Table of Contents

Articles

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  Disposition of the Dipeptidyl Peptidase 4 Inhibitor Sitagliptin in Rats and Dogs

  Maria G. Beconi, James R. Reed, Yohannes Teffera, Yuan-Qing Xia, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Charles S. Elmore, Suzanne Ciccotto, Donald F. Hora, Ralph A. Stearns and Stella H. Vincent

  Drug Metabolism and Disposition April 2007, 35 (4) 525-532; DOI: https://doi.org/10.1124/dmd.106.013110
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  Metabolism And Excretion of the Dipeptidyl Peptidase 4 Inhibitor [¹⁴C]Sitagliptin in Humans

  Stella H. Vincent, James R. Reed, Arthur J. Bergman, Charles S. Elmore, Bing Zhu, Shiyao Xu, David Ebel, Patrick Larson, Wei Zeng, Li Chen, Stacy Dilzer, Kenneth Lasseter, Keith Gottesdiener, John A. Wagner and Gary A. Herman

  Drug Metabolism and Disposition April 2007, 35 (4) 533-538; DOI: https://doi.org/10.1124/dmd.106.013136
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  Role of P-glycoprotein in the Intestinal Absorption of Glabridin, an Active Flavonoid from the Root of Glycyrrhiza glabra

  Jie Cao, Xiao Chen, Jun Liang, Xue-Qing Yu, An-Long Xu, Eli Chan, Duan Wei, Min Huang, Jing-Yuan Wen, Xi-Yong Yu, Xiao-Tian Li, Fwu-Shan Sheu and Shu-Feng Zhou

  Drug Metabolism and Disposition April 2007, 35 (4) 539-553; DOI: https://doi.org/10.1124/dmd.106.010801
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  The Absorption, Metabolism, and Excretion of the Novel Neuromodulator RWJ-333369 (1,2-Ethanediol, [1-2-Chlorophenyl]-, 2-carbamate, [S]-) in Humans

  G. S. J. Mannens, J. Hendrickx, C. G. M. Janssen, S. Chien, B. Van Hoof, T. Verhaeghe, M. Kao, M. F. Kelley, I. Goris, M. Bockx, B. Verreet, M. Bialer and W. Meuldermans

  Drug Metabolism and Disposition April 2007, 35 (4) 554-565; DOI: https://doi.org/10.1124/dmd.106.011940
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  Metabolism and Excretion of RWJ-333369 [1,2-Ethanediol, 1-(2-Chlorophenyl)-, 2-carbamate, (S)-] in Mice, Rats, Rabbits, and Dogs

  Rao N. V. S. Mamidi, Geert Mannens, Pieter Annaert, Jan Hendrickx, Ivo Goris, Mark Bockx, Cor G. M. Janssen, Mark Kao, Michael F. Kelley and Willem Meuldermans

  Drug Metabolism and Disposition April 2007, 35 (4) 566-575; DOI: https://doi.org/10.1124/dmd.106.012336
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  Interactions of Cyclosporin A with Breast Cancer Resistance Protein

  Cindy Q. Xia, Ning Liu, Gerald T. Miwa and Liang-Shang Gan

  Drug Metabolism and Disposition April 2007, 35 (4) 576-582; DOI: https://doi.org/10.1124/dmd.106.011866
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  Glucuronidation of Antiallergic Drug, Tranilast: Identification of Human UDP-Glucuronosyltransferase Isoforms and Effect of Its Phase I Metabolite

  Miki Katoh, Tomohito Matsui and Tsuyoshi Yokoi

  Drug Metabolism and Disposition April 2007, 35 (4) 583-589; DOI: https://doi.org/10.1124/dmd.106.013706
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  Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract

  Yvonne Meier, Jyrki J. Eloranta, Jutta Darimont, Manfred G. Ismair, Christian Hiller, Michael Fried, Gerd A. Kullak-Ublick and Stephan R. Vavricka

  Drug Metabolism and Disposition April 2007, 35 (4) 590-594; DOI: https://doi.org/10.1124/dmd.106.013342
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  Independent Regulation of Apical and Basolateral Drug Transporter Expression and Function in Placental Trophoblasts by Cytokines, Steroids, and Growth Factors

  Denis A. Evseenko, James W. Paxton and Jeffrey A. Keelan

  Drug Metabolism and Disposition April 2007, 35 (4) 595-601; DOI: https://doi.org/10.1124/dmd.106.011478
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  Comparison of Inhibition Potentials of Drugs against Zidovudine Glucuronidation in Rat Hepatocytes and Liver Microsomes

