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Research ArticleArticle

CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528

Masakatsu Kotsuma, Taro Tokui, Tomoko Ishizuka-Ozeki, Tomoyo Honda, Haruo Iwabuchi, Takahiro Murai, Toshihiko Ikeda and Hideo Saji
Drug Metabolism and Disposition March 2008, 36 (3) 529-534; DOI: https://doi.org/10.1124/dmd.107.018853

Article Information

vol. 36 no. 3 529-534
DOI 
https://doi.org/10.1124/dmd.107.018853
PubMed 
18056254
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 17, 2007
  • Accepted November 30, 2007
  • Published online February 22, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Masakatsu Kotsuma,
  2. Taro Tokui,
  3. Tomoko Ishizuka-Ozeki,
  4. Tomoyo Honda,
  5. Haruo Iwabuchi,
  6. Takahiro Murai,
  7. Toshihiko Ikeda and
  8. Hideo Saji
  1. Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, Japan (M.K., T.T., T.I.-O., T.H., H.I., T.M., T.I.); and Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan (H.S.)
  1. Address correspondence to:
    Dr. Masakatsu Kotsuma, Daiichisankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: kotsuma.masakatsu.gu{at}daiichisankyo.co.jp
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Research ArticleArticle

CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528

Masakatsu Kotsuma, Taro Tokui, Tomoko Ishizuka-Ozeki, Tomoyo Honda, Haruo Iwabuchi, Takahiro Murai, Toshihiko Ikeda and Hideo Saji
Drug Metabolism and Disposition March 1, 2008, 36 (3) 529-534; DOI: https://doi.org/10.1124/dmd.107.018853
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