In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Sweden (M.F., A.G., M.H.-U.); and Discovery Drug Metabolism and Pharmacokinetics & Bioanalytical Chemistry, AstraZeneca Research & Development, Mölndal, Sweden (M.F., M.A., U.B.)

Address correspondence to:
Dr. Margareta Hammarlund-Udenaes, Professor, Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden. E-mail: mhu{at}farmbio.uu.se

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