Index by author
June 01, 2007; Volume 35,Issue 6
A
Albrecht, Wolfgang
- You have accessPharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase InhibitorBernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan LauferDrug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
Amati, Francesca
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Aubrecht, Jiri
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Augustine, Lisa M.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Awad, Mohamed
- You have accessMetabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR SpectroscopyKevin Colizza, Mohamed Awad and Amin KamelDrug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
B
Bernardini, Sergio
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Biancolella, Michela
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Blanco, Javier G.
- You have accessA Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding AffinityVanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. BlancoDrug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
Boykin, David W.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Brouwer, Kim L. R.
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Bueno, Susana
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Burk, Oliver
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
C
Cai, Zongwei
- You have accessInvestigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in RatsWan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei CaiDrug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
Cao, Jianguo
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Chan, Wan
- You have accessInvestigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in RatsWan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei CaiDrug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
Cheng, Christopher H. K.
- You have accessMorin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney CellsZhifeng Yu, Wing Ping Fong and Christopher H. K. ChengDrug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
Cheng, Yuen-Kit
- You have accessInvestigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in RatsWan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei CaiDrug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
Cherrington, Nathan J.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Cheung, Jennifer R.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Chiang, Phoebe
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Chillemi, Giovanni
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Choudhary, Dharamainder
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
Coelho, Richard V.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Coffing, Stephanie L.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Colizza, Kevin
- You have accessMetabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR SpectroscopyKevin Colizza, Mohamed Awad and Amin KamelDrug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
Cybulski, Zbigniew R.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
D
Dalvie, Deepak K.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Decicco, Carl P.
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
de Graaf, I. A. M.
- You have accessInduction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in VitroE. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. GroothuisDrug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
de Jager, M. H.
- You have accessInduction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in VitroE. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. GroothuisDrug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
DeMaio, William
- You have accessMetabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass SpectrometryJohn C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. TalaatDrug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
Desideri, Alessandro
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Dolzan, Vita
- You have accessCharacterization of the Novel Defective CYP2C9*24 AlleleDarja Herman, Vita Dolzan and Magnus Ingelman-SundbergDrug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722
Doukas, John
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Duan, Jingwu
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
E
Eichelbaum, Michel
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
Enokizono, Junichi
- You have accessRegional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with SulfotransferasesJunichi Enokizono, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
Erve, John C. L.
- You have accessMetabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass SpectrometryJohn C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. TalaatDrug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
F
Farcomeni, Alessio
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Farid, Nagy A.
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Federici, Giorgio
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Fisher, Craig D.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Fitzpatrick, Karen
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Fong, Wing Ping
- You have accessMorin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney CellsZhifeng Yu, Wing Ping Fong and Christopher H. K. ChengDrug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
G
Gan, Liang-Shang
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Garner, C. Edwin
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Ghosh, Debashis
- You have accessA Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding AffinityVanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. BlancoDrug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
Gleiter, Christoph H.
- You have accessPharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase InhibitorBernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan LauferDrug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
Gonzalez-Covarrubias, Vanessa
- You have accessA Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding AffinityVanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. BlancoDrug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
Gravina, Paolo
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Grime, Ken
- You have accessUse of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in VivoMatthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. RileyDrug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
Groothuis, G. M. M.
- You have accessInduction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in VitroE. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. GroothuisDrug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
H
Han, David K. M.
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
Hein, David W.
- You have accessComputational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and FunctionJason M. Walraven, John O. Trent and David W. HeinDrug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
Henderson, Simon J.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Herman, Darja
- You have accessCharacterization of the Novel Defective CYP2C9*24 AlleleDarja Herman, Vita Dolzan and Magnus Ingelman-SundbergDrug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722
Hood, John
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Houchen, Tara L.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Hu, Hanbo
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Hu, Steven X.
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Hu, Yiding
- You have accessStructure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted HeterocyclesYurong Lai, Li Xing, Gennadiy I. Poda and Yiding HuDrug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
I
Ingelman-Sundberg, Magnus
- You have accessCharacterization of the Novel Defective CYP2C9*24 AlleleDarja Herman, Vita Dolzan and Magnus Ingelman-SundbergDrug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722
J
Jansson, Ingela
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
John, Brian A.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
K
Kalgutkar, Amit S.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Kamel, Amin
- You have accessMetabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR SpectroscopyKevin Colizza, Mohamed Awad and Amin KamelDrug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
Kammerer, Bernd
- You have accessPharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase InhibitorBernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan LauferDrug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
Klaassen, Curtis D.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Klein, Kathrin
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
Kousba, Ahmed
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Kurihara, Atsushi
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Kusuhara, Hiroyuki
- You have accessRegional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with SulfotransferasesJunichi Enokizono, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
L
Lai, Yurong
- You have accessStructure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted HeterocyclesYurong Lai, Li Xing, Gennadiy I. Poda and Yiding HuDrug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
Lakhman, Sukhwinder S.
