doi.org/10.1124/dmd.106.010405
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  The Glucuronidation of Δ⁴-3-Keto C19- and C21-Hydroxysteroids by Human Liver Microsomal and Recombinant UDP-glucuronosyltransferases (UGTs): 6α- and 21-Hydroxyprogesterone Are Selective Substrates for UGT2B7

  K. Bowalgaha, D. J. Elliot, P. I. Mackenzie, K. M. Knights and J. O. Miners

  Drug Metabolism and Disposition March 2007, 35 (3) 363-370; DOI: https://doi.org/10.1124/dmd.106.013052
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  UDP-Glucuronosyltransferase 1A1 Is the Principal Enzyme Responsible for Etoposide Glucuronidation in Human Liver and Intestinal Microsomes: Structural Characterization of Phenolic and Alcoholic Glucuronides of Etoposide and Estimation of Enzyme Kinetics

  Zhiming Wen, Melanie N. Tallman, Shazia Y. Ali and Philip C. Smith

  Drug Metabolism and Disposition March 2007, 35 (3) 371-380; DOI: https://doi.org/10.1124/dmd.106.012732
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  The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting

  Charles J. O'Donnell, Ken Grime, Paul Courtney, Dean Slee and Robert J. Riley

  Drug Metabolism and Disposition March 2007, 35 (3) 381-385; DOI: https://doi.org/10.1124/dmd.106.012344
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  Constitutive and 3-Methylcholanthrene-Induced Rat ALDH3A1 Expression Is Mediated by Multiple Xenobiotic Response Elements

  Richard Reisdorph and Ronald Lindahl

  Drug Metabolism and Disposition March 2007, 35 (3) 386-393; DOI: https://doi.org/10.1124/dmd.106.012393
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  Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines

  Tomoji Maeda, Masamichi Hirayama, Daisuke Kobayashi, Keiji Miyazawa and Ikumi Tamai

  Drug Metabolism and Disposition March 2007, 35 (3) 394-401; DOI: https://doi.org/10.1124/dmd.106.012112
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  Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-α, Interleukin-1β, Interleukin-6, and Nuclear Factor-κB in Two Models of Cholestasis

  Andrew J. Lickteig, Angela L. Slitt, Melek C. Arkan, Michael Karin and Nathan J. Cherrington

  Drug Metabolism and Disposition March 2007, 35 (3) 402-409; DOI: https://doi.org/10.1124/dmd.106.012138
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  Effect of Oral Ketoconazole on Intestinal First-Pass Effect of Midazolam and Fexofenadine in Cynomolgus Monkeys

  Akihito Ogasawara, Toshiyuki Kume and Emiko Kazama

  Drug Metabolism and Disposition March 2007, 35 (3) 410-418; DOI: https://doi.org/10.1124/dmd.106.011288
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  Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation

  Kathy Senekeo-Effenberger, Shujuan Chen, Erin Brace-Sinnokrak, Jessica A. Bonzo, Mei-Fei Yueh, Upendra Argikar, Jenny Kaeding, Jocelyn Trottier, Rory P. Remmel, Joseph K. Ritter, Olivier Barbier and Robert H. Tukey

  Drug Metabolism and Disposition March 2007, 35 (3) 419-427; DOI: https://doi.org/10.1124/dmd.106.013243
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  CAR2 Displays Unique Ligand Binding and RXRα Heterodimerization Characteristics

  Scott S. Auerbach, Joshua G. DeKeyser, Matthew A. Stoner and Curtis J. Omiecinski

  Drug Metabolism and Disposition March 2007, 35 (3) 428-439; DOI: https://doi.org/10.1124/dmd.106.012641
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  Glucuronidation of Anti-HIV Drug Candidate Bevirimat: Identification of Human UDP-glucuronosyltransferases and Species Differences

  Zhiming Wen, David E. Martin, Peter Bullock, Kuo-Hsiung Lee and Philip C. Smith

  Drug Metabolism and Disposition March 2007, 35 (3) 440-448; DOI: https://doi.org/10.1124/dmd.106.012815
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  Gender-Related Differences in Mycophenolate Mofetil-Induced Gastrointestinal Toxicity in Rats

  Stephan T. Stern, Melanie N. Tallman, Kristini K. Miles, Joseph K. Ritter, Robert E. Dupuis and Philip C. Smith

  Drug Metabolism and Disposition March 2007, 35 (3) 449-454; DOI: https://doi.org/10.1124/dmd.106.012013
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  Pharmacokinetics and Pharmacodynamics of Alfentanil in P-Glycoprotein-Competent and P-Glycoprotein-Deficient Mice: P-Glycoprotein Efflux Alters Alfentanil Brain Disposition and Antinociception

  J. Cory Kalvass, Emily R. Olson and Gary M. Pollack

  Drug Metabolism and Disposition March 2007, 35 (3) 455-459; DOI: https://doi.org/10.1124/dmd.106.011445
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  Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100

  Rosie Z. Yu, Tae-Won Kim, An Hong, Tanya A. Watanabe, Hans J. Gaus and Richard S. Geary

  Drug Metabolism and Disposition March 2007, 35 (3) 460-468; DOI: https://doi.org/10.1124/dmd.106.012401
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  Characterization of the Hepatic Disposition of Lanoteplase, a Rationally Designed Variant of Tissue Plasminogen Activator in Rodents

  Kazumi Komoriya, Yukio Kato, Yujiro Hayashi, Kazuhiro Ohsuye, Ryuichiro Nishigaki and Yuichi Sugiyama

  Drug Metabolism and Disposition March 2007, 35 (3) 469-475; DOI: https://doi.org/10.1124/dmd.106.012518
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  Involvement of CYP2A6 in the Formation of a Novel Metabolite, 3-Hydroxypilocarpine, from Pilocarpine in Human Liver Microsomes

  Takuro Endo, Masaaki Ban, Kazuma Hirata, Akitoshi Yamamoto, Yoshiki Hara and Yasunori Momose

  Drug Metabolism and Disposition March 2007, 35 (3) 476-483; DOI: https://doi.org/10.1124/dmd.106.013425
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  Helices F–G Are Important for the Substrate Specificities of CYP3A7

  Nao Torimoto, Itsuko Ishii, Ken-Ichi Toyama, Masayuki Hata, Kanako Tanaka, Hitoshi Shimomura, Hiroyoshi Nakamura, Noritaka Ariyoshi, Shigeru Ohmori and Mitsukazu Kitada

  Drug Metabolism and Disposition March 2007, 35 (3) 484-492; DOI: https://doi.org/10.1124/dmd.106.011304
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  Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Human CYP51 Inhibitors

  Sean Ekins, Dayna C. Mankowski, Dennis J. Hoover, Michael P. Lawton, Judith L. Treadway and H. James Harwood

  Drug Metabolism and Disposition March 2007, 35 (3) 493-500; DOI: https://doi.org/10.1124/dmd.106.013888