Footnotes

• ↵1 Mary Hare started her career as a Duke graduate student, and her thesis involved the discovery of amine oxidases. She subsequently married Frederick Bernheim, and the two went on to a successful series of studies emphasizing in vitro techniques.

• ↵2 The accounts of the developments of the sulfa compounds and the passage of the food and drug act are wonderfully recorded in The Demon Under the Microscope (Hager, 2006).

• ↵3 A review of the first 50 years of Pharmacological Reviews has been presented by Robert Stitzel (1999). The review also contains interesting insight into the early days of ASPET.

• ↵4 Thomas Butler has written an entertaining memoir discussing the earliest days of pharmacology and drug metabolism (Butler, 1971).

• ↵5 This is Gil Mannering's first venture into drug metabolism—the start of a long distinguished career. See autobiographical article in Drug Metab Rev 33:81–116 (2001).

• ↵6 This article represents Jim Gillette's start in his illustrious career at the National Institutes of Health. Jim died in 2001, and a tribute to his career is presented in Drug Metab Dispos 31:2003.

• Article, publication date, and citation information can be found at http://dmd.aspetjournals.org.

• doi:10.1124/dmd.107.017079.

• ABBREVIATION: SKF 525a, β-diethylaminoethyldiphenylpropylacetate hydrochloride.

• • Received June 6, 2007.
  • Accepted July 30, 2007.