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Research ArticleArticle

6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine1A Receptor Occupancy in Rats

Harvey Wong, Randy C. Dockens, Lori Pajor, Suresh Yeola, James E. Grace Jr., Arlene D. Stark, Rebecca A. Taub, Frank D. Yocca, Robert C. Zaczek and Yu-Wen Li
Drug Metabolism and Disposition August 2007, 35 (8) 1387-1392; DOI: https://doi.org/10.1124/dmd.107.015768

Article Information

vol. 35 no. 8 1387-1392
DOI 
https://doi.org/10.1124/dmd.107.015768
PubMed 
17494642
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 16, 2007
  • Accepted May 8, 2007
  • Published online July 19, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Harvey Wong1,
  2. Randy C. Dockens,
  3. Lori Pajor,
  4. Suresh Yeola,
  5. James E. Grace, Jr.,
  6. Arlene D. Stark,
  7. Rebecca A. Taub2,
  8. Frank D. Yocca3,
  9. Robert C. Zaczek and
  10. Yu-Wen Li
  1. Departments of Metabolism and Pharmacokinetics (H.W., L.P., J.E.G.), Clinical Discovery (R.C.D.), Biotransformation (S.Y.), and Neuroscience Biology (A.D.S., R.A.T., F.D.Y., R.C.Z., Y.W.L.), Pharmaceutical Research Institute, Bristol-Myers Squibb, Wallingford, Connecticut
  1. Address correspondence to:
    Dr. Yu-Wen Li, Neuroscience Biology, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492-7660. E-mail: yu-wen.li{at}bms.com
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Research ArticleArticle

6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine1A Receptor Occupancy in Rats

Harvey Wong, Randy C. Dockens, Lori Pajor, Suresh Yeola, James E. Grace, Arlene D. Stark, Rebecca A. Taub, Frank D. Yocca, Robert C. Zaczek and Yu-Wen Li
Drug Metabolism and Disposition August 1, 2007, 35 (8) 1387-1392; DOI: https://doi.org/10.1124/dmd.107.015768
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