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Research ArticleArticle

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho Jr., Victor F. Soliman and Klaas Schildknegt
Drug Metabolism and Disposition June 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
Amit S. Kalgutkar
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Deepak K. Dalvie
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Jiri Aubrecht
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Evan B. Smith
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Stephanie L. Coffing
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Jennifer R. Cheung
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Chandra Vage
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Mary E. Lame
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Phoebe Chiang
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Kim F. McClure
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Tristan S. Maurer
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Richard V. Coelho Jr.
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Victor F. Soliman
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Article Information

vol. 35 no. 6 848-858
DOI 
https://doi.org/10.1124/dmd.106.013649
PubMed 
17344339

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 1, 2006
  • Accepted March 2, 2007
  • Published online May 18, 2007.

Article Versions

  • Earlier version (March 7, 2007 - 08:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amit S. Kalgutkar,
  2. Deepak K. Dalvie,
  3. Jiri Aubrecht,
  4. Evan B. Smith,
  5. Stephanie L. Coffing,
  6. Jennifer R. Cheung,
  7. Chandra Vage,
  8. Mary E. Lame,
  9. Phoebe Chiang,
  10. Kim F. McClure,
  11. Tristan S. Maurer,
  12. Richard V. Coelho, Jr.,
  13. Victor F. Soliman and
  14. Klaas Schildknegt
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut (A.S.K., C.V., M.E.L., T.S.M., V.F.S.) and La Jolla, California (D.K.D., E.B.S.); and Safety Sciences (J.A., S.L.C., J.R.C.), Cardiovascular and Metabolic Diseases Chemistry (P.C., K.F.M.), and Chemical Research and Development (K.S., R.V.C.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Amit S. Kalgutkar, Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, CT 06340. E-mail: amit.kalgutkar{at}pfizer.com
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Drug Metabolism and Disposition: 35 (6)
Drug Metabolism and Disposition
Vol. 35, Issue 6
1 Jun 2007
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Research ArticleArticle

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
Drug Metabolism and Disposition June 1, 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649

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Research ArticleArticle

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Victor F. Soliman and Klaas Schildknegt
Drug Metabolism and Disposition June 1, 2007, 35 (6) 848-858; DOI: https://doi.org/10.1124/dmd.106.013649
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