Table of Contents

Articles

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  Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid

  Anand K. Deo and Stelvio M. Bandiera

  Drug Metabolism and Disposition October 2008, 36 (10) 1983-1991; DOI: https://doi.org/10.1124/dmd.108.022194
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  Re-engineering of CYP2C9 to Probe Acid-Base Substrate Selectivity

  Guoying Tai, Leslie J. Dickmann, Nicholas Matovic, James J. DeVoss, Elizabeth M. J. Gillam and Allan E. Rettie

  Drug Metabolism and Disposition October 2008, 36 (10) 1992-1997; DOI: https://doi.org/10.1124/dmd.108.022186
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  Extractive Biotransformation for Production of Metabolites of Poorly Soluble Compounds: Synthesis of 32-Hydroxy-rifalazil

  Vadim V. Mozhaev, Lyudmila V. Mozhaeva, Peter C. Michels and Yuri L. Khmelnitsky

  Drug Metabolism and Disposition October 2008, 36 (10) 1998-2004; DOI: https://doi.org/10.1124/dmd.108.021832
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  Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone

  Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund-Udenaes, Tetsuya Terasaki and Yoshiharu Deguchi

  Drug Metabolism and Disposition October 2008, 36 (10) 2005-2013; DOI: https://doi.org/10.1124/dmd.108.022087
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  Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

  Satoshi Kitamura, Kazuya Maeda, Yi Wang and Yuichi Sugiyama

  Drug Metabolism and Disposition October 2008, 36 (10) 2014-2023; DOI: https://doi.org/10.1124/dmd.108.021410
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  Pharmacokinetics of the Novel Nicotinic Receptor Antagonist N,N′-Dodecane-1,12-diyl-bis-3-picolinium Dibromide in the Rat

  Zaineb A. Fadhel Albayati, Linda P. Dwoskin and Peter A. Crooks

  Drug Metabolism and Disposition October 2008, 36 (10) 2024-2029; DOI: https://doi.org/10.1124/dmd.108.020354
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  Suppression of CYP2B Induction by Alendronate-Mediated Farnesyl Diphosphate Synthase Inhibition in Primary Cultured Rat Hepatocytes

  Nancy M. Jackson and Thomas A. Kocarek

  Drug Metabolism and Disposition October 2008, 36 (10) 2030-2036; DOI: https://doi.org/10.1124/dmd.108.022558
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  Stereoselective First-Pass Metabolism of Verapamil in the Small Intestine and Liver in Rats

  Kazuhiko Hanada, Yasutaka Ikemi, Kazutaka Kukita, Kiyoshi Mihara and Hiroyasu Ogata

  Drug Metabolism and Disposition October 2008, 36 (10) 2037-2042; DOI: https://doi.org/10.1124/dmd.107.020339
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  Biodistribution and Plasma Protein Binding of Zoledronic Acid

  H. Markus Weiss, Ulrike Pfaar, Alain Schweitzer, Hansjörg Wiegand, Andrej Skerjanec and Horst Schran

  Drug Metabolism and Disposition October 2008, 36 (10) 2043-2049; DOI: https://doi.org/10.1124/dmd.108.021071
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  Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action

  Wenchang Guo, Philip Reigan, David Siegel and David Ross

  Drug Metabolism and Disposition October 2008, 36 (10) 2050-2057; DOI: https://doi.org/10.1124/dmd.108.022004
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  Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo

  Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata and Yasushi Yamazoe

  Drug Metabolism and Disposition October 2008, 36 (10) 2058-2063; DOI: https://doi.org/10.1124/dmd.108.021501
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  Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and ¹H Nuclear Magnetic Resonance

  Chandra Prakash, Weichao Chen, Michelle Rossulek, Kim Johnson, Chenghong Zhang, Thomas O'Connell, Michael Potchoiba and Deepak Dalvie

  Drug Metabolism and Disposition October 2008, 36 (10) 2064-2079; DOI: https://doi.org/10.1124/dmd.108.022277
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  Enhancement of Zidovudine Uptake by Dehydroepiandrosterone Sulfate in Rat Syncytiotrophoblast Cell Line TR-TBT 18d-1

  Tomohiro Nishimura, Yoshiaki Seki, Kazuko Sato, Takuya Chishu, Noriko Kose, Tetsuya Terasaki, Young-Sook Kang, Yoshimichi Sai and Emi Nakashima

  Drug Metabolism and Disposition October 2008, 36 (10) 2080-2085; DOI: https://doi.org/10.1124/dmd.108.021345
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  Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

  Kristina K. Wolf, Kenneth R. Brouwer, Gary M. Pollack and Kim L. R. Brouwer

  Drug Metabolism and Disposition October 2008, 36 (10) 2086-2092; DOI: https://doi.org/10.1124/dmd.108.020842
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  CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance

  Chandra Prakash, Weiwei Wang, Thomas O'Connell and Kim A. Johnson

  Drug Metabolism and Disposition October 2008, 36 (10) 2093-2103; DOI: https://doi.org/10.1124/dmd.108.022897
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  Biotransformation of the Chemopreventive Agent 2′,4′,4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases

  Jian Guo, Ang Liu, Hongmei Cao, Yan Luo, John M. Pezzuto and Richard B. van Breemen

  Drug Metabolism and Disposition October 2008, 36 (10) 2104-2112; DOI: https://doi.org/10.1124/dmd.108.021857
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  Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver

  Nina Kassner, Klaus Huse, Hans-Jörg Martin, Ute Gödtel-Armbrust, Annegret Metzger, Ingolf Meineke, Jürgen Brockmöller, Kathrin Klein, Ulrich M. Zanger, Edmund Maser and Leszek Wojnowski

  Drug Metabolism and Disposition October 2008, 36 (10) 2113-2120; DOI: https://doi.org/10.1124/dmd.108.022251
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  Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract

  Mélanie Grondin, Francine Hamel, Fathey Sarhan and Diana A. Averill-Bates

  Drug Metabolism and Disposition October 2008, 36 (10) 2121-2129; DOI: https://doi.org/10.1124/dmd.108.021162
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  In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

  Hua Gao, Lili Yao, Heather W. Mathieu, Ying Zhang, Tristan S. Maurer, Matthew D. Troutman, Dennis O. Scott, Roger B. Ruggeri and Jing Lin

  Drug Metabolism and Disposition October 2008, 36 (10) 2130-2135; DOI: https://doi.org/10.1124/dmd.107.020131
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  Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

  Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf and Gordon C. K. Roberts

  Drug Metabolism and Disposition October 2008, 36 (10) 2136-2144; DOI: https://doi.org/10.1124/dmd.108.021733
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  Lipopolysaccharide Increases Cell Surface P-glycoprotein That Exhibits Diminished Activity in Intestinal Epithelial Cells

  Jayshree Mishra, Qiuye Zhang, Jessica L. Rosson, John Moran, John M. Dopp and Brien L. Neudeck

  Drug Metabolism and Disposition October 2008, 36 (10) 2145-2149; DOI: https://doi.org/10.1124/dmd.108.022632