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Drug Metabolism & Disposition

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Index by author

June 01, 2007; Volume 35,Issue 6
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Albrecht, Wolfgang

    1. You have access
      Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
      Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
      Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
  2. Amati, Francesca

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  3. Aubrecht, Jiri

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  4. Augustine, Lisa M.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  5. Awad, Mohamed

    1. You have access
      Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy
      Kevin Colizza, Mohamed Awad and Amin Kamel
      Drug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266

B

  1. Bernardini, Sergio

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  2. Biancolella, Michela

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  3. Blanco, Javier G.

    1. You have access
      A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
      Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
      Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
  4. Boykin, David W.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  5. Brouwer, Kim L. R.

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  6. Bueno, Susana

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  7. Burk, Oliver

    1. You have access
      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565

C

  1. Cai, Zongwei

    1. You have access
      Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
      Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
      Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
  2. Cao, Jianguo

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  3. Chan, Wan

    1. You have access
      Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
      Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
      Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
  4. Cheng, Christopher H. K.

    1. You have access
      Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells
      Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng
      Drug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187
  5. Cheng, Yuen-Kit

    1. You have access
      Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
      Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
      Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
  6. Cherrington, Nathan J.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  7. Cheung, Jennifer R.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  8. Chiang, Phoebe

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  9. Chillemi, Giovanni

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  10. Choudhary, Dharamainder

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  11. Coelho, Richard V.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  12. Coffing, Stephanie L.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  13. Colizza, Kevin

    1. You have access
      Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy
      Kevin Colizza, Mohamed Awad and Amin Kamel
      Drug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
  14. Cybulski, Zbigniew R.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391

D

  1. Dalvie, Deepak K.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  2. Decicco, Carl P.

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  3. de Graaf, I. A. M.

    1. You have access
      Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
      E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis
      Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
  4. de Jager, M. H.

    1. You have access
      Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
      E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis
      Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
  5. DeMaio, William

    1. You have access
      Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
      John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat
      Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
  6. Desideri, Alessandro

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  7. Dolzan, Vita

    1. You have access
      Characterization of the Novel Defective CYP2C9*24 Allele
      Darja Herman, Vita Dolzan and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722
  8. Doukas, John

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  9. Duan, Jingwu

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946

E

  1. Eichelbaum, Michel

    1. You have access
      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
  2. Enokizono, Junichi

    1. You have access
      Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases
      Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239
  3. Erve, John C. L.

    1. You have access
      Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
      John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat
      Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219

F

  1. Farcomeni, Alessio

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  2. Farid, Nagy A.

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  3. Federici, Giorgio

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  4. Fisher, Craig D.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  5. Fitzpatrick, Karen

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  6. Fong, Wing Ping

    1. You have access
      Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells
      Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng
      Drug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187

G

  1. Gan, Liang-Shang

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  2. Garner, C. Edwin

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  3. Ghosh, Debashis

    1. You have access
      A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
      Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
      Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
  4. Gleiter, Christoph H.

    1. You have access
      Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
      Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
      Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
  5. Gonzalez-Covarrubias, Vanessa

    1. You have access
      A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
      Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
      Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
  6. Gravina, Paolo

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  7. Grime, Ken

    1. You have access
      Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
      Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
      Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
  8. Groothuis, G. M. M.

    1. You have access
      Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
      E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis
      Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563

H

  1. Han, David K. M.

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  2. Hein, David W.

    1. You have access
      Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function
      Jason M. Walraven, John O. Trent and David W. Hein
      Drug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
  3. Henderson, Simon J.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  4. Herman, Darja

    1. You have access
      Characterization of the Novel Defective CYP2C9*24 Allele
      Darja Herman, Vita Dolzan and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722
  5. Hood, John

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  6. Houchen, Tara L.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  7. Hu, Hanbo

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  8. Hu, Steven X.

