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Drug Metabolism & Disposition

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Table of Contents

May 01, 2007; Volume 35,Issue 5

Short Communication

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    Resveratrol in Human Hepatoma HepG2 Cells: Metabolism and Inducibility of Detoxifying Enzymes
    Allan Lançon, Nathalie Hanet, Brigitte Jannin, Dominique Delmas, Jean-Marie Heydel, Gérard Lizard, Marie-Christine Chagnon, Yves Artur and Norbert Latruffe
    Drug Metabolism and Disposition May 2007, 35 (5) 699-703; DOI: https://doi.org/10.1124/dmd.106.013664

Articles

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    Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A
    Ping Zhao, Caroline A. Lee and Kent L. Kunze
    Drug Metabolism and Disposition May 2007, 35 (5) 704-712; DOI: https://doi.org/10.1124/dmd.106.013847
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    Oxidation of Vinyl Carbamate and Formation of 1,N6-Ethenodeoxyadenosine in Murine Lung
    Poh-Gek Forkert, Martin Kaufmann, Gordon Black, Raymond Bowers, Heidi Chen, Kathy Collins, Ashish Sharma and Glenville Jones
    Drug Metabolism and Disposition May 2007, 35 (5) 713-720; DOI: https://doi.org/10.1124/dmd.106.013805
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    Identification of N-Acetyltransferase 2 (NAT2) Transcription Start Sites and Quantitation of NAT2-Specific mRNA in Human Tissues
    Anwar Husain, Xiaoyan Zhang, Mark A. Doll, J. Christopher States, David F. Barker and David W. Hein
    Drug Metabolism and Disposition May 2007, 35 (5) 721-727; DOI: https://doi.org/10.1124/dmd.106.014621
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    Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene
    Tsutomu Matsubara, Wachiraporn Noracharttiyapot, Takayoshi Toriyabe, Kouichi Yoshinari, Kiyoshi Nagata and Yasushi Yamazoe
    Drug Metabolism and Disposition May 2007, 35 (5) 728-733; DOI: https://doi.org/10.1124/dmd.106.013144
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    Genetic Polymorphism of Aldehyde Oxidase in Donryu Rats
    Kunio Itoh, Akiko Masubuchi, Takamitsu Sasaki, Mayuko Adachi, Nobuaki Watanabe, Kiyoshi Nagata, Yasushi Yamazoe, Masahiro Hiratsuka, Michinao Mizugaki and Yorihisa Tanaka
    Drug Metabolism and Disposition May 2007, 35 (5) 734-739; DOI: https://doi.org/10.1124/dmd.106.011502
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    Variable Sulfation of Dietary Polyphenols by Recombinant Human Sulfotransferase (SULT) 1A1 Genetic Variants and SULT1E1
    Din Ung and Swati Nagar
    Drug Metabolism and Disposition May 2007, 35 (5) 740-746; DOI: https://doi.org/10.1124/dmd.106.013987
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    Effects of Coexpression of UGT1A9 on Enzymatic Activities of Human UGT1A Isoforms
    Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Akiko Nakamura, Miki Katoh, Shin-ichi Ikushiro, Toshiyuki Sakaki and Tsuyoshi Yokoi
    Drug Metabolism and Disposition May 2007, 35 (5) 747-757; DOI: https://doi.org/10.1124/dmd.106.014191
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    Studies on the Metabolism of Tolmetin to the Chemically Reactive Acyl-Coenzyme A Thioester Intermediate in Rats
    Jørgen Olsen, Chunze Li, Christian Skonberg, Inga Bjørnsdottir, Ulrik Sidenius, Leslie Z. Benet and Steen Honoré Hansen
    Drug Metabolism and Disposition May 2007, 35 (5) 758-764; DOI: https://doi.org/10.1124/dmd.106.013334
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    Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver
    Caroline Fradette, Joëlle Batonga, Shirley Teng, Micheline Piquette-Miller and Patrick du Souich
