Index by author
December 01, 2008; Volume 36,Issue 12
B
Barker, David F.
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
Barter, Z. E.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
Bendaly, Jean
- You have accessSystemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic RatDavid W. Hein, Jean Bendaly, Jason R. Neale and Mark A. DollDrug Metabolism and Disposition December 2008, 36 (12) 2452-2459; DOI: https://doi.org/10.1124/dmd.108.023960
Bhide, Rajeev S.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Boernsen, K.-Olaf
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Boutros, Paul C.
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
Bruin, Gerard J. M.
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Brun, Marie-Elise
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Burczynski, Michael E.
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
C
Celius, Trine
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
Chang, Shu-Ying
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Cheung, Connie
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Chowdry, J. E.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
Christopher, Lisa J.
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
Clarke, Stephen E.
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Cole, Susan P. C.
- You have accessStructural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. DeeleyDrug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
Connolly, Sandra M.
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Cui, Donghui
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
D
D'Esposito, Fabrizio
- You have accessInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesWei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael MurrayDrug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
Davis, Charles B.
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Dawson, Paul A.
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Deeley, Roger G.
- You have accessStructural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. DeeleyDrug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
DeGorter, Marianne K.
- You have accessStructural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. DeeleyDrug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
DeVore, Natasha M.
- You have accessKey Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A EnzymesNatasha M. DeVore, Brian D. Smith, Michael J. Urban and Emily E. ScottDrug Metabolism and Disposition December 2008, 36 (12) 2582-2590; DOI: https://doi.org/10.1124/dmd.108.023770
Doll, Mark A.
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
- You have accessSystemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic RatDavid W. Hein, Jean Bendaly, Jason R. Neale and Mark A. DollDrug Metabolism and Disposition December 2008, 36 (12) 2452-2459; DOI: https://doi.org/10.1124/dmd.108.023960
Dumontet, C.
- You have accessDifferential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. TavtigianDrug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
E
Edwards, Robert J.
- You have accessInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesWei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael MurrayDrug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
Elfarra, Adnan A.
- You have accessPurification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney MicrosomesRachel M. Novick and Adnan A. ElfarraDrug Metabolism and Disposition December 2008, 36 (12) 2468-2474; DOI: https://doi.org/10.1124/dmd.108.021436
Empey, Philip E.
- You have accessN-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into MilkLipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamaraDrug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
F
Faller, Thomas
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Fardel, Olivier
- You have accessActivation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)Patricia Monteiro, David Gilot, Sophie Langouet and Olivier FardelDrug Metabolism and Disposition December 2008, 36 (12) 2556-2563; DOI: https://doi.org/10.1124/dmd.108.023333
Fatato, Penny
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Foti, Robert S.
- You have accessThe Combination of Chemical and Antibody Inhibitors for Superior P450 3A Inhibition in Reaction Phenotyping StudiesDan A. Rock, Robert S. Foti and Josh T. PearsonDrug Metabolism and Disposition December 2008, 36 (12) 2410-2413; DOI: https://doi.org/10.1124/dmd.108.023572
Franklin, Michael R.
- You have access2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) Revisited: Comparative Cytochrome P450 Inhibition in Human Liver Microsomes by SKF525A, Its Metabolites, and SKF-Acid and SKF-AlcoholMichael R. Franklin and Laura B. HathawayDrug Metabolism and Disposition December 2008, 36 (12) 2539-2546; DOI: https://doi.org/10.1124/dmd.108.023549
Funk, Christoph
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
G
Gao, Mian
- You have accessStructural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. DeeleyDrug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
Garver, Eric
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Gilot, David
- You have accessActivation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)Patricia Monteiro, David Gilot, Sophie Langouet and Olivier FardelDrug Metabolism and Disposition December 2008, 36 (12) 2556-2563; DOI: https://doi.org/10.1124/dmd.108.023333
Gonzalez, Frank J.
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Goswami, Mamta
- You have accessN-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into MilkLipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamaraDrug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
Grant, Caroline E.
- You have accessStructural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole and Roger G. DeeleyDrug Metabolism and Disposition December 2008, 36 (12) 2571-2581; DOI: https://doi.org/10.1124/dmd.108.022491
Grimm, Hans-Peter
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Guico-Pabia, Christine
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
H
Han, Chao
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Harlow, J. R.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
Harper, Patricia A.
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
Hathaway, Laura B.
- You have access2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) Revisited: Comparative Cytochrome P450 Inhibition in Human Liver Microsomes by SKF525A, Its Metabolites, and SKF-Acid and SKF-AlcoholMichael R. Franklin and Laura B. HathawayDrug Metabolism and Disposition December 2008, 36 (12) 2539-2546; DOI: https://doi.org/10.1124/dmd.108.023549
He, Kan
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
Hein, David W.
