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Drug Metabolism & Disposition

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Table of Contents

June 01, 2007; Volume 35,Issue 6

Short Communication

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    Characterization of the Novel Defective CYP2C9*24 Allele
    Darja Herman, Vita Dolzan and Magnus Ingelman-Sundberg
    Drug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722

Articles

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    Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
    Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
    Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
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    Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
    Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
    Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
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    Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
    Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
    Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
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    Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
    Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
    Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
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    Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
    Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
    Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
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    Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
    Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
    Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
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    Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy
    Kevin Colizza, Mohamed Awad and Amin Kamel
    Drug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
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    Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
    E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis
    Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
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    Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
    John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat
    Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
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    Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
    Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
    Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
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    Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases
    Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
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    Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
    Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
    Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
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    Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
    Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu
    Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
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    Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
    Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
    Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
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    Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
    Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
    Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
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    Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
    Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
    Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
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    A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
    Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
    Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
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    Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells
    Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng
    Drug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
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    Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
    Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
    Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
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    Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
    Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
    Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
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    Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function
    Jason M. Walraven, John O. Trent and David W. Hein
    Drug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
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Drug Metabolism and Disposition: 35 (6)
Drug Metabolism and Disposition
Vol. 35, Issue 6
1 Jun 2007
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