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Research ArticleArticle

Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A

Ping Zhao, Caroline A. Lee and Kent L. Kunze
Drug Metabolism and Disposition May 2007, 35 (5) 704-712; DOI: https://doi.org/10.1124/dmd.106.013847

Article Information

vol. 35 no. 5 704-712
DOI 
https://doi.org/10.1124/dmd.106.013847
PubMed 
17293381
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 9, 2006
  • Accepted February 7, 2007
  • Published online April 19, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ping Zhao,
  2. Caroline A. Lee and
  3. Kent L. Kunze
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla Laboratories, La Jolla, California (P.Z., C.A.L.); and Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington (K.L.K.)
  1. Address correspondence to:
    Dr. Ping Zhao, Sonus Pharmaceuticals, Inc., 22026 20th Ave SE, Bothell, WA 98021. E-mail: pingz{at}sonuspharma.com
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Research ArticleArticle

Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A

Ping Zhao, Caroline A. Lee and Kent L. Kunze
Drug Metabolism and Disposition May 1, 2007, 35 (5) 704-712; DOI: https://doi.org/10.1124/dmd.106.013847
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