Drug Metabolism and Disposition: 36 (11)

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About the cover: Simulated relationship of predicted DDIs as a function of in vivo free concentration of inducer ([Ind]_max,ss) and fraction of drug cleared by CYP3A4 (f_{m, CYP3A4}). See article by Shou et al. on page 2355 of this issue.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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