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Research ArticleArticle

Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the α-Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption

A. Collett, R. H. Stephens, M. D. Harwood, M. Humphrey, L. Dallman, J. Bennett, J. Davis, G. L. Carlson and G. Warhurst
Drug Metabolism and Disposition January 2008, 36 (1) 87-94; DOI: https://doi.org/10.1124/dmd.107.016865

Article Information

vol. 36 no. 1 87-94
DOI 
https://doi.org/10.1124/dmd.107.016865
PubMed 
17932223
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 25, 2007
  • Accepted October 9, 2007
  • Published online December 26, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. A. Collett,
  2. R. H. Stephens,
  3. M. D. Harwood,
  4. M. Humphrey,
  5. L. Dallman,
  6. J. Bennett,
  7. J. Davis,
  8. G. L. Carlson and
  9. G. Warhurst
  1. Gut Barrier Group, Faculty of Medical and Human Sciences, University of Manchester, Hope Hospital, Salford, UK (A.C., R.H.S., M.D.H., G.L.C., G.W.); and Pharmaceutical Sciences (M.H., L.D., J.B.) and Clinical Pharmacology (J.D.), Pfizer Global Research and Development, Sandwich, Kent, UK
  1. Address correspondence to:
    Dr. Geoffrey Warhurst, Gut Barrier Group, Faculty of Medical and Human Sciences, University of Manchester, Hope Hospital, Salford M6 8HD, UK. E-mail: geoffrey.warhurst{at}manchester.ac.uk
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Research ArticleArticle

Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the α-Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption

A. Collett, R. H. Stephens, M. D. Harwood, M. Humphrey, L. Dallman, J. Bennett, J. Davis, G. L. Carlson and G. Warhurst
Drug Metabolism and Disposition January 1, 2008, 36 (1) 87-94; DOI: https://doi.org/10.1124/dmd.107.016865
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