Drug Metabolism and Disposition: 36 (12)

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About the cover: Comparison of the active sites of CYP2A6 (purple, PDB IZ10, molecule B), CYP2A6 I208S/I300F/G301A/G369S with phenacetin (green, molecule A), and CYP2A13 (orange, PDB 2P85, molecule A). See article by DeVore et al. on page 2582.

In this issue

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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