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Drug Metabolism & Disposition

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Table of Contents

July 01, 2007; Volume 35,Issue 7

Perspective

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    CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies
    Qiang Ma and Anthony Y. H. Lu
    Drug Metabolism and Disposition July 2007, 35 (7) 1009-1016; DOI: https://doi.org/10.1124/dmd.107.015826

Short Communication

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    The Phosphoinositide-Specific Phospholipase C Inhibitor U73122 (1-(6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) Spontaneously Forms Conjugates with Common Components of Cell Culture Medium
    Nicola E. Wilsher, Will J. Court, Ruth Ruddle, Yvette M. Newbatt, Wynne Aherne, Peter W. Sheldrake, Neil P. Jones, Matilda Katan, Suzanne A. Eccles and Florence I. Raynaud
    Drug Metabolism and Disposition July 2007, 35 (7) 1017-1022; DOI: https://doi.org/10.1124/dmd.106.014498

Articles

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    Esterase Inhibition Attribute of Grapefruit Juice Leading to a New Drug Interaction
    Ping Li, Patrick S. Callery, Liang-Shang Gan and Suresh K. Balani
    Drug Metabolism and Disposition July 2007, 35 (7) 1023-1031; DOI: https://doi.org/10.1124/dmd.106.013268
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    Valproic Acid Induces CYP3A4 and MDR1 Gene Expression by Activation of Constitutive Androstane Receptor and Pregnane X Receptor Pathways
    Lukas Cerveny, Lucie Svecova, Eva Anzenbacherova, Radim Vrzal, Frantisek Staud, Zdenek Dvorak, Jitka Ulrichova, Pavel Anzenbacher and Petr Pavek
    Drug Metabolism and Disposition July 2007, 35 (7) 1032-1041; DOI: https://doi.org/10.1124/dmd.106.014456
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    Biotransformation of 6-Methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes
    Hsien-Tsung Yao, Yu-Shan Wu, Yi-Wei Chang, Hsing-Pang Hsieh, Wei-Cheng Chen, Shih-Jung Lan, Chiung-Tong Chen, Yu-Sheng Chao, Ling Chang, Hsu-Yi Sun and Teng-Kuang Yeh
    Drug Metabolism and Disposition July 2007, 35 (7) 1042-1049; DOI: https://doi.org/10.1124/dmd.106.014597
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    Possible Bioactivation Pathways of Lamotrigine
    Wei Lu and Jack P. Uetrecht
    Drug Metabolism and Disposition July 2007, 35 (7) 1050-1056; DOI: https://doi.org/10.1124/dmd.107.015271
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    Effect of Perinatal Low Protein Diets on the Ontogeny of Select Hepatic Cytochrome P450 Enzymes and Cytochrome P450 Reductase in the Rat
    Ganesh Cherala, Bernard H. Shapiro and Anil P. D'mello
    Drug Metabolism and Disposition July 2007, 35 (7) 1057-1063; DOI: https://doi.org/10.1124/dmd.106.013748
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    Effect of Arylamine Acetyltransferase Nat3 Gene Knockout on N-Acetylation in the Mouse
    K. S. Sugamori, D. Brenneman, S. Wong, A. Gaedigk, V. Yu, H. Abramovici, R. Rozmahel and D. M. Grant
    Drug Metabolism and Disposition July 2007, 35 (7) 1064-1070; DOI: https://doi.org/10.1124/dmd.107.015396
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    Metabolism, Pharmacokinetics, and Excretion of a Nonpeptidic Substance P Receptor Antagonist, Ezlopitant, in Normal Healthy Male Volunteers: Characterization of Polar Metabolites by Chemical Derivatization with Dansyl Chloride
    Chandra Prakash, John O'Donnell and S. Cyrus Khojasteh-Bakht
    Drug Metabolism and Disposition July 2007, 35 (7) 1071-1080; DOI: https://doi.org/10.1124/dmd.107.015362
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    Identification of a Novel Glutathione Conjugate of Flutamide in Incubations with Human Liver Microsomes
    Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou and Alan Deese
    Drug Metabolism and Disposition July 2007, 35 (7) 1081-1088; DOI: https://doi.org/10.1124/dmd.107.014860
