Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

David Hallifax and J. Brian Houston
Drug Metabolism and Disposition August 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131
David Hallifax
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Brian Houston
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 35 no. 8 1325-1332
DOI 
https://doi.org/10.1124/dmd.107.015131
PubMed 
17470525

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 8, 2007
  • Accepted April 26, 2007
  • Published online July 19, 2007.

Article Versions

  • Earlier version (April 30, 2007 - 07:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David Hallifax and
  2. J. Brian Houston
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
  1. Address correspondence to:
    Professor J. B. Houston, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, UK. E-mail: brian.houston{at}manchester.ac.uk
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to March 2023

AbstractFullPdf
Aug 201711514
Sep 201721316
Oct 201712821
Nov 20171198
Dec 201722110
Jan 20180163
Feb 20181194
Mar 20181145
Apr 201832912
May 20183115
Jun 20180163
Jul 2018185
Aug 201801513
Sep 20180116
Oct 20180113
Nov 20180247
Dec 20181272
Jan 201912514
Feb 20192246
Mar 20191246
Apr 20192012
May 20192309
Jun 20191406
Jul 201917221
Aug 20191712
Oct 20191011
Nov 20193035
Dec 20191631
Jan 20201011
Feb 20201810
Mar 20201843
May 20201633
Jun 20201203
Jul 20201642
Aug 20201125
Sep 20201011
Oct 2020413
Nov 20201543
Dec 20204389
Jan 20213194
Feb 202129136
Mar 20212831
Apr 20213877
May 20212252
Jun 20213077
Jul 20213056
Aug 20212131
Sep 20213641
Oct 20212554
Nov 20212888
Dec 20213743
Jan 20222942
Feb 20225734
Mar 20221653
Apr 20223293
May 20223263
Jun 20221843
Jul 202227510
Aug 20222153
Sep 20222744
Oct 202221102
Nov 20222744
Dec 20221335
Jan 202350146
Feb 20233242
Mar 20233423

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 35 (8)
Drug Metabolism and Disposition
Vol. 35, Issue 8
1 Aug 2007
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

David Hallifax and J. Brian Houston
Drug Metabolism and Disposition August 1, 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

David Hallifax and J. Brian Houston
Drug Metabolism and Disposition August 1, 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Appendix 1: Calculation of Kp Due to pH Difference between Cytosol and External Medium (eq. 4)
    • Appendix 2: Calculation of Total Inclubation fu at Maximal Uptake (eq. 5)
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • AKRs and GUSs in Testosterone Disposition
  • Olanzapine Glucuronidation in Humanized Mice
  • rs2242480 Regulates the Expression of CYP3A4 and CYP3A5
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics