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Research ArticleArticle

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles and Kan He
Drug Metabolism and Disposition February 2008, 36 (2) 303-315; DOI: https://doi.org/10.1124/dmd.107.018416
Donglu Zhang
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Nirmala Raghavan
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Shiang-Yuan Chen
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Haiying Zhang
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Mimi Quan
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Lloyd Lecureux
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Laura M. Patrone
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Patrick Y. S. Lam
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Samuel J. Bonacorsi
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Robert M. Knabb
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Gary L. Skiles
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Kan He
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Article Information

vol. 36 no. 2 303-315
DOI 
https://doi.org/10.1124/dmd.107.018416
PubMed 
17984286

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 21, 2007
  • Accepted October 31, 2007
  • Published online January 24, 2008.

Article Versions

  • Earlier version (November 5, 2007 - 10:27).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Donglu Zhang,
  2. Nirmala Raghavan,
  3. Shiang-Yuan Chen,
  4. Haiying Zhang,
  5. Mimi Quan,
  6. Lloyd Lecureux,
  7. Laura M. Patrone,
  8. Patrick Y. S. Lam,
  9. Samuel J. Bonacorsi,
  10. Robert M. Knabb,
  11. Gary L. Skiles1 and
  12. Kan He
  1. Pharmaceutical Candidate Optimization (D.Z., N.R., H.Z., L.L., G.L.S., K.H.), Radiochemistry (S.-Y.C., S.J.B.), Discovery Chemistry (M.Q., P.Y.S.L.), Drug Safety Evaluation (L.M.P.), and Discovery Biology (R.M.K.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Dr. Donglu Zhang, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543. E-mail: donglu.zhang{at}bms.com
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Drug Metabolism and Disposition: 36 (2)
Drug Metabolism and Disposition
Vol. 36, Issue 2
1 Feb 2008
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Research ArticleArticle

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles and Kan He
Drug Metabolism and Disposition February 1, 2008, 36 (2) 303-315; DOI: https://doi.org/10.1124/dmd.107.018416

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Research ArticleArticle

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles and Kan He
Drug Metabolism and Disposition February 1, 2008, 36 (2) 303-315; DOI: https://doi.org/10.1124/dmd.107.018416
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