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Drug Metabolism & Disposition

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Table of Contents

October 01, 2008; Volume 36,Issue 10

CENTENNIAL PERSPECTIVE

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    The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 3, 1984–2008
    Patrick J. Murphy
    Drug Metabolism and Disposition October 2008, 36 (10) 1977-1982; DOI: https://doi.org/10.1124/dmd.108.023226

Articles

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    Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid
    Anand K. Deo and Stelvio M. Bandiera
    Drug Metabolism and Disposition October 2008, 36 (10) 1983-1991; DOI: https://doi.org/10.1124/dmd.108.022194
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    Re-engineering of CYP2C9 to Probe Acid-Base Substrate Selectivity
    Guoying Tai, Leslie J. Dickmann, Nicholas Matovic, James J. DeVoss, Elizabeth M. J. Gillam and Allan E. Rettie
    Drug Metabolism and Disposition October 2008, 36 (10) 1992-1997; DOI: https://doi.org/10.1124/dmd.108.022186
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    Extractive Biotransformation for Production of Metabolites of Poorly Soluble Compounds: Synthesis of 32-Hydroxy-rifalazil
    Vadim V. Mozhaev, Lyudmila V. Mozhaeva, Peter C. Michels and Yuri L. Khmelnitsky
    Drug Metabolism and Disposition October 2008, 36 (10) 1998-2004; DOI: https://doi.org/10.1124/dmd.108.021832
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    Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone
    Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund-Udenaes, Tetsuya Terasaki and Yoshiharu Deguchi
    Drug Metabolism and Disposition October 2008, 36 (10) 2005-2013; DOI: https://doi.org/10.1124/dmd.108.022087
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    Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
    Satoshi Kitamura, Kazuya Maeda, Yi Wang and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2008, 36 (10) 2014-2023; DOI: https://doi.org/10.1124/dmd.108.021410
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    Pharmacokinetics of the Novel Nicotinic Receptor Antagonist N,N′-Dodecane-1,12-diyl-bis-3-picolinium Dibromide in the Rat
    Zaineb A. Fadhel Albayati, Linda P. Dwoskin and Peter A. Crooks
    Drug Metabolism and Disposition October 2008, 36 (10) 2024-2029; DOI: https://doi.org/10.1124/dmd.108.020354
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    Suppression of CYP2B Induction by Alendronate-Mediated Farnesyl Diphosphate Synthase Inhibition in Primary Cultured Rat Hepatocytes
    Nancy M. Jackson and Thomas A. Kocarek
    Drug Metabolism and Disposition October 2008, 36 (10) 2030-2036; DOI: https://doi.org/10.1124/dmd.108.022558
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    Stereoselective First-Pass Metabolism of Verapamil in the Small Intestine and Liver in Rats
    Kazuhiko Hanada, Yasutaka Ikemi, Kazutaka Kukita, Kiyoshi Mihara and Hiroyasu Ogata
    Drug Metabolism and Disposition October 2008, 36 (10) 2037-2042; DOI: https://doi.org/10.1124/dmd.107.020339
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    Biodistribution and Plasma Protein Binding of Zoledronic Acid
    H. Markus Weiss, Ulrike Pfaar, Alain Schweitzer, Hansjörg Wiegand, Andrej Skerjanec and Horst Schran
    Drug Metabolism and Disposition October 2008, 36 (10) 2043-2049; DOI: https://doi.org/10.1124/dmd.108.021071
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    Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action
    Wenchang Guo, Philip Reigan, David Siegel and David Ross
    Drug Metabolism and Disposition October 2008, 36 (10) 2050-2057; DOI: https://doi.org/10.1124/dmd.108.022004
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    Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo
    Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata and Yasushi Yamazoe
    Drug Metabolism and Disposition October 2008, 36 (10) 2058-2063; DOI: https://doi.org/10.1124/dmd.108.021501
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    Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance
    Chandra Prakash, Weichao Chen, Michelle Rossulek, Kim Johnson, Chenghong Zhang, Thomas O'Connell, Michael Potchoiba and Deepak Dalvie
    Drug Metabolism and Disposition October 2008, 36 (10) 2064-2079; DOI: https://doi.org/10.1124/dmd.108.022277
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    Enhancement of Zidovudine Uptake by Dehydroepiandrosterone Sulfate in Rat Syncytiotrophoblast Cell Line TR-TBT 18d-1
    Tomohiro Nishimura, Yoshiaki Seki, Kazuko Sato, Takuya Chishu, Noriko Kose, Tetsuya Terasaki, Young-Sook Kang, Yoshimichi Sai and Emi Nakashima
    Drug Metabolism and Disposition October 2008, 36 (10) 2080-2085; DOI: https://doi.org/10.1124/dmd.108.021345
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    Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes
    Kristina K. Wolf, Kenneth R. Brouwer, Gary M. Pollack and Kim L. R. Brouwer
    Drug Metabolism and Disposition October 2008, 36 (10) 2086-2092; DOI: https://doi.org/10.1124/dmd.108.020842
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    CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance
    Chandra Prakash, Weiwei Wang, Thomas O'Connell and Kim A. Johnson
    Drug Metabolism and Disposition October 2008, 36 (10) 2093-2103; DOI: https://doi.org/10.1124/dmd.108.022897
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    Biotransformation of the Chemopreventive Agent 2′,4′,4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases
    Jian Guo, Ang Liu, Hongmei Cao, Yan Luo, John M. Pezzuto and Richard B. van Breemen
    Drug Metabolism and Disposition October 2008, 36 (10) 2104-2112; DOI: https://doi.org/10.1124/dmd.108.021857
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    Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver
    Nina Kassner, Klaus Huse, Hans-Jörg Martin, Ute Gödtel-Armbrust, Annegret Metzger, Ingolf Meineke, Jürgen Brockmöller, Kathrin Klein, Ulrich M. Zanger, Edmund Maser and Leszek Wojnowski
    Drug Metabolism and Disposition October 2008, 36 (10) 2113-2120; DOI: https://doi.org/10.1124/dmd.108.022251
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    Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract
    Mélanie Grondin, Francine Hamel, Fathey Sarhan and Diana A. Averill-Bates
    Drug Metabolism and Disposition October 2008, 36 (10) 2121-2129; DOI: https://doi.org/10.1124/dmd.108.021162
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    In Silico Modeling of Nonspecific Binding to Human Liver Microsomes
    Hua Gao, Lili Yao, Heather W. Mathieu, Ying Zhang, Tristan S. Maurer, Matthew D. Troutman, Dennis O. Scott, Roger B. Ruggeri and Jing Lin
    Drug Metabolism and Disposition October 2008, 36 (10) 2130-2135; DOI: https://doi.org/10.1124/dmd.107.020131
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    Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules
    Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf and Gordon C. K. Roberts
    Drug Metabolism and Disposition October 2008, 36 (10) 2136-2144; DOI: https://doi.org/10.1124/dmd.108.021733
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    Lipopolysaccharide Increases Cell Surface P-glycoprotein That Exhibits Diminished Activity in Intestinal Epithelial Cells
    Jayshree Mishra, Qiuye Zhang, Jessica L. Rosson, John Moran, John M. Dopp and Brien L. Neudeck
    Drug Metabolism and Disposition October 2008, 36 (10) 2145-2149; DOI: https://doi.org/10.1124/dmd.108.022632
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In this issue

Drug Metabolism and Disposition: 36 (10)
Drug Metabolism and Disposition
Vol. 36, Issue 10
1 Oct 2008
  • Table of Contents
  • Table of Contents (PDF)
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  • Back Matter (PDF)
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  • CENTENNIAL PERSPECTIVE
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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