Table of Contents

Articles

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  Gender Differences in mRNA Expression of ATP-Binding Cassette Efflux and Bile Acid Transporters in Kidney, Liver, and Intestine of 5/6 Nephrectomized Rats

  Hong Lu and Curtis Klaassen

  Drug Metabolism and Disposition January 2008, 36 (1) 16-23; DOI: https://doi.org/10.1124/dmd.107.014845
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  Disposition and Metabolism of [¹⁴C]Brasofensine in Rats, Monkeys, and Humans

  Mingshe Zhu, Daisy B. Whigan, Shu Y. Chang and Randy C. Dockens

  Drug Metabolism and Disposition January 2008, 36 (1) 24-35; DOI: https://doi.org/10.1124/dmd.107.016139
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  Pharmacokinetics and Metabolism of ¹⁴C-Brivaracetam, a Novel SV2A Ligand, in Healthy Subjects

  Maria Laura Sargentini-Maier, Pascal Espié, Alain Coquette and Armel Stockis

  Drug Metabolism and Disposition January 2008, 36 (1) 36-45; DOI: https://doi.org/10.1124/dmd.107.017129
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  Glucuronidation of Mycophenolic Acid by Wistar and Mrp2-Deficient TR^- Rat Liver Microsomes

  Ian S. Westley, Raymond G. Morris, Allan M. Evans and Benedetta C. Sallustio

  Drug Metabolism and Disposition January 2008, 36 (1) 46-50; DOI: https://doi.org/10.1124/dmd.107.017210
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  Hepatic UDP-Glucuronosyltransferases Responsible for Glucuronidation of Thyroxine in Humans

  Yoshihisa Kato, Shin-ichi Ikushiro, Yoshikazu Emi, Sekihiro Tamaki, Hiroshi Suzuki, Toshiyuki Sakaki, Shizuo Yamada and Masakuni Degawa

  Drug Metabolism and Disposition January 2008, 36 (1) 51-55; DOI: https://doi.org/10.1124/dmd.107.018184
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  Regulation of CYP2A6 Protein Expression by Skatole, Indole, and Testicular Steroids in Primary Cultured Pig Hepatocytes

  Gang Chen, Rebecca-Ayme Cue, Kerstin Lundstrom, Jeffrey D. Wood and Olena Doran

  Drug Metabolism and Disposition January 2008, 36 (1) 56-60; DOI: https://doi.org/10.1124/dmd.107.017285
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  Multidrug Resistance-Associated Protein 2 Is Primarily Responsible for the Biliary Excretion of Fexofenadine in Mice

  Xianbin Tian, Maciej J. Zamek-Gliszczynski, Jun Li, Arlene S. Bridges, Ken-ichi Nezasa, Nita J. Patel, Thomas J. Raub and Kim L. R. Brouwer

  Drug Metabolism and Disposition January 2008, 36 (1) 61-64; DOI: https://doi.org/10.1124/dmd.107.017319
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  Pharmacokinetics and Metabolic Profile of Free, Conjugated, and Total Silymarin Flavonolignans in Human Plasma after Oral Administration of Milk Thistle Extract

  Zhiming Wen, Todd E. Dumas, Sarah J. Schrieber, Roy L. Hawke, Michael W. Fried and Philip C. Smith

  Drug Metabolism and Disposition January 2008, 36 (1) 65-72; DOI: https://doi.org/10.1124/dmd.107.017566
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  Trimethoprim and the CYP2C8^*3 Allele Have Opposite Effects on the Pharmacokinetics of Pioglitazone

  Aleksi Tornio, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman

  Drug Metabolism and Disposition January 2008, 36 (1) 73-80; DOI: https://doi.org/10.1124/dmd.107.018010
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  Subdomain IIIA of Dog Albumin Contains a Binding Site Similar to Site II of Human Albumin

  Ken-ichi Kaneko, Hikaru Fukuda, Victor Tuan Giam Chuang, Keishi Yamasaki, Kohichi Kawahara, Hitoshi Nakayama, Ayaka Suenaga, Toru Maruyama and Masaki Otagiri

  Drug Metabolism and Disposition January 2008, 36 (1) 81-86; DOI: https://doi.org/10.1124/dmd.107.016873
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  Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the α-Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption

  A. Collett, R. H. Stephens, M. D. Harwood, M. Humphrey, L. Dallman, J. Bennett, J. Davis, G. L. Carlson and G. Warhurst

  Drug Metabolism and Disposition January 2008, 36 (1) 87-94; DOI: https://doi.org/10.1124/dmd.107.016865
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  Regulation of Hepatic Drug-Metabolizing Enzyme Genes by Toll-Like Receptor 4 Signaling Is Independent of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein