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  9. Hu, Yiding

    1. You have access
      Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
      Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu
      Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250

I

  1. Ingelman-Sundberg, Magnus

    1. You have access
      Characterization of the Novel Defective CYP2C9*24 Allele
      Darja Herman, Vita Dolzan and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition June 2007, 35 (6) 831-834; DOI: https://doi.org/10.1124/dmd.106.013722

J

  1. Jansson, Ingela

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  2. John, Brian A.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391

K

  1. Kalgutkar, Amit S.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  2. Kamel, Amin

    1. You have access
      Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy
      Kevin Colizza, Mohamed Awad and Amin Kamel
      Drug Metabolism and Disposition June 2007, 35 (6) 884-897; DOI: https://doi.org/10.1124/dmd.106.014266
  3. Kammerer, Bernd

    1. You have access
      Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
      Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
      Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
  4. Klaassen, Curtis D.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  5. Klein, Kathrin

    1. You have access
      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
  6. Kousba, Ahmed

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  7. Kurihara, Atsushi

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  8. Kusuhara, Hiroyuki

    1. You have access
      Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases
      Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239

L

  1. Lai, Yurong

    1. You have access
      Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
      Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu
      Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
  2. Lakhman, Sukhwinder S.

    1. You have access
      A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
      Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
      Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
  3. Lame, Mary E.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  4. Laufer, Stefan

    1. You have access
      Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
      Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
      Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
  5. Lee, Frank W.

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  6. Lehman-McKeeman, Lois D.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  7. Liu, Hanlan

    1. You have access
      Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
      Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
      Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
  8. Lohse, Daniel L.

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  9. Luo, Gang

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  10. Luo, Hai-Bin

    1. You have access
      Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
      Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
      Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979

M

  1. Maduskuie, Thomas

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  2. Maher, Jonathan M.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  3. Martin, Michael

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  4. Maurer, Tristan S.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  5. McBurney, Alan

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  6. McClure, Kim F.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  7. McPherson, Andrew

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  8. Miano, Roberto

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  9. Midgley, Ian

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391

N

  1. Nelson, David M.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  2. Noronha, Glenn

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  3. Novelli, Giuseppe

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662

O

  1. O'Shea, Thomas J.

    1. You have access
      Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
      Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
      Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472

P

  1. Pendyala, Lakshmi

    1. You have access
      A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
      Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala and Javier G. Blanco
      Drug Metabolism and Disposition June 2007, 35 (6) 973-980; DOI: https://doi.org/10.1124/dmd.107.014779
  2. Poda, Gennadiy I.

    1. You have access
      Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
      Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu
      Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250

R

  1. Renick, Joel

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  2. Rezaul, Karim

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  3. Richards, Lauren E.

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  4. Riley, Robert J.

    1. You have access
      Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
      Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
      Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
  5. Ruterbories, Kenneth J.

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530

S

  1. Sarfarazi, Mansoor

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  2. Scheible, Holger

    1. You have access
      Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
      Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter and Stefan Laufer
      Drug Metabolism and Disposition June 2007, 35 (6) 875-883; DOI: https://doi.org/10.1124/dmd.106.013409
  3. Schenkman, John B.

    1. You have access
      Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
      Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi and John B. Schenkman
      Drug Metabolism and Disposition June 2007, 35 (6) 987-994; DOI: https://doi.org/10.1124/dmd.106.014282
  4. Schildknegt, Klaas

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  5. Schnabel, Anke

    1. You have access
      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
  6. Shen, Helen

    1. You have access
      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946
  7. Skell, Jeffrey

    1. You have access
      Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
      Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
      Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
  8. Slitt, Angela L.

    1. You have access
      Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
      Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2007, 35 (6) 995-1000; DOI: https://doi.org/10.1124/dmd.106.014340
  9. Smith, Evan B.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  10. Soars, Matthew G.

    1. You have access
      Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
      Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
      Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
  11. Soliman, Victor F.

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  12. Soll, Richard

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  13. Sproston, Joanne L.

    1. You have access
      Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
      Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
      Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
  14. Sudsakorn, Sirimas

    1. You have access
      Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
      Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
      Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
  15. Sugiyama, Yuichi

    1. You have access
      Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases
      Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition June 2007, 35 (6) 922-928; DOI: https://doi.org/10.1124/dmd.106.011239

T

  1. Tabak, Arek

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  2. Talaat, Rasmy E.

    1. You have access
      Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
      John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat
      Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
  3. Taylor, Lynne M.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  4. Tegude, Heike

    1. You have access
      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
  5. Tian, Ye

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  6. Trendler, Kerri L.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391
  7. Trent, John O.