    Drug Metabolism and Disposition May 2007, 35 (5) 765-771; DOI: https://doi.org/10.1124/dmd.106.013508
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    Kinetic Analysis of the Transport of Salicylic Acid, a Nonsteroidal Anti-inflammatory Drug, across Human Placenta
    Kyohei Shintaku, Yuka Arima, Yukihiko Dan, Tsutomu Takeda, Kentaro Kogushi, Masayuki Tsujimoto, Hideaki Nagata, Shoji Satoh, Kiyomi Tsukimori, Hitoo Nakano, Satoko Hori, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition May 2007, 35 (5) 772-778; DOI: https://doi.org/10.1124/dmd.106.013029
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    The Influence of Macrolide Antibiotics on the Uptake of Organic Anions and Drugs Mediated by OATP1B1 and OATP1B3
    Annick Seithel, Sonja Eberl, Katrin Singer, Daniel Auge, Georg Heinkele, Nadine B. Wolf, Frank Dörje, Martin F. Fromm and Jörg König
    Drug Metabolism and Disposition May 2007, 35 (5) 779-786; DOI: https://doi.org/10.1124/dmd.106.014407
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    Regulation of CYP2A5 Gene by the Transcription Factor Nuclear Factor (Erythroid-Derived 2)-Like 2
    A'edah Abu-Bakar, Virpi Lämsä, Satu Arpiainen, Michael R. Moore, Matti A. Lang and Jukka Hakkola
    Drug Metabolism and Disposition May 2007, 35 (5) 787-794; DOI: https://doi.org/10.1124/dmd.106.014423
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    Reduction of Site-Specific CYP3A-Mediated Metabolism for Dual Angiotensin and Endothelin Receptor Antagonists in Various in Vitro Systems and in Cynomolgus Monkeys
    Hongjian Zhang, Donglu Zhang, Wenying Li, Ming Yao, Celia D'Arienzo, Yi-Xin Li, William R. Ewing, Zhengxiang Gu, Yeheng Zhu, Natesan Murugesan, Wen-Chyi Shyu and W. Griffith Humphreys
    Drug Metabolism and Disposition May 2007, 35 (5) 795-805; DOI: https://doi.org/10.1124/dmd.106.012781
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    Metabolic Profile of a Peptide-Conjugated Chlorin-Type Photosensitizer Targeting Neuropilin-1: An in Vivo and in Vitro Study
    Loraine Tirand, Noémie Thomas, Marc Dodeller, Dominique Dumas, Céline Frochot, Benoît Maunit, François Guillemin and Muriel Barberi-Heyob
    Drug Metabolism and Disposition May 2007, 35 (5) 806-813; DOI: https://doi.org/10.1124/dmd.106.013763
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    Chemical Modification of Interleukin-10 with Mannose 6-Phosphate Groups Yields a Liver-Selective Cytokine
    Heni Rachmawati, Catharina Reker-Smit, Marjolijn N. Lub-de Hooge, Annemiek van Loenen-Weemaes, Klaas Poelstra and Leonie Beljaars
    Drug Metabolism and Disposition May 2007, 35 (5) 814-821; DOI: https://doi.org/10.1124/dmd.106.013490
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    Differential Subcellular Distribution of Mitoxantrone in Relation to Chemosensitization in Two Human Breast Cancer Cell Lines
    Sophie Vibet, Karine Mahéo, Jacques Goré, Pierre Dubois, Philippe Bougnoux and Igor Chourpa
    Drug Metabolism and Disposition May 2007, 35 (5) 822-828; DOI: https://doi.org/10.1124/dmd.106.013474

Erratum

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    Correction to “Stereoselective Metabolism of Endosulfan by Human Liver Microsomes and Human Cytochrome P540 Isoforms”
    Drug Metabolism and Disposition May 2007, 35 (5) 829-830; DOI: https://doi.org/10.1124/dmd.35.5.829
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In this issue

Drug Metabolism and Disposition: 35 (5)
Drug Metabolism and Disposition
Vol. 35, Issue 5
1 May 2007
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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