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Research ArticleArticle

Identification of the in Vitro Metabolites of 3,4-Dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; β-Lapachone) in Whole Blood

Xiu-Sheng Miao, Pengfei Song, Ronald E. Savage, Caiyun Zhong, Rui-Yang Yang, Darin Kizer, Hui Wu, Erika Volckova, Mark A. Ashwell, Jeffrey G. Supko, Xiaoying He and Thomas C. K. Chan
Drug Metabolism and Disposition April 2008, 36 (4) 641-648; DOI: https://doi.org/10.1124/dmd.107.018572

Article Information

vol. 36 no. 4 641-648
DOI 
https://doi.org/10.1124/dmd.107.018572
PubMed 
18180274
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 28, 2007
  • Accepted January 2, 2008
  • Published online March 21, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiu-Sheng Miao,
  2. Pengfei Song,
  3. Ronald E. Savage,
  4. Caiyun Zhong,
  5. Rui-Yang Yang,
  6. Darin Kizer,
  7. Hui Wu,
  8. Erika Volckova,
  9. Mark A. Ashwell,
  10. Jeffrey G. Supko,
  11. Xiaoying He and
  12. Thomas C. K. Chan
  1. Departments of Preclinical Development and Clinical Pharmacology (X.-S.M., P.S., R.E.S., C.Z., T.C.K.C.) and Chemistry (R.-Y.Y., D.K., H.W., E.V., M.A.A.), ArQule, Inc., Woburn, Massachusetts; and Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.G.S., X.H.)
  1. Address correspondence to:
    Dr. Thomas Chan, ArQule, Inc., 19 Presidential Way, Woburn, MA 01801. E-mail: tchan{at}arqule.com
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Research ArticleArticle

Identification of the in Vitro Metabolites of 3,4-Dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; β-Lapachone) in Whole Blood

Xiu-Sheng Miao, Pengfei Song, Ronald E. Savage, Caiyun Zhong, Rui-Yang Yang, Darin Kizer, Hui Wu, Erika Volckova, Mark A. Ashwell, Jeffrey G. Supko, Xiaoying He and Thomas C. K. Chan
Drug Metabolism and Disposition April 1, 2008, 36 (4) 641-648; DOI: https://doi.org/10.1124/dmd.107.018572
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