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Drug Metabolism & Disposition

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Table of Contents

September 01, 2007; Volume 35,Issue 9

Short Communications

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    Hepatic Metabolism of MK-0457, a Potent Aurora Kinase Inhibitor: Interspecies Comparison and Role of Human Cytochrome P450 and Flavin-Containing Monooxygenase
    J. E. Ballard, T. Prueksaritanont and C. Tang
    Drug Metabolism and Disposition September 2007, 35 (9) 1447-1451; DOI: https://doi.org/10.1124/dmd.107.015438
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    Inhibition of Human Thiopurine S-Methyltransferase by Various Nonsteroidal Anti-inflammatory Drugs in Vitro: A Mechanism for Possible Drug Interactions
    Kersti Oselin and Kaili Anier
    Drug Metabolism and Disposition September 2007, 35 (9) 1452-1454; DOI: https://doi.org/10.1124/dmd.107.016287
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    Cholesterol-Lowering Effect of Ezetimibe in Uridine Diphosphate Glucuronosyltransferase 1A-Deficient (Gunn) Rats
    Takehito Yamamoto, Kousei Ito, Masashi Honma, Tappei Takada and Hiroshi Suzuki
    Drug Metabolism and Disposition September 2007, 35 (9) 1455-1458; DOI: https://doi.org/10.1124/dmd.107.015628
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    Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid
    Amal Kaddoumi, Sung-Up Choi, Loren Kinman, Dale Whittington, Che-Chung Tsai, Rodney J.Y. Ho, Bradley D. Anderson and Jashvant D. Unadkat
    Drug Metabolism and Disposition September 2007, 35 (9) 1459-1462; DOI: https://doi.org/10.1124/dmd.107.016220
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    Detection of Haptenated Proteins in Organotypic Human Skin Explant Cultures Exposed to Dapsone
    Sanjoy Roychowdhury, Albert E. Cram, Al Aly and Craig K. Svensson
    Drug Metabolism and Disposition September 2007, 35 (9) 1463-1465; DOI: https://doi.org/10.1124/dmd.107.015560

