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Drug Metabolism & Disposition

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Table of Contents

December 01, 2008; Volume 36,Issue 12

Short Communications

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    Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
    Z. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-Hodjegan
    Drug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
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    The Combination of Chemical and Antibody Inhibitors for Superior P450 3A Inhibition in Reaction Phenotyping Studies
    Dan A. Rock, Robert S. Foti and Josh T. Pearson
    Drug Metabolism and Disposition December 2008, 36 (12) 2410-2413; DOI: https://doi.org/10.1124/dmd.108.023572
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    Structural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver Microsomes
    Shuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang Shou
    Drug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
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    Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53
    L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. Tavtigian
    Drug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
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    Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites
    Joseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin Park
    Drug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246

Articles

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    CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver
    Tae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru Ohta
    Drug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
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    Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model
    Agnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph Funk
    Drug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
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    Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat
    David F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. Hein
    Drug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
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    Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat
    David W. Hein, Jean Bendaly, Jason R. Neale and Mark A. Doll
    Drug Metabolism and Disposition December 2008, 36 (12) 2452-2459; DOI: https://doi.org/10.1124/dmd.108.023960
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    Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)
    Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro Hiratsuka
    Drug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
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    Purification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney Microsomes
    Rachel M. Novick and Adnan A. Elfarra
    Drug Metabolism and Disposition December 2008, 36 (12) 2468-2474; DOI: https://doi.org/10.1124/dmd.108.021436
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    Metabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus Monkey
    Benjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong Shu
    Drug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
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    An Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy Subjects
    Albena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. Nichols
    Drug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
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    Involvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the Rat
    Eric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao Han
    Drug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
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    Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver
    Trine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. Okey
    Drug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
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    A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4
    Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. Gonzalez
    Drug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
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    Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro
    Shu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David Rodrigues
    Drug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
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    Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in Rats
    Gerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix Waldmeier
    Drug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
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    2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) Revisited: Comparative Cytochrome P450 Inhibition in Human Liver Microsomes by SKF525A, Its Metabolites, and SKF-Acid and SKF-Alcohol
    Michael R. Franklin and Laura B. Hathaway
    Drug Metabolism and Disposition December 2008, 36 (12) 2539-2546; DOI: https://doi.org/10.1124/dmd.108.023549
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    Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes
    Wei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael Murray
    Drug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
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    Activation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)
    Patricia Monteiro, David Gilot, Sophie Langouet and Olivier Fardel
    Drug Metabolism and Disposition December 2008, 36 (12) 2556-2563; DOI: https://doi.org/10.1124/dmd.108.023333
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    Lacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in Rats
    Kan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. Christopher
    Drug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
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    Structural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
    Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. Deeley
    Drug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
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    Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes
    Natasha M. DeVore, Brian D. Smith, Michael J. Urban and Emily E. Scott
    Drug Metabolism and Disposition December 2008, 36 (12) 2582-2590; DOI: https://doi.org/10.1124/dmd.108.023770
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    N-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into Milk
    Lipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamara
    Drug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
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Drug Metabolism and Disposition: 36 (12)
Drug Metabolism and Disposition
Vol. 36, Issue 12
1 Dec 2008
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