Table of Contents

Articles

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  Identification of Stereoisomeric Metabolites of Meisoindigo in Rat Liver Microsomes by Achiral and Chiral Liquid Chromatography/Tandem Mass Spectrometry

  Meng Huang, Lin Tang Goh and Paul C. Ho

  Drug Metabolism and Disposition November 2008, 36 (11) 2171-2184; DOI: https://doi.org/10.1124/dmd.108.021956
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  Pharmacokinetics, Metabolism, and Excretion of Torcetrapib, a Cholesteryl Ester Transfer Protein Inhibitor, in Humans

  Deepak Dalvie, Weichao Chen, Chenghong Zhang, Alfin D. Vaz, Teresa A. Smolarek, Loretta M. Cox, Jian Lin and R. Scott Obach

  Drug Metabolism and Disposition November 2008, 36 (11) 2185-2198; DOI: https://doi.org/10.1124/dmd.108.023176
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  The Molecular Basis of CYP2D6-Mediated N-Dealkylation: Balance between Metabolic Clearance Routes and Enzyme Inhibition

  Britta Bonn, Collen M. Masimirembwa, Yasmin Aristei and Ismael Zamora

  Drug Metabolism and Disposition November 2008, 36 (11) 2199-2210; DOI: https://doi.org/10.1124/dmd.108.022376
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  Identification of Hydroxywarfarin Binding Site in Human UDP Glucuronosyltransferase 1A10: Phenylalanine⁹⁰ Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin

  Grover P. Miller, Cheryl F. Lichti, Agnieszka K. Zielinska, Anna Mazur, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Jeffery H. Moran and Anna Radominska-Pandya

  Drug Metabolism and Disposition November 2008, 36 (11) 2211-2218; DOI: https://doi.org/10.1124/dmd.108.022863
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  Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)

  Sonia R. Miranda, Jin Kyung Lee, Kim L. R. Brouwer, Zhiming Wen, Philip C. Smith and Roy L. Hawke

  Drug Metabolism and Disposition November 2008, 36 (11) 2219-2226; DOI: https://doi.org/10.1124/dmd.108.021790
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  Enzyme Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting Ribonucleotide Reductase

  Xiaohui Wei, Guowei Dai, Zhongfa Liu, Hao Cheng, Zhiliang Xie, Rebecca Klisovic, Guido Marcucci and Kenneth K. Chan

  Drug Metabolism and Disposition November 2008, 36 (11) 2227-2233; DOI: https://doi.org/10.1124/dmd.108.021295
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  Differential Inhibition of Cytochromes P450 3A4 and 3A5 by the Newly Synthesized Coumarin Derivatives 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether

  Chitra Sridar, Ute M. Kent, Kate Noon, Alecia McCall, Bill Alworth, Maryam Foroozesh and Paul F. Hollenberg

  Drug Metabolism and Disposition November 2008, 36 (11) 2234-2243; DOI: https://doi.org/10.1124/dmd.108.021493
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  Effects of L-Lactate and D-Mannitol on γ-Hydroxybutyrate Toxicokinetics and Toxicodynamics in Rats

  Qi Wang, Xiaodong Wang and Marilyn E. Morris

  Drug Metabolism and Disposition November 2008, 36 (11) 2244-2251; DOI: https://doi.org/10.1124/dmd.108.022996
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  l-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid

  Joseph T. Dever and Adnan A. Elfarra

  Drug Metabolism and Disposition November 2008, 36 (11) 2252-2260; DOI: https://doi.org/10.1124/dmd.108.023390
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  Oxidative in Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen β-Receptor Agonist MF101

  René Kupfer, Leah Swanson, Sylvia Chow, Richard E. Staub, Yan Ling Zhang, Isaac Cohen and Uwe Christians

  Drug Metabolism and Disposition November 2008, 36 (11) 2261-2269; DOI: https://doi.org/10.1124/dmd.108.021402
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  Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor

  Eugene Y. H. Yeung, Tatsuya Sueyoshi, Masahiko Negishi and Thomas K. H. Chang

  Drug Metabolism and Disposition November 2008, 36 (11) 2270-2276; DOI: https://doi.org/10.1124/dmd.108.023499
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  Modulation of Cytochrome P450 Gene Expression and Arachidonic Acid Metabolism during Isoproterenol-Induced Cardiac Hypertrophy in Rats

  Beshay N. M. Zordoky, Mona E. Aboutabl and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition November 2008, 36 (11) 2277-2286; DOI: https://doi.org/10.1124/dmd.108.023077
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  Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone

  Mitsue Miyazaki, Katsunori Nakamura, Yukiyoshi Fujita, F. Peter Guengerich, Ryuya Horiuchi and Koujirou Yamamoto