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
- You have accessSystemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic RatDavid W. Hein, Jean Bendaly, Jason R. Neale and Mark A. DollDrug Metabolism and Disposition December 2008, 36 (12) 2452-2459; DOI: https://doi.org/10.1124/dmd.108.023960
Hiratsuka, Masahiro
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Hollis, Frank J.
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Horie, Toru
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
Hugger, Erin D.
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Humphreys, William G.
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
I
Idle, Jeffrey R.
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Inoue, Tae
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
Ishikawa, Masaaki
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Isler, Jennifer A.
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Iyer, Ramaswamy A.
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
J
Jiang, Qin
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Johnson, Benjamin M.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Jordheim, L. P.
- You have accessDifferential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. TavtigianDrug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
K
Kamath, Amrita V.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Kansy, Manfred
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Kitamura, Shigeyuki
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
Krausz, Kristopher W.
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
L
Lago, Michael W.
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
Langouet, Sophie
- You have accessActivation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)Patricia Monteiro, David Gilot, Sophie Langouet and Olivier FardelDrug Metabolism and Disposition December 2008, 36 (12) 2556-2563; DOI: https://doi.org/10.1124/dmd.108.023333
Lavé, Thierry
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Leet, John E.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Leggas, Markos
- You have accessN-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into MilkLipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamaraDrug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
Li, Wenying
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Lipscomb, J. C.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
Liu, Xiaohong
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Lombardo, Louis J.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
M
Ma, Shuguang
- You have accessStructural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver MicrosomesShuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang ShouDrug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
Ma, Xiaochao
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Maggs, James L.
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Matthews, Jason
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
McNamara, Patrick J.
- You have accessN-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into MilkLipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamaraDrug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
Mizugaki, Michinao
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Monteiro, Patricia
- You have accessActivation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)Patricia Monteiro, David Gilot, Sophie Langouet and Olivier FardelDrug Metabolism and Disposition December 2008, 36 (12) 2556-2563; DOI: https://doi.org/10.1124/dmd.108.023333
Murray, Michael
- You have accessInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesWei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael MurrayDrug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
N
Naisbitt, Dean J.
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Neale, Jason R.
- You have accessSystemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic RatDavid W. Hein, Jean Bendaly, Jason R. Neale and Mark A. DollDrug Metabolism and Disposition December 2008, 36 (12) 2452-2459; DOI: https://doi.org/10.1124/dmd.108.023960
Nguyen-Dumont, T.
- You have accessDifferential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. TavtigianDrug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
Nichols, Alice I.
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Nick, Hanspeter
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Nitta, Kayoko
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
Novick, Rachel M.
- You have accessPurification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney MicrosomesRachel M. Novick and Adnan A. ElfarraDrug Metabolism and Disposition December 2008, 36 (12) 2468-2474; DOI: https://doi.org/10.1124/dmd.108.021436
O
Obata, Kanako
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Ohta, Shigeru
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
Okey, Allan B.
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
P
Park, B. Kevin
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Patroneva, Albena
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Paul, Jeffrey
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Pearson, Josh T.
- You have accessThe Combination of Chemical and Antibody Inhibitors for Superior P450 3A Inhibition in Reaction Phenotyping StudiesDan A. Rock, Robert S. Foti and Josh T. PearsonDrug Metabolism and Disposition December 2008, 36 (12) 2410-2413; DOI: https://doi.org/10.1124/dmd.108.023572
Pedersen, Ron
- You have accessAn Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy SubjectsAlbena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski and Alice I. NicholsDrug Metabolism and Disposition December 2008, 36 (12) 2484-2491; DOI: https://doi.org/10.1124/dmd.108.021527
Pohjanvirta, Raimo
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
Poirier, Agnès
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Portmann, Renée
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Q
Qian, Ligang
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
R
Ramzan, Iqbal
- You have accessInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesWei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael MurrayDrug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
Rao, Anuradha
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Ristagno, Elizabeth H.
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
Roblin, Steven
- You have accessAryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse LiverTrine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta and Allan B. OkeyDrug Metabolism and Disposition December 2008, 36 (12) 2499-2505; DOI: https://doi.org/10.1124/dmd.108.023457
Rock, Dan A.
- You have accessThe Combination of Chemical and Antibody Inhibitors for Superior P450 3A Inhibition in Reaction Phenotyping StudiesDan A. Rock, Robert S. Foti and Josh T. PearsonDrug Metabolism and Disposition December 2008, 36 (12) 2410-2413; DOI: https://doi.org/10.1124/dmd.108.023572
Rodrigues, A. David
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Rostami-Hodjegan, A.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
S
Sakuyama, Kanako
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Sanderson, Joseph P.
- You have accessNonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole MetabolitesJoseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt and B. Kevin ParkDrug Metabolism and Disposition December 2008, 36 (12) 2424-2428; DOI: https://doi.org/10.1124/dmd.108.021246
Sasaki, Takamitsu
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Schneider, Josef
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Schrag, Michael
- You have accessStructural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver MicrosomesShuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang ShouDrug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
Schweitzer, Alain
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Scott, Emily E.
