Drug Metabolism and Disposition: 35 (9)

September 01, 2007; Volume 35,Issue 9

Short Communications

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Hepatic Metabolism of MK-0457, a Potent Aurora Kinase Inhibitor: Interspecies Comparison and Role of Human Cytochrome P450 and Flavin-Containing Monooxygenase
J. E. Ballard, T. Prueksaritanont and C. Tang

Drug Metabolism and Disposition September 2007, 35 (9) 1447-1451; DOI: https://doi.org/10.1124/dmd.107.015438
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Inhibition of Human Thiopurine S-Methyltransferase by Various Nonsteroidal Anti-inflammatory Drugs in Vitro: A Mechanism for Possible Drug Interactions
Kersti Oselin and Kaili Anier

Drug Metabolism and Disposition September 2007, 35 (9) 1452-1454; DOI: https://doi.org/10.1124/dmd.107.016287
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Cholesterol-Lowering Effect of Ezetimibe in Uridine Diphosphate Glucuronosyltransferase 1A-Deficient (Gunn) Rats
Takehito Yamamoto, Kousei Ito, Masashi Honma, Tappei Takada and Hiroshi Suzuki

Drug Metabolism and Disposition September 2007, 35 (9) 1455-1458; DOI: https://doi.org/10.1124/dmd.107.015628
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Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid
Amal Kaddoumi, Sung-Up Choi, Loren Kinman, Dale Whittington, Che-Chung Tsai, Rodney J.Y. Ho, Bradley D. Anderson and Jashvant D. Unadkat

Drug Metabolism and Disposition September 2007, 35 (9) 1459-1462; DOI: https://doi.org/10.1124/dmd.107.016220
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Detection of Haptenated Proteins in Organotypic Human Skin Explant Cultures Exposed to Dapsone
Sanjoy Roychowdhury, Albert E. Cram, Al Aly and Craig K. Svensson

Drug Metabolism and Disposition September 2007, 35 (9) 1463-1465; DOI: https://doi.org/10.1124/dmd.107.015560

Articles

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Computational Approaches That Predict Metabolic Intermediate Complex Formation with CYP3A4 (+b₅)
David R. Jones, Sean Ekins, Lang Li and Stephen D. Hall

Drug Metabolism and Disposition September 2007, 35 (9) 1466-1475; DOI: https://doi.org/10.1124/dmd.106.014613
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Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells
Kilian Bartholomé, Maria Rius, Katrin Letschert, Daniela Keller, Jens Timmer and Dietrich Keppler

Drug Metabolism and Disposition September 2007, 35 (9) 1476-1481; DOI: https://doi.org/10.1124/dmd.107.015636
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Kinetic Studies of 25-Hydroxy-19-nor-vitamin D₃ and 1α,25-Dihydroxy-19-nor-vitamin D₃ Hydroxylation by CYP27B1 and CYP24A1
Naoko Urushino, Sachie Nakabayashi, Midori A. Arai, Atsushi Kittaka, Tai C. Chen, Keiko Yamamoto, Keiko Hayashi, Shigeaki Kato, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro and Toshiyuki Sakaki

Drug Metabolism and Disposition September 2007, 35 (9) 1482-1488; DOI: https://doi.org/10.1124/dmd.107.015602
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Subcellular Trafficking Signals of Constitutive Androstane Receptor: Evidence for a Nuclear Export Signal in the DNA-Binding Domain
Jun Xia and Byron Kemper

Drug Metabolism and Disposition September 2007, 35 (9) 1489-1494; DOI: https://doi.org/10.1124/dmd.107.016493
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Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor
Krisztina Kőhalmy, Viola Tamási, László Kóbori, Enikő Sárváry, Jean-Marc Pascussi, Pálma Porrogi, Damjana Rozman, Russell A. Prough, Urs A. Meyer and Katalin Monostory

Drug Metabolism and Disposition September 2007, 35 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.107.016303
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Preparation and In Vivo Evaluation of a Water-Soluble Prodrug for 2R-γ-Tocotrienol and as a Two-Step Prodrug for 2,7,8-Trimethyl-2S-(β-carboxyethyl)-6-hydroxychroman (S-γ-CEHC) in Rat
Nami Akaho, Jiro Takata, Takeshi Fukushima, Kazuhisa Matsunaga, Akihiro Hattori, Ryoji Hidaka, Kosuke Fukui, Miyako Yoshida, Toshihiro Fujioka, Yoshiharu Karube and Kazuhiro Imai

