Table of Contents

Articles

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  Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study

  Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan

  Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
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  Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes

  Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu

  Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
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  Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine_2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

  Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt

  Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
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  Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo

  Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley

  Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
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  Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats

  Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai

  Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
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  Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor

  Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer

  Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
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  Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy

  Kevin Colizza, Mohamed Awad and Amin Kamel

  Drug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
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  Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro

  E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis

  Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
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  Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry

  John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat

  Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
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  Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method

  Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid

  Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
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  Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases

  Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
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  Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)

  Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin

  Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
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  Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles

  Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu

  Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
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  Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine

  Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk

  Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
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  Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)

  Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler

  Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
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  Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line

  Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini

  Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
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  A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity

  Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco

  Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
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  Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells

  Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng

  Drug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
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  Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study

  Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman

  Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
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  Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

  Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington

  Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
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  Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function

  Jason M. Walraven, John O. Trent and David W. Hein

  Drug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040