Abstract
This is the first of three articles covering the development of drug metabolism research in the United States during the first 100 years of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Before 1909, the majority of drug metabolism research was performed in Europe. The period from 1909 to 1958 saw extensive development of the methods required for modern metabolism studies. Examples of trends and specific discoveries are drawn from the archives of ASPET publications.
Footnotes
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↵1 Mary Hare started her career as a Duke graduate student, and her thesis involved the discovery of amine oxidases. She subsequently married Frederick Bernheim, and the two went on to a successful series of studies emphasizing in vitro techniques.
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↵2 The accounts of the developments of the sulfa compounds and the passage of the food and drug act are wonderfully recorded in The Demon Under the Microscope (Hager, 2006).
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↵3 A review of the first 50 years of Pharmacological Reviews has been presented by Robert Stitzel (1999). The review also contains interesting insight into the early days of ASPET.
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↵4 Thomas Butler has written an entertaining memoir discussing the earliest days of pharmacology and drug metabolism (Butler, 1971).
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↵5 This is Gil Mannering's first venture into drug metabolism—the start of a long distinguished career. See autobiographical article in Drug Metab Rev 33:81–116 (2001).
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↵6 This article represents Jim Gillette's start in his illustrious career at the National Institutes of Health. Jim died in 2001, and a tribute to his career is presented in Drug Metab Dispos 31:2003.
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Article, publication date, and citation information can be found at http://dmd.aspetjournals.org.
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doi:10.1124/dmd.107.017079.
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ABBREVIATION: SKF 525a, β-diethylaminoethyldiphenylpropylacetate hydrochloride.
- Received June 6, 2007.
- Accepted July 30, 2007.
- The American Society for Pharmacology and Experimental Therapeutics
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In this issue
The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 1, 1909–1958