    1. You have access
      Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function
      Jason M. Walraven, John O. Trent and David W. Hein
      Drug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040

V

  1. Vage, Chandra

    1. You have access
      Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
      Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
      Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
  2. Valentini, Alessandra

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662
  3. van de Kerkhof, E. G.

    1. You have access
      Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
      E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager and G. M. M. Groothuis
      Drug Metabolism and Disposition June 2007, 35 (6) 898-907; DOI: https://doi.org/10.1124/dmd.106.014563
  4. Vashishtha, Sarvesh C.

    1. You have access
      Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
      John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio and Rasmy E. Talaat
      Drug Metabolism and Disposition June 2007, 35 (6) 908-916; DOI: https://doi.org/10.1124/dmd.106.013219
  5. Verburg, Elizabeth M.

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  6. Vespasiani, Giuseppe

    1. You have access
      Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
      Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli and Sergio Bernardini
      Drug Metabolism and Disposition June 2007, 35 (6) 968-972; DOI: https://doi.org/10.1124/dmd.107.014662

W

  1. Walraven, Jason M.

    1. You have access
      Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function
      Jason M. Walraven, John O. Trent and David W. Hein
      Drug Metabolism and Disposition June 2007, 35 (6) 1001-1007; DOI: https://doi.org/10.1124/dmd.107.015040
  2. Webborn, Peter J. H.

    1. You have access
      Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
      Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn and Robert J. Riley
      Drug Metabolism and Disposition June 2007, 35 (6) 859-865; DOI: https://doi.org/10.1124/dmd.106.014464
  3. Weerakkody, Govinda J.

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  4. Wickremsinhe, Enaksha R.

    1. You have access
      Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
      Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara and Nagy A. Farid
      Drug Metabolism and Disposition June 2007, 35 (6) 917-921; DOI: https://doi.org/10.1124/dmd.106.014530
  5. Williams, David A.

    1. You have access
      Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
      Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea and Hanlan Liu
      Drug Metabolism and Disposition June 2007, 35 (6) 841-847; DOI: https://doi.org/10.1124/dmd.106.014472
  6. Wright, Sarah J.

    1. You have access
      Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
      Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin and Kerri L. Trendler
      Drug Metabolism and Disposition June 2007, 35 (6) 955-967; DOI: https://doi.org/10.1124/dmd.106.013391

X

  1. Xing, Li

    1. You have access
      Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
      Yurong Lai, Li Xing, Gennadiy I. Poda and Yiding Hu
      Drug Metabolism and Disposition June 2007, 35 (6) 937-945; DOI: https://doi.org/10.1124/dmd.106.013250
  2. Xiong, Hao

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      Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
      Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee and Liang-Shang Gan
      Drug Metabolism and Disposition June 2007, 35 (6) 835-840; DOI: https://doi.org/10.1124/dmd.106.013946

Y

  1. Yee, Shiyin

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  2. Yu, Xiyun

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  3. Yu, Zhifeng

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      Morin (3,5,7,2′,4′-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells
      Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng
      Drug Metabolism and Disposition June 2007, 35 (6) 981-986; DOI: https://doi.org/10.1124/dmd.106.012187

Z

  1. Zanger, Ulrich M.

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      Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
      Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum and Oliver Burk
      Drug Metabolism and Disposition June 2007, 35 (6) 946-954; DOI: https://doi.org/10.1124/dmd.106.013565
  2. Zeng, Binqi

    1. You have access
      Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
      Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha and Michael Martin
      Drug Metabolism and Disposition June 2007, 35 (6) 929-936; DOI: https://doi.org/10.1124/dmd.106.014290
  3. Zheng, Yufang

    1. You have access
      Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
      Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng and Zongwei Cai
      Drug Metabolism and Disposition June 2007, 35 (6) 866-874; DOI: https://doi.org/10.1124/dmd.106.013979
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Drug Metabolism and Disposition: 35 (6)
Drug Metabolism and Disposition
Vol. 35, Issue 6
1 Jun 2007
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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