Table of Contents

Articles

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  UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms and Total Bilirubin Levels in an Ethnically Diverse Cohort of Women

  Andrew L. Hong, Dezheng Huo, Hee-Jin Kim, Qun Niu, Donna L. Fackenthal, Shelly A. Cummings, Esther M. John, Dee W. West, Alice S. Whittemore, Soma Das and Olufunmilayo I. Olopade

  Drug Metabolism and Disposition August 2007, 35 (8) 1254-1261; DOI: https://doi.org/10.1124/dmd.106.014183
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  Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2)

  Gary Williamson, Isabelle Aeberli, Laurence Miguet, Ziding Zhang, M.-Belen Sanchez, Vanessa Crespy, Denis Barron, Paul Needs, Paul A. Kroon, H. Glavinas, Peter Krajcsi and Martin Grigorov

  Drug Metabolism and Disposition August 2007, 35 (8) 1262-1268; DOI: https://doi.org/10.1124/dmd.106.014241
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  Identification of Metabolites of 4-Nonylphenol Isomer 4-(3′,6′-Dimethyl-3′-Heptyl) Phenol by Rat and Human Liver Microsomes

  Xiaoyun Ye, Amber M. Bishop, Larry L. Needham and Antonia M. Calafat

  Drug Metabolism and Disposition August 2007, 35 (8) 1269-1274; DOI: https://doi.org/10.1124/dmd.107.015578
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  Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey

  Tomohiro Nishimura, Nobuyuki Amano, Yoshiyuki Kubo, Midori Ono, Yukio Kato, Hisashi Fujita, Yoshiaki Kimura and Akira Tsuji

  Drug Metabolism and Disposition August 2007, 35 (8) 1275-1284; DOI: https://doi.org/10.1124/dmd.106.013037
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  The Use of Microdialysis for the Study of Drug Kinetics: Central Nervous System Pharmacokinetics of Diphenhydramine in Fetal, Newborn, and Adult Sheep

  Sam C.S. Au-Yeung, K. Wayne Riggs, Nancy Gruber and Dan W. Rurak

  Drug Metabolism and Disposition August 2007, 35 (8) 1285-1291; DOI: https://doi.org/10.1124/dmd.106.013995
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  Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17

  Hongwu Shen, Minxia M. He, Houfu Liu, Steven A. Wrighton, Li Wang, Bin Guo and Chuan Li

  Drug Metabolism and Disposition August 2007, 35 (8) 1292-1300; DOI: https://doi.org/10.1124/dmd.107.015354
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  Cytochrome P450 3A-Dependent Metabolism of a Potent and Selective γ-Aminobutyric Acid_Aα2/3 Receptor Agonist in Vitro: Involvement of Cytochrome P450 3A5 Displaying Biphasic Kinetics

  Bennett Ma, Stacey L. Polsky-Fisher, Stanley Vickers, Donghui Cui and A. David Rodrigues

  Drug Metabolism and Disposition August 2007, 35 (8) 1301-1307; DOI: https://doi.org/10.1124/dmd.107.014753
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  Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3

  Johannes Noé, Renée Portmann, Marie-Elise Brun and Christoph Funk

  Drug Metabolism and Disposition August 2007, 35 (8) 1308-1314; DOI: https://doi.org/10.1124/dmd.106.012930
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  Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid

  Theunis C. Goosen, Jonathan N. Bauman, John A. Davis, Chongwoo Yu, Susan I. Hurst, J. Andrew Williams and Cho-Ming Loi

  Drug Metabolism and Disposition August 2007, 35 (8) 1315-1324; DOI: https://doi.org/10.1124/dmd.107.015230
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  Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

  David Hallifax and J. Brian Houston

  Drug Metabolism and Disposition August 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131
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  Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

  Constanze Hilgendorf, Gustav Ahlin, Annick Seithel, Per Artursson, Anna-Lena Ungell and Johan Karlsson

  Drug Metabolism and Disposition August 2007, 35 (8) 1333-1340; DOI: https://doi.org/10.1124/dmd.107.014902
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  Central Nervous System Pharmacokinetics of the Mdr1 P-Glycoprotein Substrate CP-615,003: Intersite Differences and Implications for Human Receptor Occupancy Projections from Cerebrospinal Fluid Exposures