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    Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum
    Kenji Masaki, Mitsuru Hashimoto and Teruko Imai
    Drug Metabolism and Disposition July 2007, 35 (7) 1089-1095; DOI: https://doi.org/10.1124/dmd.106.013862
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    The Disposition of Prasugrel, a Novel Thienopyridine, in Humans
    Nagy A. Farid, Richard L. Smith, Todd A. Gillespie, T. James Rash, Patrick E. Blair, Atsushi Kurihara and Mark J. Goldberg
    Drug Metabolism and Disposition July 2007, 35 (7) 1096-1104; DOI: https://doi.org/10.1124/dmd.106.014522
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    Selective Tissue Distribution of Tibolone Metabolites in Mature Ovariectomized Female Cynomolgus Monkeys after Multiple Doses of Tibolone
    H. A. M. Verheul, M. L. P. S. van Iersel, L. P. C. Delbressine and H. J. Kloosterboer
    Drug Metabolism and Disposition July 2007, 35 (7) 1105-1111; DOI: https://doi.org/10.1124/dmd.106.014118
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    Pharmacokinetic Parameters of Tibolone and Metabolites in Plasma, Urine, Feces, and Bile from Ovariectomized Cynomolgus Monkeys after a Single Dose or Multiple Doses of Tibolone
    H. A. M. Verheul, C. J. Timmer, M. L. P. S. van Iersel, L. P. C. Delbressine and H. J. Kloosterboer
    Drug Metabolism and Disposition July 2007, 35 (7) 1112-1118; DOI: https://doi.org/10.1124/dmd.106.014159
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    Application of the Dispersion Model to Describe Disposition Kinetics of Markers in the Dual Perfused Rat Liver
    Selma Sahin and Malcolm Rowland
    Drug Metabolism and Disposition July 2007, 35 (7) 1119-1125; DOI: https://doi.org/10.1124/dmd.106.013813
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    Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor α
    Valerie Y. Ng, Yong Huang, L. Manmohan Reddy, John R. Falck, Emil T. Lin and Deanna L. Kroetz
    Drug Metabolism and Disposition July 2007, 35 (7) 1126-1134; DOI: https://doi.org/10.1124/dmd.106.013839
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    Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6
    Marjo Volotinen, Miia Turpeinen, Ari Tolonen, Jouko Uusitalo, Jukka Mäenpää and Olavi Pelkonen
    Drug Metabolism and Disposition July 2007, 35 (7) 1135-1141; DOI: https://doi.org/10.1124/dmd.106.012906
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    Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients
    Tetsuo Yamagata, Hiroyuki Kusuhara, Mariko Morishita, Kozo Takayama, Hassan Benameur and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2007, 35 (7) 1142-1148; DOI: https://doi.org/10.1124/dmd.106.014217
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    The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole
    Marta Robert, Miquel Salvà, Rosa Segarra, Marco Pavesi, Ramón Esbri, David Roberts and Georg Golor
    Drug Metabolism and Disposition July 2007, 35 (7) 1149-1156; DOI: https://doi.org/10.1124/dmd.106.010835
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    In Vitro Metabolic Characterization, Phenotyping, and Kinetic Studies of 9cUAB30, a Retinoid X Receptor-Specific Retinoid
    Gregory S. Gorman, Lori Coward, Corenna Kerstner-Wood, Lea Cork, Izet M. Kapetanovic, Wayne J. Brouillette and Donald D. Muccio
    Drug Metabolism and Disposition July 2007, 35 (7) 1157-1164; DOI: https://doi.org/10.1124/dmd.106.013938
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    Abcg2/Bcrp1 Mediates the Polarized Transport of Antiretroviral Nucleosides Abacavir and Zidovudine
    Guoyu Pan, Nagdeep Giri and William F. Elmquist
    Drug Metabolism and Disposition July 2007, 35 (7) 1165-1173; DOI: https://doi.org/10.1124/dmd.106.014274
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    CYP2C9 Protein Interactions with Cytochrome b5: Effects on the Coupling of Catalysis
    Charles W. Locuson, Larry C. Wienkers, Jeffrey P. Jones and Timothy S. Tracy
