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Research ArticleArticle

Establishment of a Set of Double Transfectants Coexpressing Organic Anion Transporting Polypeptide 1B3 and Hepatic Efflux Transporters for the Characterization of the Hepatobiliary Transport of Telmisartan Acylglucuronide

Naoki Ishiguro, Kazuya Maeda, Asami Saito, Wataru Kishimoto, Soichiro Matsushima, Thomas Ebner, Willy Roth, Takashi Igarashi and Yuichi Sugiyama
Drug Metabolism and Disposition April 2008, 36 (4) 796-805; DOI: https://doi.org/10.1124/dmd.107.018903

Article Information

vol. 36 no. 4 796-805
DOI 
https://doi.org/10.1124/dmd.107.018903
PubMed 
18180273
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 19, 2007
  • Accepted January 2, 2008
  • Published online March 21, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Naoki Ishiguro,
  2. Kazuya Maeda,
  3. Asami Saito,
  4. Wataru Kishimoto,
  5. Soichiro Matsushima,
  6. Thomas Ebner,
  7. Willy Roth,
  8. Takashi Igarashi and
  9. Yuichi Sugiyama
  1. Department of Pharmacokinetics and Non-Clinical Safety, Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Yato, Kawanishi, Hyogo, Japan (N.I., A.S., W.K., T.I.); Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan (K.M., S.M., Y.S.); and Department of Pharmacokinetics and Drug Metabolism, Boehringer Ingelheim Pharma KG, Biberach on der Riss, Germany (T.E., W.R.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleArticle

Establishment of a Set of Double Transfectants Coexpressing Organic Anion Transporting Polypeptide 1B3 and Hepatic Efflux Transporters for the Characterization of the Hepatobiliary Transport of Telmisartan Acylglucuronide

Naoki Ishiguro, Kazuya Maeda, Asami Saito, Wataru Kishimoto, Soichiro Matsushima, Thomas Ebner, Willy Roth, Takashi Igarashi and Yuichi Sugiyama
Drug Metabolism and Disposition April 1, 2008, 36 (4) 796-805; DOI: https://doi.org/10.1124/dmd.107.018903
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