  Karthik Venkatakrishnan, Elaine Tseng, Frederick R. Nelson, Hans Rollema, Jonathan L. French, Irina V. Kaplan, Weldon E. Horner and Megan A. Gibbs

  Drug Metabolism and Disposition August 2007, 35 (8) 1341-1349; DOI: https://doi.org/10.1124/dmd.106.013953
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  Metabolism, Distribution and Excretion of a Selective N-Methyl-d-Aspartate Receptor Antagonist, Traxoprodil, in Rats and Dogs

  Chandra Prakash, Donghui Cui, Michael J. Potchoiba and Todd Butler

  Drug Metabolism and Disposition August 2007, 35 (8) 1350-1364; DOI: https://doi.org/10.1124/dmd.107.016105
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  Mutation of a Single Residue (K262R) in P450 2B6 Leads to Loss of Mechanism-Based Inactivation by Phencyclidine

  Mohamad Shebley and Paul F. Hollenberg

  Drug Metabolism and Disposition August 2007, 35 (8) 1365-1371; DOI: https://doi.org/10.1124/dmd.107.014985
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  Mutational Analysis of a Highly Conserved Proline Residue in MRP1, MRP2, and MRP3 Reveals a Partially Conserved Function

  Isabelle J. Létourneau, Andrew J. Slot, Roger G. Deeley and Susan P. C. Cole

  Drug Metabolism and Disposition August 2007, 35 (8) 1372-1379; DOI: https://doi.org/10.1124/dmd.107.015479
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  Kinetics of Valproic Acid Glucuronidation: Evidence for in Vivo Autoactivation

  Harvey Wong, Vincent Tong, K. Wayne Riggs, Dan W. Rurak, Frank S. Abbott and Sanjeev Kumar

  Drug Metabolism and Disposition August 2007, 35 (8) 1380-1386; DOI: https://doi.org/10.1124/dmd.107.015719
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  6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine_1A Receptor Occupancy in Rats

  Harvey Wong, Randy C. Dockens, Lori Pajor, Suresh Yeola, James E. Grace, Arlene D. Stark, Rebecca A. Taub, Frank D. Yocca, Robert C. Zaczek and Yu-Wen Li

  Drug Metabolism and Disposition August 2007, 35 (8) 1387-1392; DOI: https://doi.org/10.1124/dmd.107.015768
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  The Role of Monocarboxylate Transporter 2 and 4 in the Transport of γ-Hydroxybutyric Acid in Mammalian Cells

  Qi Wang and Marilyn E. Morris

  Drug Metabolism and Disposition August 2007, 35 (8) 1393-1399; DOI: https://doi.org/10.1124/dmd.107.014852
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  Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil

  Alexander Treiber, Ralph Schneiter, Stephanie Häusler and Bruno Stieger

  Drug Metabolism and Disposition August 2007, 35 (8) 1400-1407; DOI: https://doi.org/10.1124/dmd.106.013615
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  Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin

  Micaela C. Damsten, Jan N. M. Commandeur, Alex Fidder, Albert G. Hulst, Daan Touw, Daan Noort and Nico P. E. Vermeulen

  Drug Metabolism and Disposition August 2007, 35 (8) 1408-1417; DOI: https://doi.org/10.1124/dmd.106.014233
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  Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers

  Felix Waldmeier, Ulrike Glaenzel, Bernard Wirz, Lukas Oberer, Dietmar Schmid, Michael Seiberling, Jessica Valencia, Gilles-Jacques Riviere, Peter End and Sujata Vaidyanathan

  Drug Metabolism and Disposition August 2007, 35 (8) 1418-1428; DOI: https://doi.org/10.1124/dmd.106.013797
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  Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate

  Naomi Mizuno, Tsuyoshi Takahashi, Yumiko Iwase, Hiroyuki Kusuhara, Takuro Niwa and Yuichi Sugiyama

  Drug Metabolism and Disposition August 2007, 35 (8) 1429-1434; DOI: https://doi.org/10.1124/dmd.106.013912
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  Impact of Physicochemical and Structural Properties on the Pharmacokinetics of a Series of α1_L-Adrenoceptor Antagonists

  Alison Betts, Fidelma Atkinson, Iain Gardner, David Fox, Rob Webster, Kevin Beaumont and Paul Morgan

  Drug Metabolism and Disposition August 2007, 35 (8) 1435-1445; DOI: https://doi.org/10.1124/dmd.107.015180