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Research ArticleArticle

P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier

Atsushi Ose, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Takuya Fujita, Akira Yamamoto and Yuichi Sugiyama
Drug Metabolism and Disposition February 2008, 36 (2) 427-434; DOI: https://doi.org/10.1124/dmd.107.018556
Atsushi Ose
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Hiroyuki Kusuhara
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Kenzo Yamatsugu
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Motomu Kanai
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Masakatsu Shibasaki
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Takuya Fujita
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Akira Yamamoto
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Yuichi Sugiyama
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Article Information

vol. 36 no. 2 427-434
DOI 
https://doi.org/10.1124/dmd.107.018556
PubMed 
18039806

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 27, 2007
  • Accepted November 20, 2007
  • Published online January 24, 2008.

Article Versions

  • Earlier version (November 26, 2007 - 09:00).
  • Earlier version (December 3, 2007 - 08:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Atsushi Ose,
  2. Hiroyuki Kusuhara,
  3. Kenzo Yamatsugu,
  4. Motomu Kanai,
  5. Masakatsu Shibasaki,
  6. Takuya Fujita,
  7. Akira Yamamoto and
  8. Yuichi Sugiyama
  1. The Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (A.O., H.K., K.Y., M.K., M.S., Y.S.); Ritsumeikan University, Kusatsu, Shiga, Japan (T.F.); and Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan (A.Y.)
  1. Address correspondence to:
    Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Drug Metabolism and Disposition: 36 (2)
Drug Metabolism and Disposition
Vol. 36, Issue 2
1 Feb 2008
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Research ArticleArticle

P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier

Atsushi Ose, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Takuya Fujita, Akira Yamamoto and Yuichi Sugiyama
Drug Metabolism and Disposition February 1, 2008, 36 (2) 427-434; DOI: https://doi.org/10.1124/dmd.107.018556

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Research ArticleArticle

P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier

Atsushi Ose, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Takuya Fujita, Akira Yamamoto and Yuichi Sugiyama
Drug Metabolism and Disposition February 1, 2008, 36 (2) 427-434; DOI: https://doi.org/10.1124/dmd.107.018556
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