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Drug Metabolism & Disposition

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Table of Contents

April 01, 2007; Volume 35,Issue 4

Short Communications

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    Zonal Gene Expression in Mouse Liver Resembles Expression Patterns of Ha-ras and β-Catenin Mutated Hepatomas
    Albert Braeuning, Carina Ittrich, Christoph Köhle, Albrecht Buchmann and Michael Schwarz
    Drug Metabolism and Disposition April 2007, 35 (4) 503-507; DOI: https://doi.org/10.1124/dmd.106.013656
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    Inhibitory Effects of Neurotransmitters and Steroids on Human CYP2A6
    Eriko Higashi, Miki Nakajima, Miki Katoh, Shogo Tokudome and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 2007, 35 (4) 508-514; DOI: https://doi.org/10.1124/dmd.106.014084
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    A Novel Duplication Type of CYP2A6 Gene in African-American Population
    Tatsuki Fukami, Miki Nakajima, Hiroyuki Yamanaka, Yasunari Fukushima, Howard L. Mcleod and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 2007, 35 (4) 515-520; DOI: https://doi.org/10.1124/dmd.106.013557
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    Characterization of Two Cyclic Metabolites of Sitagliptin
    David Q. Liu, Byron H. Arison, Ralph A. Stearns, Dooseop Kim and Stella H. Vincent
    Drug Metabolism and Disposition April 2007, 35 (4) 521-524; DOI: https://doi.org/10.1124/dmd.106.013128