Drug Metabolism and Disposition September 2007, 35 (9) 1502-1510; DOI: https://doi.org/10.1124/dmd.106.014365
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Involvement of Up-Regulation of Hepatic Breast Cancer Resistance Protein in Decreased Plasma Concentration of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Coadministration of S-1 in Rats
Koji Yokoo, Akinobu Hamada, Hiroshi Watanabe, Takanobu Matsuzaki, Tomoyuki Imai, Hiromi Fujimoto, Kengo Masa, Teruko Imai and Hideyuki Saito

Drug Metabolism and Disposition September 2007, 35 (9) 1511-1517; DOI: https://doi.org/10.1124/dmd.107.015164
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Characterization of Benidipine and Its Enantiomers' Metabolism by Human Liver Cytochrome P450 Enzymes
Yune-Jung Yoon, Kwon-Bok Kim, Hyunmi Kim, Kyung-Ah Seo, Ho-Sook Kim, In-June Cha, Eun-Young Kim, Kwang-Hyeon Liu and Jae-Gook Shin

Drug Metabolism and Disposition September 2007, 35 (9) 1518-1524; DOI: https://doi.org/10.1124/dmd.106.013607
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A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach
Michael Weiss, Tom C. Krejcie and Michael J. Avram

Drug Metabolism and Disposition September 2007, 35 (9) 1525-1532; DOI: https://doi.org/10.1124/dmd.106.014209
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ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions
Hristos Glavinas, Emese Kis, Ákos Pál, Rita Kovács, Márton Jani, Erika Vági, Éva Molnár, Száva Bánsághi, Zoltán Kele, Tamás Janáky, György Báthori, Oliver von Richter, Gerrit-Jan Koomen and Péter Krajcsi

Drug Metabolism and Disposition September 2007, 35 (9) 1533-1542; DOI: https://doi.org/10.1124/dmd.106.014605
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Metabolism, Excretion, and Pharmacokinetics of [¹⁴C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects
Matthew Hoffmann, William DeMaio, Ronald A. Jordan, Rasmy Talaat, Dawn Harper, John Speth and JoAnn Scatina

Drug Metabolism and Disposition September 2007, 35 (9) 1543-1553; DOI: https://doi.org/10.1124/dmd.107.015735
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In Vitro Metabolic Study of Temsirolimus: Preparation, Isolation, and Identification of the Metabolites
Ping Cai, Rushung Tsao and Mark E. Ruppen

Drug Metabolism and Disposition September 2007, 35 (9) 1554-1563; DOI: https://doi.org/10.1124/dmd.107.014746
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Isolation and Identification of Phase 1 Metabolites of Demethoxycurcumin in Rats
Yongchi Zeng, Feng Qiu, Yuan Liu, Gexia Qu and Xinsheng Yao

Drug Metabolism and Disposition September 2007, 35 (9) 1564-1573; DOI: https://doi.org/10.1124/dmd.107.015008
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Decrease in Intracellular Concentration Causes the Shift in K_m Value of Efflux Pump Substrates
Timo Korjamo, Heidi Kemiläinen, Aki T. Heikkinen and Jukka Mönkkönen

Drug Metabolism and Disposition September 2007, 35 (9) 1574-1579; DOI: https://doi.org/10.1124/dmd.107.016014
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Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats
Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazoe and Ikumi Tamai

Drug Metabolism and Disposition September 2007, 35 (9) 1580-1586; DOI: https://doi.org/10.1124/dmd.107.015842
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Pediatric Development of Glucuronidation: The Ontogeny of Hepatic UGT1A4
Shogo J. Miyagi and Abby C. Collier

Drug Metabolism and Disposition September 2007, 35 (9) 1587-1592; DOI: https://doi.org/10.1124/dmd.107.015214
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Evaluation of Capravirine as a CYP3A Probe Substrate: In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs
Hai-Zhi Bu, Ping Zhao, Ping Kang, William F. Pool, Ellen Y. Wu and Bhasker V. Shetty

Drug Metabolism and Disposition September 2007, 35 (9) 1593-1602; DOI: https://doi.org/10.1124/dmd.107.016147
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Effect of Silibinin on the Pharmacokinetics of Pyrazinamide and Pyrazinoic Acid in Rats
Jhy-Wen Wu and Tung-Hu Tsai

Drug Metabolism and Disposition September 2007, 35 (9) 1603-1610; DOI: https://doi.org/10.1124/dmd.107.014894
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Decrease in Plasma Concentrations of Antiangiogenic Agent TSU-68 ((Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid) during Oral Administration Twice a Day to Rats
Ryuichi Kitamura, Yoshio Yamamoto, Sekio Nagayama and Masaki Otagiri

