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Research ArticleArticle

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles and Kan He
Drug Metabolism and Disposition February 2008, 36 (2) 303-315; DOI: https://doi.org/10.1124/dmd.107.018416

Article Information

vol. 36 no. 2 303-315
DOI 
https://doi.org/10.1124/dmd.107.018416
PubMed 
17984286
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 21, 2007
  • Accepted October 31, 2007
  • Published online January 24, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Donglu Zhang,
  2. Nirmala Raghavan,
  3. Shiang-Yuan Chen,
  4. Haiying Zhang,
  5. Mimi Quan,
  6. Lloyd Lecureux,
  7. Laura M. Patrone,
  8. Patrick Y. S. Lam,
  9. Samuel J. Bonacorsi,
  10. Robert M. Knabb,
  11. Gary L. Skiles1 and
  12. Kan He
  1. Pharmaceutical Candidate Optimization (D.Z., N.R., H.Z., L.L., G.L.S., K.H.), Radiochemistry (S.-Y.C., S.J.B.), Discovery Chemistry (M.Q., P.Y.S.L.), Drug Safety Evaluation (L.M.P.), and Discovery Biology (R.M.K.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Dr. Donglu Zhang, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543. E-mail: donglu.zhang{at}bms.com
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Research ArticleArticle

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles and Kan He
Drug Metabolism and Disposition February 1, 2008, 36 (2) 303-315; DOI: https://doi.org/10.1124/dmd.107.018416
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