  Yuji Mano, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition April 2007, 35 (4) 602-606; DOI: https://doi.org/10.1124/dmd.106.014225
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  Deacetylclivorine: A Gender-Selective Metabolite of Clivorine Formed in Female Sprague-Dawley Rat Liver Microsomes

  Ge Lin, Jun Tang, Xiao Quan Liu, Yan Jiang and Jiang Zheng

  Drug Metabolism and Disposition April 2007, 35 (4) 607-613; DOI: https://doi.org/10.1124/dmd.106.014100
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  Visible Spectra of Type II Cytochrome P450-Drug Complexes: Evidence that “Incomplete” Heme Coordination Is Common

  Charles W. Locuson, J. Matthew Hutzler and Timothy S. Tracy

  Drug Metabolism and Disposition April 2007, 35 (4) 614-622; DOI: https://doi.org/10.1124/dmd.106.012609
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  Identification and Functional Assessment of BCRP Polymorphisms in a Korean Population

  Sang Seop Lee, Hye-Eun Jeong, Joo-Mi Yi, Hyun-Ju Jung, Jae-Eun Jang, Eun-Young Kim, Su-Jun Lee and Jae-Gook Shin

  Drug Metabolism and Disposition April 2007, 35 (4) 623-632; DOI: https://doi.org/10.1124/dmd.106.012302
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  Metabolism of a Heterocyclic Amine Colon Carcinogen in Young and Old Rats

  Harvey J. Armbrecht, Vijaya M. Lakshmi, Jason Wickstra, Fong Fu Hsu and Terry V. Zenser

  Drug Metabolism and Disposition April 2007, 35 (4) 633-639; DOI: https://doi.org/10.1124/dmd.106.013532
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  Development of Three Parallel Cytochrome P450 Enzyme Affinity Detection Systems Coupled On-line to Gradient High-Performance Liquid Chromatography

  Jeroen Kool, Sebastiaan M. van Liempd, Huub van Rossum, Danny A. van Elswijk, Hubertus Irth, Jan N. M. Commandeur and Nico P. E. Vermeulen

  Drug Metabolism and Disposition April 2007, 35 (4) 640-648; DOI: https://doi.org/10.1124/dmd.106.012245
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  The Prediction of Drug Metabolism, Tissue Distribution, and Bioavailability of 50 Structurally Diverse Compounds in Rat Using Mechanism-Based Absorption, Distribution, and Metabolism Prediction Tools

  Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Ron A. Gilissen, Claire E. Mackie and Marjoleen J. Nijsen

  Drug Metabolism and Disposition April 2007, 35 (4) 649-659; DOI: https://doi.org/10.1124/dmd.106.014027
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  Use of Plasma and Brain Unbound Fractions to Assess the Extent of Brain Distribution of 34 Drugs: Comparison of Unbound Concentration Ratios to in Vivo P-Glycoprotein Efflux Ratios

  J. Cory Kalvass, Tristan S. Maurer and Gary M. Pollack

  Drug Metabolism and Disposition April 2007, 35 (4) 660-666; DOI: https://doi.org/10.1124/dmd.106.012294
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  Identification and Functional Characterization of Genetic Variants of Human Organic Cation Transporters in a Korean Population

  Ho-Jin Kang, Im-Sook Song, Ho Jung Shin, Woo-Young Kim, Choong-Hee Lee, Joo-Cheol Shim, Hong-Hao Zhou, Sang Seop Lee and Jae-Gook Shin

  Drug Metabolism and Disposition April 2007, 35 (4) 667-675; DOI: https://doi.org/10.1124/dmd.106.013581
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  Formation and Uptake of Arylhydroxylamine-Haptenated Proteins in Human Dendritic Cells

  Sanjoy Roychowdhury, Piyush M. Vyas and Craig K. Svensson

  Drug Metabolism and Disposition April 2007, 35 (4) 676-681; DOI: https://doi.org/10.1124/dmd.106.013680
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  Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues

  Tracy C. DeLozier, Grace E. Kissling, Sherry J. Coulter, Diana Dai, Julie F. Foley, J. Alyce Bradbury, Elizabeth Murphy, Charles Steenbergen, Darryl C. Zeldin and Joyce A. Goldstein

  Drug Metabolism and Disposition April 2007, 35 (4) 682-688; DOI: https://doi.org/10.1124/dmd.106.012823
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  Possible Pathway(s) of Metyrapone Egress from the Active Site of Cytochrome P450 3A4: A Molecular Dynamics Simulation

  Weihua Li, Hong Liu, Xiaomin Luo, Weiliang Zhu, Yun Tang, James R. Halpert and Hualiang Jiang

  Drug Metabolism and Disposition April 2007, 35 (4) 689-696; DOI: https://doi.org/10.1124/dmd.106.014019