  Drug Metabolism and Disposition November 2008, 36 (11) 2287-2291; DOI: https://doi.org/10.1124/dmd.108.021816
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  Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate

  Jiang-Wei Zhang, Yong Liu, Jiu-Yang Zhao, Li-Ming Wang, Guang-Bo Ge, Yang Gao, Wei Li, Hong-Tao Liu, Hui-Xin Liu, Yan-Yan Zhang, Jie Sun and Ling Yang

  Drug Metabolism and Disposition November 2008, 36 (11) 2292-2298; DOI: https://doi.org/10.1124/dmd.108.022525
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  Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer

  Sachiko Yokoo, Satohiro Masuda, Atsushi Yonezawa, Tomohiro Terada, Toshiya Katsura and Ken-ichi Inui

  Drug Metabolism and Disposition November 2008, 36 (11) 2299-2306; DOI: https://doi.org/10.1124/dmd.108.023168
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  The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of β-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases

  Katriina Itäaho, Peter I. Mackenzie, Shin-ichi Ikushiro, John O. Miners and Moshe Finel

  Drug Metabolism and Disposition November 2008, 36 (11) 2307-2315; DOI: https://doi.org/10.1124/dmd.108.022731
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  Characterization of CYP2A13^*2, a Variant Cytochrome P450 Allele Previously Found to Be Associated with Decreased Incidences of Lung Adenocarcinoma in Smokers

  Jaime D'Agostino, Xiuling Zhang, Hong Wu, Guoyu Ling, Suping Wang, Qing-Yu Zhang, Fucai Liu and Xinxin Ding

  Drug Metabolism and Disposition November 2008, 36 (11) 2316-2323; DOI: https://doi.org/10.1124/dmd.108.022822
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  Intravenous Formulation of N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for Inhibition of Rat Brain 20-Hydroxyeicosatetraenoic Acid Formation

  Ying Mu, Megan M. Klamerus, Tricia M. Miller, Lisa C. Rohan, Steven H. Graham and Samuel M. Poloyac

  Drug Metabolism and Disposition November 2008, 36 (11) 2324-2330; DOI: https://doi.org/10.1124/dmd.108.023150
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  The Expression of Most UDP-Glucuronosyltransferases (UGTs) Is Increased Significantly during Caco-2 Cell Differentiation, whereas UGT1A6 Is Highly Expressed Also in Undifferentiated Cells

  Sanna Siissalo, Hongbo Zhang, Eric Stilgenbauer, Ann Marie Kaukonen, Jouni Hirvonen and Moshe Finel

  Drug Metabolism and Disposition November 2008, 36 (11) 2331-2336; DOI: https://doi.org/10.1124/dmd.108.022335
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  Metabolism and Disposition of Fluticasone Furoate, an Enhanced-Affinity Glucocorticoid, in Humans

  Stephen C. Hughes, Peter C. Shardlow, Frank J. Hollis, Rebecca J. Scott, Dimple S. Motivaras, Ann Allen and Victoria M. Rousell

  Drug Metabolism and Disposition November 2008, 36 (11) 2337-2344; DOI: https://doi.org/10.1124/dmd.108.022137
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  The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers

  Markus R. Meyer, Frank T. Peters and Hans H. Maurer

  Drug Metabolism and Disposition November 2008, 36 (11) 2345-2354; DOI: https://doi.org/10.1124/dmd.108.021543
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  Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

  Magang Shou, Mike Hayashi, Yvonne Pan, Yang Xu, Kari Morrissey, Lilly Xu and Gary L. Skiles

  Drug Metabolism and Disposition November 2008, 36 (11) 2355-2370; DOI: https://doi.org/10.1124/dmd.108.020602
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  Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants

  Youbin Tu, Rahul Deshmukh, Meena Sivaneri and Grazyna D. Szklarz

  Drug Metabolism and Disposition November 2008, 36 (11) 2371-2380; DOI: https://doi.org/10.1124/dmd.108.022640
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  Metabolism of Phenylahistin Enantiomers by Cytochromes P450: A Possible Explanation for Their Different Cytotoxicity

  Lionel Perrin, Caroline Aninat, Véronique Hamon, Yoshio Hayashi, Catherine Abadie, Bruno Heyd, François André and Marcel Delaforge

  Drug Metabolism and Disposition November 2008, 36 (11) 2381-2392; DOI: https://doi.org/10.1124/dmd.107.019919
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  Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist

  James M. Fujitaki, Edward E. Cable, Bruce R. Ito, Bao-Hong Zhang, Jinzhao Hou, Chun Yang, David A. Bullough, James L. Ferrero, Paul D. van Poelje, David L. Linemeyer and Mark D. Erion

  Drug Metabolism and Disposition November 2008, 36 (11) 2393-2403; DOI: https://doi.org/10.1124/dmd.108.021642