- You have accessKey Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A EnzymesNatasha M. DeVore, Brian D. Smith, Michael J. Urban and Emily E. ScottDrug Metabolism and Disposition December 2008, 36 (12) 2582-2590; DOI: https://doi.org/10.1124/dmd.108.023770
Senner, Frank
- You have accessDesign, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro ModelAgnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph FunkDrug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Shah, Yatrik M.
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Shearn, Shawn P.
- You have accessInvolvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the RatEric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis and Chao HanDrug Metabolism and Disposition December 2008, 36 (12) 2492-2498; DOI: https://doi.org/10.1124/dmd.108.022285
Shou, Magang
- You have accessStructural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver MicrosomesShuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang ShouDrug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
Shu, Yue-Zhong
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Shyu, Wen-Chyi
- You have accessLacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in RatsKan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys and Lisa J. ChristopherDrug Metabolism and Disposition December 2008, 36 (12) 2564-2570; DOI: https://doi.org/10.1124/dmd.108.022764
Smith, Brian D.
- You have accessKey Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A EnzymesNatasha M. DeVore, Brian D. Smith, Michael J. Urban and Emily E. ScottDrug Metabolism and Disposition December 2008, 36 (12) 2582-2590; DOI: https://doi.org/10.1124/dmd.108.023770
Snawder, J. E.
- You have accessCovariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data PoolingZ. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb and A. Rostami-HodjeganDrug Metabolism and Disposition December 2008, 36 (12) 2405-2409; DOI: https://doi.org/10.1124/dmd.108.021311
States, J. Christopher
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
Subramanian, Raju
- You have accessStructural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver MicrosomesShuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang ShouDrug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
Sugihara, Kazumi
- You have accessCYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized LiverTae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura and Shigeru OhtaDrug Metabolism and Disposition December 2008, 36 (12) 2429-2433; DOI: https://doi.org/10.1124/dmd.108.022830
T
Tavtigian, S. V.
- You have accessDifferential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. TavtigianDrug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
Tejwani, Ravindra W.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Thomas, X.
- You have accessDifferential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet and S. V. TavtigianDrug Metabolism and Disposition December 2008, 36 (12) 2419-2423; DOI: https://doi.org/10.1124/dmd.108.023184
Traeger, Sarah C.
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
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Ujiie, Shuta
- You have accessFunctional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa and Masahiro HiratsukaDrug Metabolism and Disposition December 2008, 36 (12) 2460-2467; DOI: https://doi.org/10.1124/dmd.108.023242
Urban, Michael J.
- You have accessKey Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A EnzymesNatasha M. DeVore, Brian D. Smith, Michael J. Urban and Emily E. ScottDrug Metabolism and Disposition December 2008, 36 (12) 2582-2590; DOI: https://doi.org/10.1124/dmd.108.023770
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Waldmeier, Felix
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
Walraven, Jason M.
- You have accessQuantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the RatDavid F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States and David W. HeinDrug Metabolism and Disposition December 2008, 36 (12) 2445-2451; DOI: https://doi.org/10.1124/dmd.108.023564
Wang, Bei
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Wang, Lipeng
- You have accessN-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into MilkLipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey and Patrick J. McNamaraDrug Metabolism and Disposition December 2008, 36 (12) 2591-2596; DOI: https://doi.org/10.1124/dmd.108.021980
Wang, Ting
- You have accessA Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle and Frank J. GonzalezDrug Metabolism and Disposition December 2008, 36 (12) 2506-2512; DOI: https://doi.org/10.1124/dmd.108.022723
Wei, Donna D.
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
Wen, Bo
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Wiegand, Hansjörg
- You have accessPharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in RatsGerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen and Felix WaldmeierDrug Metabolism and Disposition December 2008, 36 (12) 2523-2538; DOI: https://doi.org/10.1124/dmd.108.022962
X
Xu, Yang
- You have accessStructural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver MicrosomesShuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag and Magang ShouDrug Metabolism and Disposition December 2008, 36 (12) 2414-2418; DOI: https://doi.org/10.1124/dmd.108.023085
Z
Zhang, Hongjian
- You have accessConfirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in VitroShu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen and A. David RodriguesDrug Metabolism and Disposition December 2008, 36 (12) 2513-2522; DOI: https://doi.org/10.1124/dmd.108.022970
Zhang, Wei V.
- You have accessInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesWei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan and Michael MurrayDrug Metabolism and Disposition December 2008, 36 (12) 2547-2555; DOI: https://doi.org/10.1124/dmd.108.023671
Zhang, Yueping
- You have accessMetabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyBenjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo and Yue-Zhong ShuDrug Metabolism and Disposition December 2008, 36 (12) 2475-2483; DOI: https://doi.org/10.1124/dmd.108.022624
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