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Drug Metabolism & Disposition

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Table of Contents

November 01, 2008; Volume 36,Issue 11

Short Communications

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    Principal Component Analysis of CYP2C9 and CYP3A4 Probe Substrate/Inhibitor Panels
    Abhinav Nath and William Atkins
    Drug Metabolism and Disposition November 2008, 36 (11) 2151-2155; DOI: https://doi.org/10.1124/dmd.108.022061
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    Apparent Differences in Mechanisms of Harmol Sulfate Biliary Excretion in Mice and Rats
    Maciej J. Zamek-Gliszczynski, Keith A. Hoffmaster, Ken-ichi Nezasa and Kim L. R. Brouwer
    Drug Metabolism and Disposition November 2008, 36 (11) 2156-2158; DOI: https://doi.org/10.1124/dmd.108.022053
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    Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
    Feng Qiu, Zhiyong Zhu, Ning Kang, Shujuan Piao, Gengyao Qin and Xinsheng Yao
    Drug Metabolism and Disposition November 2008, 36 (11) 2159-2165; DOI: https://doi.org/10.1124/dmd.108.021659
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    Generation of Human Metabolites of 7-Ethoxycoumarin by Bacterial Cytochrome P450 BM3
    Dong-Hyun Kim, Keon-Hee Kim, Dae-Hwan Kim, Kwang-Hyeon Liu, Heung-Chae Jung, Jae-Gu Pan and Chul-Ho Yun
    Drug Metabolism and Disposition November 2008, 36 (11) 2166-2170; DOI: https://doi.org/10.1124/dmd.108.021220

