Table of Contents

Articles

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  Esterase Inhibition Attribute of Grapefruit Juice Leading to a New Drug Interaction

  Ping Li, Patrick S. Callery, Liang-Shang Gan and Suresh K. Balani

  Drug Metabolism and Disposition July 2007, 35 (7) 1023-1031; DOI: https://doi.org/10.1124/dmd.106.013268
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  Valproic Acid Induces CYP3A4 and MDR1 Gene Expression by Activation of Constitutive Androstane Receptor and Pregnane X Receptor Pathways

  Lukas Cerveny, Lucie Svecova, Eva Anzenbacherova, Radim Vrzal, Frantisek Staud, Zdenek Dvorak, Jitka Ulrichova, Pavel Anzenbacher and Petr Pavek

  Drug Metabolism and Disposition July 2007, 35 (7) 1032-1041; DOI: https://doi.org/10.1124/dmd.106.014456
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  Biotransformation of 6-Methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes

  Hsien-Tsung Yao, Yu-Shan Wu, Yi-Wei Chang, Hsing-Pang Hsieh, Wei-Cheng Chen, Shih-Jung Lan, Chiung-Tong Chen, Yu-Sheng Chao, Ling Chang, Hsu-Yi Sun and Teng-Kuang Yeh

  Drug Metabolism and Disposition July 2007, 35 (7) 1042-1049; DOI: https://doi.org/10.1124/dmd.106.014597
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  Possible Bioactivation Pathways of Lamotrigine

  Wei Lu and Jack P. Uetrecht

  Drug Metabolism and Disposition July 2007, 35 (7) 1050-1056; DOI: https://doi.org/10.1124/dmd.107.015271
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  Effect of Perinatal Low Protein Diets on the Ontogeny of Select Hepatic Cytochrome P450 Enzymes and Cytochrome P450 Reductase in the Rat

  Ganesh Cherala, Bernard H. Shapiro and Anil P. D'mello

  Drug Metabolism and Disposition July 2007, 35 (7) 1057-1063; DOI: https://doi.org/10.1124/dmd.106.013748
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  Effect of Arylamine Acetyltransferase Nat3 Gene Knockout on N-Acetylation in the Mouse

  K. S. Sugamori, D. Brenneman, S. Wong, A. Gaedigk, V. Yu, H. Abramovici, R. Rozmahel and D. M. Grant

  Drug Metabolism and Disposition July 2007, 35 (7) 1064-1070; DOI: https://doi.org/10.1124/dmd.107.015396
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  Metabolism, Pharmacokinetics, and Excretion of a Nonpeptidic Substance P Receptor Antagonist, Ezlopitant, in Normal Healthy Male Volunteers: Characterization of Polar Metabolites by Chemical Derivatization with Dansyl Chloride

  Chandra Prakash, John O'Donnell and S. Cyrus Khojasteh-Bakht

  Drug Metabolism and Disposition July 2007, 35 (7) 1071-1080; DOI: https://doi.org/10.1124/dmd.107.015362
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  Identification of a Novel Glutathione Conjugate of Flutamide in Incubations with Human Liver Microsomes

  Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou and Alan Deese

  Drug Metabolism and Disposition July 2007, 35 (7) 1081-1088; DOI: https://doi.org/10.1124/dmd.107.014860
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  Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum

  Kenji Masaki, Mitsuru Hashimoto and Teruko Imai

  Drug Metabolism and Disposition July 2007, 35 (7) 1089-1095; DOI: https://doi.org/10.1124/dmd.106.013862
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  The Disposition of Prasugrel, a Novel Thienopyridine, in Humans

  Nagy A. Farid, Richard L. Smith, Todd A. Gillespie, T. James Rash, Patrick E. Blair, Atsushi Kurihara and Mark J. Goldberg

  Drug Metabolism and Disposition July 2007, 35 (7) 1096-1104; DOI: https://doi.org/10.1124/dmd.106.014522
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  Selective Tissue Distribution of Tibolone Metabolites in Mature Ovariectomized Female Cynomolgus Monkeys after Multiple Doses of Tibolone

  H. A. M. Verheul, M. L. P. S. van Iersel, L. P. C. Delbressine and H. J. Kloosterboer

  Drug Metabolism and Disposition July 2007, 35 (7) 1105-1111; DOI: https://doi.org/10.1124/dmd.106.014118
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  Pharmacokinetic Parameters of Tibolone and Metabolites in Plasma, Urine, Feces, and Bile from Ovariectomized Cynomolgus Monkeys after a Single Dose or Multiple Doses of Tibolone

  H. A. M. Verheul, C. J. Timmer, M. L. P. S. van Iersel, L. P. C. Delbressine and H. J. Kloosterboer

  Drug Metabolism and Disposition July 2007, 35 (7) 1112-1118; DOI: https://doi.org/10.1124/dmd.106.014159
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  Application of the Dispersion Model to Describe Disposition Kinetics of Markers in the Dual Perfused Rat Liver

  Selma Sahin and Malcolm Rowland

  Drug Metabolism and Disposition July 2007, 35 (7) 1119-1125; DOI: https://doi.org/10.1124/dmd.106.013813
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  Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor α

  Valerie Y. Ng, Yong Huang, L. Manmohan Reddy, John R. Falck, Emil T. Lin and Deanna L. Kroetz

  Drug Metabolism and Disposition July 2007, 35 (7) 1126-1134; DOI: https://doi.org/10.1124/dmd.106.013839
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  Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

  Marjo Volotinen, Miia Turpeinen, Ari Tolonen, Jouko Uusitalo, Jukka Mäenpää and Olavi Pelkonen