Articles

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    Computational Approaches That Predict Metabolic Intermediate Complex Formation with CYP3A4 (+b5)
    David R. Jones, Sean Ekins, Lang Li and Stephen D. Hall
    Drug Metabolism and Disposition September 2007, 35 (9) 1466-1475; DOI: https://doi.org/10.1124/dmd.106.014613
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    Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells
    Kilian Bartholomé, Maria Rius, Katrin Letschert, Daniela Keller, Jens Timmer and Dietrich Keppler
    Drug Metabolism and Disposition September 2007, 35 (9) 1476-1481; DOI: https://doi.org/10.1124/dmd.107.015636
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    Kinetic Studies of 25-Hydroxy-19-nor-vitamin D3 and 1α,25-Dihydroxy-19-nor-vitamin D3 Hydroxylation by CYP27B1 and CYP24A1
    Naoko Urushino, Sachie Nakabayashi, Midori A. Arai, Atsushi Kittaka, Tai C. Chen, Keiko Yamamoto, Keiko Hayashi, Shigeaki Kato, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro and Toshiyuki Sakaki
    Drug Metabolism and Disposition September 2007, 35 (9) 1482-1488; DOI: https://doi.org/10.1124/dmd.107.015602
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    Subcellular Trafficking Signals of Constitutive Androstane Receptor: Evidence for a Nuclear Export Signal in the DNA-Binding Domain
    Jun Xia and Byron Kemper
    Drug Metabolism and Disposition September 2007, 35 (9) 1489-1494; DOI: https://doi.org/10.1124/dmd.107.016493
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    Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor
    Krisztina Kőhalmy, Viola Tamási, László Kóbori, Enikő Sárváry, Jean-Marc Pascussi, Pálma Porrogi, Damjana Rozman, Russell A. Prough, Urs A. Meyer and Katalin Monostory
    Drug Metabolism and Disposition September 2007, 35 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.107.016303
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    Preparation and In Vivo Evaluation of a Water-Soluble Prodrug for 2R-γ-Tocotrienol and as a Two-Step Prodrug for 2,7,8-Trimethyl-2S-(β-carboxyethyl)-6-hydroxychroman (S-γ-CEHC) in Rat
    Nami Akaho, Jiro Takata, Takeshi Fukushima, Kazuhisa Matsunaga, Akihiro Hattori, Ryoji Hidaka, Kosuke Fukui, Miyako Yoshida, Toshihiro Fujioka, Yoshiharu Karube and Kazuhiro Imai
    Drug Metabolism and Disposition September 2007, 35 (9) 1502-1510; DOI: https://doi.org/10.1124/dmd.106.014365
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    Involvement of Up-Regulation of Hepatic Breast Cancer Resistance Protein in Decreased Plasma Concentration of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Coadministration of S-1 in Rats
    Koji Yokoo, Akinobu Hamada, Hiroshi Watanabe, Takanobu Matsuzaki, Tomoyuki Imai, Hiromi Fujimoto, Kengo Masa, Teruko Imai and Hideyuki Saito
    Drug Metabolism and Disposition September 2007, 35 (9) 1511-1517; DOI: https://doi.org/10.1124/dmd.107.015164
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    Characterization of Benidipine and Its Enantiomers' Metabolism by Human Liver Cytochrome P450 Enzymes
    Yune-Jung Yoon, Kwon-Bok Kim, Hyunmi Kim, Kyung-Ah Seo, Ho-Sook Kim, In-June Cha, Eun-Young Kim, Kwang-Hyeon Liu and Jae-Gook Shin
    Drug Metabolism and Disposition September 2007, 35 (9) 1518-1524; DOI: https://doi.org/10.1124/dmd.106.013607
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    A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach
    Michael Weiss, Tom C. Krejcie and Michael J. Avram
    Drug Metabolism and Disposition September 2007, 35 (9) 1525-1532; DOI: https://doi.org/10.1124/dmd.106.014209
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    ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions
    Hristos Glavinas, Emese Kis, Ákos Pál, Rita Kovács, Márton Jani, Erika Vági, Éva Molnár, Száva Bánsághi, Zoltán Kele, Tamás Janáky, György Báthori, Oliver von Richter, Gerrit-Jan Koomen and Péter Krajcsi
    Drug Metabolism and Disposition September 2007, 35 (9) 1533-1542; DOI: https://doi.org/10.1124/dmd.106.014605
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    Metabolism, Excretion, and Pharmacokinetics of [14C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects
    Matthew Hoffmann, William DeMaio, Ronald A. Jordan, Rasmy Talaat, Dawn Harper, John Speth and JoAnn Scatina
    Drug Metabolism and Disposition September 2007, 35 (9) 1543-1553; DOI: https://doi.org/10.1124/dmd.107.015735
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    In Vitro Metabolic Study of Temsirolimus: Preparation, Isolation, and Identification of the Metabolites
    Ping Cai, Rushung Tsao and Mark E. Ruppen
    Drug Metabolism and Disposition September 2007, 35 (9) 1554-1563; DOI: https://doi.org/10.1124/dmd.107.014746
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    Isolation and Identification of Phase 1 Metabolites of Demethoxycurcumin in Rats
    Yongchi Zeng, Feng Qiu, Yuan Liu, Gexia Qu and Xinsheng Yao
    Drug Metabolism and Disposition September 2007, 35 (9) 1564-1573; DOI: https://doi.org/10.1124/dmd.107.015008
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    Decrease in Intracellular Concentration Causes the Shift in Km Value of Efflux Pump Substrates
    Timo Korjamo, Heidi Kemiläinen, Aki T. Heikkinen and Jukka Mönkkönen
    Drug Metabolism and Disposition September 2007, 35 (9) 1574-1579; DOI: https://doi.org/10.1124/dmd.107.016014
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    Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats
    Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazoe and Ikumi Tamai
    Drug Metabolism and Disposition September 2007, 35 (9) 1580-1586; DOI: https://doi.org/10.1124/dmd.107.015842
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    Pediatric Development of Glucuronidation: The Ontogeny of Hepatic UGT1A4
    Shogo J. Miyagi and Abby C. Collier
    Drug Metabolism and Disposition September 2007, 35 (9) 1587-1592; DOI: https://doi.org/10.1124/dmd.107.015214