Articles

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    Disposition of the Dipeptidyl Peptidase 4 Inhibitor Sitagliptin in Rats and Dogs
    Maria G. Beconi, James R. Reed, Yohannes Teffera, Yuan-Qing Xia, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Charles S. Elmore, Suzanne Ciccotto, Donald F. Hora, Ralph A. Stearns and Stella H. Vincent
    Drug Metabolism and Disposition April 2007, 35 (4) 525-532; DOI: https://doi.org/10.1124/dmd.106.013110
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    Metabolism And Excretion of the Dipeptidyl Peptidase 4 Inhibitor [14C]Sitagliptin in Humans
    Stella H. Vincent, James R. Reed, Arthur J. Bergman, Charles S. Elmore, Bing Zhu, Shiyao Xu, David Ebel, Patrick Larson, Wei Zeng, Li Chen, Stacy Dilzer, Kenneth Lasseter, Keith Gottesdiener, John A. Wagner and Gary A. Herman
    Drug Metabolism and Disposition April 2007, 35 (4) 533-538; DOI: https://doi.org/10.1124/dmd.106.013136
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    Role of P-glycoprotein in the Intestinal Absorption of Glabridin, an Active Flavonoid from the Root of Glycyrrhiza glabra
    Jie Cao, Xiao Chen, Jun Liang, Xue-Qing Yu, An-Long Xu, Eli Chan, Duan Wei, Min Huang, Jing-Yuan Wen, Xi-Yong Yu, Xiao-Tian Li, Fwu-Shan Sheu and Shu-Feng Zhou
    Drug Metabolism and Disposition April 2007, 35 (4) 539-553; DOI: https://doi.org/10.1124/dmd.106.010801
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    The Absorption, Metabolism, and Excretion of the Novel Neuromodulator RWJ-333369 (1,2-Ethanediol, [1-2-Chlorophenyl]-, 2-carbamate, [S]-) in Humans
    G. S. J. Mannens, J. Hendrickx, C. G. M. Janssen, S. Chien, B. Van Hoof, T. Verhaeghe, M. Kao, M. F. Kelley, I. Goris, M. Bockx, B. Verreet, M. Bialer and W. Meuldermans
    Drug Metabolism and Disposition April 2007, 35 (4) 554-565; DOI: https://doi.org/10.1124/dmd.106.011940
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    Metabolism and Excretion of RWJ-333369 [1,2-Ethanediol, 1-(2-Chlorophenyl)-, 2-carbamate, (S)-] in Mice, Rats, Rabbits, and Dogs
    Rao N. V. S. Mamidi, Geert Mannens, Pieter Annaert, Jan Hendrickx, Ivo Goris, Mark Bockx, Cor G. M. Janssen, Mark Kao, Michael F. Kelley and Willem Meuldermans
    Drug Metabolism and Disposition April 2007, 35 (4) 566-575; DOI: https://doi.org/10.1124/dmd.106.012336
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    Interactions of Cyclosporin A with Breast Cancer Resistance Protein
    Cindy Q. Xia, Ning Liu, Gerald T. Miwa and Liang-Shang Gan
    Drug Metabolism and Disposition April 2007, 35 (4) 576-582; DOI: https://doi.org/10.1124/dmd.106.011866
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    Glucuronidation of Antiallergic Drug, Tranilast: Identification of Human UDP-Glucuronosyltransferase Isoforms and Effect of Its Phase I Metabolite
    Miki Katoh, Tomohito Matsui and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 2007, 35 (4) 583-589; DOI: https://doi.org/10.1124/dmd.106.013706
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    Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract
    Yvonne Meier, Jyrki J. Eloranta, Jutta Darimont, Manfred G. Ismair, Christian Hiller, Michael Fried, Gerd A. Kullak-Ublick and Stephan R. Vavricka
    Drug Metabolism and Disposition April 2007, 35 (4) 590-594; DOI: https://doi.org/10.1124/dmd.106.013342
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    Independent Regulation of Apical and Basolateral Drug Transporter Expression and Function in Placental Trophoblasts by Cytokines, Steroids, and Growth Factors
    Denis A. Evseenko, James W. Paxton and Jeffrey A. Keelan
    Drug Metabolism and Disposition April 2007, 35 (4) 595-601; DOI: https://doi.org/10.1124/dmd.106.011478
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    Comparison of Inhibition Potentials of Drugs against Zidovudine Glucuronidation in Rat Hepatocytes and Liver Microsomes
    Yuji Mano, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition April 2007, 35 (4) 602-606; DOI: https://doi.org/10.1124/dmd.106.014225
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    Deacetylclivorine: A Gender-Selective Metabolite of Clivorine Formed in Female Sprague-Dawley Rat Liver Microsomes
    Ge Lin, Jun Tang, Xiao Quan Liu, Yan Jiang and Jiang Zheng
    Drug Metabolism and Disposition April 2007, 35 (4) 607-613; DOI: https://doi.org/10.1124/dmd.106.014100
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    Visible Spectra of Type II Cytochrome P450-Drug Complexes: Evidence that “Incomplete” Heme Coordination Is Common
    Charles W. Locuson, J. Matthew Hutzler and Timothy S. Tracy
    Drug Metabolism and Disposition April 2007, 35 (4) 614-622; DOI: https://doi.org/10.1124/dmd.106.012609
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    Identification and Functional Assessment of BCRP Polymorphisms in a Korean Population
    Sang Seop Lee, Hye-Eun Jeong, Joo-Mi Yi, Hyun-Ju Jung, Jae-Eun Jang, Eun-Young Kim, Su-Jun Lee and Jae-Gook Shin
    Drug Metabolism and Disposition April 2007, 35 (4) 623-632; DOI: https://doi.org/10.1124/dmd.106.012302
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    Metabolism of a Heterocyclic Amine Colon Carcinogen in Young and Old Rats
    Harvey J. Armbrecht, Vijaya M. Lakshmi, Jason Wickstra, Fong Fu Hsu and Terry V. Zenser
    Drug Metabolism and Disposition April 2007, 35 (4) 633-639; DOI: https://doi.org/10.1124/dmd.106.013532
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    Development of Three Parallel Cytochrome P450 Enzyme Affinity Detection Systems Coupled On-line to Gradient High-Performance Liquid Chromatography
    Jeroen Kool, Sebastiaan M. van Liempd, Huub van Rossum, Danny A. van Elswijk, Hubertus Irth, Jan N. M. Commandeur and Nico P. E. Vermeulen
    Drug Metabolism and Disposition April 2007, 35 (4) 640-648; DOI: https://doi.org/10.1124/dmd.106.012245
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    The Prediction of Drug Metabolism, Tissue Distribution, and Bioavailability of 50 Structurally Diverse Compounds in Rat Using Mechanism-Based Absorption, Distribution, and Metabolism Prediction Tools
    Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Ron A. Gilissen, Claire E. Mackie and Marjoleen J. Nijsen
    Drug Metabolism and Disposition April 2007, 35 (4) 649-659; DOI: https://doi.org/10.1124/dmd.106.014027
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    Use of Plasma and Brain Unbound Fractions to Assess the Extent of Brain Distribution of 34 Drugs: Comparison of Unbound Concentration Ratios to in Vivo P-Glycoprotein Efflux Ratios
    J. Cory Kalvass, Tristan S. Maurer and Gary M. Pollack
    Drug Metabolism and Disposition April 2007, 35 (4) 660-666; DOI: https://doi.org/10.1124/dmd.106.012294
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    Identification and Functional Characterization of Genetic Variants of Human Organic Cation Transporters in a Korean Population
    Ho-Jin Kang, Im-Sook Song, Ho Jung Shin, Woo-Young Kim, Choong-Hee Lee, Joo-Cheol Shim, Hong-Hao Zhou, Sang Seop Lee and Jae-Gook Shin
    Drug Metabolism and Disposition April 2007, 35 (4) 667-675; DOI: https://doi.org/10.1124/dmd.106.013581
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    Formation and Uptake of Arylhydroxylamine-Haptenated Proteins in Human Dendritic Cells
    Sanjoy Roychowdhury, Piyush M. Vyas and Craig K. Svensson
    Drug Metabolism and Disposition April 2007, 35 (4) 676-681; DOI: https://doi.org/10.1124/dmd.106.013680
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    Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues
    Tracy C. DeLozier, Grace E. Kissling, Sherry J. Coulter, Diana Dai, Julie F. Foley, J. Alyce Bradbury, Elizabeth Murphy, Charles Steenbergen, Darryl C. Zeldin and Joyce A. Goldstein
    Drug Metabolism and Disposition April 2007, 35 (4) 682-688; DOI: https://doi.org/10.1124/dmd.106.012823
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    Possible Pathway(s) of Metyrapone Egress from the Active Site of Cytochrome P450 3A4: A Molecular Dynamics Simulation
    Weihua Li, Hong Liu, Xiaomin Luo, Weiliang Zhu, Yun Tang, James R. Halpert and Hualiang Jiang
    Drug Metabolism and Disposition April 2007, 35 (4) 689-696; DOI: https://doi.org/10.1124/dmd.106.014019

Letter to the Editor

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    The Time to Move Cytochrome P450 Induction into Mainstream Pharmacology Is Long Overdue
    Dennis A. Smith, Maurice Dickins, Odette A. Fahmi, Kazuhide Iwasaki, Caroline Lee, R. Scott Obach, Guy Padbury, Sonia M. De Morais, Sharon L. Ripp, Jeff Stevens, Richard Voorman and Kuresh Youdim
    Drug Metabolism and Disposition April 2007, 35 (4) 697-698; DOI: https://doi.org/10.1124/dmd.106.013284
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Drug Metabolism and Disposition: 35 (4)
Drug Metabolism and Disposition
Vol. 35, Issue 4
1 Apr 2007
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