  Drug Metabolism and Disposition July 2007, 35 (7) 1135-1141; DOI: https://doi.org/10.1124/dmd.106.012906
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  Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients

  Tetsuo Yamagata, Hiroyuki Kusuhara, Mariko Morishita, Kozo Takayama, Hassan Benameur and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2007, 35 (7) 1142-1148; DOI: https://doi.org/10.1124/dmd.106.014217
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  The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole

  Marta Robert, Miquel Salvà, Rosa Segarra, Marco Pavesi, Ramón Esbri, David Roberts and Georg Golor

  Drug Metabolism and Disposition July 2007, 35 (7) 1149-1156; DOI: https://doi.org/10.1124/dmd.106.010835
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  In Vitro Metabolic Characterization, Phenotyping, and Kinetic Studies of 9cUAB30, a Retinoid X Receptor-Specific Retinoid

  Gregory S. Gorman, Lori Coward, Corenna Kerstner-Wood, Lea Cork, Izet M. Kapetanovic, Wayne J. Brouillette and Donald D. Muccio

  Drug Metabolism and Disposition July 2007, 35 (7) 1157-1164; DOI: https://doi.org/10.1124/dmd.106.013938
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  Abcg2/Bcrp1 Mediates the Polarized Transport of Antiretroviral Nucleosides Abacavir and Zidovudine

  Guoyu Pan, Nagdeep Giri and William F. Elmquist

  Drug Metabolism and Disposition July 2007, 35 (7) 1165-1173; DOI: https://doi.org/10.1124/dmd.106.014274
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  CYP2C9 Protein Interactions with Cytochrome b₅: Effects on the Coupling of Catalysis

  Charles W. Locuson, Larry C. Wienkers, Jeffrey P. Jones and Timothy S. Tracy

  Drug Metabolism and Disposition July 2007, 35 (7) 1174-1181; DOI: https://doi.org/10.1124/dmd.107.014910
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  Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver

  Yuji Mano, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition July 2007, 35 (7) 1182-1187; DOI: https://doi.org/10.1124/dmd.107.015347
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  Metabolism and Disposition of a Selective α₇ Nicotinic Acetylcholine Receptor Agonist in Humans

  Christopher L. Shaffer, Mithat Gunduz, Renato J. Scialis and Annie F. Fang

  Drug Metabolism and Disposition July 2007, 35 (7) 1188-1195; DOI: https://doi.org/10.1124/dmd.106.014449
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  Absorption, Metabolism, and Excretion of [¹⁴C]MK-0524, a Prostaglandin D₂ Receptor Antagonist, in Humans

  Bindhu Karanam, Maria Madeira, Scott Bradley, Larissa Wenning, Rajesh Desai, Eric Soli, David Schenk, Allen Jones, Brian Dean, George Doss, Graigory Garrett, Tami Crumley, Ajay Nirula and Eseng Lai

  Drug Metabolism and Disposition July 2007, 35 (7) 1196-1202; DOI: https://doi.org/10.1124/dmd.107.014696
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  Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction

  Ping Li, Patrick S. Callery, Liang-Shang Gan and Suresh K. Balani

  Drug Metabolism and Disposition July 2007, 35 (7) 1203-1208; DOI: https://doi.org/10.1124/dmd.106.013904
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  Impact of Genetic Knockout of PEPT2 on Cefadroxil Pharmacokinetics, Renal Tubular Reabsorption, and Brain Penetration in Mice

  Hong Shen, Scott M. Ocheltree, Yongjun Hu, Richard F. Keep and David E. Smith

  Drug Metabolism and Disposition July 2007, 35 (7) 1209-1216; DOI: https://doi.org/10.1124/dmd.107.015263
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  Selective Toxicity of Aristolochic Acids I and II

  Shinya Shibutani, Huan Dong, Naomi Suzuki, Shiro Ueda, Frederick Miller and Arthur P. Grollman

  Drug Metabolism and Disposition July 2007, 35 (7) 1217-1222; DOI: https://doi.org/10.1124/dmd.107.014688
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  Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice

  Kristina K. Wolf, Sheryl G. Wood, Jenna L. Allard, Jane A. Hunt, Nadia Gorman, Brooke W. Walton-Strong, Juliana G. Szakacs, Su X. Duan, Qin Hao, Michael H. Court, Lisa L. von Moltke, David J. Greenblatt, Vsevolod Kostrubsky, Elizabeth H. Jeffery, Steven A. Wrighton, Frank J. Gonzalez, Peter R. Sinclair and Jacqueline F. Sinclair

  Drug Metabolism and Disposition July 2007, 35 (7) 1223-1231; DOI: https://doi.org/10.1124/dmd.107.014738
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  Risk Assessment for Drug-Drug Interaction Caused by Metabolism-Based Inhibition of CYP3A Using Automated in Vitro Assay Systems and Its Application in the Early Drug Discovery Process

  Akiko Watanabe, Koichi Nakamura, Noriko Okudaira, Osamu Okazaki and Ken-ichi Sudo

  Drug Metabolism and Disposition July 2007, 35 (7) 1232-1238; DOI: https://doi.org/10.1124/dmd.107.015016
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  Isolation and Characterization of Polyspecific Mouse Organic Solute Carrier Protein 1 (mOscp1)

  Yasuna Kobayashi, Ayumi Tsuchiya, Tomofumi Hayashi, Noriko Kohyama, Masayuki Ohbayashi and Toshinori Yamamoto

  Drug Metabolism and Disposition July 2007, 35 (7) 1239-1245; DOI: https://doi.org/10.1124/dmd.107.014795