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Drug Metabolism & Disposition

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Table of Contents

March 01, 2008; Volume 36,Issue 3

Short Communications

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    Hepatic Synthesis and Urinary Elimination of Acetaminophen Glucuronide Are Exacerbated in Bile Duct-Ligated Rats
    Silvina S. M. Villanueva, María L. Ruiz, Carolina I. Ghanem, Marcelo G. Luquita, Viviana A. Catania and Aldo D. Mottino
    Drug Metabolism and Disposition March 2008, 36 (3) 475-480; DOI: https://doi.org/10.1124/dmd.107.018127
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    In Vitro-to-in Vivo Prediction of P-glycoprotein-Based Drug Interactions at the Human and Rodent Blood-Brain Barrier
    Peng Hsiao, Tot Bui, Rodney J. Y. Ho and Jashvant D. Unadkat
    Drug Metabolism and Disposition March 2008, 36 (3) 481-484; DOI: https://doi.org/10.1124/dmd.107.018176
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    Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes
    Hye Hyun Yoo, Hye Jin Chung, Jaeick Lee, Chang-Seok Lee, Min Jung Kang and Dong-Hyun Kim
    Drug Metabolism and Disposition March 2008, 36 (3) 485-489; DOI: https://doi.org/10.1124/dmd.107.019133