- You have accessA Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding AffinityVanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. BlancoDrug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
Lame, Mary E.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Laufer, Stefan
- You have accessPharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase InhibitorBernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan LauferDrug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
Lee, Frank W.
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Lehman-McKeeman, Lois D.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Liu, Hanlan
- You have accessEvaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver MicrosomesSirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan LiuDrug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
Lohse, Daniel L.
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Luo, Gang
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Luo, Hai-Bin
- You have accessInvestigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in RatsWan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei CaiDrug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
M
Maduskuie, Thomas
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Maher, Jonathan M.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Martin, Michael
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Maurer, Tristan S.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
McBurney, Alan
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
McClure, Kim F.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
McPherson, Andrew
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Miano, Roberto
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
Midgley, Ian
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
N
Nelson, David M.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Noronha, Glenn
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Novelli, Giuseppe
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
O
O'Shea, Thomas J.
- You have accessEvaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver MicrosomesSirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan LiuDrug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
P
Pendyala, Lakshmi
- You have accessA Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding AffinityVanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. BlancoDrug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
Poda, Gennadiy I.
- You have accessStructure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted HeterocyclesYurong Lai, Li Xing, Gennadiy I. Poda and Yiding HuDrug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
R
Renick, Joel
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Rezaul, Karim
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
Richards, Lauren E.
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Riley, Robert J.
- You have accessUse of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in VivoMatthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. RileyDrug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
Ruterbories, Kenneth J.
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
S
Sarfarazi, Mansoor
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
Scheible, Holger
- You have accessPharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase InhibitorBernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan LauferDrug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
Schenkman, John B.
- You have accessCyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical StudyDharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. SchenkmanDrug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
Schildknegt, Klaas
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Schnabel, Anke
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
Shen, Helen
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Skell, Jeffrey
- You have accessEvaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver MicrosomesSirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan LiuDrug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
Slitt, Angela L.
- You have accessInduction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. CherringtonDrug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
Smith, Evan B.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Soars, Matthew G.
- You have accessUse of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in VivoMatthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. RileyDrug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
Soliman, Victor F.
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Soll, Richard
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Sproston, Joanne L.
- You have accessUse of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in VivoMatthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. RileyDrug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
Sudsakorn, Sirimas
- You have accessEvaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver MicrosomesSirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan LiuDrug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
Sugiyama, Yuichi
- You have accessRegional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with SulfotransferasesJunichi Enokizono, Hiroyuki Kusuhara and Yuichi SugiyamaDrug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
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Tabak, Arek
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Talaat, Rasmy E.
- You have accessMetabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass SpectrometryJohn C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. TalaatDrug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
Taylor, Lynne M.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Tegude, Heike
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
Tian, Ye
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Trendler, Kerri L.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
Trent, John O.
- You have accessComputational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and FunctionJason M. Walraven, John O. Trent and David W. HeinDrug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
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Vage, Chandra
- You have accessGenotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic ActivationAmit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas SchildknegtDrug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Valentini, Alessandra
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
van de Kerkhof, E. G.
- You have accessInduction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in VitroE. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. GroothuisDrug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
Vashishtha, Sarvesh C.
- You have accessMetabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass SpectrometryJohn C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. TalaatDrug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
Verburg, Elizabeth M.
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Vespasiani, Giuseppe
- You have accessValproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell LineAlessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio BernardiniDrug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
W
Walraven, Jason M.
- You have accessComputational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and FunctionJason M. Walraven, John O. Trent and David W. HeinDrug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
Webborn, Peter J. H.
- You have accessUse of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in VivoMatthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. RileyDrug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
Weerakkody, Govinda J.
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Wickremsinhe, Enaksha R.
- You have accessStereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry MethodEnaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. FaridDrug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
Williams, David A.
- You have accessEvaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver MicrosomesSirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan LiuDrug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
Wright, Sarah J.
- You have accessPharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. TrendlerDrug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
X
Xing, Li
- You have accessStructure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted HeterocyclesYurong Lai, Li Xing, Gennadiy I. Poda and Yiding HuDrug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
Xiong, Hao
- You have accessEffect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case StudyGang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang GanDrug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
Y
Yee, Shiyin
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Yu, Xiyun
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Yu, Zhifeng
- You have accessMorin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney CellsZhifeng Yu, Wing Ping Fong and Christopher H. K. ChengDrug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
Z
Zanger, Ulrich M.
- You have accessMolecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the IntestineHeike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver BurkDrug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
Zeng, Binqi
- You have accessMetabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael MartinDrug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
Zheng, Yufang
- You have accessInvestigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in RatsWan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei CaiDrug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
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