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    Evaluation of Capravirine as a CYP3A Probe Substrate: In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs
    Hai-Zhi Bu, Ping Zhao, Ping Kang, William F. Pool, Ellen Y. Wu and Bhasker V. Shetty
    Drug Metabolism and Disposition September 2007, 35 (9) 1593-1602; DOI: https://doi.org/10.1124/dmd.107.016147
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    Effect of Silibinin on the Pharmacokinetics of Pyrazinamide and Pyrazinoic Acid in Rats
    Jhy-Wen Wu and Tung-Hu Tsai
    Drug Metabolism and Disposition September 2007, 35 (9) 1603-1610; DOI: https://doi.org/10.1124/dmd.107.014894
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    Decrease in Plasma Concentrations of Antiangiogenic Agent TSU-68 ((Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid) during Oral Administration Twice a Day to Rats
    Ryuichi Kitamura, Yoshio Yamamoto, Sekio Nagayama and Masaki Otagiri
    Drug Metabolism and Disposition September 2007, 35 (9) 1611-1616; DOI: https://doi.org/10.1124/dmd.106.014068
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    Role of Small Intestinal Cytochromes P450 in the Bioavailability of Oral Nifedipine
    Qing-Yu Zhang, Laurence S. Kaminsky, Deborah Dunbar, Jin Zhang and Xinxin Ding
    Drug Metabolism and Disposition September 2007, 35 (9) 1617-1623; DOI: https://doi.org/10.1124/dmd.107.016543
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    Absorption, Metabolism, and Excretion of [14C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects
    Satoshi Ohmori, Masahiro Miura, Chifuyu Toriumi, Yoshiaki Satoh and Tsuyoshi Ooie
    Drug Metabolism and Disposition September 2007, 35 (9) 1624-1633; DOI: https://doi.org/10.1124/dmd.107.016030
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    Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes
    Khaled Abass, Petri Reponen, Miia Turpeinen, Jorma Jalonen and Olavi Pelkonen
    Drug Metabolism and Disposition September 2007, 35 (9) 1634-1641; DOI: https://doi.org/10.1124/dmd.107.016295
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    Glucuronidation of Thyroxine in Human Liver, Jejunum, and Kidney Microsomes
    Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh and Tsuyoshi Yokoi
    Drug Metabolism and Disposition September 2007, 35 (9) 1642-1648; DOI: https://doi.org/10.1124/dmd.107.016097
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    Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements
    Anwar Husain, Xiaoyan Zhang, Mark A. Doll, J. Christopher States, David F. Barker and David W. Hein
    Drug Metabolism and Disposition September 2007, 35 (9) 1649-1656; DOI: https://doi.org/10.1124/dmd.107.016485
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    Metabolism and Disposition in Humans of Raltegravir (MK-0518), an Anti-AIDS Drug Targeting the Human Immunodeficiency Virus 1 Integrase Enzyme
    Kelem Kassahun, Ian McIntosh, Donghui Cui, David Hreniuk, Shelia Merschman, Kenneth Lasseter, Neal Azrolan, Marian Iwamoto, John A. Wagner and Larissa A. Wenning
    Drug Metabolism and Disposition September 2007, 35 (9) 1657-1663; DOI: https://doi.org/10.1124/dmd.107.016196
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    Identification of Rat and Human Cytochrome P450 Isoforms and a Rat Serum Esterase That Metabolize the Pyrethroid Insecticides Deltamethrin and Esfenvalerate
    Stephen J. Godin, J. Allen Crow, Edward J. Scollon, Michael F. Hughes, Michael J. DeVito and Matthew K. Ross
    Drug Metabolism and Disposition September 2007, 35 (9) 1664-1671; DOI: https://doi.org/10.1124/dmd.107.015388
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    Interspecies Comparisons of Pharmacokinetics and Pharmacodynamics of Recombinant Human Erythropoietin
    Sukyung Woo and William J. Jusko
    Drug Metabolism and Disposition September 2007, 35 (9) 1672-1678; DOI: https://doi.org/10.1124/dmd.107.015248
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    Stereoselective Glucuronidation of 5-(4′-Hydroxyphenyl)-5-phenylhydantoin by Human UDP-Glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: Effects of UGT-UGT Interactions
    Miki Nakajima, Hiroyuki Yamanaka, Ryoichi Fujiwara, Miki Katoh and Tsuyoshi Yokoi
    Drug Metabolism and Disposition September 2007, 35 (9) 1679-1686; DOI: https://doi.org/10.1124/dmd.107.015909
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    Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
    Alison E. Aitken and Edward T. Morgan
    Drug Metabolism and Disposition September 2007, 35 (9) 1687-1693; DOI: https://doi.org/10.1124/dmd.107.015511
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    Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress
    Martin Wagner, Gernot Zollner, Peter Fickert, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Jaspreet S. Gujral, Kurt Zatloukal, Helmut Denk, Hartmut Jaeschke and Michael Trauner
    Drug Metabolism and Disposition September 2007, 35 (9) 1694-1699; DOI: https://doi.org/10.1124/dmd.107.015610
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    Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4α, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver
    Matthew Wortham, Maciej Czerwinski, Lin He, Andrew Parkinson and Yu-Jui Yvonne Wan
    Drug Metabolism and Disposition September 2007, 35 (9) 1700-1710; DOI: https://doi.org/10.1124/dmd.107.016436
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    In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids
    Markus Fridén, Anubha Gupta, Madeleine Antonsson, Ulf Bredberg and Margareta Hammarlund-Udenaes
    Drug Metabolism and Disposition September 2007, 35 (9) 1711-1719; DOI: https://doi.org/10.1124/dmd.107.015222
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Drug Metabolism and Disposition: 35 (9)
Drug Metabolism and Disposition
Vol. 35, Issue 9
1 Sep 2007
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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