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Drug Metabolism & Disposition

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Table of Contents

August 01, 2007; Volume 35,Issue 8

Short Communications

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    A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6
    Kathrin Klein, Stephan Tatzel, Sebastian Raimundo, Tanja Saussele, Elisabeth Hustert, Jürgen Pleiss, Michel Eichelbaum and Ulrich M. Zanger
    Drug Metabolism and Disposition August 2007, 35 (8) 1247-1250; DOI: https://doi.org/10.1124/dmd.107.015149
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    Frequency of the Frame-Shifting CYP2D7 138delT Polymorphism in a Large, Ethnically Diverse Sample Population
    Anahita Bhathena, Toby Mueller, David R. Grimm, Ken Idler, Alan Tsurutani, Brian B. Spear and David A. Katz
    Drug Metabolism and Disposition August 2007, 35 (8) 1251-1253; DOI: https://doi.org/10.1124/dmd.107.014993

Articles

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    UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms and Total Bilirubin Levels in an Ethnically Diverse Cohort of Women
    Andrew L. Hong, Dezheng Huo, Hee-Jin Kim, Qun Niu, Donna L. Fackenthal, Shelly A. Cummings, Esther M. John, Dee W. West, Alice S. Whittemore, Soma Das and Olufunmilayo I. Olopade
    Drug Metabolism and Disposition August 2007, 35 (8) 1254-1261; DOI: https://doi.org/10.1124/dmd.106.014183
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    Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2)
    Gary Williamson, Isabelle Aeberli, Laurence Miguet, Ziding Zhang, M.-Belen Sanchez, Vanessa Crespy, Denis Barron, Paul Needs, Paul A. Kroon, H. Glavinas, Peter Krajcsi and Martin Grigorov
    Drug Metabolism and Disposition August 2007, 35 (8) 1262-1268; DOI: https://doi.org/10.1124/dmd.106.014241
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    Identification of Metabolites of 4-Nonylphenol Isomer 4-(3′,6′-Dimethyl-3′-Heptyl) Phenol by Rat and Human Liver Microsomes
    Xiaoyun Ye, Amber M. Bishop, Larry L. Needham and Antonia M. Calafat
    Drug Metabolism and Disposition August 2007, 35 (8) 1269-1274; DOI: https://doi.org/10.1124/dmd.107.015578
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    Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey
    Tomohiro Nishimura, Nobuyuki Amano, Yoshiyuki Kubo, Midori Ono, Yukio Kato, Hisashi Fujita, Yoshiaki Kimura and Akira Tsuji
    Drug Metabolism and Disposition August 2007, 35 (8) 1275-1284; DOI: https://doi.org/10.1124/dmd.106.013037
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    The Use of Microdialysis for the Study of Drug Kinetics: Central Nervous System Pharmacokinetics of Diphenhydramine in Fetal, Newborn, and Adult Sheep
    Sam C.S. Au-Yeung, K. Wayne Riggs, Nancy Gruber and Dan W. Rurak
    Drug Metabolism and Disposition August 2007, 35 (8) 1285-1291; DOI: https://doi.org/10.1124/dmd.106.013995
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    Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17
    Hongwu Shen, Minxia M. He, Houfu Liu, Steven A. Wrighton, Li Wang, Bin Guo and Chuan Li
    Drug Metabolism and Disposition August 2007, 35 (8) 1292-1300; DOI: https://doi.org/10.1124/dmd.107.015354
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    Cytochrome P450 3A-Dependent Metabolism of a Potent and Selective γ-Aminobutyric AcidAα2/3 Receptor Agonist in Vitro: Involvement of Cytochrome P450 3A5 Displaying Biphasic Kinetics
    Bennett Ma, Stacey L. Polsky-Fisher, Stanley Vickers, Donghui Cui and A. David Rodrigues
    Drug Metabolism and Disposition August 2007, 35 (8) 1301-1307; DOI: https://doi.org/10.1124/dmd.107.014753
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    Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3
    Johannes Noé, Renée Portmann, Marie-Elise Brun and Christoph Funk
    Drug Metabolism and Disposition August 2007, 35 (8) 1308-1314; DOI: https://doi.org/10.1124/dmd.106.012930
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    Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid
    Theunis C. Goosen, Jonathan N. Bauman, John A. Davis, Chongwoo Yu, Susan I. Hurst, J. Andrew Williams and Cho-Ming Loi
    Drug Metabolism and Disposition August 2007, 35 (8) 1315-1324; DOI: https://doi.org/10.1124/dmd.107.015230
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    Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction
    David Hallifax and J. Brian Houston
    Drug Metabolism and Disposition August 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131
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    Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines
    Constanze Hilgendorf, Gustav Ahlin, Annick Seithel, Per Artursson, Anna-Lena Ungell and Johan Karlsson
