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Research ArticleArticle

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

Agnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph Funk
Drug Metabolism and Disposition December 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
Agnès Poirier
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Thierry Lavé
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Renée Portmann
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Marie-Elise Brun
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Frank Senner
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Manfred Kansy
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Hans-Peter Grimm
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Christoph Funk
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Article Information

vol. 36 no. 12 2434-2444
DOI 
https://doi.org/10.1124/dmd.108.020750
PubMed 
18809732

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 1, 2008
  • Accepted September 19, 2008
  • Published online November 18, 2008.

Article Versions

  • Earlier version (September 22, 2008 - 11:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Agnès Poirier,
  2. Thierry Lavé,
  3. Renée Portmann,
  4. Marie-Elise Brun,
  5. Frank Senner,
  6. Manfred Kansy,
  7. Hans-Peter Grimm and
  8. Christoph Funk
  1. F. Hoffmann-La Roche Ltd., Non-Clinical Development, Drug Safety, Basel, Switzerland
  1. Address correspondence to:
    Dr. Christoph Funk, F. Hoffmann La Roche A.G., Non-Clinical Drug Safety, 69/154, Grenzacherstrasse 124, 4070 Basel, Switzerland. E-mail: christoph.funk{at}roche.com
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Drug Metabolism and Disposition: 36 (12)
Drug Metabolism and Disposition
Vol. 36, Issue 12
1 Dec 2008
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Research ArticleArticle

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

Agnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph Funk
Drug Metabolism and Disposition December 1, 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750

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Research ArticleArticle

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

Agnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm and Christoph Funk
Drug Metabolism and Disposition December 1, 2008, 36 (12) 2434-2444; DOI: https://doi.org/10.1124/dmd.108.020750
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