    Drug Metabolism and Disposition July 2007, 35 (7) 1174-1181; DOI: https://doi.org/10.1124/dmd.107.014910
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    Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver
    Yuji Mano, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition July 2007, 35 (7) 1182-1187; DOI: https://doi.org/10.1124/dmd.107.015347
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    Metabolism and Disposition of a Selective α7 Nicotinic Acetylcholine Receptor Agonist in Humans
    Christopher L. Shaffer, Mithat Gunduz, Renato J. Scialis and Annie F. Fang
    Drug Metabolism and Disposition July 2007, 35 (7) 1188-1195; DOI: https://doi.org/10.1124/dmd.106.014449
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    Absorption, Metabolism, and Excretion of [14C]MK-0524, a Prostaglandin D2 Receptor Antagonist, in Humans
    Bindhu Karanam, Maria Madeira, Scott Bradley, Larissa Wenning, Rajesh Desai, Eric Soli, David Schenk, Allen Jones, Brian Dean, George Doss, Graigory Garrett, Tami Crumley, Ajay Nirula and Eseng Lai
    Drug Metabolism and Disposition July 2007, 35 (7) 1196-1202; DOI: https://doi.org/10.1124/dmd.107.014696
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    Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction
    Ping Li, Patrick S. Callery, Liang-Shang Gan and Suresh K. Balani
    Drug Metabolism and Disposition July 2007, 35 (7) 1203-1208; DOI: https://doi.org/10.1124/dmd.106.013904
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    Impact of Genetic Knockout of PEPT2 on Cefadroxil Pharmacokinetics, Renal Tubular Reabsorption, and Brain Penetration in Mice
    Hong Shen, Scott M. Ocheltree, Yongjun Hu, Richard F. Keep and David E. Smith
    Drug Metabolism and Disposition July 2007, 35 (7) 1209-1216; DOI: https://doi.org/10.1124/dmd.107.015263
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    Selective Toxicity of Aristolochic Acids I and II
    Shinya Shibutani, Huan Dong, Naomi Suzuki, Shiro Ueda, Frederick Miller and Arthur P. Grollman
    Drug Metabolism and Disposition July 2007, 35 (7) 1217-1222; DOI: https://doi.org/10.1124/dmd.107.014688
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    Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice
    Kristina K. Wolf, Sheryl G. Wood, Jenna L. Allard, Jane A. Hunt, Nadia Gorman, Brooke W. Walton-Strong, Juliana G. Szakacs, Su X. Duan, Qin Hao, Michael H. Court, Lisa L. von Moltke, David J. Greenblatt, Vsevolod Kostrubsky, Elizabeth H. Jeffery, Steven A. Wrighton, Frank J. Gonzalez, Peter R. Sinclair and Jacqueline F. Sinclair
    Drug Metabolism and Disposition July 2007, 35 (7) 1223-1231; DOI: https://doi.org/10.1124/dmd.107.014738
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    Risk Assessment for Drug-Drug Interaction Caused by Metabolism-Based Inhibition of CYP3A Using Automated in Vitro Assay Systems and Its Application in the Early Drug Discovery Process
    Akiko Watanabe, Koichi Nakamura, Noriko Okudaira, Osamu Okazaki and Ken-ichi Sudo
    Drug Metabolism and Disposition July 2007, 35 (7) 1232-1238; DOI: https://doi.org/10.1124/dmd.107.015016
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    Isolation and Characterization of Polyspecific Mouse Organic Solute Carrier Protein 1 (mOscp1)
    Yasuna Kobayashi, Ayumi Tsuchiya, Tomofumi Hayashi, Noriko Kohyama, Masayuki Ohbayashi and Toshinori Yamamoto
    Drug Metabolism and Disposition July 2007, 35 (7) 1239-1245; DOI: https://doi.org/10.1124/dmd.107.014795

Erratum

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    CORRECTION TO “THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF HUMAN CYP51 INHIBITORS”
    Drug Metabolism and Disposition July 2007, 35 (7) 1246; DOI: https://doi.org/10.1124/dmd.35.7.1246
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Drug Metabolism and Disposition: 35 (7)
Drug Metabolism and Disposition
Vol. 35, Issue 7
1 Jul 2007
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