Articles

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    Identification of Stereoisomeric Metabolites of Meisoindigo in Rat Liver Microsomes by Achiral and Chiral Liquid Chromatography/Tandem Mass Spectrometry
    Meng Huang, Lin Tang Goh and Paul C. Ho
    Drug Metabolism and Disposition November 2008, 36 (11) 2171-2184; DOI: https://doi.org/10.1124/dmd.108.021956
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    Pharmacokinetics, Metabolism, and Excretion of Torcetrapib, a Cholesteryl Ester Transfer Protein Inhibitor, in Humans
    Deepak Dalvie, Weichao Chen, Chenghong Zhang, Alfin D. Vaz, Teresa A. Smolarek, Loretta M. Cox, Jian Lin and R. Scott Obach
    Drug Metabolism and Disposition November 2008, 36 (11) 2185-2198; DOI: https://doi.org/10.1124/dmd.108.023176
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    The Molecular Basis of CYP2D6-Mediated N-Dealkylation: Balance between Metabolic Clearance Routes and Enzyme Inhibition
    Britta Bonn, Collen M. Masimirembwa, Yasmin Aristei and Ismael Zamora
    Drug Metabolism and Disposition November 2008, 36 (11) 2199-2210; DOI: https://doi.org/10.1124/dmd.108.022376
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    Identification of Hydroxywarfarin Binding Site in Human UDP Glucuronosyltransferase 1A10: Phenylalanine90 Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin
    Grover P. Miller, Cheryl F. Lichti, Agnieszka K. Zielinska, Anna Mazur, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Jeffery H. Moran and Anna Radominska-Pandya
    Drug Metabolism and Disposition November 2008, 36 (11) 2211-2218; DOI: https://doi.org/10.1124/dmd.108.022863
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    Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)
    Sonia R. Miranda, Jin Kyung Lee, Kim L. R. Brouwer, Zhiming Wen, Philip C. Smith and Roy L. Hawke
    Drug Metabolism and Disposition November 2008, 36 (11) 2219-2226; DOI: https://doi.org/10.1124/dmd.108.021790
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    Enzyme Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting Ribonucleotide Reductase
    Xiaohui Wei, Guowei Dai, Zhongfa Liu, Hao Cheng, Zhiliang Xie, Rebecca Klisovic, Guido Marcucci and Kenneth K. Chan
    Drug Metabolism and Disposition November 2008, 36 (11) 2227-2233; DOI: https://doi.org/10.1124/dmd.108.021295
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    Differential Inhibition of Cytochromes P450 3A4 and 3A5 by the Newly Synthesized Coumarin Derivatives 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether
    Chitra Sridar, Ute M. Kent, Kate Noon, Alecia McCall, Bill Alworth, Maryam Foroozesh and Paul F. Hollenberg
    Drug Metabolism and Disposition November 2008, 36 (11) 2234-2243; DOI: https://doi.org/10.1124/dmd.108.021493
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    Effects of L-Lactate and D-Mannitol on γ-Hydroxybutyrate Toxicokinetics and Toxicodynamics in Rats
    Qi Wang, Xiaodong Wang and Marilyn E. Morris
    Drug Metabolism and Disposition November 2008, 36 (11) 2244-2251; DOI: https://doi.org/10.1124/dmd.108.022996
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    l-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid
    Joseph T. Dever and Adnan A. Elfarra
    Drug Metabolism and Disposition November 2008, 36 (11) 2252-2260; DOI: https://doi.org/10.1124/dmd.108.023390
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    Oxidative in Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen β-Receptor Agonist MF101
    René Kupfer, Leah Swanson, Sylvia Chow, Richard E. Staub, Yan Ling Zhang, Isaac Cohen and Uwe Christians
    Drug Metabolism and Disposition November 2008, 36 (11) 2261-2269; DOI: https://doi.org/10.1124/dmd.108.021402
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    Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor
    Eugene Y. H. Yeung, Tatsuya Sueyoshi, Masahiko Negishi and Thomas K. H. Chang
    Drug Metabolism and Disposition November 2008, 36 (11) 2270-2276; DOI: https://doi.org/10.1124/dmd.108.023499
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    Modulation of Cytochrome P450 Gene Expression and Arachidonic Acid Metabolism during Isoproterenol-Induced Cardiac Hypertrophy in Rats
    Beshay N. M. Zordoky, Mona E. Aboutabl and Ayman O. S. El-Kadi
    Drug Metabolism and Disposition November 2008, 36 (11) 2277-2286; DOI: https://doi.org/10.1124/dmd.108.023077
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    Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone
    Mitsue Miyazaki, Katsunori Nakamura, Yukiyoshi Fujita, F. Peter Guengerich, Ryuya Horiuchi and Koujirou Yamamoto
    Drug Metabolism and Disposition November 2008, 36 (11) 2287-2291; DOI: https://doi.org/10.1124/dmd.108.021816
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    Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate
    Jiang-Wei Zhang, Yong Liu, Jiu-Yang Zhao, Li-Ming Wang, Guang-Bo Ge, Yang Gao, Wei Li, Hong-Tao Liu, Hui-Xin Liu, Yan-Yan Zhang, Jie Sun and Ling Yang
    Drug Metabolism and Disposition November 2008, 36 (11) 2292-2298; DOI: https://doi.org/10.1124/dmd.108.022525
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    Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer
    Sachiko Yokoo, Satohiro Masuda, Atsushi Yonezawa, Tomohiro Terada, Toshiya Katsura and Ken-ichi Inui
    Drug Metabolism and Disposition November 2008, 36 (11) 2299-2306; DOI: https://doi.org/10.1124/dmd.108.023168
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    The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of β-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases
    Katriina Itäaho, Peter I. Mackenzie, Shin-ichi Ikushiro, John O. Miners and Moshe Finel
    Drug Metabolism and Disposition November 2008, 36 (11) 2307-2315; DOI: https://doi.org/10.1124/dmd.108.022731
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    Characterization of CYP2A13*2, a Variant Cytochrome P450 Allele Previously Found to Be Associated with Decreased Incidences of Lung Adenocarcinoma in Smokers
    Jaime D'Agostino, Xiuling Zhang, Hong Wu, Guoyu Ling, Suping Wang, Qing-Yu Zhang, Fucai Liu and Xinxin Ding
    Drug Metabolism and Disposition November 2008, 36 (11) 2316-2323; DOI: https://doi.org/10.1124/dmd.108.022822
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    Intravenous Formulation of N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for Inhibition of Rat Brain 20-Hydroxyeicosatetraenoic Acid Formation
    Ying Mu, Megan M. Klamerus, Tricia M. Miller, Lisa C. Rohan, Steven H. Graham and Samuel M. Poloyac
    Drug Metabolism and Disposition November 2008, 36 (11) 2324-2330; DOI: https://doi.org/10.1124/dmd.108.023150
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    The Expression of Most UDP-Glucuronosyltransferases (UGTs) Is Increased Significantly during Caco-2 Cell Differentiation, whereas UGT1A6 Is Highly Expressed Also in Undifferentiated Cells
    Sanna Siissalo, Hongbo Zhang, Eric Stilgenbauer, Ann Marie Kaukonen, Jouni Hirvonen and Moshe Finel
    Drug Metabolism and Disposition November 2008, 36 (11) 2331-2336; DOI: https://doi.org/10.1124/dmd.108.022335
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    Metabolism and Disposition of Fluticasone Furoate, an Enhanced-Affinity Glucocorticoid, in Humans
    Stephen C. Hughes, Peter C. Shardlow, Frank J. Hollis, Rebecca J. Scott, Dimple S. Motivaras, Ann Allen and Victoria M. Rousell
    Drug Metabolism and Disposition November 2008, 36 (11) 2337-2344; DOI: https://doi.org/10.1124/dmd.108.022137
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    The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers
    Markus R. Meyer, Frank T. Peters and Hans H. Maurer
    Drug Metabolism and Disposition November 2008, 36 (11) 2345-2354; DOI: https://doi.org/10.1124/dmd.108.021543
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    Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction
    Magang Shou, Mike Hayashi, Yvonne Pan, Yang Xu, Kari Morrissey, Lilly Xu and Gary L. Skiles
    Drug Metabolism and Disposition November 2008, 36 (11) 2355-2370; DOI: https://doi.org/10.1124/dmd.108.020602
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    Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants
    Youbin Tu, Rahul Deshmukh, Meena Sivaneri and Grazyna D. Szklarz
    Drug Metabolism and Disposition November 2008, 36 (11) 2371-2380; DOI: https://doi.org/10.1124/dmd.108.022640
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    Metabolism of Phenylahistin Enantiomers by Cytochromes P450: A Possible Explanation for Their Different Cytotoxicity
    Lionel Perrin, Caroline Aninat, Véronique Hamon, Yoshio Hayashi, Catherine Abadie, Bruno Heyd, François André and Marcel Delaforge
    Drug Metabolism and Disposition November 2008, 36 (11) 2381-2392; DOI: https://doi.org/10.1124/dmd.107.019919
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    Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist
    James M. Fujitaki, Edward E. Cable, Bruce R. Ito, Bao-Hong Zhang, Jinzhao Hou, Chun Yang, David A. Bullough, James L. Ferrero, Paul D. van Poelje, David L. Linemeyer and Mark D. Erion
    Drug Metabolism and Disposition November 2008, 36 (11) 2393-2403; DOI: https://doi.org/10.1124/dmd.108.021642
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In this issue

Drug Metabolism and Disposition: 36 (11)
Drug Metabolism and Disposition
Vol. 36, Issue 11
1 Nov 2008
  • Table of Contents
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  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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