Drug Metabolism and Disposition September 2007, 35 (9) 1611-1616; DOI: https://doi.org/10.1124/dmd.106.014068
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Role of Small Intestinal Cytochromes P450 in the Bioavailability of Oral Nifedipine
Qing-Yu Zhang, Laurence S. Kaminsky, Deborah Dunbar, Jin Zhang and Xinxin Ding

Drug Metabolism and Disposition September 2007, 35 (9) 1617-1623; DOI: https://doi.org/10.1124/dmd.107.016543
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Absorption, Metabolism, and Excretion of [¹⁴C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects
Satoshi Ohmori, Masahiro Miura, Chifuyu Toriumi, Yoshiaki Satoh and Tsuyoshi Ooie

Drug Metabolism and Disposition September 2007, 35 (9) 1624-1633; DOI: https://doi.org/10.1124/dmd.107.016030
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Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes
Khaled Abass, Petri Reponen, Miia Turpeinen, Jorma Jalonen and Olavi Pelkonen

Drug Metabolism and Disposition September 2007, 35 (9) 1634-1641; DOI: https://doi.org/10.1124/dmd.107.016295
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Glucuronidation of Thyroxine in Human Liver, Jejunum, and Kidney Microsomes
Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh and Tsuyoshi Yokoi

Drug Metabolism and Disposition September 2007, 35 (9) 1642-1648; DOI: https://doi.org/10.1124/dmd.107.016097
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Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements
Anwar Husain, Xiaoyan Zhang, Mark A. Doll, J. Christopher States, David F. Barker and David W. Hein

Drug Metabolism and Disposition September 2007, 35 (9) 1649-1656; DOI: https://doi.org/10.1124/dmd.107.016485
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Metabolism and Disposition in Humans of Raltegravir (MK-0518), an Anti-AIDS Drug Targeting the Human Immunodeficiency Virus 1 Integrase Enzyme
Kelem Kassahun, Ian McIntosh, Donghui Cui, David Hreniuk, Shelia Merschman, Kenneth Lasseter, Neal Azrolan, Marian Iwamoto, John A. Wagner and Larissa A. Wenning

Drug Metabolism and Disposition September 2007, 35 (9) 1657-1663; DOI: https://doi.org/10.1124/dmd.107.016196
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Identification of Rat and Human Cytochrome P450 Isoforms and a Rat Serum Esterase That Metabolize the Pyrethroid Insecticides Deltamethrin and Esfenvalerate
Stephen J. Godin, J. Allen Crow, Edward J. Scollon, Michael F. Hughes, Michael J. DeVito and Matthew K. Ross

Drug Metabolism and Disposition September 2007, 35 (9) 1664-1671; DOI: https://doi.org/10.1124/dmd.107.015388
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Interspecies Comparisons of Pharmacokinetics and Pharmacodynamics of Recombinant Human Erythropoietin
Sukyung Woo and William J. Jusko

Drug Metabolism and Disposition September 2007, 35 (9) 1672-1678; DOI: https://doi.org/10.1124/dmd.107.015248
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Stereoselective Glucuronidation of 5-(4′-Hydroxyphenyl)-5-phenylhydantoin by Human UDP-Glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: Effects of UGT-UGT Interactions
Miki Nakajima, Hiroyuki Yamanaka, Ryoichi Fujiwara, Miki Katoh and Tsuyoshi Yokoi

Drug Metabolism and Disposition September 2007, 35 (9) 1679-1686; DOI: https://doi.org/10.1124/dmd.107.015909
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Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
Alison E. Aitken and Edward T. Morgan

Drug Metabolism and Disposition September 2007, 35 (9) 1687-1693; DOI: https://doi.org/10.1124/dmd.107.015511
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Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress
Martin Wagner, Gernot Zollner, Peter Fickert, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Jaspreet S. Gujral, Kurt Zatloukal, Helmut Denk, Hartmut Jaeschke and Michael Trauner

Drug Metabolism and Disposition September 2007, 35 (9) 1694-1699; DOI: https://doi.org/10.1124/dmd.107.015610
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Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4α, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver
Matthew Wortham, Maciej Czerwinski, Lin He, Andrew Parkinson and Yu-Jui Yvonne Wan

Drug Metabolism and Disposition September 2007, 35 (9) 1700-1710; DOI: https://doi.org/10.1124/dmd.107.016436
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In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids
Markus Fridén, Anubha Gupta, Madeleine Antonsson, Ulf Bredberg and Margareta Hammarlund-Udenaes

Drug Metabolism and Disposition September 2007, 35 (9) 1711-1719; DOI: https://doi.org/10.1124/dmd.107.015222

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