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Research ArticleArticle

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

David Hallifax and J. Brian Houston
Drug Metabolism and Disposition August 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131

Article Information

vol. 35 no. 8 1325-1332
DOI 
https://doi.org/10.1124/dmd.107.015131
PubMed 
17470525
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 8, 2007
  • Accepted April 26, 2007
  • Published online July 19, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David Hallifax and
  2. J. Brian Houston
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
  1. Address correspondence to:
    Professor J. B. Houston, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, UK. E-mail: brian.houston{at}manchester.ac.uk
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Research ArticleArticle

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

David Hallifax and J. Brian Houston
Drug Metabolism and Disposition August 1, 2007, 35 (8) 1325-1332; DOI: https://doi.org/10.1124/dmd.107.015131
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