Articles

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    CYP3A4-Mediated Carbamazepine (CBZ) Metabolism: Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic Profile
    Ping Kang, Mingxiang Liao, Michael R. Wester, J. Steven Leeder, Robin E. Pearce and Maria Almira Correia
    Drug Metabolism and Disposition March 2008, 36 (3) 490-499; DOI: https://doi.org/10.1124/dmd.107.016501
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    A Human Immunodeficiency Virus Protease Inhibitor Is a Novel Functional Inhibitor of Human Pregnane X Receptor
    Christine Healan-Greenberg, Jeffrey F. Waring, Dale J. Kempf, Eric A. G. Blomme, Rommel G. Tirona and Richard B. Kim
    Drug Metabolism and Disposition March 2008, 36 (3) 500-507; DOI: https://doi.org/10.1124/dmd.107.019547
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    Characterization and Comparative Studies of Zebrafish and Human Recombinant Dihydrofolate Reductases—Inhibition by Folic Acid and Polyphenols
    Tseng-Ting Kao, Kuan-Chieh Wang, Wen-Ni Chang, Chia-Ying Lin, Bing-Hung Chen, Hua-Lin Wu, Guey-Yueh Shi, Jen-Ning Tsai and Tzu-Fun Fu
    Drug Metabolism and Disposition March 2008, 36 (3) 508-516; DOI: https://doi.org/10.1124/dmd.107.019299
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    The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis
    Yan Xiong, Anne-Sisko Patana, Michael J. Miley, Agnieszka K. Zielinska, Stacie M. Bratton, Grover P. Miller, Adrian Goldman, Moshe Finel, Matt R. Redinbo and Anna Radominska-Pandya
    Drug Metabolism and Disposition March 2008, 36 (3) 517-522; DOI: https://doi.org/10.1124/dmd.107.016469
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    CYP2C19 Inhibition: The Impact of Substrate Probe Selection on in Vitro Inhibition Profiles
    Robert S. Foti and Jan L. Wahlstrom
    Drug Metabolism and Disposition March 2008, 36 (3) 523-528; DOI: https://doi.org/10.1124/dmd.107.019265
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    CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528
    Masakatsu Kotsuma, Taro Tokui, Tomoko Ishizuka-Ozeki, Tomoyo Honda, Haruo Iwabuchi, Takahiro Murai, Toshihiko Ikeda and Hideo Saji
    Drug Metabolism and Disposition March 2008, 36 (3) 529-534; DOI: https://doi.org/10.1124/dmd.107.018853
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    Drug Lipophilicity and Microsomal Protein Concentration as Determinants in the Prediction of the Fraction Unbound in Microsomal Incubations
    Michael Gertz, Peter J. Kilford, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition March 2008, 36 (3) 535-542; DOI: https://doi.org/10.1124/dmd.107.018713
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    Regulation of Aryl Hydrocarbon Receptor Expression and Function by Glucocorticoids in Mouse Hepatoma Cells
    Kirsten A. Bielefeld, Chunja Lee and David S. Riddick
    Drug Metabolism and Disposition March 2008, 36 (3) 543-551; DOI: https://doi.org/10.1124/dmd.107.019703
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    Modulation of Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) Transport Activities by Endogenous and Exogenous Glutathione-Conjugated Catechol Metabolites
    Andrew J. Slot, Dana D. Wise, Roger G. Deeley, Terrence J. Monks and Susan P. C. Cole
    Drug Metabolism and Disposition March 2008, 36 (3) 552-560; DOI: https://doi.org/10.1124/dmd.107.019661
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    Metabolism of the Trisubstituted Purine Cyclin-Dependent Kinase Inhibitor Seliciclib (R-Roscovitine) in Vitro and in Vivo
    Steven J. McClue and Iain Stuart
    Drug Metabolism and Disposition March 2008, 36 (3) 561-570; DOI: https://doi.org/10.1124/dmd.107.019232
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    Aryl-Propionamide-Derived Selective Androgen Receptor Modulators: Liquid Chromatography-Tandem Mass Spectrometry Characterization of the in Vitro Synthesized Metabolites for Doping Control Purposes
    Tiia Kuuranne, Antti Leinonen, Wilhelm Schänzer, Matthias Kamber, Risto Kostiainen and Mario Thevis
    Drug Metabolism and Disposition March 2008, 36 (3) 571-581; DOI: https://doi.org/10.1124/dmd.107.017954
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    Physical Incorporation of NADPH-Cytochrome P450 Reductase and Cytochrome P450 into Phospholipid Vesicles Using Glycocholate and Bio-Beads
    James R. Reed, Lauren M. Brignac-Huber and Wayne L. Backes
    Drug Metabolism and Disposition March 2008, 36 (3) 582-588; DOI: https://doi.org/10.1124/dmd.107.018473
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    Hepatobiliary Excretion of Silibinin in Normal and Liver Cirrhotic Rats
    Jhy-Wen Wu, Lie-Chwen Lin, Shih-Chieh Hung, Chi-Hung Lin, Chin-Wen Chi and Tung-Hu Tsai
    Drug Metabolism and Disposition March 2008, 36 (3) 589-596; DOI: https://doi.org/10.1124/dmd.107.017004
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    Down-Regulation of Hepatic Cytochrome P450 Enzymes in Rats with Trinitrobenzene Sulfonic Acid-Induced Colitis
    Yasuhiro Masubuchi, Kanako Enoki and Toshiharu Horie
    Drug Metabolism and Disposition March 2008, 36 (3) 597-603; DOI: https://doi.org/10.1124/dmd.107.018754
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    Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro
    Esther G. van de Kerkhof, Inge A. M. de Graaf, Anna-Lena B. Ungell and Geny M. M. Groothuis
    Drug Metabolism and Disposition March 2008, 36 (3) 604-613; DOI: https://doi.org/10.1124/dmd.107.018820
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    High-Affinity Binding of [3H]Cimetidine to a Heme-Containing Protein in Rat Brain
    Rebecca Stadel, Jun Yang, Julia W. Nalwalk, James G. Phillips and Lindsay B. Hough
    Drug Metabolism and Disposition March 2008, 36 (3) 614-621; DOI: https://doi.org/10.1124/dmd.107.017889

Erratum

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    CORRECTION TO “THE DEVELOPMENT OF DRUG METABOLISM RESEARCH AS EXPRESSED IN THE PUBLICATIONS OF ASPET: PART 1, 1909–1958”
    Drug Metabolism and Disposition March 2008, 36 (3) 622; DOI: https://doi.org/10.1124/dmd.36.3.622
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Drug Metabolism and Disposition: 36 (3)
Drug Metabolism and Disposition
Vol. 36, Issue 3
1 Mar 2008
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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