Table of Contents

Articles

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  Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

  Hideo Takakusa, Hiroshi Masumoto, Ayako Mitsuru, Osamu Okazaki and Kenichi Sudo

  Drug Metabolism and Disposition May 2008, 36 (5) 816-823; DOI: https://doi.org/10.1124/dmd.107.018002
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  Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10

  Gang Chen, Ryan W. Dellinger, Dongxiao Sun, Thomas E. Spratt and Philip Lazarus

  Drug Metabolism and Disposition May 2008, 36 (5) 824-830; DOI: https://doi.org/10.1124/dmd.107.019406
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  Biotransformation of 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a Novel 5-Hydroxytryptamine (5-HT)_1A Agonist/5-HT₃ Antagonist, in Human Hepatic Cytochrome P450 Enzymes

  Kouichi Minato, Ryota Suzuki, Akira Asagarasu, Teruaki Matsui and Michitaka Sato

  Drug Metabolism and Disposition May 2008, 36 (5) 831-840; DOI: https://doi.org/10.1124/dmd.107.018168
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  Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

  Bo Wen, Li Ma, A. David Rodrigues and Mingshe Zhu

  Drug Metabolism and Disposition May 2008, 36 (5) 841-850; DOI: https://doi.org/10.1124/dmd.107.019471
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  Contribution of the N-Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans

  Sylvie Klieber, Sébastien Hugla, Robert Ngo, Catherine Arabeyre-Fabre, Viviane Meunier, Freddy Sadoun, Olivier Fedeli, Martine Rival, Martine Bourrie, François Guillou, Patrick Maurel and Gérard Fabre

  Drug Metabolism and Disposition May 2008, 36 (5) 851-862; DOI: https://doi.org/10.1124/dmd.107.019539
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  Differential Roles of P-Glycoprotein, Multidrug Resistance-Associated Protein 2, and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats

  Helen H. Usansky, Peidi Hu and Patrick J. Sinko

  Drug Metabolism and Disposition May 2008, 36 (5) 863-869; DOI: https://doi.org/10.1124/dmd.107.017483
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  The “Albumin Effect” and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

  Andrew Rowland, David J. Elliot, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners

  Drug Metabolism and Disposition May 2008, 36 (5) 870-877; DOI: https://doi.org/10.1124/dmd.107.019885
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  Synergism of Glucocorticoid Hormone with Growth Hormone for Female-Specific Mouse Cyp3a44 Gene Expression

  Tsutomu Sakuma, Wattanaporn Bhadhprasit, Tadahiro Hashita and Nobuo Nemoto

  Drug Metabolism and Disposition May 2008, 36 (5) 878-884; DOI: https://doi.org/10.1124/dmd.107.019935
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  Effect of Breed upon Cytochromes P450 and Phase II Enzyme Expression in Cattle Liver

  Mery Giantin, Monica Carletti, Francesca Capolongo, Sara Pegolo, Rosa Maria Lopparelli, Federica Gusson, Carlo Nebbia, Michela Cantiello, Pascal Martin, Thierry Pineau and Mauro Dacasto

  Drug Metabolism and Disposition May 2008, 36 (5) 885-893; DOI: https://doi.org/10.1124/dmd.107.019042
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  In Vitro Metabolism of 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] Acetic Acid (Licofelone, ML3000), an Inhibitor of Cyclooxygenase-1 and -2 and 5-Lipoxygenase

  Wolfgang Albrecht, Anke Unger, Andreas K. Nussler and Stefan Laufer

  Drug Metabolism and Disposition May 2008, 36 (5) 894-903; DOI: https://doi.org/10.1124/dmd.108.020347
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  Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin

  Onkar S. Bains, Ryan H. Takahashi, Tom A. Pfeifer, Thomas A. Grigliatti, Ronald E. Reid and K. Wayne Riggs

  Drug Metabolism and Disposition May 2008, 36 (5) 904-910; DOI: https://doi.org/10.1124/dmd.107.018895
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  Impact of Basolateral Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 on the Hepatobiliary Disposition of Fexofenadine in Perfused Mouse Livers

  Xianbin Tian, Brandon Swift, Maciej J. Zamek-Gliszczynski, Martin G. Belinsky, Gary D. Kruh and Kim L. R. Brouwer

  Drug Metabolism and Disposition May 2008, 36 (5) 911-915; DOI: https://doi.org/10.1124/dmd.107.019273
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  Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo

  Yoshiyuki Shirasaka, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma and Shinji Yamashita

  Drug Metabolism and Disposition May 2008, 36 (5) 916-922; DOI: https://doi.org/10.1124/dmd.107.020040
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  Unique Transcription Start Sites and Distinct Promoter Regions Differentiate the Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2

  Leslie M. Tompkins, Tim L. Sit and Andrew D. Wallace

  Drug Metabolism and Disposition May 2008, 36 (5) 923-929; DOI: https://doi.org/10.1124/dmd.107.018317
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  Slipping Past UGT1A1 and Multidrug Resistance-Associated Protein 2 in the Liver: Effects of Steric Compression and Hydrogen Bonding on the Hepatobiliary Elimination of Synthetic Bilirubins

  Antony F. McDonagh, Stefan E. Boiadjiev and David A. Lightner

  Drug Metabolism and Disposition May 2008, 36 (5) 930-936; DOI: https://doi.org/10.1124/dmd.107.019778
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  Role of Haptoglobin on the Uptake of Native and β-Chain [Trimesoyl-(Lys82)β-(Lys82)β] Cross-Linked Human Hemoglobins in Isolated Perfused Rat Livers

  Edwin C. Y. Chow, Lichuan Liu, Noam Ship, Ronald H. Kluger and K. Sandy Pang

  Drug Metabolism and Disposition May 2008, 36 (5) 937-945; DOI: https://doi.org/10.1124/dmd.107.019174
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  Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells

  Rucha S. Sane, Donna J. Buckley, Arthur R. Buckley, Srikanth C. Nallani and Pankaj B. Desai

  Drug Metabolism and Disposition May 2008, 36 (5) 946-954; DOI: https://doi.org/10.1124/dmd.107.018598
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  Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression

  Susanne Löfgren, R. Michael Baldwin, Masahiro Hiratsuka, Annelie Lindqvist, Anne Carlberg, Sarah C. Sim, Meint Schülke, Michael Snait, Anne Edenro, Ronny Fransson-Steen, Ylva Terelius and Magnus Ingelman-Sundberg

  Drug Metabolism and Disposition May 2008, 36 (5) 955-962; DOI: https://doi.org/10.1124/dmd.107.019349
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  CYP1B1 Is Not a Major Determinant of the Disposition of Aromatase Inhibitors in Epithelial Cells of Invasive Ductal Carcinoma

  Mostafizur Rahman, Sigurd F. Lax, Carrie H. Sutter, Quynh T. Tran, Gaylene L. Stevens, Gary L. Emmert, Jose Russo, Richard J. Santen and Thomas R. Sutter

  Drug Metabolism and Disposition May 2008, 36 (5) 963-970; DOI: https://doi.org/10.1124/dmd.107.018960
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  Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes

  Elke Dopp, Ursula von Recklinghausen, Louise M. Hartmann, Inga Stueckradt, Ilona Pollok, Sasan Rabieh, Liping Hao, Andreas Nussler, Cindy Katier, Alfred V. Hirner and Albert W. Rettenmeier

  Drug Metabolism and Disposition May 2008, 36 (5) 971-979; DOI: https://doi.org/10.1124/dmd.107.019034