    Drug Metabolism and Disposition August 2007, 35 (8) 1333-1340; DOI: https://doi.org/10.1124/dmd.107.014902
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    Central Nervous System Pharmacokinetics of the Mdr1 P-Glycoprotein Substrate CP-615,003: Intersite Differences and Implications for Human Receptor Occupancy Projections from Cerebrospinal Fluid Exposures
    Karthik Venkatakrishnan, Elaine Tseng, Frederick R. Nelson, Hans Rollema, Jonathan L. French, Irina V. Kaplan, Weldon E. Horner and Megan A. Gibbs
    Drug Metabolism and Disposition August 2007, 35 (8) 1341-1349; DOI: https://doi.org/10.1124/dmd.106.013953
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    Metabolism, Distribution and Excretion of a Selective N-Methyl-d-Aspartate Receptor Antagonist, Traxoprodil, in Rats and Dogs
    Chandra Prakash, Donghui Cui, Michael J. Potchoiba and Todd Butler
    Drug Metabolism and Disposition August 2007, 35 (8) 1350-1364; DOI: https://doi.org/10.1124/dmd.107.016105
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    Mutation of a Single Residue (K262R) in P450 2B6 Leads to Loss of Mechanism-Based Inactivation by Phencyclidine
    Mohamad Shebley and Paul F. Hollenberg
    Drug Metabolism and Disposition August 2007, 35 (8) 1365-1371; DOI: https://doi.org/10.1124/dmd.107.014985
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    Mutational Analysis of a Highly Conserved Proline Residue in MRP1, MRP2, and MRP3 Reveals a Partially Conserved Function
    Isabelle J. Létourneau, Andrew J. Slot, Roger G. Deeley and Susan P. C. Cole
    Drug Metabolism and Disposition August 2007, 35 (8) 1372-1379; DOI: https://doi.org/10.1124/dmd.107.015479
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    Kinetics of Valproic Acid Glucuronidation: Evidence for in Vivo Autoactivation
    Harvey Wong, Vincent Tong, K. Wayne Riggs, Dan W. Rurak, Frank S. Abbott and Sanjeev Kumar
    Drug Metabolism and Disposition August 2007, 35 (8) 1380-1386; DOI: https://doi.org/10.1124/dmd.107.015719
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    6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine1A Receptor Occupancy in Rats
    Harvey Wong, Randy C. Dockens, Lori Pajor, Suresh Yeola, James E. Grace, Arlene D. Stark, Rebecca A. Taub, Frank D. Yocca, Robert C. Zaczek and Yu-Wen Li
    Drug Metabolism and Disposition August 2007, 35 (8) 1387-1392; DOI: https://doi.org/10.1124/dmd.107.015768
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    The Role of Monocarboxylate Transporter 2 and 4 in the Transport of γ-Hydroxybutyric Acid in Mammalian Cells
    Qi Wang and Marilyn E. Morris
    Drug Metabolism and Disposition August 2007, 35 (8) 1393-1399; DOI: https://doi.org/10.1124/dmd.107.014852
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    Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil
    Alexander Treiber, Ralph Schneiter, Stephanie Häusler and Bruno Stieger
    Drug Metabolism and Disposition August 2007, 35 (8) 1400-1407; DOI: https://doi.org/10.1124/dmd.106.013615
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    Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin
    Micaela C. Damsten, Jan N. M. Commandeur, Alex Fidder, Albert G. Hulst, Daan Touw, Daan Noort and Nico P. E. Vermeulen
    Drug Metabolism and Disposition August 2007, 35 (8) 1408-1417; DOI: https://doi.org/10.1124/dmd.106.014233
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    Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers
    Felix Waldmeier, Ulrike Glaenzel, Bernard Wirz, Lukas Oberer, Dietmar Schmid, Michael Seiberling, Jessica Valencia, Gilles-Jacques Riviere, Peter End and Sujata Vaidyanathan
    Drug Metabolism and Disposition August 2007, 35 (8) 1418-1428; DOI: https://doi.org/10.1124/dmd.106.013797
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    Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate
    Naomi Mizuno, Tsuyoshi Takahashi, Yumiko Iwase, Hiroyuki Kusuhara, Takuro Niwa and Yuichi Sugiyama
    Drug Metabolism and Disposition August 2007, 35 (8) 1429-1434; DOI: https://doi.org/10.1124/dmd.106.013912
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    Impact of Physicochemical and Structural Properties on the Pharmacokinetics of a Series of α1L-Adrenoceptor Antagonists
    Alison Betts, Fidelma Atkinson, Iain Gardner, David Fox, Rob Webster, Kevin Beaumont and Paul Morgan
    Drug Metabolism and Disposition August 2007, 35 (8) 1435-1445; DOI: https://doi.org/10.1124/dmd.107.015180
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Drug Metabolism and Disposition: 35 (8)
Drug Metabolism and Disposition
Vol. 35, Issue 8
1 Aug 2007
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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