  Romi Ghose, Damara White, Tao Guo, Jesus Vallejo and Saul J. Karpen

  Drug Metabolism and Disposition January 2008, 36 (1) 95-101; DOI: https://doi.org/10.1124/dmd.107.018051
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  Permeability, Transport, and Metabolism of Solutes in Caco-2 Cell Monolayers: A Theoretical Study

  Huadong Sun and K. Sandy Pang

  Drug Metabolism and Disposition January 2008, 36 (1) 102-123; DOI: https://doi.org/10.1124/dmd.107.015321
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  Effects of Chronic Renal Failure on Liver Drug Transporters

  Judith Naud, Josée Michaud, Francois A. Leblond, Stéphane Lefrancois, Alain Bonnardeaux and Vincent Pichette

  Drug Metabolism and Disposition January 2008, 36 (1) 124-128; DOI: https://doi.org/10.1124/dmd.107.018192
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  Effect of Resveratrol on 17β-Estradiol Sulfation by Human Hepatic and Jejunal S9 and Recombinant Sulfotransferase 1E1

  Anna M. Furimsky, Carol E. Green, Lewanne E. Hunt Sharp, Paul Catz, Araba A. Adjei, Toufan Parman, Izet M. Kapetanovic, Richard M. Weinshilboum and Lalitha V. Iyer

  Drug Metabolism and Disposition January 2008, 36 (1) 129-136; DOI: https://doi.org/10.1124/dmd.107.016725
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  HepaRG Cells as an in Vitro Model for Evaluation of Cytochrome P450 Induction in Humans

  Kajsa P. Kanebratt and Tommy B. Andersson

  Drug Metabolism and Disposition January 2008, 36 (1) 137-145; DOI: https://doi.org/10.1124/dmd.107.017418
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  The Influence of CYP3A5 Expression on the Extent of Hepatic CYP3A Inhibition Is Substrate-Dependent: An in Vitro-in Vivo Evaluation

  Nina Isoherranen, Shana R. Ludington, Raymond C. Givens, Jatinder K. Lamba, Susan N. Pusek, E. Claire Dees, David K. Blough, Kazunori Iwanaga, Roy L. Hawke, Erin G. Schuetz, Paul B. Watkins, Kenneth E. Thummel and Mary F. Paine

  Drug Metabolism and Disposition January 2008, 36 (1) 146-154; DOI: https://doi.org/10.1124/dmd.107.018382
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  Mechanism-Based Inactivation of Lung-Selective Cytochrome P450 CYP2F Enzymes

  Jaya S. Kartha and Garold S. Yost

  Drug Metabolism and Disposition January 2008, 36 (1) 155-162; DOI: https://doi.org/10.1124/dmd.107.017897
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  Identification of Cytochrome P450 Enzymes Involved in the Metabolism of the New Designer Drug 4′-Methyl-α-pyrrolidinobutyrophenone

  Frank T. Peters, Markus R. Meyer, Denis S. Theobald and Hans H. Maurer

  Drug Metabolism and Disposition January 2008, 36 (1) 163-168; DOI: https://doi.org/10.1124/dmd.107.017293
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  Novel Single Nucleotide Polymorphisms in the Promoter and Intron 1 of Human Pregnane X Receptor/NR1I2 and Their Association with CYP3A4 Expression

  Jatinder Lamba, Vishal Lamba, Stephen Strom, Raman Venkataramanan and Erin Schuetz

  Drug Metabolism and Disposition January 2008, 36 (1) 169-181; DOI: https://doi.org/10.1124/dmd.107.016600
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  Transcription Factor and Drug-Metabolizing Enzyme Gene Expression in Lymphocytes from Healthy Human Subjects

  Gérard Siest, Elise Jeannesson, Jean-Brice Marteau, Anastasia Samara, Bérangère Marie, Michèle Pfister and Sophie Visvikis-Siest

  Drug Metabolism and Disposition January 2008, 36 (1) 182-189; DOI: https://doi.org/10.1124/dmd.107.017228
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  Transport and Metabolism of Ferulic Acid through the Colonic Epithelium

  Laure Poquet, Michael N. Clifford and Gary Williamson

  Drug Metabolism and Disposition January 2008, 36 (1) 190-197; DOI: https://doi.org/10.1124/dmd.107.017558
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  Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in Freshly Isolated Rat Hepatocytes

  Daniel A. J. Bow, Jennifer L. Perry, David S. Miller, John B. Pritchard and Kim L. R. Brouwer

  Drug Metabolism and Disposition January 2008, 36 (1) 198-202; DOI: https://doi.org/10.1124/dmd.107.018200