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Research ArticleArticle

Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation

Kathy Senekeo-Effenberger, Shujuan Chen, Erin Brace-Sinnokrak, Jessica A. Bonzo, Mei-Fei Yueh, Upendra Argikar, Jenny Kaeding, Jocelyn Trottier, Rory P. Remmel, Joseph K. Ritter, Olivier Barbier and Robert H. Tukey
Drug Metabolism and Disposition March 2007, 35 (3) 419-427; DOI: https://doi.org/10.1124/dmd.106.013243
Kathy Senekeo-Effenberger
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Shujuan Chen
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Erin Brace-Sinnokrak
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Jessica A. Bonzo
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Mei-Fei Yueh
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Upendra Argikar
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Jenny Kaeding
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Jocelyn Trottier
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Rory P. Remmel
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Joseph K. Ritter
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Olivier Barbier
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Robert H. Tukey
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Article Information

vol. 35 no. 3 419-427
DOI 
https://doi.org/10.1124/dmd.106.013243
PubMed 
17151188

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 9, 2006
  • Accepted December 5, 2006
  • Published online February 26, 2007.

Article Versions

  • Earlier version (December 6, 2006 - 08:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kathy Senekeo-Effenberger,
  2. Shujuan Chen,
  3. Erin Brace-Sinnokrak,
  4. Jessica A. Bonzo,
  5. Mei-Fei Yueh,
  6. Upendra Argikar,
  7. Jenny Kaeding,
  8. Jocelyn Trottier,
  9. Rory P. Remmel,
  10. Joseph K. Ritter,
  11. Olivier Barbier and
  12. Robert H. Tukey
  1. Laboratory of Environmental Toxicology, Department of Chemistry & Biochemistry and Department of Pharmacology, University of California, San Diego, La Jolla, California (K.S-E., S.C., E.B-S., J.A.B., M-F.Y., R.H.T.); Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (U.A., R.P.R.); Molecular Endocrinology and Oncology Research Center, CHUL Research Center and the Faculty of Pharmacy, Laval University, Québec, Québec, Canada (J.K., J.T., O.B.); and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond, Virginia (J.K.R.)
  1. Address correspondence to:
    Dr. Robert H. Tukey, 9500 Gilman Dr., Leichtag Biomedical Research Building, University of California, San Diego, La Jolla, CA 92093-0722. E-mail: rtukey{at}ucsd.edu
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Drug Metabolism and Disposition: 35 (3)
Drug Metabolism and Disposition
Vol. 35, Issue 3
1 Mar 2007
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Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation
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Research ArticleArticle

Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation

Kathy Senekeo-Effenberger, Shujuan Chen, Erin Brace-Sinnokrak, Jessica A. Bonzo, Mei-Fei Yueh, Upendra Argikar, Jenny Kaeding, Jocelyn Trottier, Rory P. Remmel, Joseph K. Ritter, Olivier Barbier and Robert H. Tukey
Drug Metabolism and Disposition March 1, 2007, 35 (3) 419-427; DOI: https://doi.org/10.1124/dmd.106.013243

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Research ArticleArticle

Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation

Kathy Senekeo-Effenberger, Shujuan Chen, Erin Brace-Sinnokrak, Jessica A. Bonzo, Mei-Fei Yueh, Upendra Argikar, Jenny Kaeding, Jocelyn Trottier, Rory P. Remmel, Joseph K. Ritter, Olivier Barbier and Robert H. Tukey
Drug Metabolism and Disposition March 1, 2007, 35 (3) 419-427; DOI: https://doi.org/10.1124/dmd.106.013243
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